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Protein

Clavesin-1

Gene

Clvs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Clavesin-1
Alternative name(s):
Retinaldehyde-binding protein 1-like 1
Gene namesi
Name:Clvs1
Synonyms:Rlbp1l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921688. Clvs1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Clavesin-1PRO_0000297656Add
BLAST

Proteomic databases

MaxQBiQ9D4C9.
PaxDbiQ9D4C9.
PRIDEiQ9D4C9.

PTM databases

iPTMnetiQ9D4C9.
PhosphoSiteiQ9D4C9.

Expressioni

Gene expression databases

BgeeiQ9D4C9.
CleanExiMM_RLBP1L1.
GenevisibleiQ9D4C9. MM.

Interactioni

Subunit structurei

Forms a complex with clathrin heavy chain and gamma-adaptin.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035649.

Structurei

3D structure databases

ProteinModelPortaliQ9D4C9.
SMRiQ9D4C9. Positions 34-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 279162CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST

Domaini

The CRAL-TRIO domain is required for targeting to the membrane and for binding PtdIns(3,5)P2.By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000059544.
HOVERGENiHBG101105.
InParanoidiQ9D4C9.
OMAiILHQDIQ.
OrthoDBiEOG7H4DTZ.
PhylomeDBiQ9D4C9.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028634. Clavesin-1.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF72. PTHR10174:SF72. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D4C9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPVSVLPSP QSLSTWEGDL AKMTHLQAGL SPDTIEKARL ELNENPDILH
60 70 80 90 100
QDIQQVRDMI ITRPDIGFLR TDDAFILRFL RARKFHQADA FRLLAQYFQY
110 120 130 140 150
RQLNLDMFKN FKADDPGIKR ALIDGFPGVL ENRDHYGRKI LLLFAANWDQ
160 170 180 190 200
SRNSFTDILR AILLSLEVLI EDPELQINGF ILIIDWSNFS FKQASKLTPS
210 220 230 240 250
ILKLAIEGLQ DSFPARFGGV HFVNQPWYIH ALYTLIKPFL KDKTRKRIFL
260 270 280 290 300
HGNNLNSLHQ LIHPEFLPSE FGGTLPPYDM GTWARTLLGP DYSDENDYTH
310 320 330 340 350
TSYNAMHVKH TCSNLERECS PKPMKRSQSV VEAGTLKHEE KGENENTQPL

LALD
Length:354
Mass (Da):40,613
Last modified:June 1, 2001 - v1
Checksum:i894F8BB1EE4E8AEF
GO
Isoform 2 (identifier: Q9D4C9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-354: Missing.

Show »
Length:152
Mass (Da):17,596
Checksum:i30111D338AF002D3
GO
Isoform 3 (identifier: Q9D4C9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-279: Missing.

Show »
Length:75
Mass (Da):8,492
Checksum:i7F305E81196FF556
GO

Sequence cautioni

The sequence BAE22811.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti307 – 3071H → Q in BAE22811 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 279279Missing in isoform 3. 1 PublicationVSP_027330Add
BLAST
Alternative sequencei153 – 354202Missing in isoform 2. 1 PublicationVSP_027331Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016622 mRNA. Translation: BAB30342.1.
AK043072 mRNA. Translation: BAC31451.1.
AK084350 mRNA. Translation: BAC39166.1.
AK136083 mRNA. Translation: BAE22811.1. Different initiation.
AL671970, AL844180 Genomic DNA. Translation: CAM15541.1.
AL844180, AL671970 Genomic DNA. Translation: CAM23455.1.
BC062923 mRNA. Translation: AAH62923.1.
BC100556 mRNA. Translation: AAI00557.1.
CCDSiCCDS17957.1. [Q9D4C9-1]
RefSeqiNP_083216.1. NM_028940.2. [Q9D4C9-1]
XP_011248427.1. XM_011250125.1. [Q9D4C9-1]
UniGeneiMm.473368.

Genome annotation databases

EnsembliENSMUST00000038841; ENSMUSP00000035649; ENSMUSG00000041216. [Q9D4C9-1]
ENSMUST00000108348; ENSMUSP00000103985; ENSMUSG00000041216. [Q9D4C9-1]
GeneIDi74438.
KEGGimmu:74438.
UCSCiuc008ryc.2. mouse. [Q9D4C9-2]
uc008rye.2. mouse. [Q9D4C9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016622 mRNA. Translation: BAB30342.1.
AK043072 mRNA. Translation: BAC31451.1.
AK084350 mRNA. Translation: BAC39166.1.
AK136083 mRNA. Translation: BAE22811.1. Different initiation.
AL671970, AL844180 Genomic DNA. Translation: CAM15541.1.
AL844180, AL671970 Genomic DNA. Translation: CAM23455.1.
BC062923 mRNA. Translation: AAH62923.1.
BC100556 mRNA. Translation: AAI00557.1.
CCDSiCCDS17957.1. [Q9D4C9-1]
RefSeqiNP_083216.1. NM_028940.2. [Q9D4C9-1]
XP_011248427.1. XM_011250125.1. [Q9D4C9-1]
UniGeneiMm.473368.

3D structure databases

ProteinModelPortaliQ9D4C9.
SMRiQ9D4C9. Positions 34-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035649.

PTM databases

iPTMnetiQ9D4C9.
PhosphoSiteiQ9D4C9.

Proteomic databases

MaxQBiQ9D4C9.
PaxDbiQ9D4C9.
PRIDEiQ9D4C9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038841; ENSMUSP00000035649; ENSMUSG00000041216. [Q9D4C9-1]
ENSMUST00000108348; ENSMUSP00000103985; ENSMUSG00000041216. [Q9D4C9-1]
GeneIDi74438.
KEGGimmu:74438.
UCSCiuc008ryc.2. mouse. [Q9D4C9-2]
uc008rye.2. mouse. [Q9D4C9-1]

Organism-specific databases

CTDi157807.
MGIiMGI:1921688. Clvs1.

Phylogenomic databases

eggNOGiKOG1471. Eukaryota.
ENOG410XRSQ. LUCA.
GeneTreeiENSGT00550000074253.
HOGENOMiHOG000059544.
HOVERGENiHBG101105.
InParanoidiQ9D4C9.
OMAiILHQDIQ.
OrthoDBiEOG7H4DTZ.
PhylomeDBiQ9D4C9.

Enzyme and pathway databases

ReactomeiR-MMU-432720. Lysosome Vesicle Biogenesis.

Miscellaneous databases

PROiQ9D4C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D4C9.
CleanExiMM_RLBP1L1.
GenevisibleiQ9D4C9. MM.

Family and domain databases

Gene3Di3.40.525.10. 1 hit.
InterProiIPR028634. Clavesin-1.
IPR001071. CRAL-bd_toc_tran.
IPR001251. CRAL-TRIO_dom.
IPR011074. CRAL/TRIO_N_dom.
[Graphical view]
PANTHERiPTHR10174:SF72. PTHR10174:SF72. 1 hit.
PfamiPF00650. CRAL_TRIO. 1 hit.
PF03765. CRAL_TRIO_N. 1 hit.
[Graphical view]
PRINTSiPR00180. CRETINALDHBP.
SMARTiSM01100. CRAL_TRIO_N. 1 hit.
SM00516. SEC14. 1 hit.
[Graphical view]
SUPFAMiSSF46938. SSF46938. 1 hit.
SSF52087. SSF52087. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Cerebellum, Egg, Eye and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCLVS1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4C9
Secondary accession number(s): Q3UWV3
, Q497H3, Q8BJE8, Q8BXX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binding to PtdIns(3,5)P2 is not required for localization.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.