Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GRIP and coiled-coil domain-containing protein 1

Gene

Gcc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP and coiled-coil domain-containing protein 1
Alternative name(s):
Golgi coiled-coil protein 1
Gene namesi
Name:Gcc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1921625. Gcc1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900731 – 778GRIP and coiled-coil domain-containing protein 1Add BLAST778

Proteomic databases

EPDiQ9D4H2.
MaxQBiQ9D4H2.
PaxDbiQ9D4H2.
PeptideAtlasiQ9D4H2.
PRIDEiQ9D4H2.

PTM databases

iPTMnetiQ9D4H2.
PhosphoSitePlusiQ9D4H2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029708.
CleanExiMM_GCC1.
ExpressionAtlasiQ9D4H2. baseline and differential.
GenevisibleiQ9D4H2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067395.

Structurei

3D structure databases

ProteinModelPortaliQ9D4H2.
SMRiQ9D4H2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini716 – 766GRIPPROSITE-ProRule annotationAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili13 – 61Sequence analysisAdd BLAST49
Coiled coili152 – 702Sequence analysisAdd BLAST551

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEHR. Eukaryota.
ENOG410Y6HA. LUCA.
GeneTreeiENSGT00440000039893.
HOGENOMiHOG000252925.
HOVERGENiHBG039459.
InParanoidiQ9D4H2.
KOiK20281.
OMAiSEPTFFL.
OrthoDBiEOG091G0R8Q.
PhylomeDBiQ9D4H2.
TreeFamiTF324186.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D4H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFGMNFGG GPSKKDLLET IETQKKQLLQ YQARLKDVVR AYKSLLKEKE
60 70 80 90 100
ALEASIKVLS VSHEADVGLS GVQPPGLTFP DSVDDRCSTH SEDSTGTATS
110 120 130 140 150
LDTAASLTSV KGEFGVEDDR AARGPLPPKS EEASGSESGV SSSSGDGPSA
160 170 180 190 200
GSEMDKRVHQ LKTQLATLTS SLATVTQEKS RMEASYLADK KKMKQDLEDA
210 220 230 240 250
NKKAEEERGR LEGDLKVLQE QIAETKARLI TQQHDRAQEQ SDHALMLREL
260 270 280 290 300
QKLLQEERTQ RQDLELRLEE TREALAGRAY AADQVEGFEL QTKQLTREVE
310 320 330 340 350
ELKGELQTIR DEKNRPDPRL QELQQEAARL KSHFQAQLQQ EMRKTALAED
360 370 380 390 400
QLRQQSQVEE QRVAALESQI SEVSELLGTY EKAKQKDQLA IQKLKERLLQ
410 420 430 440 450
LDLENKTLAL AASSRSSLDI HGDESSLDIN VLKDKMEKLK KLLQVAARKS
460 470 480 490 500
QVTLDVEKLC DPEIMANSEA ADGEKATALY YQQELKQLKE EFERYKMRAQ
510 520 530 540 550
VVLKSKNTKD GSLGKELEAA QEQLAELKDK YISLRLSCEE LESQHQQEAE
560 570 580 590 600
DWKQELARLQ QLHRQELERS QLDFRDRTLK LEEELHKQRD RALAVLAEKD
610 620 630 640 650
LELEQLRSVA LSSGLPGRRS PVGGVGGGGL GDPADTASSD SLTQALQLAA
660 670 680 690 700
ANEPTFFLYA EQLARKEVEI TSLRKQKHRL EVEAHQLQER LLEEGERHRE
710 720 730 740 750
EVGALQSHIE KNMRDQSREG ANLEYLKNII YRFLTLPDSL GRQQTLTAIL
760 770
TILHFSPEEK QVLMRLPSGG SWWPSGKR
Length:778
Mass (Da):87,678
Last modified:July 11, 2003 - v2
Checksum:i10443331CB480A2B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456V → M in BAC27780 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032253 mRNA. Translation: BAC27780.1.
BC066807 mRNA. Translation: AAH66807.1.
CCDSiCCDS19951.1.
RefSeqiNP_083176.3. NM_028900.4.
UniGeneiMm.332950.

Genome annotation databases

EnsembliENSMUST00000064377; ENSMUSP00000067395; ENSMUSG00000029708.
ENSMUST00000090511; ENSMUSP00000087997; ENSMUSG00000029708.
GeneIDi74375.
KEGGimmu:74375.
UCSCiuc009bco.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032253 mRNA. Translation: BAC27780.1.
BC066807 mRNA. Translation: AAH66807.1.
CCDSiCCDS19951.1.
RefSeqiNP_083176.3. NM_028900.4.
UniGeneiMm.332950.

3D structure databases

ProteinModelPortaliQ9D4H2.
SMRiQ9D4H2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000067395.

PTM databases

iPTMnetiQ9D4H2.
PhosphoSitePlusiQ9D4H2.

Proteomic databases

EPDiQ9D4H2.
MaxQBiQ9D4H2.
PaxDbiQ9D4H2.
PeptideAtlasiQ9D4H2.
PRIDEiQ9D4H2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064377; ENSMUSP00000067395; ENSMUSG00000029708.
ENSMUST00000090511; ENSMUSP00000087997; ENSMUSG00000029708.
GeneIDi74375.
KEGGimmu:74375.
UCSCiuc009bco.2. mouse.

Organism-specific databases

CTDi79571.
MGIiMGI:1921625. Gcc1.

Phylogenomic databases

eggNOGiENOG410IEHR. Eukaryota.
ENOG410Y6HA. LUCA.
GeneTreeiENSGT00440000039893.
HOGENOMiHOG000252925.
HOVERGENiHBG039459.
InParanoidiQ9D4H2.
KOiK20281.
OMAiSEPTFFL.
OrthoDBiEOG091G0R8Q.
PhylomeDBiQ9D4H2.
TreeFamiTF324186.

Enzyme and pathway databases

ReactomeiR-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiGcc1. mouse.
PROiQ9D4H2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029708.
CleanExiMM_GCC1.
ExpressionAtlasiQ9D4H2. baseline and differential.
GenevisibleiQ9D4H2. MM.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGCC1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4H2
Secondary accession number(s): Q8CCR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: July 11, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.