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Protein

Synapse-associated protein 1

Gene

Syap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein 1
Gene namesi
Name:Syap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914293. Syap1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Synapse-associated protein 1PRO_0000072356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621PhosphothreonineCombined sources
Modified residuei283 – 2831PhosphoserineCombined sources
Modified residuei298 – 2981PhosphoserineCombined sources
Modified residuei327 – 3271PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D5V6.
MaxQBiQ9D5V6.
PaxDbiQ9D5V6.
PRIDEiQ9D5V6.

2D gel databases

REPRODUCTION-2DPAGEIPI00317599.

PTM databases

iPTMnetiQ9D5V6.
PhosphoSiteiQ9D5V6.

Expressioni

Gene expression databases

BgeeiQ9D5V6.
CleanExiMM_SYAP1.
GenevisibleiQ9D5V6. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-4085079.
STRINGi10090.ENSMUSP00000033723.

Structurei

3D structure databases

ProteinModelPortaliQ9D5V6.
SMRiQ9D5V6. Positions 144-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini172 – 22453BSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BSD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4310. Eukaryota.
ENOG410ZPSV. LUCA.
GeneTreeiENSGT00390000007662.
HOGENOMiHOG000231677.
HOVERGENiHBG057553.
InParanoidiQ9D5V6.
OMAiCNLDQED.
OrthoDBiEOG7WDN49.
PhylomeDBiQ9D5V6.
TreeFamiTF319666.

Family and domain databases

InterProiIPR005607. BSD_dom.
[Graphical view]
PfamiPF03909. BSD. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 1 hit.
[Graphical view]
PROSITEiPS50858. BSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D5V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGGLSSWLG LKPPEGAAAE GEEPPSRDGD KLSAGAAPSE ESPERPVEPT
60 70 80 90 100
EEQQQQPPTE DPQFLHQAKG LGNYLYNFAS AATKKITESV TETAQTIKKS
110 120 130 140 150
VEEGKIDDIL DKTILGDFQK EQKKFVEEQN TKKSEAAVPP WVESHDEETI
160 170 180 190 200
QQQILALSAD KRNFLRDPPA GVQFNFDFDQ MYPVALVMLQ EDELLSKMRF
210 220 230 240 250
ALVPKLVKEE VFWRNYFYRI SLIKQSAQLT ALAAQQQASG KEEKSSNRDD
260 270 280 290 300
NLPLTEAVRP KTPPVVIKSQ LKSQEDEEEI STSPGVSEFV SDAFDTCSLN
310 320 330 340 350
QEDLRKEMEQ LVLDKKQEEA TALEEDSTDW EKELQQELQE YEVVAESEKR
360
DENWDKEIEK MLQES
Length:365
Mass (Da):41,350
Last modified:June 1, 2001 - v1
Checksum:i7553E79C0C50E96B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431E → K in BAB25643 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008390 mRNA. Translation: BAB25643.1.
AK014893 mRNA. Translation: BAB29608.1.
AK051251 mRNA. Translation: BAC34575.1.
AK147055 mRNA. Translation: BAE27639.1.
BC021373 mRNA. Translation: AAH21373.1.
CCDSiCCDS30511.1.
RefSeqiNP_080208.2. NM_025932.2.
UniGeneiMm.44207.

Genome annotation databases

EnsembliENSMUST00000033723; ENSMUSP00000033723; ENSMUSG00000031357.
GeneIDi67043.
KEGGimmu:67043.
UCSCiuc009uun.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008390 mRNA. Translation: BAB25643.1.
AK014893 mRNA. Translation: BAB29608.1.
AK051251 mRNA. Translation: BAC34575.1.
AK147055 mRNA. Translation: BAE27639.1.
BC021373 mRNA. Translation: AAH21373.1.
CCDSiCCDS30511.1.
RefSeqiNP_080208.2. NM_025932.2.
UniGeneiMm.44207.

3D structure databases

ProteinModelPortaliQ9D5V6.
SMRiQ9D5V6. Positions 144-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4085079.
STRINGi10090.ENSMUSP00000033723.

PTM databases

iPTMnetiQ9D5V6.
PhosphoSiteiQ9D5V6.

2D gel databases

REPRODUCTION-2DPAGEIPI00317599.

Proteomic databases

EPDiQ9D5V6.
MaxQBiQ9D5V6.
PaxDbiQ9D5V6.
PRIDEiQ9D5V6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033723; ENSMUSP00000033723; ENSMUSG00000031357.
GeneIDi67043.
KEGGimmu:67043.
UCSCiuc009uun.2. mouse.

Organism-specific databases

CTDi94056.
MGIiMGI:1914293. Syap1.

Phylogenomic databases

eggNOGiKOG4310. Eukaryota.
ENOG410ZPSV. LUCA.
GeneTreeiENSGT00390000007662.
HOGENOMiHOG000231677.
HOVERGENiHBG057553.
InParanoidiQ9D5V6.
OMAiCNLDQED.
OrthoDBiEOG7WDN49.
PhylomeDBiQ9D5V6.
TreeFamiTF319666.

Miscellaneous databases

PROiQ9D5V6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D5V6.
CleanExiMM_SYAP1.
GenevisibleiQ9D5V6. MM.

Family and domain databases

InterProiIPR005607. BSD_dom.
[Graphical view]
PfamiPF03909. BSD. 1 hit.
[Graphical view]
SMARTiSM00751. BSD. 1 hit.
[Graphical view]
PROSITEiPS50858. BSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart, Small intestine, Spinal ganglion and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-262; SER-283 AND SER-298, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSYAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5V6
Secondary accession number(s): Q3UI67, Q9D870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.