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Protein

Synapse-associated protein 1

Gene

Syap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation (PubMed:23300339).1 Publication

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cellular response to epidermal growth factor stimulus Source: UniProtKB
  • cellular response to insulin-like growth factor stimulus Source: UniProtKB
  • cellular response to insulin stimulus Source: UniProtKB
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of protein homodimerization activity Source: UniProtKB
  • positive regulation of protein serine/threonine kinase activity Source: UniProtKB
  • TORC2 signaling Source: UniProtKB

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Synapse-associated protein 1Curated
Alternative name(s):
BSD domain-containing signal transducer and Akt interactor proteinBy similarity
Short name:
BSTABy similarity
Gene namesi
Name:Syap1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914293 Syap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice appear normal and healthy (PubMed:27344443). Display no alteration on the survival or axonal elongation in primary embryonic motoneurons (PubMed:27344443). Show no alteration in total AKT phosphorylation in primary embryonic motoneurons (PubMed:27344443).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723561 – 365Synapse-associated protein 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphothreonineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei327PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated (PubMed:23300339). Phosphorylation increases in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation (PubMed:23300339).1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D5V6
MaxQBiQ9D5V6
PaxDbiQ9D5V6
PeptideAtlasiQ9D5V6
PRIDEiQ9D5V6

2D gel databases

REPRODUCTION-2DPAGEIPI00317599

PTM databases

iPTMnetiQ9D5V6
PhosphoSitePlusiQ9D5V6

Expressioni

Tissue specificityi

Expressed in the liver, kidney, skeletal muscle and in white and brown adipose tissues (PubMed:23300339, PubMed:27344443). Expressed in the cortex, cerebellum, thalamus, hippocampus, braistem, olfactory bulb, spinal cord and striatum of the brain (PubMed:27344443). Expressed in most neuropil regions containing glutamatergic synaptic terminals (PubMed:27344443). Expressed in the CA1, CA2 and CA3 perikarya of the hippocampus (PubMed:27344443). Expressed in neurons and Purkinje cells (at the protein level) (PubMed:27344443).2 Publications

Inductioni

Up-regulated during adipocyte differentiation (at protein level) (PubMed:23300339).1 Publication

Gene expression databases

BgeeiENSMUSG00000031357
CleanExiMM_SYAP1
GenevisibleiQ9D5V6 MM

Interactioni

Subunit structurei

Interacts (via phosphorylated form and BSD domain) with AKT1; this interaction is enhanced in a mTORC2-mediated manner in response to epidermal growth factor (EGF) stimulation and activates AKT1 (PubMed:23300339).1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033723

Structurei

3D structure databases

ProteinModelPortaliQ9D5V6
SMRiQ9D5V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 224BSDPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

eggNOGiKOG4310 Eukaryota
ENOG410ZPSV LUCA
GeneTreeiENSGT00390000007662
HOGENOMiHOG000231677
HOVERGENiHBG057553
InParanoidiQ9D5V6
OMAiETADWEK
OrthoDBiEOG091G0HAT
PhylomeDBiQ9D5V6
TreeFamiTF319666

Family and domain databases

Gene3Di1.10.3970.10, 1 hit
InterProiView protein in InterPro
IPR005607 BSD_dom
IPR035925 BSD_dom_sf
PfamiView protein in Pfam
PF03909 BSD, 1 hit
SMARTiView protein in SMART
SM00751 BSD, 1 hit
PROSITEiView protein in PROSITE
PS50858 BSD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D5V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGGLSSWLG LKPPEGAAAE GEEPPSRDGD KLSAGAAPSE ESPERPVEPT
60 70 80 90 100
EEQQQQPPTE DPQFLHQAKG LGNYLYNFAS AATKKITESV TETAQTIKKS
110 120 130 140 150
VEEGKIDDIL DKTILGDFQK EQKKFVEEQN TKKSEAAVPP WVESHDEETI
160 170 180 190 200
QQQILALSAD KRNFLRDPPA GVQFNFDFDQ MYPVALVMLQ EDELLSKMRF
210 220 230 240 250
ALVPKLVKEE VFWRNYFYRI SLIKQSAQLT ALAAQQQASG KEEKSSNRDD
260 270 280 290 300
NLPLTEAVRP KTPPVVIKSQ LKSQEDEEEI STSPGVSEFV SDAFDTCSLN
310 320 330 340 350
QEDLRKEMEQ LVLDKKQEEA TALEEDSTDW EKELQQELQE YEVVAESEKR
360
DENWDKEIEK MLQES
Length:365
Mass (Da):41,350
Last modified:June 1, 2001 - v1
Checksum:i7553E79C0C50E96B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243E → K in BAB25643 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008390 mRNA Translation: BAB25643.1
AK014893 mRNA Translation: BAB29608.1
AK051251 mRNA Translation: BAC34575.1
AK147055 mRNA Translation: BAE27639.1
BC021373 mRNA Translation: AAH21373.1
CCDSiCCDS30511.1
RefSeqiNP_080208.2, NM_025932.2
UniGeneiMm.44207

Genome annotation databases

EnsembliENSMUST00000033723; ENSMUSP00000033723; ENSMUSG00000031357
GeneIDi67043
KEGGimmu:67043
UCSCiuc009uun.2 mouse

Similar proteinsi

Entry informationi

Entry nameiSYAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5V6
Secondary accession number(s): Q3UI67, Q9D870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health