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Q9D4G9

- RMI1_MOUSE

UniProt

Q9D4G9 - RMI1_MOUSE

Protein

RecQ-mediated genome instability protein 1

Gene

Rmi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability By similarity.By similarity

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. glucose homeostasis Source: MGI
    3. multicellular organism growth Source: MGI
    4. reduction of food intake in response to dietary excess Source: MGI
    5. response to dietary excess Source: MGI
    6. response to glucose Source: MGI

    Keywords - Biological processi

    DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RecQ-mediated genome instability protein 1
    Gene namesi
    Name:Rmi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1921636. Rmi1.

    Subcellular locationi

    Nucleus By similarity
    Note: Forms foci in response to DNA damage.By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 616616RecQ-mediated genome instability protein 1PRO_0000227547Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei225 – 2251PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PRIDEiQ9D4G9.

    PTM databases

    PhosphoSiteiQ9D4G9.

    Expressioni

    Gene expression databases

    BgeeiQ9D4G9.
    GenevestigatoriQ9D4G9.

    Interactioni

    Subunit structurei

    Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct By similarity.By similarity

    Protein-protein interaction databases

    BioGridi216710. 7 interactions.
    IntActiQ9D4G9. 6 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D4G9.
    SMRiQ9D4G9. Positions 2-215, 473-616.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RMI1 family.Curated

    Phylogenomic databases

    eggNOGiNOG261197.
    GeneTreeiENSGT00740000115530.
    HOGENOMiHOG000154148.
    HOVERGENiHBG061190.
    InParanoidiQ9D4G9.
    KOiK10990.
    OMAiAMDLYSP.
    OrthoDBiEOG7F7W8R.
    PhylomeDBiQ9D4G9.
    TreeFamiTF316491.

    Family and domain databases

    InterProiIPR013894. DUF1767.
    [Graphical view]
    PfamiPF08585. DUF1767. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D4G9-1 [UniParc]FASTAAdd to Basket

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    MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK    50
    QVLEQWLLTD LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY 100
    SQIQKLRGKN TTNDLVSAET QSTPKPWEVR PSRMLMLQLT DGVTHIQGME 150
    YQSIPALHSG LPPGTKILVR GCILFRLGVL LLKPENVKVL GGEVDGLSEE 200
    NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL GPSDEELLAS 250
    LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP 300
    PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM 350
    EIFSHKPSSL NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR 400
    FSAHDFTNDS KISEVDDAAQ QTLSSSNVHC LRNKILNRKL DLSEKSSQIS 450
    KENGHPFQAC SSRSFENNTY LSIGMDLHSP PFIYLSVLMA RKPKEVTTVT 500
    VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI LTSMIGYSVP 550
    EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ 600
    DVGMEHVENL KKRLNK 616
    Length:616
    Mass (Da):68,465
    Last modified:June 1, 2001 - v1
    Checksum:i2C70E918FD911803
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731I → V in AAH37694. (PubMed:15489334)Curated
    Sequence conflicti74 – 741L → S in BAC37651. (PubMed:16141072)Curated
    Sequence conflicti170 – 1701R → H in AAH37694. (PubMed:15489334)Curated
    Sequence conflicti252 – 2521D → G in AAH37694. (PubMed:15489334)Curated
    Sequence conflicti411 – 4111K → E in AAH37694. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016542 mRNA. Translation: BAB30292.1.
    AK032229 mRNA. Translation: BAC27772.1.
    AK079457 mRNA. Translation: BAC37651.1.
    BC037694 mRNA. Translation: AAH37694.1.
    CCDSiCCDS26571.1.
    RefSeqiNP_001161720.1. NM_001168248.1.
    NP_083180.3. NM_028904.3.
    XP_006517483.1. XM_006517420.1.
    XP_006517484.1. XM_006517421.1.
    UniGeneiMm.85289.

    Genome annotation databases

    EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367.
    GeneIDi74386.
    KEGGimmu:74386.
    UCSCiuc007qua.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016542 mRNA. Translation: BAB30292.1 .
    AK032229 mRNA. Translation: BAC27772.1 .
    AK079457 mRNA. Translation: BAC37651.1 .
    BC037694 mRNA. Translation: AAH37694.1 .
    CCDSi CCDS26571.1.
    RefSeqi NP_001161720.1. NM_001168248.1.
    NP_083180.3. NM_028904.3.
    XP_006517483.1. XM_006517420.1.
    XP_006517484.1. XM_006517421.1.
    UniGenei Mm.85289.

    3D structure databases

    ProteinModelPortali Q9D4G9.
    SMRi Q9D4G9. Positions 2-215, 473-616.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 216710. 7 interactions.
    IntActi Q9D4G9. 6 interactions.

    PTM databases

    PhosphoSitei Q9D4G9.

    Proteomic databases

    PRIDEi Q9D4G9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042450 ; ENSMUSP00000041035 ; ENSMUSG00000035367 .
    GeneIDi 74386.
    KEGGi mmu:74386.
    UCSCi uc007qua.2. mouse.

    Organism-specific databases

    CTDi 80010.
    MGIi MGI:1921636. Rmi1.

    Phylogenomic databases

    eggNOGi NOG261197.
    GeneTreei ENSGT00740000115530.
    HOGENOMi HOG000154148.
    HOVERGENi HBG061190.
    InParanoidi Q9D4G9.
    KOi K10990.
    OMAi AMDLYSP.
    OrthoDBi EOG7F7W8R.
    PhylomeDBi Q9D4G9.
    TreeFami TF316491.

    Miscellaneous databases

    NextBioi 340617.
    PROi Q9D4G9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D4G9.
    Genevestigatori Q9D4G9.

    Family and domain databases

    InterProi IPR013894. DUF1767.
    [Graphical view ]
    Pfami PF08585. DUF1767. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb, Testis and Vagina.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiRMI1_MOUSE
    AccessioniPrimary (citable) accession number: Q9D4G9
    Secondary accession number(s): Q8C560, Q8CI20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3