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Protein

Pseudouridine-5'-phosphatase

Gene

Pudp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.By similarity

Catalytic activityi

Pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei19NucleophileBy similarity1
Metal bindingi19MagnesiumBy similarity1
Active sitei21Proton donorBy similarity1
Metal bindingi21MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphataseBy similarity (EC:3.1.3.96)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 1
Haloacid dehalogenase-like hydrolase domain-containing protein 1A
Pseudouridine-5'-monophosphatase
Short name:
5'-PsiMPase
Gene namesi
Name:PudpBy similarity
Synonyms:Hdhd1, Hdhd1aImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914615 Pudp

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003201031 – 234Pseudouridine-5'-phosphataseAdd BLAST234

Proteomic databases

PaxDbiQ9D5U5
PRIDEiQ9D5U5

PTM databases

PhosphoSitePlusiQ9D5U5

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057378

Structurei

3D structure databases

ProteinModelPortaliQ9D5U5
SMRiQ9D5U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2914 Eukaryota
COG0637 LUCA
HOGENOMiHOG000248341
HOVERGENiHBG005917
InParanoidiQ9D5U5
KOiK17623
PhylomeDBiQ9D5U5
TreeFamiTF105946

Family and domain databases

Gene3Di1.10.150.240, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR023214 HAD_sf
IPR023198 PGP-like_dom2
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01509 HAD-SF-IA-v3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D5U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPVPQF RPVTPLIFDL DGLILNTEDL YTDVFEEICN RYGKKYNWDV
60 70 80 90 100
KSLVMGKKAL ETAQTIVEFL NLPISKEELL KESQEKLQMV LHTAGFMPGA
110 120 130 140 150
EELIHHLKKH RLPFALATSS ETVTFQTKTS RHTGFFGLFH HIVLGDDPEV
160 170 180 190 200
KNGKPGMDIF LTCAKRFSPP PDPKDCLVFE DSPNGVEAAI HCGMQVVMVP
210 220 230
HENLSADLTR KATLVLSSLH DFKPELFGLP AFTE
Length:234
Mass (Da):26,161
Last modified:June 1, 2001 - v1
Checksum:i246AFF9DCF2ED9FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 4AAA → GGG in BAB24906 (PubMed:16141072).Curated3
Sequence conflicti15P → H in BAB24906 (PubMed:16141072).Curated1
Sequence conflicti15P → H in AAH48447 (PubMed:15489334).Curated1
Sequence conflicti20 – 23LDGL → REGF in BAB24906 (PubMed:16141072).Curated4
Sequence conflicti214L → Q in BAB24906 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA Translation: BAB24906.1
AK014922 mRNA Translation: BAB29622.1
BC048447 mRNA Translation: AAH48447.1
CCDSiCCDS29244.1
RefSeqiNP_080384.2, NM_026108.3
UniGeneiMm.158150

Genome annotation databases

GeneIDi67365
KEGGimmu:67365
UCSCiuc008ewy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHDHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5U5
Secondary accession number(s): Q5RL33, Q9D9A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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