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Q9D5H8

- Q9D5H8_MOUSE

UniProt

Q9D5H8 - Q9D5H8_MOUSE

Protein
Submitted name:

TGF-beta receptor type-1

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. receptor signaling protein serine/threonine kinase activity Source: InterPro
    4. transforming growth factor beta-activated receptor activity Source: MGI
    5. transforming growth factor beta binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. artery morphogenesis Source: MGI
    4. blastocyst development Source: MGI
    5. collagen fibril organization Source: MGI
    6. embryonic cranial skeleton morphogenesis Source: MGI
    7. endothelial cell migration Source: MGI
    8. germ cell migration Source: MGI
    9. heart development Source: MGI
    10. in utero embryonic development Source: MGI
    11. kidney development Source: MGI
    12. lens development in camera-type eye Source: MGI
    13. negative regulation of apoptotic process Source: MGI
    14. negative regulation of endothelial cell proliferation Source: MGI
    15. neuron fate commitment Source: MGI
    16. palate development Source: MGI
    17. parathyroid gland development Source: MGI
    18. pharyngeal system development Source: MGI
    19. positive regulation of filopodium assembly Source: MGI
    20. post-embryonic development Source: MGI
    21. regulation of gene expression Source: MGI
    22. regulation of protein binding Source: MGI
    23. skeletal system development Source: MGI
    24. skeletal system morphogenesis Source: MGI
    25. thymus development Source: MGI
    26. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TGF-beta receptor type-1Imported
    Gene namesi
    Name:Tgfbr1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:98728. Tgfbr1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane raft Source: MGI

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ9D5H8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00730000110337.
    HOGENOMiHOG000230587.
    HOVERGENiHBG054502.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view]
    SMARTiSM00467. GS. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D5H8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP    50
    VCFVCIALML MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD 100
    MTTSGSGSGL PLLVQRTIAR TIVLQESIGK GRFGEVWRGK WRGEEVAVKI 150
    FSSREERSWF REAEIYQTVM LRHENILGFI AADNKDNGTW TQLWLVSDYH 200
    EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT QGKPAIAHRD 250
    LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV 300
    LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP 350
    SDPSVEEMRK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL 400
    TALRIKKTLS QLSQQEGIKM 420
    Length:420
    Mass (Da):47,575
    Last modified:June 1, 2001 - v1
    Checksum:iAD5E784393D3D2A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772150 Genomic DNA. No translation available.
    AL772232 Genomic DNA. No translation available.
    AK015337 mRNA. Translation: BAB29802.1.
    UniGeneiMm.197552.

    Genome annotation databases

    EnsembliENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
    UCSCiuc008sup.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL772150 Genomic DNA. No translation available.
    AL772232 Genomic DNA. No translation available.
    AK015337 mRNA. Translation: BAB29802.1 .
    UniGenei Mm.197552.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000107725 ; ENSMUSP00000103353 ; ENSMUSG00000007613 .
    UCSCi uc008sup.1. mouse.

    Organism-specific databases

    MGIi MGI:98728. Tgfbr1.

    Phylogenomic databases

    GeneTreei ENSGT00730000110337.
    HOGENOMi HOG000230587.
    HOVERGENi HBG054502.

    Miscellaneous databases

    ChiTaRSi TGFBR1. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9D5H8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR003605. TGF_beta_rcpt_GS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    PF08515. TGF_beta_GS. 1 hit.
    [Graphical view ]
    SMARTi SM00467. GS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51256. GS. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    7. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    8. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: TestisImported.
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    10. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ9D5H8_MOUSE
    AccessioniPrimary (citable) accession number: Q9D5H8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3