TGF-beta receptor type-1 - Mus musculus (Mouse)

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Q9D5H8 (Q9D5H8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
TGF-beta receptor type-1 Ensembl ENSMUSP00000103353

Gene names

Name:

Tgfbr1 MGI 98728 Ensembl ENSMUSP00000103353

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from mutant phenotype PubMed 11285230. Source: MGI anterior/posterior pattern specification Inferred from genetic interaction PubMed 16845371. Source: MGI artery morphogenesis Inferred from mutant phenotype PubMed 17078885. Source: MGI blastocyst development Inferred from direct assay PubMed 9921650. Source: MGI collagen fibril organization Inferred from mutant phenotype PubMed 15993878. Source: MGI embryonic cranial skeleton morphogenesis Inferred from mutant phenotype PubMed 16806156. Source: MGI endothelial cell migration Inferred from mutant phenotype PubMed 11285230. Source: MGI germ cell migration Inferred from mutant phenotype PubMed 15993878. Source: MGI heart development Inferred from mutant phenotype PubMed 17078885. Source: MGI induction of apoptosis Inferred from mutant phenotype PubMed 16806156. Source: MGI kidney development Inferred from genetic interaction PubMed 16845371. Source: MGI lens development in camera-type eye Inferred from mutant phenotype PubMed 11641223. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 17078885. Source: MGI negative regulation of endothelial cell proliferation Inferred from genetic interaction PubMed 21832243. Source: MGI neuron fate commitment Inferred from mutant phenotype PubMed 15744664. Source: MGI palate development Inferred from mutant phenotype PubMed 16806156. Source: MGI parathyroid gland development Inferred from mutant phenotype PubMed 17078885. Source: MGI pharyngeal system development Inferred from mutant phenotype PubMed 17078885. Source: MGI positive regulation of filopodium assembly Inferred from mutant phenotype PubMed 16806156. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of gene expression Inferred from mutant phenotype PubMed 16806156. Source: MGI regulation of protein binding Inferred from mutant phenotype PubMed 16601693. Source: MGI thymus development Inferred from mutant phenotype PubMed 17078885. Source: MGI transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 14580334 PubMed 15820682. Source: MGI
Cellular_component	caveola Inferred from sequence orthology PubMed 17878231. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta-activated receptor activity Inferred from direct assay PubMed 15820682. Source: MGI
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9D5H8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AD5E784393D3D2A3
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FASTA

420

47,575

        10         20         30         40         50         60 
MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP VCFVCIALML 

        70         80         90        100        110        120 
MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD MTTSGSGSGL PLLVQRTIAR 

       130        140        150        160        170        180 
TIVLQESIGK GRFGEVWRGK WRGEEVAVKI FSSREERSWF REAEIYQTVM LRHENILGFI 

       190        200        210        220        230        240 
AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT 

       250        260        270        280        290        300 
QGKPAIAHRD LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV 

       310        320        330        340        350        360 
LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP SDPSVEEMRK 

       370        380        390        400        410        420 
VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL TALRIKKTLS QLSQQEGIKM

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[4]	Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. Hayashizaki Y. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB29802.1. Tissue: Testis EMBL BAB29802.1.
[9]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000103353.
[10]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000103353.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL772150 Genomic DNA. No translation available. AL772232 Genomic DNA. No translation available. AK015337 mRNA. Translation: BAB29802.1.
IPI	IPI00107992.
UniGene	Mm.197552.
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
SMR	Q9D5H8. Positions 92-417.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
UCSC	uc008sup.1. mouse.
Organism-specific databases
MGI	MGI:98728. Tgfbr1.
Phylogenomic databases
GeneTree	ENSGT00560000076615.
HOGENOM	HOG000230587.
HOVERGEN	HBG054502.
Gene expression databases
Genevestigator	Q9D5H8.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TGFBR1. mouse.
SOURCE	Search...

Entry information

Entry name

Q9D5H8_MOUSE

Accession

Primary (citable) accession number: Q9D5H8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information