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Protein

Keratin-associated protein 3-2

Gene

Krtap3-2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).By similarity

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin-associated protein 3-2Imported
Alternative name(s):
Keratin-associated protein 3-3
Gene namesi
Name:Krtap3-2Imported
Synonyms:Krtap3-3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1913958. Krtap3-2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003585952 – 99Keratin-associated protein 3-2Add BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9D638.
PRIDEiQ9D638.

PTM databases

PhosphoSitePlusiQ9D638.

Expressioni

Gene expression databases

BgeeiENSMUSG00000069721.
CleanExiMM_KRTAP3-3.
GenevisibleiQ9D638. MM.

Interactioni

Subunit structurei

Interacts with hair keratins.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000090374.

Structurei

3D structure databases

ProteinModelPortaliQ9D638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 71Sequence analysis5
Repeati8 – 122Sequence analysis5
Repeati47 – 513Sequence analysis5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 593 X 5 AA repeats of C-C-X(3)Sequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the KRTAP type 3 family.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4726. Eukaryota.
ENOG410XY8D. LUCA.
GeneTreeiENSGT00390000001157.
HOGENOMiHOG000230984.
HOVERGENiHBG108073.
InParanoidiQ9D638.
OMAiPCIPRNC.
OrthoDBiEOG091G0Z0W.
PhylomeDBiQ9D638.
TreeFamiTF338042.

Family and domain databases

InterProiView protein in InterPro
IPR007659. Keratin_matx.
PANTHERiPTHR23260. PTHR23260. 1 hit.
PfamiView protein in Pfam
PF04579. Keratin_matx. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010562. Keratin_matx. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACCVARCCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTI WQLEPTCCDN
60 70 80 90
CPPPCHIPQP CVPTCFLLNS CHPTPDLLTV NLTTYVQPGC EEPCVPRCC
Length:99
Mass (Da):10,574
Last modified:December 16, 2008 - v2
Checksum:iF0E5542FA890302B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → A in BAB29484 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003615 mRNA. Translation: BAB22891.1.
AK009410 mRNA. Translation: BAB26270.1.
AK010142 mRNA. Translation: BAB26727.1.
AK014641 mRNA. Translation: BAB29484.1.
AL591417 Genomic DNA. Translation: CAM19193.1.
AL591417 Genomic DNA. Translation: CAM19194.1.
BC117058 mRNA. Translation: AAI17059.1.
BC117092 mRNA. Translation: AAI17093.1.
BC120760 mRNA. Translation: AAI20761.1.
BC120762 mRNA. Translation: AAI20763.1.
CCDSiCCDS25385.1.
CCDS25386.1.
RefSeqiNP_079800.1. NM_025524.2.
NP_079996.2. NM_025720.3.
UniGeneiMm.30539.
Mm.46389.

Genome annotation databases

EnsembliENSMUST00000092699; ENSMUSP00000090373; ENSMUSG00000069721.
ENSMUST00000092700; ENSMUSP00000090374; ENSMUSG00000069722.
GeneIDi66380.
66708.
KEGGimmu:66380.
mmu:66708.
UCSCiuc007liz.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiKRA32_MOUSE
AccessioniPrimary (citable) accession number: Q9D638
Secondary accession number(s): Q9CPW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: June 7, 2017
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families