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Q9D5H8

- Q9D5H8_MOUSE

UniProt

Q9D5H8 - Q9D5H8_MOUSE

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Protein
Submitted name:

TGF-beta receptor type-1

Gene

Tgfbr1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. receptor signaling protein serine/threonine kinase activity Source: InterPro
  3. transforming growth factor beta-activated receptor activity Source: MGI
  4. transforming growth factor beta binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. artery morphogenesis Source: MGI
  4. blastocyst development Source: MGI
  5. collagen fibril organization Source: MGI
  6. embryonic cranial skeleton morphogenesis Source: MGI
  7. endothelial cell migration Source: MGI
  8. germ cell migration Source: MGI
  9. heart development Source: MGI
  10. in utero embryonic development Source: MGI
  11. kidney development Source: MGI
  12. lens development in camera-type eye Source: MGI
  13. male gonad development Source: MGI
  14. negative regulation of apoptotic process Source: MGI
  15. negative regulation of endothelial cell proliferation Source: MGI
  16. neuron fate commitment Source: MGI
  17. palate development Source: MGI
  18. parathyroid gland development Source: MGI
  19. pharyngeal system development Source: MGI
  20. positive regulation of filopodium assembly Source: MGI
  21. post-embryonic development Source: MGI
  22. regulation of gene expression Source: MGI
  23. regulation of protein binding Source: MGI
  24. skeletal system development Source: MGI
  25. skeletal system morphogenesis Source: MGI
  26. thymus development Source: MGI
  27. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
TGF-beta receptor type-1Imported
Gene namesi
Name:Tgfbr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:98728. Tgfbr1.

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane raft Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

GenevestigatoriQ9D5H8.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118876.
HOGENOMiHOG000230587.
HOVERGENiHBG054502.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTiSM00467. GS. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D5H8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP
60 70 80 90 100
VCFVCIALML MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD
110 120 130 140 150
MTTSGSGSGL PLLVQRTIAR TIVLQESIGK GRFGEVWRGK WRGEEVAVKI
160 170 180 190 200
FSSREERSWF REAEIYQTVM LRHENILGFI AADNKDNGTW TQLWLVSDYH
210 220 230 240 250
EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT QGKPAIAHRD
260 270 280 290 300
LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV
310 320 330 340 350
LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP
360 370 380 390 400
SDPSVEEMRK VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL
410 420
TALRIKKTLS QLSQQEGIKM
Length:420
Mass (Da):47,575
Last modified:June 1, 2001 - v1
Checksum:iAD5E784393D3D2A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.
AK015337 mRNA. Translation: BAB29802.1.
UniGeneiMm.197552.

Genome annotation databases

EnsembliENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
UCSCiuc008sup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.
AK015337 mRNA. Translation: BAB29802.1 .
UniGenei Mm.197552.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000107725 ; ENSMUSP00000103353 ; ENSMUSG00000007613 .
UCSCi uc008sup.1. mouse.

Organism-specific databases

MGIi MGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreei ENSGT00760000118876.
HOGENOMi HOG000230587.
HOVERGENi HBG054502.

Miscellaneous databases

ChiTaRSi TGFBR1. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9D5H8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view ]
SMARTi SM00467. GS. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  7. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  8. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  10. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9D5H8_MOUSE
AccessioniPrimary (citable) accession number: Q9D5H8
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3