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Q9D4G9 (RMI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
RecQ-mediated genome instability protein 1
Gene names
Name:Rmi1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability By similarity.

Subunit structure

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct By similarity.

Subcellular location

Nucleus By similarity. Note: Forms foci in response to DNA damage By similarity.

Sequence similarities

Belongs to the RMI1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 616616RecQ-mediated genome instability protein 1
PRO_0000227547

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue2251Phosphoserine By similarity

Experimental info

Sequence conflict731I → V in AAH37694. Ref.2
Sequence conflict741L → S in BAC37651. Ref.1
Sequence conflict1701R → H in AAH37694. Ref.2
Sequence conflict2521D → G in AAH37694. Ref.2
Sequence conflict4111K → E in AAH37694. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9D4G9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2C70E918FD911803

FASTA61668,465
        10         20         30         40         50         60 
MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK QVLEQWLLTD 

        70         80         90        100        110        120 
LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY SQIQKLRGKN TTNDLVSAET 

       130        140        150        160        170        180 
QSTPKPWEVR PSRMLMLQLT DGVTHIQGME YQSIPALHSG LPPGTKILVR GCILFRLGVL 

       190        200        210        220        230        240 
LLKPENVKVL GGEVDGLSEE NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL 

       250        260        270        280        290        300 
GPSDEELLAS LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP 

       310        320        330        340        350        360 
PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM EIFSHKPSSL 

       370        380        390        400        410        420 
NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR FSAHDFTNDS KISEVDDAAQ 

       430        440        450        460        470        480 
QTLSSSNVHC LRNKILNRKL DLSEKSSQIS KENGHPFQAC SSRSFENNTY LSIGMDLHSP 

       490        500        510        520        530        540 
PFIYLSVLMA RKPKEVTTVT VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI 

       550        560        570        580        590        600 
LTSMIGYSVP EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ 

       610 
DVGMEHVENL KKRLNK 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Olfactory bulb, Testis and Vagina.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK016542 mRNA. Translation: BAB30292.1.
AK032229 mRNA. Translation: BAC27772.1.
AK079457 mRNA. Translation: BAC37651.1.
BC037694 mRNA. Translation: AAH37694.1.
CCDSCCDS26571.1.
RefSeqNP_001161720.1. NM_001168248.1.
NP_083180.3. NM_028904.3.
XP_006517483.1. XM_006517420.1.
XP_006517484.1. XM_006517421.1.
UniGeneMm.85289.

3D structure databases

ProteinModelPortalQ9D4G9.
SMRQ9D4G9. Positions 2-215, 473-616.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid216710. 7 interactions.
IntActQ9D4G9. 6 interactions.

PTM databases

PhosphoSiteQ9D4G9.

Proteomic databases

PRIDEQ9D4G9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367.
GeneID74386.
KEGGmmu:74386.
UCSCuc007qua.2. mouse.

Organism-specific databases

CTD80010.
MGIMGI:1921636. Rmi1.

Phylogenomic databases

eggNOGNOG261197.
GeneTreeENSGT00740000115530.
HOGENOMHOG000154148.
HOVERGENHBG061190.
InParanoidQ9D4G9.
KOK10990.
OMAAMDLYSP.
OrthoDBEOG7F7W8R.
PhylomeDBQ9D4G9.
TreeFamTF316491.

Gene expression databases

BgeeQ9D4G9.
GenevestigatorQ9D4G9.

Family and domain databases

InterProIPR013894. DUF1767.
[Graphical view]
PfamPF08585. DUF1767. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio340617.
PROQ9D4G9.
SOURCESearch...

Entry information

Entry nameRMI1_MOUSE
AccessionPrimary (citable) accession number: Q9D4G9
Secondary accession number(s): Q8C560, Q8CI20
Entry history
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot