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Protein

Gamma-tubulin complex component 4

Gene

Tubgcp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 4
Short name:
GCP-4
Gene namesi
Name:Tubgcp4
Synonyms:D2Ertd435e, Gcp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1196293. Tubgcp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Gamma-tubulin complex component 4PRO_0000078125Add
BLAST

Proteomic databases

EPDiQ9D4F8.
MaxQBiQ9D4F8.
PaxDbiQ9D4F8.
PRIDEiQ9D4F8.

PTM databases

PhosphoSiteiQ9D4F8.

Expressioni

Gene expression databases

BgeeiQ9D4F8.
CleanExiMM_TUBGCP4.
ExpressionAtlasiQ9D4F8. baseline and differential.
GenevisibleiQ9D4F8. MM.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.By similarity

Protein-protein interaction databases

BioGridi206244. 8 interactions.
IntActiQ9D4F8. 8 interactions.
STRINGi10090.ENSMUSP00000044049.

Structurei

3D structure databases

ProteinModelPortaliQ9D4F8.
SMRiQ9D4F8. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2065. Eukaryota.
ENOG410XPES. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000234444.
HOVERGENiHBG023386.
InParanoidiQ9D4F8.
KOiK16571.
OMAiKHSSEFH.
PhylomeDBiQ9D4F8.
TreeFamiTF324188.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D4F8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT
60 70 80 90 100
DYIRFTEFIE QYTGHVQQQD HHPPQQGQGG LHGIYLRAFC TGLDSVLQPY
110 120 130 140 150
RQALLDLEQE FLADPHLSIS HVNYSLDQFQ LLFPSVMVVV EQIKSQKIHG
160 170 180 190 200
CQILETVYKH SCGGLPPVRS ALEKILAVCH GVMYKQLSAW MLHGLLLDQH
210 220 230 240 250
EEFFIKQGPS SGTLSAQLEE DEEDLGIGGL TGKQLRELQD LRLIEEENML
260 270 280 290 300
APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL
310 320 330 340 350
KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL
360 370 380 390 400
LGQLKIIKDF YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA
410 420 430 440 450
HKVLLDDDNL LPLLHLTIEY HGKDHKADAT QPREVPSRET SPREAPSSGW
460 470 480 490 500
AALGLSYKVQ WPLHILFTPA VLEKYNVVFK YLLSVRRVQA ELQHCWALQM
510 520 530 540 550
QRKHLKSNQT DAVKWRLRNH MAFLVDNLQY YLQVDVLESQ FSQLLHQINS
560 570 580 590 600
TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN
610 620 630 640 650
LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD
660
YNKYYTQAGG TLGSFGM
Length:667
Mass (Da):76,126
Last modified:August 2, 2002 - v2
Checksum:i32CC26F5D69D2CF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029106 mRNA. Translation: AAH29106.1.
AK016563 mRNA. No translation available.
CCDSiCCDS16637.1.
RefSeqiNP_700436.1. NM_153387.3.
UniGeneiMm.383499.

Genome annotation databases

EnsembliENSMUST00000039541; ENSMUSP00000044049; ENSMUSG00000027263.
GeneIDi51885.
KEGGimmu:51885.
UCSCiuc008lxv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC029106 mRNA. Translation: AAH29106.1.
AK016563 mRNA. No translation available.
CCDSiCCDS16637.1.
RefSeqiNP_700436.1. NM_153387.3.
UniGeneiMm.383499.

3D structure databases

ProteinModelPortaliQ9D4F8.
SMRiQ9D4F8. Positions 1-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206244. 8 interactions.
IntActiQ9D4F8. 8 interactions.
STRINGi10090.ENSMUSP00000044049.

PTM databases

PhosphoSiteiQ9D4F8.

Proteomic databases

EPDiQ9D4F8.
MaxQBiQ9D4F8.
PaxDbiQ9D4F8.
PRIDEiQ9D4F8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039541; ENSMUSP00000044049; ENSMUSG00000027263.
GeneIDi51885.
KEGGimmu:51885.
UCSCiuc008lxv.2. mouse.

Organism-specific databases

CTDi27229.
MGIiMGI:1196293. Tubgcp4.

Phylogenomic databases

eggNOGiKOG2065. Eukaryota.
ENOG410XPES. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000234444.
HOVERGENiHBG023386.
InParanoidiQ9D4F8.
KOiK16571.
OMAiKHSSEFH.
PhylomeDBiQ9D4F8.
TreeFamiTF324188.

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

NextBioi308190.
PROiQ9D4F8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D4F8.
CleanExiMM_TUBGCP4.
ExpressionAtlasiQ9D4F8. baseline and differential.
GenevisibleiQ9D4F8. MM.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 1 hit.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 26-338.
    Strain: C57BL/6J.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiGCP4_MOUSE
AccessioniPrimary (citable) accession number: Q9D4F8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: August 2, 2002
Last modified: May 11, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.