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Protein

Pseudouridine-5'-phosphatase

Gene

Pudp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.By similarity

Catalytic activityi

Pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19NucleophileBy similarity1
Metal bindingi19MagnesiumBy similarity1
Active sitei21Proton donorBy similarity1
Metal bindingi21MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphataseBy similarity (EC:3.1.3.96)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 1
Haloacid dehalogenase-like hydrolase domain-containing protein 1A
Pseudouridine-5'-monophosphatase
Short name:
5'-PsiMPase
Gene namesi
Name:PudpBy similarity
Synonyms:Hdhd1, Hdhd1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914615. Pudp.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201031 – 234Pseudouridine-5'-phosphataseAdd BLAST234

Proteomic databases

PaxDbiQ9D5U5.
PRIDEiQ9D5U5.

PTM databases

PhosphoSitePlusiQ9D5U5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057378.

Structurei

3D structure databases

ProteinModelPortaliQ9D5U5.
SMRiQ9D5U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2914. Eukaryota.
COG0637. LUCA.
HOGENOMiHOG000248341.
HOVERGENiHBG005917.
InParanoidiQ9D5U5.
KOiK17623.
PhylomeDBiQ9D5U5.
TreeFamiTF105946.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
IPR023198. PGP_dom2.
PfamiView protein in Pfam
PF13419. HAD_2. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D5U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPVPQF RPVTPLIFDL DGLILNTEDL YTDVFEEICN RYGKKYNWDV
60 70 80 90 100
KSLVMGKKAL ETAQTIVEFL NLPISKEELL KESQEKLQMV LHTAGFMPGA
110 120 130 140 150
EELIHHLKKH RLPFALATSS ETVTFQTKTS RHTGFFGLFH HIVLGDDPEV
160 170 180 190 200
KNGKPGMDIF LTCAKRFSPP PDPKDCLVFE DSPNGVEAAI HCGMQVVMVP
210 220 230
HENLSADLTR KATLVLSSLH DFKPELFGLP AFTE
Length:234
Mass (Da):26,161
Last modified:June 1, 2001 - v1
Checksum:i246AFF9DCF2ED9FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 4AAA → GGG in BAB24906 (PubMed:16141072).Curated3
Sequence conflicti15P → H in BAB24906 (PubMed:16141072).Curated1
Sequence conflicti15P → H in AAH48447 (PubMed:15489334).Curated1
Sequence conflicti20 – 23LDGL → REGF in BAB24906 (PubMed:16141072).Curated4
Sequence conflicti214L → Q in BAB24906 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA. Translation: BAB24906.1.
AK014922 mRNA. Translation: BAB29622.1.
BC048447 mRNA. Translation: AAH48447.1.
CCDSiCCDS29244.1.
RefSeqiNP_080384.2. NM_026108.3.
UniGeneiMm.158150.

Genome annotation databases

GeneIDi67365.
KEGGimmu:67365.
UCSCiuc008ewy.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHDHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5U5
Secondary accession number(s): Q5RL33, Q9D9A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families