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Q9D5H4

- FTMT_MOUSE

UniProt

Q9D5H4 - FTMT_MOUSE

Protein

Ferritin, mitochondrial

Gene

Ftmt

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi83 – 831Iron 1PROSITE-ProRule annotation
    Metal bindingi118 – 1181Iron 1PROSITE-ProRule annotation
    Metal bindingi118 – 1181Iron 2PROSITE-ProRule annotation
    Metal bindingi121 – 1211Iron 1PROSITE-ProRule annotation
    Metal bindingi163 – 1631Iron 2PROSITE-ProRule annotation
    Metal bindingi197 – 1971Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: MGI
    3. iron ion binding Source: MGI

    GO - Biological processi

    1. cellular iron ion homeostasis Source: MGI
    2. iron ion transport Source: InterPro
    3. positive regulation of cell proliferation Source: Ensembl
    4. positive regulation of lyase activity Source: Ensembl
    5. positive regulation of oxidoreductase activity Source: Ensembl
    6. positive regulation of transferase activity Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin, mitochondrial (EC:1.16.3.1)
    Gene namesi
    Name:Ftmt
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1914884. Ftmt.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4949MitochondrionSequence AnalysisAdd
    BLAST
    Chaini50 – 237188Ferritin, mitochondrialPRO_0000008851Add
    BLAST

    Proteomic databases

    PaxDbiQ9D5H4.
    PRIDEiQ9D5H4.

    Expressioni

    Gene expression databases

    BgeeiQ9D5H4.
    CleanExiMM_FTMT.
    GenevestigatoriQ9D5H4.

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D5H4.
    SMRiQ9D5H4. Positions 62-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 215150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1528.
    GeneTreeiENSGT00700000104283.
    HOGENOMiHOG000223383.
    HOVERGENiHBG000410.
    InParanoidiQ14BZ8.
    KOiK00522.
    OMAiFANFYIQ.
    OrthoDBiEOG7DRJ49.
    PhylomeDBiQ9D5H4.
    TreeFamiTF313885.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D5H4-1 [UniParc]FASTAAdd to Basket

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    MLSCFWFFSK HISSALMSLP RVLHRFTAPQ CLASRYPLGP LLASPRRLLA    50
    SVASSQDSTR PSRVRQNFHP DSEAAINRQI NLELYASYVY LSMAYYFSRD 100
    DVALYNFSKY FLRQSLEERE HAEKLMKLQN QRGGRICLQD IKKPDKDDWE 150
    CGLRAMECAL LLEKNVNQSL LDLHTLASEK GDPHLCDFLE THYLHEQVKS 200
    IKELGDHVHN LVTMGAPAAG LAEYLFDKHT LGSESKH 237
    Length:237
    Mass (Da):27,158
    Last modified:April 26, 2005 - v2
    Checksum:i6EC3D9B1539B3B5E
    GO

    Sequence cautioni

    The sequence BAB29806.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631E → G in BAB29831. (PubMed:16141072)Curated
    Sequence conflicti164 – 1641K → R in BAB29806. (PubMed:16141072)Curated
    Sequence conflicti167 – 1671N → T in BAB29806. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015346 mRNA. Translation: BAB29806.1. Different initiation.
    AK015400 mRNA. Translation: BAB29831.1.
    AK133009 mRNA. Translation: BAE21468.1.
    BC115514 mRNA. Translation: AAI15515.1.
    BC115515 mRNA. Translation: AAI15516.1.
    CCDSiCCDS29246.1.
    RefSeqiNP_080562.2. NM_026286.3.
    UniGeneiMm.179144.

    Genome annotation databases

    EnsembliENSMUST00000025388; ENSMUSP00000025388; ENSMUSG00000024510.
    GeneIDi67634.
    KEGGimmu:67634.
    UCSCiuc008exc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK015346 mRNA. Translation: BAB29806.1 . Different initiation.
    AK015400 mRNA. Translation: BAB29831.1 .
    AK133009 mRNA. Translation: BAE21468.1 .
    BC115514 mRNA. Translation: AAI15515.1 .
    BC115515 mRNA. Translation: AAI15516.1 .
    CCDSi CCDS29246.1.
    RefSeqi NP_080562.2. NM_026286.3.
    UniGenei Mm.179144.

    3D structure databases

    ProteinModelPortali Q9D5H4.
    SMRi Q9D5H4. Positions 62-231.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9D5H4.
    PRIDEi Q9D5H4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025388 ; ENSMUSP00000025388 ; ENSMUSG00000024510 .
    GeneIDi 67634.
    KEGGi mmu:67634.
    UCSCi uc008exc.2. mouse.

    Organism-specific databases

    CTDi 94033.
    MGIi MGI:1914884. Ftmt.

    Phylogenomic databases

    eggNOGi COG1528.
    GeneTreei ENSGT00700000104283.
    HOGENOMi HOG000223383.
    HOVERGENi HBG000410.
    InParanoidi Q14BZ8.
    KOi K00522.
    OMAi FANFYIQ.
    OrthoDBi EOG7DRJ49.
    PhylomeDBi Q9D5H4.
    TreeFami TF313885.

    Miscellaneous databases

    NextBioi 325089.
    PROi Q9D5H4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D5H4.
    CleanExi MM_FTMT.
    Genevestigatori Q9D5H4.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00540. FERRITIN_1. 1 hit.
    PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiFTMT_MOUSE
    AccessioniPrimary (citable) accession number: Q9D5H4
    Secondary accession number(s): Q14BZ8, Q3V0N6, Q9D5F4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3