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Q9D658

- TP4A3_MOUSE

UniProt

Q9D658 - TP4A3_MOUSE

Protein

Protein tyrosine phosphatase type IVA 3

Gene

Ptp4a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Enzyme regulationi

    Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721Proton donorBy similarity
    Active sitei104 – 1041Phosphocysteine intermediateBy similarity
    Binding sitei110 – 1101SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase type IVA 3 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4a3
    Protein-tyrosine phosphatase of regenerating liver 3
    Short name:
    PRL-3
    Gene namesi
    Name:Ptp4a3
    Synonyms:Prl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1277098. Ptp4a3.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi72 – 721D → A: Loss of enzymatic activity; reduced migration-promoting activity. 1 Publication
    Mutagenesisi104 – 1041C → S: Loss of enzymatic activity; reduced migration-promoting activity. 1 Publication

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Protein tyrosine phosphatase type IVA 3PRO_0000094789Add
    BLAST
    Propeptidei171 – 1733Removed in mature formBy similarityPRO_0000396655

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 104By similarity
    Modified residuei170 – 1701Cysteine methyl esterBy similarity
    Lipidationi170 – 1701S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiQ9D658.
    PRIDEiQ9D658.

    PTM databases

    PhosphoSiteiQ9D658.

    Expressioni

    Tissue specificityi

    Present in the small intestine, where it is located in the differentiated epithelial cells of the villus but not in the proliferating crypt cells (at protein level). Expressed in heart and skeletal muscle, and at lower levels in lung, spleen and testis.2 Publications

    Inductioni

    Down-regulated upon skeletal muscle denervation.1 Publication

    Gene expression databases

    ArrayExpressiQ9D658.
    BgeeiQ9D658.
    CleanExiMM_PTP4A3.
    GenevestigatoriQ9D658.

    Interactioni

    Subunit structurei

    Interacts with tubulin.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000060956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D658.
    SMRiQ9D658. Positions 1-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14867Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00390000009788.
    HOGENOMiHOG000231265.
    HOVERGENiHBG071295.
    InParanoidiQ9D658.
    KOiK18041.
    OMAiKAKFCDD.
    PhylomeDBiQ9D658.
    TreeFamiTF313384.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D658-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARMNRPAPV EVSYRHMRFL ITHNPSNATL STFIEDLKKY GATTVVRVCE    50
    VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLLKA KFYNDPGSCV 100
    AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE 150
    KYRPKQRLRF KDPHTHKTRC CVM 173
    Length:173
    Mass (Da):19,652
    Last modified:June 1, 2001 - v1
    Checksum:i262718AA2040F126
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti101 – 1011A → L(PubMed:9514946)Curated
    Sequence conflicti101 – 1011A → L(PubMed:15161639)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035645 mRNA. Translation: AAC15875.1.
    AK003954 mRNA. Translation: BAB23091.1.
    AK014601 mRNA. Translation: BAB29456.1.
    AK143702 mRNA. Translation: BAE25506.1.
    AK172192 mRNA. Translation: BAE42875.1.
    BC027445 mRNA. Translation: AAH27445.1.
    BC066043 mRNA. Translation: AAH66043.1.
    CCDSiCCDS27519.1.
    PIRiJC5982.
    RefSeqiNP_001159860.1. NM_001166388.1.
    NP_001159861.1. NM_001166389.1.
    NP_001159862.1. NM_001166390.1.
    NP_033001.2. NM_008975.3.
    XP_006520703.1. XM_006520640.1.
    XP_006520704.1. XM_006520641.1.
    XP_006520705.1. XM_006520642.1.
    UniGeneiMm.390807.

    Genome annotation databases

    EnsembliENSMUST00000053232; ENSMUSP00000060956; ENSMUSG00000059895.
    ENSMUST00000163582; ENSMUSP00000131281; ENSMUSG00000059895.
    ENSMUST00000165541; ENSMUSP00000132097; ENSMUSG00000059895.
    GeneIDi19245.
    KEGGimmu:19245.
    UCSCiuc007wcj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF035645 mRNA. Translation: AAC15875.1 .
    AK003954 mRNA. Translation: BAB23091.1 .
    AK014601 mRNA. Translation: BAB29456.1 .
    AK143702 mRNA. Translation: BAE25506.1 .
    AK172192 mRNA. Translation: BAE42875.1 .
    BC027445 mRNA. Translation: AAH27445.1 .
    BC066043 mRNA. Translation: AAH66043.1 .
    CCDSi CCDS27519.1.
    PIRi JC5982.
    RefSeqi NP_001159860.1. NM_001166388.1.
    NP_001159861.1. NM_001166389.1.
    NP_001159862.1. NM_001166390.1.
    NP_033001.2. NM_008975.3.
    XP_006520703.1. XM_006520640.1.
    XP_006520704.1. XM_006520641.1.
    XP_006520705.1. XM_006520642.1.
    UniGenei Mm.390807.

    3D structure databases

    ProteinModelPortali Q9D658.
    SMRi Q9D658. Positions 1-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000060956.

    PTM databases

    PhosphoSitei Q9D658.

    Proteomic databases

    PaxDbi Q9D658.
    PRIDEi Q9D658.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053232 ; ENSMUSP00000060956 ; ENSMUSG00000059895 .
    ENSMUST00000163582 ; ENSMUSP00000131281 ; ENSMUSG00000059895 .
    ENSMUST00000165541 ; ENSMUSP00000132097 ; ENSMUSG00000059895 .
    GeneIDi 19245.
    KEGGi mmu:19245.
    UCSCi uc007wcj.1. mouse.

    Organism-specific databases

    CTDi 11156.
    MGIi MGI:1277098. Ptp4a3.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00390000009788.
    HOGENOMi HOG000231265.
    HOVERGENi HBG071295.
    InParanoidi Q9D658.
    KOi K18041.
    OMAi KAKFCDD.
    PhylomeDBi Q9D658.
    TreeFami TF313384.

    Miscellaneous databases

    NextBioi 296066.
    PROi Q9D658.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D658.
    Bgeei Q9D658.
    CleanExi MM_PTP4A3.
    Genevestigatori Q9D658.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1."
      Zeng Q., Hong W., Tan Y.H.
      Biochem. Biophys. Res. Commun. 244:421-427(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells."
      Wu X., Zeng H., Zhang X., Zhao Y., Sha H., Ge X., Zhang M., Gao X., Xu Q.
      Am. J. Pathol. 164:2039-2054(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, ENZYME REGULATION, MUTAGENESIS OF ASP-72 AND CYS-104, FUNCTION.
      Strain: C57BL/6.
      Tissue: Heart.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Skin and Spleen.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain and Eye.
    5. "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome."
      Zeng Q., Si X., Horstmann H., Xu Y., Hong W., Pallen C.J.
      J. Biol. Chem. 275:21444-21452(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: ISOPRENYLATION AT CYS-170, SUBCELLULAR LOCATION.
    6. "Denervation-induced alterations in gene expression in mouse skeletal muscle."
      Magnusson C., Svensson A., Christerson U., Taagerud S.
      Eur. J. Neurosci. 21:577-580(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiTP4A3_MOUSE
    AccessioniPrimary (citable) accession number: Q9D658
    Secondary accession number(s): O70275, Q3T9Z5, Q9CTC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3