Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9D600 (PSF2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
GINS complex subunit 2
Gene names
Name:Gins2
Synonyms:Psf2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length185 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA By similarity.

Subunit structure

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GINS2/PSF2 family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 185185DNA replication complex GINS protein PSF2
PRO_0000194814

Amino acid modifications

Modified residue1801Phosphothreonine Ref.3
Modified residue1821Phosphoserine Ref.3

Experimental info

Sequence conflict281L → P in BAC25914. Ref.1
Sequence conflict1481L → M in BAC25914. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D600 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 4DA756C71BD6EF1B

FASTA18521,236
        10         20         30         40         50         60 
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVDVPLWLAI NLKQRQKCRL 

        70         80         90        100        110        120 
LPPEWMDVEK LEQMRDEERK EETFTPVPSP HYMEITKLLL NHASDNIPKA DTIRTLIKDL 

       130        140        150        160        170        180 
WDTRMAKLRV SADSFVRQQE AHAKLDNLTL MEISSSGAFL TQALNHMYKL RTNLQPSEST 


QSQDF

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Eye.
[3]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-180 AND SER-182, MASS SPECTROMETRY.
Tissue: Embryonic kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK014776 mRNA. Translation: BAB29546.1.
AK028375 mRNA. Translation: BAC25914.1.
AK030758 mRNA. Translation: BAC27124.1.
BC082565 mRNA. Translation: AAH82565.1.
IPIIPI00108254.
RefSeqNP_849187.1. NM_178856.1.
UniGeneMm.275910.

3D structure databases

ProteinModelPortalQ9D600.
SMRQ9D600. Positions 1-175.
ModBaseSearch...

PTM databases

PhosphoSiteQ9D600.

Proteomic databases

PaxDbQ9D600.
PRIDEQ9D600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034278; ENSMUSP00000034278; ENSMUSG00000031821.
GeneID272551.
KEGGmmu:272551.
UCSCuc009nrd.1. mouse.

Organism-specific databases

CTD51659.
MGIMGI:1921019. Gins2.

Phylogenomic databases

eggNOGCOG5093.
GeneTreeENSGT00390000007838.
HOGENOMHOG000246603.
HOVERGENHBG044983.
InParanoidQ9D600.
KOK10733.
OMAVGPFRAG.
OrthoDBEOG4WSWBN.

Gene expression databases

ArrayExpressQ9D600.
BgeeQ9D600.
CleanExMM_GINS2.
GenevestigatorQ9D600.
GermOnlineENSMUSG00000031821. Mus musculus.

Family and domain databases

InterProIPR021151. GINS_complex.
IPR007257. GINS_Psf2.
IPR016906. GINS_Psf2_subgr.
[Graphical view]
PANTHERPTHR12772. PTHR12772. 1 hit.
PfamPF05916. Sld5. 1 hit.
[Graphical view]
PIRSFPIRSF028998. GINS_Psf2_subgr. 1 hit.
ProtoNetSearch...

Other

NextBio393602.
SOURCESearch...

Entry information

Entry namePSF2_MOUSE
AccessionPrimary (citable) accession number: Q9D600
Secondary accession number(s): Q8BMT2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents