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Q9D5H8 (Q9D5H8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Tgfbr1 MGI 98728 Ensembl ENSMUSP00000103353
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   LigandATP-binding RuleBase RU000304
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase RuleBase RU000305
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from mutant phenotype PubMed 11285230. Source: MGI

anterior/posterior pattern specification

Inferred from genetic interaction PubMed 16845371. Source: MGI

artery morphogenesis

Inferred from mutant phenotype PubMed 17078885. Source: MGI

blastocyst development

Inferred from direct assay PubMed 9921650. Source: MGI

collagen fibril organization

Inferred from mutant phenotype PubMed 15993878. Source: MGI

embryo development

Inferred from mutant phenotype PubMed 14729481PubMed 16344855. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from mutant phenotype PubMed 16806156. Source: MGI

endothelial cell migration

Inferred from mutant phenotype PubMed 11285230. Source: MGI

germ cell migration

Inferred from mutant phenotype PubMed 15993878. Source: MGI

heart development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 11285230PubMed 14729481PubMed 17078885. Source: MGI

kidney development

Inferred from genetic interaction PubMed 16845371. Source: MGI

lens development in camera-type eye

Inferred from mutant phenotype PubMed 11641223. Source: MGI

negative regulation of apoptotic process

Inferred from mutant phenotype PubMed 16806156PubMed 17078885. Source: MGI

negative regulation of endothelial cell proliferation

Inferred from genetic interaction PubMed 21832243. Source: MGI

neuron fate commitment

Inferred from mutant phenotype PubMed 15744664. Source: MGI

palate development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

parathyroid gland development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

pharyngeal system development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

positive regulation of filopodium assembly

Inferred from mutant phenotype PubMed 16806156. Source: MGI

post-embryonic development

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 16806156. Source: MGI

regulation of protein binding

Inferred from mutant phenotype PubMed 16601693. Source: MGI

skeletal system development

Inferred from genetic interaction PubMed 16845371. Source: MGI

skeletal system morphogenesis

Inferred from genetic interaction PubMed 16845371. Source: MGI

thymus development

Inferred from mutant phenotype PubMed 17078885. Source: MGI

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 14580334PubMed 15820682. Source: MGI

   Cellular_componentcaveola

Inferred from sequence orthology PubMed 17878231. Source: MGI

membrane raft

Inferred from sequence orthology PubMed 17878231. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

transforming growth factor beta binding

Inferred from physical interaction PubMed 17878231. Source: MGI

transforming growth factor beta-activated receptor activity

Inferred from direct assay PubMed 15820682. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9D5H8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AD5E784393D3D2A3

FASTA42047,575
        10         20         30         40         50         60 
MDLKSLIMVM MEDYKDITPL KKLQENKGPF SEKQSAGLGP VELAAVIAGP VCFVCIALML 

        70         80         90        100        110        120 
MVYICHNRTV IHHRVPNEED PSLDRPFISE GTTLKDLIYD MTTSGSGSGL PLLVQRTIAR 

       130        140        150        160        170        180 
TIVLQESIGK GRFGEVWRGK WRGEEVAVKI FSSREERSWF REAEIYQTVM LRHENILGFI 

       190        200        210        220        230        240 
AADNKDNGTW TQLWLVSDYH EHGSLFDYLN RYTVTVEGMI KLALSTASGL AHLHMEIVGT 

       250        260        270        280        290        300 
QGKPAIAHRD LKSKNILVKK NGTCCIADLG LAVRHDSATD TIDIAPNHRV GTKRYMAPEV 

       310        320        330        340        350        360 
LDDSINMKHF ESFKRADIYA MGLVFWEIAR RCSIGGIHED YQLPYYDLVP SDPSVEEMRK 

       370        380        390        400        410        420 
VVCEQKLRPN IPNRWQSCEA LRVMAKIMRE CWYANGAARL TALRIKKTLS QLSQQEGIKM 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB29802.1.
Tissue: Testis EMBL BAB29802.1.
[9]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000103353.
[10]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000103353.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL772150 Genomic DNA. No translation available.
AL772232 Genomic DNA. No translation available.
AK015337 mRNA. Translation: BAB29802.1.
UniGeneMm.197552.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000107725; ENSMUSP00000103353; ENSMUSG00000007613.
UCSCuc008sup.1. mouse.

Organism-specific databases

MGIMGI:98728. Tgfbr1.

Phylogenomic databases

GeneTreeENSGT00730000110337.
HOGENOMHOG000230587.
HOVERGENHBG054502.

Gene expression databases

GenevestigatorQ9D5H8.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTGFBR1. mouse.
SOURCESearch...

Entry information

Entry nameQ9D5H8_MOUSE
AccessionPrimary (citable) accession number: Q9D5H8
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)