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Protein

Exocyst complex component 2

Gene

Exoc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.By similarity

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Exocyst complex component 2
Alternative name(s):
Exocyst complex component Sec5
Gene namesi
Name:Exoc2
Synonyms:Sec5, Sec5l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913732. Exoc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 924924Exocyst complex component 2PRO_0000118919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei431 – 4311PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity
Modified residuei435 – 4351PhosphoserineBy similarity
Modified residuei440 – 4401PhosphothreonineBy similarity
Modified residuei454 – 4541N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9D4H1.
MaxQBiQ9D4H1.
PaxDbiQ9D4H1.
PeptideAtlasiQ9D4H1.
PRIDEiQ9D4H1.

PTM databases

iPTMnetiQ9D4H1.
PhosphoSiteiQ9D4H1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021357.
CleanExiMM_EXOC2.
GenevisibleiQ9D4H1. MM.

Interactioni

Subunit structurei

The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1. Interacts with RALA and GNEFR/DELGEF. Interaction with GNEFR occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP.1 Publication

GO - Molecular functioni

  • protein kinase binding Source: MGI
  • protein N-terminus binding Source: UniProtKB
  • Ral GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi211506. 1 interaction.
IntActiQ9D4H1. 2 interactions.
MINTiMINT-4134028.
STRINGi10090.ENSMUSP00000021785.

Structurei

Secondary structure

1
924
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146Combined sources
Beta strandi22 – 298Combined sources
Turni35 – 373Combined sources
Beta strandi41 – 433Combined sources
Turni49 – 513Combined sources
Beta strandi56 – 583Combined sources
Beta strandi60 – 634Combined sources
Beta strandi69 – 713Combined sources
Beta strandi73 – 764Combined sources
Beta strandi79 – 813Combined sources
Beta strandi85 – 873Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HK6NMR-A5-97[»]
ProteinModelPortaliQ9D4H1.
SMRiQ9D4H1. Positions 5-97.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9D4H1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 9386IPT/TIGAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili240 – 26021Sequence analysisAdd
BLAST

Domaini

Interacts with RALA through the TIG domain.

Sequence similaritiesi

Belongs to the SEC5 family.Curated
Contains 1 IPT/TIG domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2347. Eukaryota.
ENOG410XSY3. LUCA.
GeneTreeiENSGT00390000010872.
HOGENOMiHOG000044231.
HOVERGENiHBG028469.
InParanoidiQ9D4H1.
KOiK17637.
OMAiFRDITIS.
OrthoDBiEOG091G02P6.
PhylomeDBiQ9D4H1.
TreeFamiTF105891.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR029175. EXOC2/Sec5.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PANTHERiPTHR13043. PTHR13043. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D4H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSRQPPLV TGISPNEGIP WTKVTIRGEN LGTGPTDLIG LTICGHNCLL
60 70 80 90 100
TAEWMSASKI VCRVGQAKND KGDIIVTTKS GGKGTSTVSF KLLKPEKIGI
110 120 130 140 150
LDQSAVWVDE MNYYDMRTDR NKGIPPLSLR PANPLGIEIE KCKLPQKNLE
160 170 180 190 200
VLFHGMSADF TSENFSAAWY LIENHSTTSF EQLKMAVTNL KRQANKKSEG
210 220 230 240 250
SLAYVKGGLS TFFEAQDALS AIHQKLEADG TEKVEGSMTQ KLENVLNRAS
260 270 280 290 300
NTADTLFQEV LGRKDKADST RNALNVLQRF KFLFNLPLNI KRNIQKGDYD
310 320 330 340 350
VVINDYEKAK SLFGKTEVQV FKKYYAEVEA GIEDLRELLL KKLLETPSTL
360 370 380 390 400
HDQKRYIRYL SDLHAPGDPA WQCIGAQHKW TLKLMQDCKE GHMKSLKGHP
410 420 430 440 450
GPHSPMLDLD NDVRPSVLGH LSQTASLKRG SSFQSGRDDT WRYKTPHRVA
460 470 480 490 500
FVEKLTKLVL SQLPNFWKLW ISYVNGSLFS ETAEKSGQSE RSKNVRQRQN
510 520 530 540 550
DFKKMIQEVM HSLVKLIRGA LLPLSLREGD GRQYGGWEVQ AELSGQWLAH
560 570 580 590 600
VIQTIRLTYE SLTALEIPND MLQIIQDLIL DLRIRCIMVT LQHTAEEIKR
610 620 630 640 650
LAEKEDWVVD NEGLTSLPCQ FEQSIVHSLQ SLKGVVDCKP GEASVFQQPK
660 670 680 690 700
TQEEVCQLCI NIMQVFIYCL EQLSTKPDAD IDTTHLSVDV SSPDLFGSIH
710 720 730 740 750
EDFSLTSEQR LLIVLSNCCY LERHTFLNIA EHFEKHNFQG IEKITQVSMA
760 770 780 790 800
SLKELDQRLF ENYIELKADP IVGSLEPGIY AGYFDWKDCL PPAGVRNYLK
810 820 830 840 850
EALVNIIAVH AEVFTISKEL VPRVLARVVE AVSEELSRLM QCVSSFSRNG
860 870 880 890 900
ALQARLEICA LRDTVAIYLT SESRSSFKQA LEALPQLASG ADKKSLEELL
910 920
NKFKSSMHLQ LTCFQAASPA VMKT
Length:924
Mass (Da):103,959
Last modified:June 1, 2001 - v1
Checksum:i457BAD92EAA3040B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016532 mRNA. Translation: BAB30290.1.
AK050068 mRNA. Translation: BAC34056.1.
BC048154 mRNA. Translation: AAH48154.1.
BC049102 mRNA. Translation: AAH49102.1.
CCDSiCCDS26420.1.
RefSeqiNP_079864.1. NM_025588.2.
XP_006516789.1. XM_006516726.1.
UniGeneiMm.293510.

