Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9D5T0

- ATAD1_MOUSE

UniProt

Q9D5T0 - ATAD1_MOUSE

Protein

ATPase family AAA domain-containing protein 1

Gene

Atad1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent.1 Publication

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi133 – 1408ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. learning Source: UniProtKB
    3. memory Source: UniProtKB
    4. negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
    5. positive regulation of receptor internalization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
    Alternative name(s):
    Thorase
    Gene namesi
    Name:Atad1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1915229. Atad1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. mitochondrion Source: MGI
    3. peroxisomal membrane Source: Ensembl
    4. postsynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Disruption phenotypei

    About 80% of the mutant mice die of a seizure-like syndrome between postnatal days 19 and 25; the remaining 20% survive up to 8 weeks of age. No gross abnormalities in tissues analyzed, including heart, lung, spleen, kidney, thymus, liver, intestine, testis, eyes, and muscle. In the CA1 region of the hippocampus, no substantial difference in the dendritic complexity or in the number or size of dendritic spines and normal density of synapses in mutant animals compared to wild-type.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361ATPase family AAA domain-containing protein 1PRO_0000084792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki46 – 46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ9D5T0.
    PaxDbiQ9D5T0.
    PRIDEiQ9D5T0.

    PTM databases

    PhosphoSiteiQ9D5T0.

    Expressioni

    Tissue specificityi

    Widely expressed with the highest expression in the brain and testis. In the brain, relatively high expression in hippocampal CA1 pyramidal cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9D5T0.
    BgeeiQ9D5T0.
    CleanExiMM_ATAD1.
    GenevestigatoriQ9D5T0.

    Interactioni

    Subunit structurei

    Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly.1 Publication

    Protein-protein interaction databases

    BioGridi212578. 1 interaction.
    IntActiQ9D5T0. 4 interactions.
    MINTiMINT-4127126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D5T0.
    SMRiQ9D5T0. Positions 54-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    GeneTreeiENSGT00550000074823.
    HOGENOMiHOG000225141.
    HOVERGENiHBG057074.
    InParanoidiQ9D5T0.
    OMAiYNCQVIV.
    OrthoDBiEOG7SR4MJ.
    PhylomeDBiQ9D5T0.
    TreeFamiTF105016.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D5T0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE    50
    AQKQAEKLMK QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI 100
    TDLKDTVILP IKKKHLFENS RLLQPPKGVL LYGPPGCGKT LIAKATAKEA 150
    GCRFINLQPS TLTDKWYGES QKLAAAVFSL AIKLQPSIIF IDEIDSFLRN 200
    RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP QDLDSAIMRR 250
    MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK 300
    EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA 350
    FQNVLTHVCL D 361
    Length:361
    Mass (Da):40,744
    Last modified:June 1, 2001 - v1
    Checksum:i2FAE88BA7E7140BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti123 – 1231L → M in BAB26274. (PubMed:16141072)Curated
    Sequence conflicti206 – 2061H → L in BAB26274. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009419 mRNA. Translation: BAB26274.1.
    AK014967 mRNA. Translation: BAB29643.1.
    AK030719 mRNA. Translation: BAC27097.1.
    AK033639 mRNA. Translation: BAC28402.1.
    AK150469 mRNA. Translation: BAE29586.1.
    AK152059 mRNA. Translation: BAE30915.1.
    AK165953 mRNA. Translation: BAE38481.1.
    BC029085 mRNA. Translation: AAH29085.1.
    BC043051 mRNA. Translation: AAH43051.1.
    CCDSiCCDS29752.1.
    RefSeqiNP_080763.2. NM_026487.3.
    XP_006527376.1. XM_006527313.1.
    UniGeneiMm.27123.

    Genome annotation databases

    EnsembliENSMUST00000070210; ENSMUSP00000069962; ENSMUSG00000013662.
    GeneIDi67979.
    KEGGimmu:67979.
    UCSCiuc008hfo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK009419 mRNA. Translation: BAB26274.1 .
    AK014967 mRNA. Translation: BAB29643.1 .
    AK030719 mRNA. Translation: BAC27097.1 .
    AK033639 mRNA. Translation: BAC28402.1 .
    AK150469 mRNA. Translation: BAE29586.1 .
    AK152059 mRNA. Translation: BAE30915.1 .
    AK165953 mRNA. Translation: BAE38481.1 .
    BC029085 mRNA. Translation: AAH29085.1 .
    BC043051 mRNA. Translation: AAH43051.1 .
    CCDSi CCDS29752.1.
    RefSeqi NP_080763.2. NM_026487.3.
    XP_006527376.1. XM_006527313.1.
    UniGenei Mm.27123.

    3D structure databases

    ProteinModelPortali Q9D5T0.
    SMRi Q9D5T0. Positions 54-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212578. 1 interaction.
    IntActi Q9D5T0. 4 interactions.
    MINTi MINT-4127126.

    PTM databases

    PhosphoSitei Q9D5T0.

    Proteomic databases

    MaxQBi Q9D5T0.
    PaxDbi Q9D5T0.
    PRIDEi Q9D5T0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070210 ; ENSMUSP00000069962 ; ENSMUSG00000013662 .
    GeneIDi 67979.
    KEGGi mmu:67979.
    UCSCi uc008hfo.1. mouse.

    Organism-specific databases

    CTDi 84896.
    MGIi MGI:1915229. Atad1.

    Phylogenomic databases

    eggNOGi COG0464.
    GeneTreei ENSGT00550000074823.
    HOGENOMi HOG000225141.
    HOVERGENi HBG057074.
    InParanoidi Q9D5T0.
    OMAi YNCQVIV.
    OrthoDBi EOG7SR4MJ.
    PhylomeDBi Q9D5T0.
    TreeFami TF105016.

    Miscellaneous databases

    ChiTaRSi ATAD1. mouse.
    NextBioi 326122.
    PROi Q9D5T0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D5T0.
    Bgeei Q9D5T0.
    CleanExi MM_ATAD1.
    Genevestigatori Q9D5T0.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow, Cecum, Embryo, Lung, Testis and Tongue.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary tumor.
    3. Cited for: SUBCELLULAR LOCATION.
      Tissue: Kidney.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior."
      Zhang J., Wang Y., Chi Z., Keuss M.J., Pai Y.M., Kang H.C., Shin J.H., Bugayenko A., Wang H., Xiong Y., Pletnikov M.V., Mattson M.P., Dawson T.M., Dawson V.L.
      Cell 145:284-299(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GRIA2 AND GRIP1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiATAD1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D5T0
    Secondary accession number(s): Q3U8V2, Q9D7A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3