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Protein

Receptor protein serine/threonine kinase

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98728 Tgfbr1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 64HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ9D5H8
PeptideAtlasiQ9D5H8

Expressioni

Gene expression databases

BgeeiENSMUSG00000007613

Structurei

3D structure databases

SMRiQ9D5H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 121GSInterPro annotationAdd BLAST30
Domaini122 – 412Protein kinaseInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502

Family and domain databases

InterProiView protein in InterPro
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D5H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP
60 70 80 90 100
VCFVCIALML MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD
110 120 130 140 150
MTTSGSGSGL PLLVQRTIAR TIVLQESIGK GRFGEVWRGK WRGEEVAVKI
160 170 180 190 200
FSSREERSWF REAEIYQTVM LRHENILGFI AADNKDNGTW TQLWLVSDYH
210 220 230 240 250
EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT QGKPAIAHRD
260 270 280 290 300
LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV
310 320 330 340 350
LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP
360 370 380 390 400
SDPSVEEMRK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL
410 420
TALRIKKTLS QLSQQEGIKM
Length:420
Mass (Da):47,575
Last modified:June 1, 2001 - v1
Checksum:iAD5E784393D3D2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772150 Genomic DNA No translation available.
AL772232 Genomic DNA No translation available.
AK015337 mRNA Translation: BAB29802.1
RefSeqiNP_001299798.1, NM_001312869.1
UniGeneiMm.197552

Genome annotation databases

EnsembliENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613
GeneIDi21812
UCSCiuc008sup.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQ9D5H8_MOUSE
AccessioniPrimary (citable) accession number: Q9D5H8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health