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Protein

Transmembrane protein 114

Gene

Tmem114

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

TCDBi8.A.16.2.7. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 114By similarity
Alternative name(s):
Claudin-26
Gene namesi
Name:Tmem114By similarity
Synonyms:Cldn26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921970. Tmem114.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence analysisAdd
BLAST
Transmembranei105 – 12521HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15321HelicalSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • apicolateral plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi54 – 541N → K: Complete loss of glycosylation; when associated with K-88. 1 Publication
Mutagenesisi88 – 881N → K: Complete loss of glycosylation; when associated with K-54. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Transmembrane protein 114PRO_0000352760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)1 Publication
Glycosylationi88 – 881N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D563.

Expressioni

Developmental stagei

Expressed weakly in the eye from as early as E13.5, with ocular expression up-regulated postnatally. By 10 weeks, expressed strongly in the lens epithelial cells and weakly in lens fibers. In adult, expressed in eye, brain and testis.1 Publication

Gene expression databases

BgeeiQ9D563.
GenevisibleiQ9D563. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D563. 1 interaction.
MINTiMINT-8085693.
STRINGi10090.ENSMUSP00000023400.

Structurei

3D structure databases

ProteinModelPortaliQ9D563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9Y. Eukaryota.
ENOG4111IMB. LUCA.
GeneTreeiENSGT00390000011615.
HOGENOMiHOG000154605.
HOVERGENiHBG076521.
InParanoidiQ9D563.
OMAiPLMNPFW.
OrthoDBiEOG7DVDCG.
PhylomeDBiQ9D563.
TreeFamiTF327980.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVRLGALAG AAALSGALSF VLLAAAIGTD FWYIIDTERL ERSSQRMRDQ
60 70 80 90 100
GPANRSQQEP LSSHSGLWRT CRVQSSCTPL MNPFWQENVT VSDSSRQLLT
110 120 130 140 150
MHGTFVILLP LSLIVMVFGG MTGFLSFLLR AHLLLLLTGI LFLFGAMVTL
160 170 180 190 200
TGISIYIAYS AVAFREAVCL LEERALLDQV DIRFGWSLAL GWISFVSELL
210 220
TGVVFLAAAR ALSLSQRQDQ AI
Length:222
Mass (Da):24,388
Last modified:June 1, 2001 - v1
Checksum:i8AB6E66C94ECAD52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015757 mRNA. Translation: BAB29961.1.
CH466521 Genomic DNA. Translation: EDK97288.1.
BC027071 mRNA. Translation: AAH27071.1.
BC147190 mRNA. Translation: AAI47191.1.
BC147191 mRNA. Translation: AAI47192.1.
CCDSiCCDS27937.1.
RefSeqiNP_083346.1. NM_029070.2.
UniGeneiMm.159318.

Genome annotation databases

EnsembliENSMUST00000023400; ENSMUSP00000023400; ENSMUSG00000022715.
GeneIDi74720.
KEGGimmu:74720.
UCSCiuc007yck.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK015757 mRNA. Translation: BAB29961.1.
CH466521 Genomic DNA. Translation: EDK97288.1.
BC027071 mRNA. Translation: AAH27071.1.
BC147190 mRNA. Translation: AAI47191.1.
BC147191 mRNA. Translation: AAI47192.1.
CCDSiCCDS27937.1.
RefSeqiNP_083346.1. NM_029070.2.
UniGeneiMm.159318.

3D structure databases

ProteinModelPortaliQ9D563.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D563. 1 interaction.
MINTiMINT-8085693.
STRINGi10090.ENSMUSP00000023400.

Protein family/group databases

TCDBi8.A.16.2.7. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Proteomic databases

PaxDbiQ9D563.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023400; ENSMUSP00000023400; ENSMUSG00000022715.
GeneIDi74720.
KEGGimmu:74720.
UCSCiuc007yck.1. mouse.

Organism-specific databases

CTDi283953.
MGIiMGI:1921970. Tmem114.

Phylogenomic databases

eggNOGiENOG410IF9Y. Eukaryota.
ENOG4111IMB. LUCA.
GeneTreeiENSGT00390000011615.
HOGENOMiHOG000154605.
HOVERGENiHBG076521.
InParanoidiQ9D563.
OMAiPLMNPFW.
OrthoDBiEOG7DVDCG.
PhylomeDBiQ9D563.
TreeFamiTF327980.

Miscellaneous databases

NextBioi341474.
PROiQ9D563.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D563.
GenevisibleiQ9D563. MM.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: BrainImported and EyeImported.
  4. "Characterization of a familial t(16;22) balanced translocation associated with congenital cataract leads to identification of a novel gene, TMEM114, expressed in the lens and disrupted by the translocation."
    Jamieson R.V., Farrar N., Stewart K., Perveen R., Mihelec M., Carette M., Grigg J.R., McAvoy J.W., Lovicu F.J., Tam P.P.L., Scambler P., Lloyd I.C., Donnai D., Black G.C.M.
    Hum. Mutat. 28:968-977(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  6. "The cataract-associated protein TMEM114, and TMEM235, are glycosylated transmembrane proteins that are distinct from claudin family members."
    Maher G.J., Hilton E.N., Urquhart J.E., Davidson A.E., Spencer H.L., Black G.C., Manson F.D.
    FEBS Lett. 585:2187-2192(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-54 AND ASN-88, MUTAGENESIS OF ASN-54 AND ASN-88.

Entry informationi

Entry nameiTM114_MOUSE
AccessioniPrimary (citable) accession number: Q9D563
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 1, 2001
Last modified: November 11, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.