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Protein

V-type proton ATPase subunit E 2

Gene

Atp6v1e2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome.1 Publication

GO - Molecular functioni

  • proton-exporting ATPase activity, phosphorylative mechanism Source: MGI
  • proton-transporting ATPase activity, rotational mechanism Source: InterPro

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: MGI

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
R-MMU-77387 Insulin receptor recycling
R-MMU-917977 Transferrin endocytosis and recycling
R-MMU-983712 Ion channel transport

Protein family/group databases

TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit E 2
Short name:
V-ATPase subunit E 2
Alternative name(s):
Vacuolar proton pump subunit E 2
Gene namesi
Name:Atp6v1e2
Synonyms:Atp6e1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1922165 Atp6v1e2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002823451 – 226V-type proton ATPase subunit E 2Add BLAST226

Proteomic databases

MaxQBiQ9D593
PaxDbiQ9D593
PeptideAtlasiQ9D593
PRIDEiQ9D593

PTM databases

iPTMnetiQ9D593
PhosphoSitePlusiQ9D593

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSMUSG00000053375
CleanExiMM_ATP6V1E2
GenevisibleiQ9D593 MM

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi2170761 interactor.
IntActiQ9D593 3 interactors.
MINTiQ9D593
STRINGi10090.ENSMUSP00000065285

Structurei

3D structure databases

ProteinModelPortaliQ9D593
SMRiQ9D593
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase E subunit family.Curated

Phylogenomic databases

eggNOGiKOG1664 Eukaryota
COG1390 LUCA
GeneTreeiENSGT00390000002730
HOGENOMiHOG000202506
HOVERGENiHBG002309
InParanoidiQ9D593
KOiK02150
OMAiKIQMSTM
OrthoDBiEOG091G0OGO
PhylomeDBiQ9D593
TreeFamiTF313479

Family and domain databases

Gene3Di3.30.2320.301 hit
HAMAPiMF_00311 ATP_synth_E_arch, 1 hit
InterProiView protein in InterPro
IPR038495 ATPase_E_C
IPR002842 ATPase_V1_Esu
PfamiView protein in Pfam
PF01991 vATP-synt_E, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTDIDVQK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR
60 70 80 90 100
LKIMDYFEKK EKQIEQQKKI QLSTMRNQAR ITVLRARDNL ILELLKDAKM
110 120 130 140 150
RLSRIVSDEE IYQDLLDKLV LQALLRLLEP VMIVRCRPQD LHLVESAVLR
160 170 180 190 200
AIPQYMRLCQ KHLEVQVDQT EHLPSNAAGG VEVYSSDQKI KVSNTLESRL
210 220
NLAAMQKMPE IRGILFGDNT SRKFFT
Length:226
Mass (Da):26,307
Last modified:June 1, 2001 - v1
Checksum:iAE5F501F02B8F98F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55D → G in AAH61059 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074757 mRNA Translation: BAB92083.1
AK015654 mRNA Translation: BAB29919.1
BC049547 mRNA Translation: AAH49547.2
BC061059 mRNA Translation: AAH61059.1
CCDSiCCDS29009.1
RefSeqiNP_083397.3, NM_029121.3
UniGeneiMm.159369

Genome annotation databases

EnsembliENSMUST00000065758; ENSMUSP00000065285; ENSMUSG00000053375
GeneIDi74915
KEGGimmu:74915
UCSCiuc008dul.1 mouse

Similar proteinsi

Entry informationi

Entry nameiVATE2_MOUSE
AccessioniPrimary (citable) accession number: Q9D593
Secondary accession number(s): Q6P8U8, Q810S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome