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Protein

EF-hand domain-containing protein D1

Gene

Efhd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi104 – 115121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi140 – 151122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • neuron projection development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing protein D1
Alternative name(s):
EF-hand domain-containing protein 1
Swiprosin-2
Gene namesi
Name:Efhd1
Synonyms:Sws2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1921607. Efhd1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240EF-hand domain-containing protein D1PRO_0000073644Add
BLAST

Proteomic databases

EPDiQ9D4J1.
MaxQBiQ9D4J1.
PaxDbiQ9D4J1.
PRIDEiQ9D4J1.

PTM databases

iPTMnetiQ9D4J1.
PhosphoSiteiQ9D4J1.

Expressioni

Tissue specificityi

Highest expression in testis, followed by ovary, kidney, cerebrum, cerebellum, heart, liver, and spleen. In the cerebrum and cerebellum, undetectable at embryonic stages, expression increases after birth up to adult stage. In adult CNS, detected in neurons of the cerebellum, cerebrum and hippocampus formation, including dentate gyrus and Cornu Ammonis, but not in the white matter. In the testis, expressed in spermatocytes, but not in spermatogonia nor in interstitial cells. In ovary, found predominantly in mural granulosa cells and those of the cumulus oophorus. In kidney, expressed in collecting ducts, but not in glomeruli. Not detected in skeletal muscle.1 Publication

Developmental stagei

In the cerebral cortex, at birth, confined in the Purkinje cell layer (PCL) and in cerebellar nuclei. Not detected in the external germinal layer (EGL). At P5 and P10, predominantly found in the PCL and internal germinal layer (IGL). Not detected in the EGL. At P10 and P20, up-regulated. At P20, expression similar to that of the adult cerebellum.1 Publication

Gene expression databases

BgeeiQ9D4J1.
CleanExiMM_EFHD1.
GenevisibleiQ9D4J1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D4J1. 1 interaction.
MINTiMINT-4094130.
STRINGi10090.ENSMUSP00000027472.

Structurei

3D structure databases

ProteinModelPortaliQ9D4J1.
SMRiQ9D4J1. Positions 86-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 12636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini127 – 16236EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
GeneTreeiENSGT00390000012058.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ9D4J1.
OMAiRRCKVFN.
OrthoDBiEOG7H1JNV.
PhylomeDBiQ9D4J1.
TreeFamiTF320736.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D4J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEELACKL QRRLRLEVRA ETDQGDPQPA PCDAPAGHPE PEPPARAPTA
60 70 80 90 100
SADSELNLKL SRRLDIHQGT ARPGRSKVFN PYTEFPEFSR RLLKDLEKMF
110 120 130 140 150
KTYDAGRDGF IDLMELKLMM EKLGAPQTHL GLKSMIKEVD EDFDGKLSFR
160 170 180 190 200
EFLLIFHKAA AGELQEDSGL LALAKFSEID VALEGVRGAK NFFEAKAQAL
210 220 230 240
SCSSKFEAEL KAEQEERKRE EEARRLRQAA FRELKAAFSA
Length:240
Mass (Da):27,000
Last modified:June 1, 2001 - v1
Checksum:i8C8B94F1A23E6FD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016491 mRNA. Translation: BAB30268.1.
AK045911 mRNA. Translation: BAC32529.1.
AK144175 mRNA. Translation: BAE25747.1.
AK171846 mRNA. Translation: BAE42694.1.
BC019531 mRNA. Translation: AAH19531.1.
BC085088 mRNA. Translation: AAH85088.1.
CCDSiCCDS15132.1.
RefSeqiNP_083165.1. NM_028889.2.
UniGeneiMm.247951.

Genome annotation databases

EnsembliENSMUST00000027472; ENSMUSP00000027472; ENSMUSG00000026255.
ENSMUST00000118687; ENSMUSP00000112980; ENSMUSG00000026255.
GeneIDi98363.
KEGGimmu:98363.
UCSCiuc007bwo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016491 mRNA. Translation: BAB30268.1.
AK045911 mRNA. Translation: BAC32529.1.
AK144175 mRNA. Translation: BAE25747.1.
AK171846 mRNA. Translation: BAE42694.1.
BC019531 mRNA. Translation: AAH19531.1.
BC085088 mRNA. Translation: AAH85088.1.
CCDSiCCDS15132.1.
RefSeqiNP_083165.1. NM_028889.2.
UniGeneiMm.247951.

3D structure databases

ProteinModelPortaliQ9D4J1.
SMRiQ9D4J1. Positions 86-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D4J1. 1 interaction.
MINTiMINT-4094130.
STRINGi10090.ENSMUSP00000027472.

PTM databases

iPTMnetiQ9D4J1.
PhosphoSiteiQ9D4J1.

Proteomic databases

EPDiQ9D4J1.
MaxQBiQ9D4J1.
PaxDbiQ9D4J1.
PRIDEiQ9D4J1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027472; ENSMUSP00000027472; ENSMUSG00000026255.
ENSMUST00000118687; ENSMUSP00000112980; ENSMUSG00000026255.
GeneIDi98363.
KEGGimmu:98363.
UCSCiuc007bwo.1. mouse.

Organism-specific databases

CTDi80303.
MGIiMGI:1921607. Efhd1.

Phylogenomic databases

eggNOGiKOG0041. Eukaryota.
ENOG4111JG9. LUCA.
GeneTreeiENSGT00390000012058.
HOGENOMiHOG000007978.
HOVERGENiHBG051446.
InParanoidiQ9D4J1.
OMAiRRCKVFN.
OrthoDBiEOG7H1JNV.
PhylomeDBiQ9D4J1.
TreeFamiTF320736.

Miscellaneous databases

NextBioi353424.
PROiQ9D4J1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D4J1.
CleanExiMM_EFHD1.
GenevisibleiQ9D4J1. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina, Spleen and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye and Mammary gland.
  3. "Novel genes cloned from a neuronal cell line newly established from a cerebellum of an adult p53(-/-) mouse."
    Tominaga M., Tomooka Y.
    Biochem. Biophys. Res. Commun. 297:473-479(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiEFHD1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4J1
Secondary accession number(s): Q543U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: March 16, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.