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Protein

Ferritin, mitochondrial

Gene

Ftmt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Iron 1PROSITE-ProRule annotation1
Metal bindingi118Iron 1PROSITE-ProRule annotation1
Metal bindingi118Iron 2PROSITE-ProRule annotation1
Metal bindingi121Iron 1PROSITE-ProRule annotation1
Metal bindingi163Iron 2PROSITE-ProRule annotation1
Metal bindingi197Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric iron binding Source: InterPro
  • ferroxidase activity Source: MGI
  • iron ion binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, mitochondrial (EC:1.16.3.1)
Gene namesi
Name:Ftmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1914884. Ftmt.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000000885150 – 237Ferritin, mitochondrialAdd BLAST188

Proteomic databases

MaxQBiQ9D5H4.
PaxDbiQ9D5H4.
PRIDEiQ9D5H4.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024510.
CleanExiMM_FTMT.
GenevisibleiQ9D5H4. MM.

Interactioni

Subunit structurei

Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025388.

Structurei

3D structure databases

ProteinModelPortaliQ9D5H4.
SMRiQ9D5H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 215Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9D5H4.
KOiK18495.
OMAiGLFMIDR.
OrthoDBiEOG091G0J20.
PhylomeDBiQ9D5H4.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D5H4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSCFWFFSK HISSALMSLP RVLHRFTAPQ CLASRYPLGP LLASPRRLLA
60 70 80 90 100
SVASSQDSTR PSRVRQNFHP DSEAAINRQI NLELYASYVY LSMAYYFSRD
110 120 130 140 150
DVALYNFSKY FLRQSLEERE HAEKLMKLQN QRGGRICLQD IKKPDKDDWE
160 170 180 190 200
CGLRAMECAL LLEKNVNQSL LDLHTLASEK GDPHLCDFLE THYLHEQVKS
210 220 230
IKELGDHVHN LVTMGAPAAG LAEYLFDKHT LGSESKH
Length:237
Mass (Da):27,158
Last modified:April 26, 2005 - v2
Checksum:i6EC3D9B1539B3B5E
GO

Sequence cautioni

The sequence BAB29806 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti163E → G in BAB29831 (PubMed:16141072).Curated1
Sequence conflicti164K → R in BAB29806 (PubMed:16141072).Curated1
Sequence conflicti167N → T in BAB29806 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015346 mRNA. Translation: BAB29806.1. Different initiation.
AK015400 mRNA. Translation: BAB29831.1.
AK133009 mRNA. Translation: BAE21468.1.
BC115514 mRNA. Translation: AAI15515.1.
BC115515 mRNA. Translation: AAI15516.1.
CCDSiCCDS29246.1.
RefSeqiNP_080562.2. NM_026286.3.
UniGeneiMm.179144.

Genome annotation databases

EnsembliENSMUST00000025388; ENSMUSP00000025388; ENSMUSG00000024510.
GeneIDi67634.
KEGGimmu:67634.
UCSCiuc008exc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015346 mRNA. Translation: BAB29806.1. Different initiation.
AK015400 mRNA. Translation: BAB29831.1.
AK133009 mRNA. Translation: BAE21468.1.
BC115514 mRNA. Translation: AAI15515.1.
BC115515 mRNA. Translation: AAI15516.1.
CCDSiCCDS29246.1.
RefSeqiNP_080562.2. NM_026286.3.
UniGeneiMm.179144.

3D structure databases

ProteinModelPortaliQ9D5H4.
SMRiQ9D5H4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025388.

Proteomic databases

MaxQBiQ9D5H4.
PaxDbiQ9D5H4.
PRIDEiQ9D5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025388; ENSMUSP00000025388; ENSMUSG00000024510.
GeneIDi67634.
KEGGimmu:67634.
UCSCiuc008exc.2. mouse.

Organism-specific databases

CTDi94033.
MGIiMGI:1914884. Ftmt.

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9D5H4.
KOiK18495.
OMAiGLFMIDR.
OrthoDBiEOG091G0J20.
PhylomeDBiQ9D5H4.
TreeFamiTF313885.

Miscellaneous databases

PROiQ9D5H4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024510.
CleanExiMM_FTMT.
GenevisibleiQ9D5H4. MM.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTMT_MOUSE
AccessioniPrimary (citable) accession number: Q9D5H4
Secondary accession number(s): Q14BZ8, Q3V0N6, Q9D5F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.