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Q9D4G9

- RMI1_MOUSE

UniProt

Q9D4G9 - RMI1_MOUSE

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Protein
RecQ-mediated genome instability protein 1
Gene
Rmi1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability By similarity.

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. glucose homeostasis Source: MGI
  3. multicellular organism growth Source: MGI
  4. reduction of food intake in response to dietary excess Source: MGI
  5. response to dietary excess Source: MGI
  6. response to glucose Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
RecQ-mediated genome instability protein 1
Gene namesi
Name:Rmi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1921636. Rmi1.

Subcellular locationi

Nucleus By similarity
Note: Forms foci in response to DNA damage By similarity.

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 616616RecQ-mediated genome instability protein 1
PRO_0000227547Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Modified residuei225 – 2251Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRIDEiQ9D4G9.

PTM databases

PhosphoSiteiQ9D4G9.

Expressioni

Gene expression databases

BgeeiQ9D4G9.
GenevestigatoriQ9D4G9.

Interactioni

Subunit structurei

Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2 and TOP3A. May bind DHJ. Interacts (via N-terminal region) with BLM; the interaction is direct By similarity.

Protein-protein interaction databases

BioGridi216710. 7 interactions.
IntActiQ9D4G9. 6 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9D4G9.
SMRiQ9D4G9. Positions 2-215, 473-616.

Family & Domainsi

Sequence similaritiesi

Belongs to the RMI1 family.

Phylogenomic databases

eggNOGiNOG261197.
GeneTreeiENSGT00740000115530.
HOGENOMiHOG000154148.
HOVERGENiHBG061190.
InParanoidiQ9D4G9.
KOiK10990.
OMAiAMDLYSP.
OrthoDBiEOG7F7W8R.
PhylomeDBiQ9D4G9.
TreeFamiTF316491.

Family and domain databases

InterProiIPR013894. DUF1767.
[Graphical view]
PfamiPF08585. DUF1767. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D4G9-1 [UniParc]FASTAAdd to Basket

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MSVASAVLRV ETWLLATWHV KVPPMWLEAC VNWIQEENNN ATLSQAQINK    50
QVLEQWLLTD LRDLEHPLLP DDILELPKGE LNGFYALQIN SLVDVSQPAY 100
SQIQKLRGKN TTNDLVSAET QSTPKPWEVR PSRMLMLQLT DGVTHIQGME 150
YQSIPALHSG LPPGTKILVR GCILFRLGVL LLKPENVKVL GGEVDGLSEE 200
NAQEKVLARL IGELDPTVPV IPNNSIHNVP KVSGGLDAVL GPSDEELLAS 250
LDESEESAAN NDVAMERSCF STGTSSNTTP TNPSGFEPGC NISSRPKEKP 300
PNQPTHFTDG EFDDFSLEEA LLLEETVQKE QMETKASQPL TLKENTGKCM 350
EIFSHKPSSL NHTALIHKQG NSNFDEKTSE QMIHEDKFFD CASTRNHHKR 400
FSAHDFTNDS KISEVDDAAQ QTLSSSNVHC LRNKILNRKL DLSEKSSQIS 450
KENGHPFQAC SSRSFENNTY LSIGMDLHSP PFIYLSVLMA RKPKEVTTVT 500
VKAFIVTLTG NLSSSGGFWG VTAKVSDGTA YLDVDFIDEI LTSMIGYSVP 550
EMKQLRKDPL KYKTFLEGLQ KCQRDLIDLC CLMTISYDPS SCKGVVLELQ 600
DVGMEHVENL KKRLNK 616
Length:616
Mass (Da):68,465
Last modified:June 1, 2001 - v1
Checksum:i2C70E918FD911803
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731I → V in AAH37694. 1 Publication
Sequence conflicti74 – 741L → S in BAC37651. 1 Publication
Sequence conflicti170 – 1701R → H in AAH37694. 1 Publication
Sequence conflicti252 – 2521D → G in AAH37694. 1 Publication
Sequence conflicti411 – 4111K → E in AAH37694. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016542 mRNA. Translation: BAB30292.1.
AK032229 mRNA. Translation: BAC27772.1.
AK079457 mRNA. Translation: BAC37651.1.
BC037694 mRNA. Translation: AAH37694.1.
CCDSiCCDS26571.1.
RefSeqiNP_001161720.1. NM_001168248.1.
NP_083180.3. NM_028904.3.
XP_006517483.1. XM_006517420.1.
XP_006517484.1. XM_006517421.1.
UniGeneiMm.85289.

Genome annotation databases

EnsembliENSMUST00000042450; ENSMUSP00000041035; ENSMUSG00000035367.
GeneIDi74386.
KEGGimmu:74386.
UCSCiuc007qua.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK016542 mRNA. Translation: BAB30292.1 .
AK032229 mRNA. Translation: BAC27772.1 .
AK079457 mRNA. Translation: BAC37651.1 .
BC037694 mRNA. Translation: AAH37694.1 .
CCDSi CCDS26571.1.
RefSeqi NP_001161720.1. NM_001168248.1.
NP_083180.3. NM_028904.3.
XP_006517483.1. XM_006517420.1.
XP_006517484.1. XM_006517421.1.
UniGenei Mm.85289.

3D structure databases

ProteinModelPortali Q9D4G9.
SMRi Q9D4G9. Positions 2-215, 473-616.
ModBasei Search...

Protein-protein interaction databases

BioGridi 216710. 7 interactions.
IntActi Q9D4G9. 6 interactions.

PTM databases

PhosphoSitei Q9D4G9.

Proteomic databases

PRIDEi Q9D4G9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042450 ; ENSMUSP00000041035 ; ENSMUSG00000035367 .
GeneIDi 74386.
KEGGi mmu:74386.
UCSCi uc007qua.2. mouse.

Organism-specific databases

CTDi 80010.
MGIi MGI:1921636. Rmi1.

Phylogenomic databases

eggNOGi NOG261197.
GeneTreei ENSGT00740000115530.
HOGENOMi HOG000154148.
HOVERGENi HBG061190.
InParanoidi Q9D4G9.
KOi K10990.
OMAi AMDLYSP.
OrthoDBi EOG7F7W8R.
PhylomeDBi Q9D4G9.
TreeFami TF316491.

Miscellaneous databases

NextBioi 340617.
PROi Q9D4G9.
SOURCEi Search...

Gene expression databases

Bgeei Q9D4G9.
Genevestigatori Q9D4G9.

Family and domain databases

InterProi IPR013894. DUF1767.
[Graphical view ]
Pfami PF08585. DUF1767. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb, Testis and Vagina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiRMI1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4G9
Secondary accession number(s): Q8C560, Q8CI20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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