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Q9D5U5

- HDHD1_MOUSE

UniProt

Q9D5U5 - HDHD1_MOUSE

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Protein

Pseudouridine-5'-monophosphatase

Gene

Hdhd1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine (By similarity).By similarity

Catalytic activityi

Pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei19 – 191NucleophileBy similarity
Metal bindingi19 – 191MagnesiumBy similarity
Active sitei21 – 211Proton donorBy similarity
Metal bindingi21 – 211MagnesiumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleotide metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-monophosphatase (EC:3.1.3.n6)
Short name:
5'-PsiMPase
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 1
Haloacid dehalogenase-like hydrolase domain-containing protein 1A
Gene namesi
Name:Hdhd1
Synonyms:Hdhd1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1914615. Hdhd1a.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Pseudouridine-5'-monophosphatasePRO_0000320103Add
BLAST

Proteomic databases

PaxDbiQ9D5U5.
PRIDEiQ9D5U5.

PTM databases

PhosphoSiteiQ9D5U5.

Expressioni

Gene expression databases

BgeeiQ9D5U5.
GenevestigatoriQ9D5U5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057378.

Structurei

3D structure databases

ProteinModelPortaliQ9D5U5.
SMRiQ9D5U5. Positions 11-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0637.
GeneTreeiENSGT00390000014753.
HOGENOMiHOG000248341.
HOVERGENiHBG005917.
InParanoidiQ9D5U5.
KOiK17623.
OrthoDBiEOG7TF79X.
PhylomeDBiQ9D5U5.
TreeFamiTF105946.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D5U5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVPVPQF RPVTPLIFDL DGLILNTEDL YTDVFEEICN RYGKKYNWDV
60 70 80 90 100
KSLVMGKKAL ETAQTIVEFL NLPISKEELL KESQEKLQMV LHTAGFMPGA
110 120 130 140 150
EELIHHLKKH RLPFALATSS ETVTFQTKTS RHTGFFGLFH HIVLGDDPEV
160 170 180 190 200
KNGKPGMDIF LTCAKRFSPP PDPKDCLVFE DSPNGVEAAI HCGMQVVMVP
210 220 230
HENLSADLTR KATLVLSSLH DFKPELFGLP AFTE
Length:234
Mass (Da):26,161
Last modified:June 1, 2001 - v1
Checksum:i246AFF9DCF2ED9FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 43AAA → GGG in BAB24906. (PubMed:16141072)Curated
Sequence conflicti15 – 151P → H in BAB24906. (PubMed:16141072)Curated
Sequence conflicti15 – 151P → H in AAH48447. (PubMed:15489334)Curated
Sequence conflicti20 – 234LDGL → REGF in BAB24906. (PubMed:16141072)Curated
Sequence conflicti214 – 2141L → Q in BAB24906. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA. Translation: BAB24906.1.
AK014922 mRNA. Translation: BAB29622.1.
BC048447 mRNA. Translation: AAH48447.1.
CCDSiCCDS29244.1.
RefSeqiNP_080384.2. NM_026108.3.
UniGeneiMm.158150.

Genome annotation databases

EnsembliENSMUST00000056460; ENSMUSP00000057378; ENSMUSG00000048875.
GeneIDi67365.
KEGGimmu:67365.
UCSCiuc008ewy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA. Translation: BAB24906.1 .
AK014922 mRNA. Translation: BAB29622.1 .
BC048447 mRNA. Translation: AAH48447.1 .
CCDSi CCDS29244.1.
RefSeqi NP_080384.2. NM_026108.3.
UniGenei Mm.158150.

3D structure databases

ProteinModelPortali Q9D5U5.
SMRi Q9D5U5. Positions 11-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000057378.

PTM databases

PhosphoSitei Q9D5U5.

Proteomic databases

PaxDbi Q9D5U5.
PRIDEi Q9D5U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000056460 ; ENSMUSP00000057378 ; ENSMUSG00000048875 .
GeneIDi 67365.
KEGGi mmu:67365.
UCSCi uc008ewy.2. mouse.

Organism-specific databases

CTDi 67365.
MGIi MGI:1914615. Hdhd1a.

Phylogenomic databases

eggNOGi COG0637.
GeneTreei ENSGT00390000014753.
HOGENOMi HOG000248341.
HOVERGENi HBG005917.
InParanoidi Q9D5U5.
KOi K17623.
OrthoDBi EOG7TF79X.
PhylomeDBi Q9D5U5.
TreeFami TF105946.

Miscellaneous databases

NextBioi 324356.
SOURCEi Search...

Gene expression databases

Bgeei Q9D5U5.
Genevestigatori Q9D5U5.

Family and domain databases

Gene3Di 3.40.50.1000. 2 hits.
InterProi IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
[Graphical view ]
Pfami PF13419. HAD_2. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
TIGRFAMsi TIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHDHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5U5
Secondary accession number(s): Q5RL33, Q9D9A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3