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Protein

ATPase family AAA domain-containing protein 1

Gene

Atad1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent.1 Publication

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • learning Source: UniProtKB
  • memory Source: UniProtKB
  • negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
  • positive regulation of receptor internalization Source: UniProtKB

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
Alternative name(s):
Thorase
Gene namesi
Name:Atad1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1915229 Atad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

About 80% of the mutant mice die of a seizure-like syndrome between postnatal days 19 and 25; the remaining 20% survive up to 8 weeks of age. No gross abnormalities in tissues analyzed, including heart, lung, spleen, kidney, thymus, liver, intestine, testis, eyes, and muscle. In the CA1 region of the hippocampus, no substantial difference in the dendritic complexity or in the number or size of dendritic spines and normal density of synapses in mutant animals compared to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847921 – 361ATPase family AAA domain-containing protein 1Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei322PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D5T0
MaxQBiQ9D5T0
PaxDbiQ9D5T0
PeptideAtlasiQ9D5T0
PRIDEiQ9D5T0

PTM databases

iPTMnetiQ9D5T0
PhosphoSitePlusiQ9D5T0
SwissPalmiQ9D5T0

Expressioni

Tissue specificityi

Widely expressed with the highest expression in the brain and testis. In the brain, relatively high expression in hippocampal CA1 pyramidal cells (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000013662
CleanExiMM_ATAD1
GenevisibleiQ9D5T0 MM

Interactioni

Subunit structurei

Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly.1 Publication

Protein-protein interaction databases

BioGridi212578, 1 interactor
IntActiQ9D5T0, 4 interactors
MINTiQ9D5T0
STRINGi10090.ENSMUSP00000069962

Structurei

3D structure databases

ProteinModelPortaliQ9D5T0
SMRiQ9D5T0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000074823
HOGENOMiHOG000225141
HOVERGENiHBG057074
InParanoidiQ9D5T0
KOiK22530
OMAiMPHLYSH
OrthoDBiEOG091G0CJ6
PhylomeDBiQ9D5T0
TreeFamiTF105016

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D5T0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE
60 70 80 90 100
AQKQAEKLMK QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI
110 120 130 140 150
TDLKDTVILP IKKKHLFENS RLLQPPKGVL LYGPPGCGKT LIAKATAKEA
160 170 180 190 200
GCRFINLQPS TLTDKWYGES QKLAAAVFSL AIKLQPSIIF IDEIDSFLRN
210 220 230 240 250
RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP QDLDSAIMRR
260 270 280 290 300
MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK
310 320 330 340 350
EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA
360
FQNVLTHVCL D
Length:361
Mass (Da):40,744
Last modified:June 1, 2001 - v1
Checksum:i2FAE88BA7E7140BC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123L → M in BAB26274 (PubMed:16141072).Curated1
Sequence conflicti206H → L in BAB26274 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009419 mRNA Translation: BAB26274.1
AK014967 mRNA Translation: BAB29643.1
AK030719 mRNA Translation: BAC27097.1
AK033639 mRNA Translation: BAC28402.1
AK150469 mRNA Translation: BAE29586.1
AK152059 mRNA Translation: BAE30915.1
AK165953 mRNA Translation: BAE38481.1
BC029085 mRNA Translation: AAH29085.1
BC043051 mRNA Translation: AAH43051.1
CCDSiCCDS29752.1
RefSeqiNP_080763.2, NM_026487.3
XP_006527376.1, XM_006527313.2
UniGeneiMm.27123

Genome annotation databases

EnsembliENSMUST00000070210; ENSMUSP00000069962; ENSMUSG00000013662
GeneIDi67979
KEGGimmu:67979
UCSCiuc008hfo.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATAD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D5T0
Secondary accession number(s): Q3U8V2, Q9D7A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health