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Protein

Phospholipid phosphatase 6

Gene

Plpp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 6By similarity (EC:3.1.3.-)
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 2
Presqualene diphosphate phosphatase
Gene namesi
Name:Plpp6By similarity
Synonyms:Ppapdc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1921661 Plpp6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002393971 – 292Phospholipid phosphatase 6Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineBy similarity1
Modified residuei67PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D4F2
PaxDbiQ9D4F2
PeptideAtlasiQ9D4F2
PRIDEiQ9D4F2

PTM databases

iPTMnetiQ9D4F2
PhosphoSitePlusiQ9D4F2
SwissPalmiQ9D4F2

Expressioni

Gene expression databases

BgeeiENSMUSG00000040105
GenevisibleiQ9D4F2 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047776

Structurei

3D structure databases

ProteinModelPortaliQ9D4F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4268 Eukaryota
ENOG410ZVFK LUCA
GeneTreeiENSGT00390000012789
HOGENOMiHOG000231931
HOVERGENiHBG054746
InParanoidiQ9D4F2
OMAiLGYMQYS
OrthoDBiEOG091G0STF
PhylomeDBiQ9D4F2
TreeFamiTF323272

Family and domain databases

InterProiView protein in InterPro
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D4F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSPRRTIEG RPLGSSGGSS VPGSPAHGGG SGGGRFEFQS LLNCRAGADP
60 70 80 90 100
ACARLRASDS PVHRRGSFPL AASGPAQAAP APPPEDARMN LNPSFLGIAL
110 120 130 140 150
RSLLAIDLWL SKKLGVCAGE SSAWGSVRPL MKLLEISGHG IPWLLGTLYC
160 170 180 190 200
LLRSDSWAGR EVLMNLLFAL LLDLLLVAVI KGLVRRRRPA HNQKDMFFTL
210 220 230 240 250
SVDRYSFPSG HATRAALVSR FILNHLVLAI PLRVLVVLWA FVLGLSRVML
260 270 280 290
GRHNVTDVAF GFFLGYMQYS IVDYCWLSPH NVPVLFVLWN QQ
Length:292
Mass (Da):31,744
Last modified:June 1, 2001 - v1
Checksum:i8B28C6DCA0BE7F17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016572 mRNA Translation: BAB30313.1
BC052412 mRNA Translation: AAH52412.1
CCDSiCCDS29728.1
RefSeqiNP_083198.1, NM_028922.3
UniGeneiMm.441887

Genome annotation databases

EnsembliENSMUST00000045674; ENSMUSP00000047776; ENSMUSG00000040105
GeneIDi74411
KEGGimmu:74411
UCSCiuc008hcr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLPP6_MOUSE
AccessioniPrimary (citable) accession number: Q9D4F2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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