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Protein

RecQ-mediated genome instability protein 1

Gene

Rmi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity).By similarity

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. glucose homeostasis Source: MGI
  3. multicellular organism growth Source: MGI
  4. reduction of food intake in response to dietary excess Source: MGI
  5. response to dietary excess Source: MGI
  6. response to glucose Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
RecQ-mediated genome instability protein 1
Gene namesi
Name:Rmi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1921636. Rmi1.

Subcellular locationi

Nucleus By similarity
Note: Forms foci in response to DNA damage.By similarity

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616RecQ-mediated genome instability protein 1PRO_0000227547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei225 – 2251PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9D4G9.
PRIDEiQ9D4G9.

PTM databases

PhosphoSiteiQ9D4G9.

Expressioni

Gene expression databases

BgeeiQ9D4G9.
GenevestigatoriQ9D4G9.

Interactioni

Subunit structurei

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct (By similarity).By similarity

Protein-protein interaction databases

BioGridi216710. 7 interactions.
IntActiQ9D4G9. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9D4G9.
SMRiQ9D4G9. Positions 2-215, 473-616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RMI1 family.Curated

Phylogenomic databases

eggNOGiNOG261197.
GeneTreeiENSGT00740000115530.
HOGENOMiHOG000154148.
HOVERGENiHBG061190.
InParanoidiQ9D4G9.
KOiK10990.
OMAiTPKPWEA.
OrthoDBiEOG7F7W8R.
PhylomeDBiQ9D4G9.
TreeFamiTF316491.

Family and domain databases

InterProiIPR013894. DUF1767.
[Graphical view]
PfamiPF08585. DUF1767. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D4G9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK
60 70 80 90 100
QVLEQWLLTD LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY
110 120 130 140 150
SQIQKLRGKN TTNDLVSAET QSTPKPWEVR PSRMLMLQLT DGVTHIQGME
160 170 180 190 200
YQSIPALHSG LPPGTKILVR GCILFRLGVL LLKPENVKVL GGEVDGLSEE
210 220 230 240 250
NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL GPSDEELLAS
260 270 280 290 300
LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP
310 320 330 340 350
PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM
360 370 380 390 400
EIFSHKPSSL NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR
410 420 430 440 450
FSAHDFTNDS KISEVDDAAQ QTLSSSNVHC LRNKILNRKL DLSEKSSQIS
460 470 480 490 500
KENGHPFQAC SSRSFENNTY LSIGMDLHSP PFIYLSVLMA RKPKEVTTVT
510 520 530 540 550
VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI LTSMIGYSVP
560 570 580 590 600
EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ
610
DVGMEHVENL KKRLNK
Length:616
Mass (Da):68,465
Last modified:June 1, 2001 - v1
Checksum:i2C70E918FD911803
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731I → V in AAH37694. (PubMed:15489334)Curated
Sequence conflicti74 – 741L → S in BAC37651. (PubMed:16141072)Curated
Sequence conflicti170 – 1701R → H in AAH37694. (PubMed:15489334)Curated
Sequence conflicti252 – 2521D → G in AAH37694. (PubMed:15489334)Curated
Sequence conflicti411 – 4111K → E in AAH37694. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016542 mRNA. Translation: BAB30292.1.
AK032229 mRNA. Translation: BAC27772.1.
AK079457 mRNA. Translation: BAC37651.1.
BC037694 mRNA. Translation: AAH37694.1.
CCDSiCCDS26571.1.
RefSeqiNP_001161720.1. NM_001168248.1.
NP_083180.3. NM_028904.3.
XP_006517483.1. XM_006517420.1.
XP_006517484.1. XM_006517421.1.
UniGeneiMm.85289.

Genome annotation databases

EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367.
GeneIDi74386.
KEGGimmu:74386.
UCSCiuc007qua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016542 mRNA. Translation: BAB30292.1.
AK032229 mRNA. Translation: BAC27772.1.
AK079457 mRNA. Translation: BAC37651.1.
BC037694 mRNA. Translation: AAH37694.1.
CCDSiCCDS26571.1.
RefSeqiNP_001161720.1. NM_001168248.1.
NP_083180.3. NM_028904.3.
XP_006517483.1. XM_006517420.1.
XP_006517484.1. XM_006517421.1.
UniGeneiMm.85289.

3D structure databases

ProteinModelPortaliQ9D4G9.
SMRiQ9D4G9. Positions 2-215, 473-616.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216710. 7 interactions.
IntActiQ9D4G9. 6 interactions.

PTM databases

PhosphoSiteiQ9D4G9.

Proteomic databases

MaxQBiQ9D4G9.
PRIDEiQ9D4G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367.
GeneIDi74386.
KEGGimmu:74386.
UCSCiuc007qua.2. mouse.

Organism-specific databases

CTDi80010.
MGIiMGI:1921636. Rmi1.

Phylogenomic databases

eggNOGiNOG261197.
GeneTreeiENSGT00740000115530.
HOGENOMiHOG000154148.
HOVERGENiHBG061190.
InParanoidiQ9D4G9.
KOiK10990.
OMAiTPKPWEA.
OrthoDBiEOG7F7W8R.
PhylomeDBiQ9D4G9.
TreeFamiTF316491.

Miscellaneous databases

NextBioi340617.
PROiQ9D4G9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D4G9.
GenevestigatoriQ9D4G9.

Family and domain databases

InterProiIPR013894. DUF1767.
[Graphical view]
PfamiPF08585. DUF1767. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb, Testis and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRMI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4G9
Secondary accession number(s): Q8C560, Q8CI20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.