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Protein

Keratin, type I cuticular Ha4

Gene

Krt34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei275Stutter1

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha4By similarity
Alternative name(s):
Hair keratin, type I Ha4
Keratin-34By similarityImported
Short name:
K34
Gene namesi
Name:Krt34Imported
Synonyms:Ha41 Publication, Krt1-4Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1309994. Krt34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003610231 – 392Keratin, type I cuticular Ha4Add BLAST392

Proteomic databases

PaxDbiQ9D646.
PeptideAtlasiQ9D646.
PRIDEiQ9D646.

PTM databases

PhosphoSitePlusiQ9D646.

Expressioni

Tissue specificityi

Expressed in the hair root in the hair shaft cuticle and cortex.1 Publication

Gene expression databases

BgeeiENSMUSG00000043485.
GenevisibleiQ9D646. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-303N.
STRINGi10090.ENSMUSP00000056622.

Structurei

3D structure databases

ProteinModelPortaliQ9D646.
SMRiQ9D646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 392TailAdd BLAST29

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9D646.
KOiK07604.
OMAiTITPCIS.
OrthoDBiEOG091G087I.
PhylomeDBiQ9D646.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D646-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCESCLPAL SCRTSCSSRP CVPPSCHGCT LPGACNIPAN VGNCNWFCEG
60 70 80 90 100
SFNGNEKETM QFLNDRLASY MEKVRQLERE NAELECRIQE RNQQQDPLVC
110 120 130 140 150
PAYQAYFRTI EELQQKILCA KSENARLVVQ IDNAKLASDD FRTKYQTELS
160 170 180 190 200
MRQLVEADIN SLRRILDELT LCKSDLEAQV ESLREELLCL KKNHEEEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRC QYEALVETNR REVEEWFTTQ
260 270 280 290 300
SEELNKQVVS SSEQLQSCQA EIIELRRTVN ALEIELQAQH CMRNSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQCLITN VESQLGEIRA DLERQNQEYQ VLLDVRARLE
360 370 380 390
CEINTYRSLL ESEDCNLPCN PCATTNASGS CCGPCGSSKR CC
Length:392
Mass (Da):44,560
Last modified:June 1, 2001 - v1
Checksum:iF466835182AFFB32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014631 mRNA. Translation: BAB29474.1.
AL592545 Genomic DNA. Translation: CAM22480.1.
CH466662 Genomic DNA. Translation: EDL02589.1.
BC125420 mRNA. Translation: AAI25421.1.
BC125446 mRNA. Translation: AAI25447.1.
CCDSiCCDS25404.1.
PIRiA60777.
RefSeqiNP_081839.1. NM_027563.4.
UniGeneiMm.289644.

Genome annotation databases

EnsembliENSMUST00000056362; ENSMUSP00000056622; ENSMUSG00000043485.
GeneIDi16672.
KEGGimmu:16672.
UCSCiuc007lkc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014631 mRNA. Translation: BAB29474.1.
AL592545 Genomic DNA. Translation: CAM22480.1.
CH466662 Genomic DNA. Translation: EDL02589.1.
BC125420 mRNA. Translation: AAI25421.1.
BC125446 mRNA. Translation: AAI25447.1.
CCDSiCCDS25404.1.
PIRiA60777.
RefSeqiNP_081839.1. NM_027563.4.
UniGeneiMm.289644.

3D structure databases

ProteinModelPortaliQ9D646.
SMRiQ9D646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-303N.
STRINGi10090.ENSMUSP00000056622.

PTM databases

PhosphoSitePlusiQ9D646.

Proteomic databases

PaxDbiQ9D646.
PeptideAtlasiQ9D646.
PRIDEiQ9D646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056362; ENSMUSP00000056622; ENSMUSG00000043485.
GeneIDi16672.
KEGGimmu:16672.
UCSCiuc007lkc.1. mouse.

Organism-specific databases

CTDi3885.
MGIiMGI:1309994. Krt34.

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ9D646.
KOiK07604.
OMAiTITPCIS.
OrthoDBiEOG091G087I.
PhylomeDBiQ9D646.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ9D646.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043485.
GenevisibleiQ9D646. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT34_MOUSE
AccessioniPrimary (citable) accession number: Q9D646
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.