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Protein

DNA replication complex GINS protein PSF2

Gene

Gins2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
GINS complex subunit 2
Gene namesi
Name:Gins2
Synonyms:Psf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921019. Gins2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185DNA replication complex GINS protein PSF2PRO_0000194814Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei180 – 1801PhosphothreonineBy similarity
Modified residuei182 – 1821PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D600.
MaxQBiQ9D600.
PaxDbiQ9D600.
PeptideAtlasiQ9D600.
PRIDEiQ9D600.

PTM databases

iPTMnetiQ9D600.
PhosphoSiteiQ9D600.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031821.
CleanExiMM_GINS2.
GenevisibleiQ9D600. MM.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9D600. 1 interaction.
MINTiMINT-6610265.
STRINGi10090.ENSMUSP00000034278.

Structurei

3D structure databases

ProteinModelPortaliQ9D600.
SMRiQ9D600. Positions 1-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS2/PSF2 family.Curated

Phylogenomic databases

eggNOGiKOG4071. Eukaryota.
COG5093. LUCA.
GeneTreeiENSGT00390000007838.
HOGENOMiHOG000246603.
HOVERGENiHBG044983.
InParanoidiQ9D600.
KOiK10733.
OMAiALDHMYK.
OrthoDBiEOG091G0NTM.
PhylomeDBiQ9D600.
TreeFamiTF314359.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR007257. GINS_Psf2.
[Graphical view]
PANTHERiPTHR12772. PTHR12772. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]
PIRSFiPIRSF028998. GINS_Psf2_subgr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D600-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVDVPLWLAI
60 70 80 90 100
NLKQRQKCRL LPPEWMDVEK LEQMRDEERK EETFTPVPSP HYMEITKLLL
110 120 130 140 150
NHASDNIPKA DTIRTLIKDL WDTRMAKLRV SADSFVRQQE AHAKLDNLTL
160 170 180
MEISSSGAFL TQALNHMYKL RTNLQPSEST QSQDF
Length:185
Mass (Da):21,236
Last modified:June 1, 2001 - v1
Checksum:i4DA756C71BD6EF1B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281L → P in BAC25914 (PubMed:16141072).Curated
Sequence conflicti148 – 1481L → M in BAC25914 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014776 mRNA. Translation: BAB29546.1.
AK028375 mRNA. Translation: BAC25914.1.
AK030758 mRNA. Translation: BAC27124.1.
BC082565 mRNA. Translation: AAH82565.1.
CCDSiCCDS40496.1.
RefSeqiNP_849187.1. NM_178856.1.
UniGeneiMm.275910.
Mm.334856.

Genome annotation databases

EnsembliENSMUST00000034278; ENSMUSP00000034278; ENSMUSG00000031821.
GeneIDi272551.
KEGGimmu:272551.
UCSCiuc009nrd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014776 mRNA. Translation: BAB29546.1.
AK028375 mRNA. Translation: BAC25914.1.
AK030758 mRNA. Translation: BAC27124.1.
BC082565 mRNA. Translation: AAH82565.1.
CCDSiCCDS40496.1.
RefSeqiNP_849187.1. NM_178856.1.
UniGeneiMm.275910.
Mm.334856.

3D structure databases

ProteinModelPortaliQ9D600.
SMRiQ9D600. Positions 1-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D600. 1 interaction.
MINTiMINT-6610265.
STRINGi10090.ENSMUSP00000034278.

PTM databases

iPTMnetiQ9D600.
PhosphoSiteiQ9D600.

Proteomic databases

EPDiQ9D600.
MaxQBiQ9D600.
PaxDbiQ9D600.
PeptideAtlasiQ9D600.
PRIDEiQ9D600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034278; ENSMUSP00000034278; ENSMUSG00000031821.
GeneIDi272551.
KEGGimmu:272551.
UCSCiuc009nrd.1. mouse.

Organism-specific databases

CTDi51659.
MGIiMGI:1921019. Gins2.

Phylogenomic databases

eggNOGiKOG4071. Eukaryota.
COG5093. LUCA.
GeneTreeiENSGT00390000007838.
HOGENOMiHOG000246603.
HOVERGENiHBG044983.
InParanoidiQ9D600.
KOiK10733.
OMAiALDHMYK.
OrthoDBiEOG091G0NTM.
PhylomeDBiQ9D600.
TreeFamiTF314359.

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Miscellaneous databases

PROiQ9D600.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031821.
CleanExiMM_GINS2.
GenevisibleiQ9D600. MM.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR007257. GINS_Psf2.
[Graphical view]
PANTHERiPTHR12772. PTHR12772. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]
PIRSFiPIRSF028998. GINS_Psf2_subgr. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSF2_MOUSE
AccessioniPrimary (citable) accession number: Q9D600
Secondary accession number(s): Q8BMT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.