Genome annotation databases

EnsembliENSMUST00000021785; ENSMUSP00000021785; ENSMUSG00000021357.
ENSMUST00000102946; ENSMUSP00000100010; ENSMUSG00000021357.
GeneIDi66482.
KEGGimmu:66482.
UCSCiuc007pzc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016532 mRNA. Translation: BAB30290.1.
AK050068 mRNA. Translation: BAC34056.1.
BC048154 mRNA. Translation: AAH48154.1.
BC049102 mRNA. Translation: AAH49102.1.
CCDSiCCDS26420.1.
RefSeqiNP_079864.1. NM_025588.2.
XP_006516789.1. XM_006516726.1.
UniGeneiMm.293510.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HK6NMR-A5-97[»]
ProteinModelPortaliQ9D4H1.
SMRiQ9D4H1. Positions 5-97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211506. 1 interaction.
IntActiQ9D4H1. 2 interactions.
MINTiMINT-4134028.
STRINGi10090.ENSMUSP00000021785.

PTM databases

iPTMnetiQ9D4H1.
PhosphoSiteiQ9D4H1.

Proteomic databases

EPDiQ9D4H1.
MaxQBiQ9D4H1.
PaxDbiQ9D4H1.
PeptideAtlasiQ9D4H1.
PRIDEiQ9D4H1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021785; ENSMUSP00000021785; ENSMUSG00000021357.
ENSMUST00000102946; ENSMUSP00000100010; ENSMUSG00000021357.
GeneIDi66482.
KEGGimmu:66482.
UCSCiuc007pzc.1. mouse.

Organism-specific databases

CTDi55770.
MGIiMGI:1913732. Exoc2.

Phylogenomic databases

eggNOGiKOG2347. Eukaryota.
ENOG410XSY3. LUCA.
GeneTreeiENSGT00390000010872.
HOGENOMiHOG000044231.
HOVERGENiHBG028469.
InParanoidiQ9D4H1.
KOiK17637.
OMAiFRDITIS.
OrthoDBiEOG091G02P6.
PhylomeDBiQ9D4H1.
TreeFamiTF105891.

Enzyme and pathway databases

ReactomeiR-MMU-1445148. Translocation of GLUT4 to the plasma membrane.
R-MMU-264876. Insulin processing.
R-MMU-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

ChiTaRSiExoc2. mouse.
EvolutionaryTraceiQ9D4H1.
PROiQ9D4H1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021357.
CleanExiMM_EXOC2.
GenevisibleiQ9D4H1. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR029175. EXOC2/Sec5.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
[Graphical view]
PANTHERiPTHR13043. PTHR13043. 1 hit.
PfamiPF01833. TIG. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiEXOC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D4H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.