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Protein

Receptor protein serine/threonine kinase

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: MGI
  2. I-SMAD binding Source: MGI
  3. protein kinase activity Source: MGI
  4. protein serine/threonine kinase activity Source: MGI
  5. receptor signaling protein activity Source: AgBase
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. SMAD binding Source: MGI
  8. transforming growth factor beta-activated receptor activity Source: MGI
  9. transforming growth factor beta binding Source: MGI
  10. transforming growth factor beta receptor activity, type I Source: AgBase
  11. type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. activin receptor signaling pathway Source: AgBase
  3. angiogenesis Source: MGI
  4. anterior/posterior pattern specification Source: MGI
  5. artery morphogenesis Source: MGI
  6. blastocyst development Source: MGI
  7. cardiac epithelial to mesenchymal transition Source: AgBase
  8. cell motility Source: MGI
  9. cellular response to transforming growth factor beta stimulus Source: MGI
  10. collagen fibril organization Source: MGI
  11. embryonic cranial skeleton morphogenesis Source: MGI
  12. endothelial cell activation Source: AgBase
  13. endothelial cell migration Source: MGI
  14. epithelial to mesenchymal transition Source: MGI
  15. germ cell migration Source: MGI
  16. heart development Source: AgBase
  17. intracellular signal transduction Source: AgBase
  18. in utero embryonic development Source: MGI
  19. kidney development Source: MGI
  20. lens development in camera-type eye Source: MGI
  21. male gonad development Source: MGI
  22. mesenchymal cell differentiation Source: AgBase
  23. negative regulation of apoptotic process Source: MGI
  24. negative regulation of endothelial cell proliferation Source: MGI
  25. negative regulation of extrinsic apoptotic signaling pathway Source: MGI
  26. neuron fate commitment Source: MGI
  27. palate development Source: MGI
  28. parathyroid gland development Source: MGI
  29. pathway-restricted SMAD protein phosphorylation Source: MGI
  30. peptidyl-serine phosphorylation Source: MGI
  31. peptidyl-threonine phosphorylation Source: MGI
  32. pharyngeal system development Source: MGI
  33. positive regulation of apoptotic signaling pathway Source: MGI
  34. positive regulation of cell growth Source: MGI
  35. positive regulation of cell proliferation Source: MGI
  36. positive regulation of cellular component movement Source: MGI
  37. positive regulation of endothelial cell proliferation Source: AgBase
  38. positive regulation of filopodium assembly Source: MGI
  39. positive regulation of gene expression Source: AgBase
  40. positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  41. positive regulation of protein kinase B signaling Source: MGI
  42. positive regulation of SMAD protein import into nucleus Source: MGI
  43. positive regulation of transcription, DNA-templated Source: AgBase
  44. post-embryonic development Source: MGI
  45. protein phosphorylation Source: MGI
  46. regulation of epithelial to mesenchymal transition Source: AgBase
  47. regulation of gene expression Source: AgBase
  48. regulation of protein binding Source: MGI
  49. regulation of protein ubiquitination Source: MGI
  50. regulation of transcription, DNA-templated Source: MGI
  51. response to cholesterol Source: MGI
  52. signal transduction Source: MGI
  53. skeletal system development Source: MGI
  54. skeletal system morphogenesis Source: MGI
  55. thymus development Source: MGI
  56. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. cell Source: AgBase
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: AgBase
  5. membrane raft Source: MGI
  6. plasma membrane Source: MGI
  7. receptor complex Source: MGI
  8. tight junction Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ9D5H8.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D5H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP
60 70 80 90 100
VCFVCIALML MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD
110 120 130 140 150
MTTSGSGSGL PLLVQRTIAR TIVLQESIGK GRFGEVWRGK WRGEEVAVKI
160 170 180 190 200
FSSREERSWF REAEIYQTVM LRHENILGFI AADNKDNGTW TQLWLVSDYH
210 220 230 240 250
EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT QGKPAIAHRD
260 270 280 290 300
LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV
310 320 330 340 350
LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP
360 370 380 390 400
SDPSVEEMRK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL
410 420
TALRIKKTLS QLSQQEGIKM
Length:420
Mass (Da):47,575
Last modified:June 1, 2001 - v1
Checksum:iAD5E784393D3D2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.
AK015337 mRNA. Translation: BAB29802.1.
UniGeneiMm.197552.

Genome annotation databases

EnsembliENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
UCSCiuc008sup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.
AK015337 mRNA. Translation: BAB29802.1.
UniGeneiMm.197552.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
UCSCiuc008sup.1. mouse.

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.

Miscellaneous databases

ChiTaRSiTgfbr1. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9D5H8.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9D5H8_MOUSE
AccessioniPrimary (citable) accession number: Q9D5H8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.