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Protein

Ferritin, mitochondrial

Gene

Ftmt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Iron 1PROSITE-ProRule annotation
Metal bindingi118 – 1181Iron 1PROSITE-ProRule annotation
Metal bindingi118 – 1181Iron 2PROSITE-ProRule annotation
Metal bindingi121 – 1211Iron 1PROSITE-ProRule annotation
Metal bindingi163 – 1631Iron 2PROSITE-ProRule annotation
Metal bindingi197 – 1971Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: MGI
  3. iron ion binding Source: MGI

GO - Biological processi

  1. cellular iron ion homeostasis Source: MGI
  2. iron ion transport Source: InterPro
  3. positive regulation of cell proliferation Source: MGI
  4. positive regulation of lyase activity Source: MGI
  5. positive regulation of oxidoreductase activity Source: MGI
  6. positive regulation of transferase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin, mitochondrial (EC:1.16.3.1)
Gene namesi
Name:Ftmt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1914884. Ftmt.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
BLAST
Chaini50 – 237188Ferritin, mitochondrialPRO_0000008851Add
BLAST

Proteomic databases

PaxDbiQ9D5H4.
PRIDEiQ9D5H4.

Expressioni

Gene expression databases

BgeeiQ9D5H4.
CleanExiMM_FTMT.
GenevestigatoriQ9D5H4.

Interactioni

Subunit structurei

Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9D5H4.
SMRiQ9D5H4. Positions 62-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 215150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1528.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9D5H4.
KOiK18495.
OMAiGLFMIDR.
OrthoDBiEOG7DRJ49.
PhylomeDBiQ9D5H4.
TreeFamiTF313885.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D5H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSCFWFFSK HISSALMSLP RVLHRFTAPQ CLASRYPLGP LLASPRRLLA
60 70 80 90 100
SVASSQDSTR PSRVRQNFHP DSEAAINRQI NLELYASYVY LSMAYYFSRD
110 120 130 140 150
DVALYNFSKY FLRQSLEERE HAEKLMKLQN QRGGRICLQD IKKPDKDDWE
160 170 180 190 200
CGLRAMECAL LLEKNVNQSL LDLHTLASEK GDPHLCDFLE THYLHEQVKS
210 220 230
IKELGDHVHN LVTMGAPAAG LAEYLFDKHT LGSESKH
Length:237
Mass (Da):27,158
Last modified:April 26, 2005 - v2
Checksum:i6EC3D9B1539B3B5E
GO

Sequence cautioni

The sequence BAB29806.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti163 – 1631E → G in BAB29831. (PubMed:16141072)Curated
Sequence conflicti164 – 1641K → R in BAB29806. (PubMed:16141072)Curated
Sequence conflicti167 – 1671N → T in BAB29806. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015346 mRNA. Translation: BAB29806.1. Different initiation.
AK015400 mRNA. Translation: BAB29831.1.
AK133009 mRNA. Translation: BAE21468.1.
BC115514 mRNA. Translation: AAI15515.1.
BC115515 mRNA. Translation: AAI15516.1.
CCDSiCCDS29246.1.
RefSeqiNP_080562.2. NM_026286.3.
UniGeneiMm.179144.

Genome annotation databases

EnsembliENSMUST00000025388; ENSMUSP00000025388; ENSMUSG00000024510.
GeneIDi67634.
KEGGimmu:67634.
UCSCiuc008exc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015346 mRNA. Translation: BAB29806.1. Different initiation.
AK015400 mRNA. Translation: BAB29831.1.
AK133009 mRNA. Translation: BAE21468.1.
BC115514 mRNA. Translation: AAI15515.1.
BC115515 mRNA. Translation: AAI15516.1.
CCDSiCCDS29246.1.
RefSeqiNP_080562.2. NM_026286.3.
UniGeneiMm.179144.

3D structure databases

ProteinModelPortaliQ9D5H4.
SMRiQ9D5H4. Positions 62-231.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9D5H4.
PRIDEiQ9D5H4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025388; ENSMUSP00000025388; ENSMUSG00000024510.
GeneIDi67634.
KEGGimmu:67634.
UCSCiuc008exc.2. mouse.

Organism-specific databases

CTDi94033.
MGIiMGI:1914884. Ftmt.

Phylogenomic databases

eggNOGiCOG1528.
GeneTreeiENSGT00760000119129.
HOGENOMiHOG000223383.
HOVERGENiHBG000410.
InParanoidiQ9D5H4.
KOiK18495.
OMAiGLFMIDR.
OrthoDBiEOG7DRJ49.
PhylomeDBiQ9D5H4.
TreeFamiTF313885.

Miscellaneous databases

NextBioi325089.
PROiQ9D5H4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D5H4.
CleanExiMM_FTMT.
GenevestigatoriQ9D5H4.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiFTMT_MOUSE
AccessioniPrimary (citable) accession number: Q9D5H4
Secondary accession number(s): Q14BZ8, Q3V0N6, Q9D5F4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 4, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.