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Protein

Pseudouridine-5'-phosphatase

Gene

Hdhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.By similarity

Catalytic activityi

Pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei19 – 191NucleophileBy similarity
Metal bindingi19 – 191MagnesiumBy similarity
Active sitei21 – 211Proton donorBy similarity
Metal bindingi21 – 211MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphatase (EC:3.1.3.96)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 1
Haloacid dehalogenase-like hydrolase domain-containing protein 1A
Pseudouridine-5'-monophosphatase
Short name:
5'-PsiMPase
Gene namesi
Name:Hdhd1
Synonyms:Hdhd1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914615. Hdhd1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Pseudouridine-5'-phosphatasePRO_0000320103Add
BLAST

Proteomic databases

PaxDbiQ9D5U5.
PRIDEiQ9D5U5.

PTM databases

PhosphoSiteiQ9D5U5.

Expressioni

Gene expression databases

BgeeiQ9D5U5.
GenevisibleiQ9D5U5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057378.

Structurei

3D structure databases

ProteinModelPortaliQ9D5U5.
SMRiQ9D5U5. Positions 11-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000248341.
HOVERGENiHBG005917.
InParanoidiQ9D5U5.
KOiK17623.
OrthoDBiEOG7TF79X.
PhylomeDBiQ9D5U5.
TreeFamiTF105946.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D5U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPVPQF RPVTPLIFDL DGLILNTEDL YTDVFEEICN RYGKKYNWDV
60 70 80 90 100
KSLVMGKKAL ETAQTIVEFL NLPISKEELL KESQEKLQMV LHTAGFMPGA
110 120 130 140 150
EELIHHLKKH RLPFALATSS ETVTFQTKTS RHTGFFGLFH HIVLGDDPEV
160 170 180 190 200
KNGKPGMDIF LTCAKRFSPP PDPKDCLVFE DSPNGVEAAI HCGMQVVMVP
210 220 230
HENLSADLTR KATLVLSSLH DFKPELFGLP AFTE
Length:234
Mass (Da):26,161
Last modified:June 1, 2001 - v1
Checksum:i246AFF9DCF2ED9FF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 43AAA → GGG in BAB24906 (PubMed:16141072).Curated
Sequence conflicti15 – 151P → H in BAB24906 (PubMed:16141072).Curated
Sequence conflicti15 – 151P → H in AAH48447 (PubMed:15489334).Curated
Sequence conflicti20 – 234LDGL → REGF in BAB24906 (PubMed:16141072).Curated
Sequence conflicti214 – 2141L → Q in BAB24906 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA. Translation: BAB24906.1.
AK014922 mRNA. Translation: BAB29622.1.
BC048447 mRNA. Translation: AAH48447.1.
CCDSiCCDS29244.1.
RefSeqiNP_080384.2. NM_026108.3.
UniGeneiMm.158150.

Genome annotation databases

GeneIDi67365.
KEGGimmu:67365.
UCSCiuc008ewy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007231 mRNA. Translation: BAB24906.1.
AK014922 mRNA. Translation: BAB29622.1.
BC048447 mRNA. Translation: AAH48447.1.
CCDSiCCDS29244.1.
RefSeqiNP_080384.2. NM_026108.3.
UniGeneiMm.158150.

3D structure databases

ProteinModelPortaliQ9D5U5.
SMRiQ9D5U5. Positions 11-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057378.

PTM databases

PhosphoSiteiQ9D5U5.

Proteomic databases

PaxDbiQ9D5U5.
PRIDEiQ9D5U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67365.
KEGGimmu:67365.
UCSCiuc008ewy.2. mouse.

Organism-specific databases

CTDi67365.
MGIiMGI:1914615. Hdhd1a.

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000248341.
HOVERGENiHBG005917.
InParanoidiQ9D5U5.
KOiK17623.
OrthoDBiEOG7TF79X.
PhylomeDBiQ9D5U5.
TreeFamiTF105946.

Miscellaneous databases

NextBioi324356.
PROiQ9D5U5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D5U5.
GenevisibleiQ9D5U5. MM.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006439. HAD-SF_hydro_IA.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01509. HAD-SF-IA-v3. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHDHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5U5
Secondary accession number(s): Q5RL33, Q9D9A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: July 22, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.