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Protein

LRP2-binding protein

Gene

Lrp2bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an adapter that regulates LRP2 function.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
LRP2-binding protein
Gene namesi
Name:Lrp2bp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914870. Lrp2bp.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346LRP2-binding proteinPRO_0000315709Add
BLAST

Proteomic databases

PaxDbiQ9D4C6.
PRIDEiQ9D4C6.

PTM databases

PhosphoSiteiQ9D4C6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031637.
CleanExiMM_LRP2BP.
ExpressionAtlasiQ9D4C6. baseline and differential.
GenevisibleiQ9D4C6. MM.

Interactioni

Subunit structurei

Interacts with LRP2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106009.

Structurei

3D structure databases

ProteinModelPortaliQ9D4C6.
SMRiQ9D4C6. Positions 46-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati58 – 9134TPRAdd
BLAST
Repeati92 – 12433Sel1-like 1Add
BLAST
Repeati132 – 16736Sel1-like 2Add
BLAST
Repeati172 – 20534Sel1-like 3Add
BLAST
Repeati206 – 24136Sel1-like 4Add
BLAST
Repeati242 – 27635Sel1-like 5Add
BLAST
Repeati296 – 33136Sel1-like 6Add
BLAST

Sequence similaritiesi

Contains 6 Sel1-like repeats.Curated
Contains 1 TPR repeat.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000013490.
HOGENOMiHOG000007246.
HOVERGENiHBG108096.
InParanoidiQ9D4C6.
PhylomeDBiQ9D4C6.
TreeFamiTF315257.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D4C6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLSSEKLPK NPFSLSQYAA KQQKFFQWKK EKPDYYLHAN LVDTALQFLK
60 70 80 90 100
ERIRRGDAMA YFLRGQLYFE EGWYEEALAQ FEEIQEKDHQ AIYQLGVMYY
110 120 130 140 150
DGLGTIANAE KGVNYMRKIL DSSCPQTMHL KFAAAYNLGR AYFEGKGVKR
160 170 180 190 200
SDEEAERLWL LAADNGNPKA SVKAQSILGL FYSMKEPKEL EKAFFWHSEA
210 220 230 240 250
CGNGSLESQG ALGLMYFYGQ GIRQDTDAAL HCLREAAERG NVYAQGTLVE
260 270 280 290 300
YYYKMKFFTK CVSFSKRIAD YDEVHDIPMI AHVTDCLPEF IIKGMAMAAF
310 320 330 340
YHGRCLQLGL GIMKDEESAK HYYSKACRLN PTLADELHSL LIHQRI
Length:346
Mass (Da):39,746
Last modified:June 1, 2001 - v1
Checksum:iC443C1475697E2D7
GO
Isoform 2 (identifier: Q9D4C6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.

Note: No experimental confirmation available.
Show »
Length:132
Mass (Da):15,222
Checksum:i632AF74098B3E4B2
GO

Sequence cautioni

The sequence BAC25168 differs from that shown. Reason: Frameshift at several positions. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti149 – 1491K → E in BAC25168 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 214214Missing in isoform 2. 1 PublicationVSP_030665Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016626 mRNA. Translation: BAB30345.1.
AK007202 mRNA. Translation: BAC25168.1. Frameshift.
AK137605 mRNA. Translation: BAE23427.1.
BC030908 mRNA. Translation: AAH30908.1.
BC051150 mRNA. Translation: AAH51150.1.
CCDSiCCDS22286.1. [Q9D4C6-1]
RefSeqiNP_080554.1. NM_026278.3. [Q9D4C6-1]
UniGeneiMm.383914.

Genome annotation databases

EnsembliENSMUST00000110380; ENSMUSP00000106009; ENSMUSG00000031637. [Q9D4C6-1]
ENSMUST00000110381; ENSMUSP00000106010; ENSMUSG00000031637. [Q9D4C6-1]
GeneIDi67620.
KEGGimmu:67620.
UCSCiuc009lpt.1. mouse. [Q9D4C6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016626 mRNA. Translation: BAB30345.1.
AK007202 mRNA. Translation: BAC25168.1. Frameshift.
AK137605 mRNA. Translation: BAE23427.1.
BC030908 mRNA. Translation: AAH30908.1.
BC051150 mRNA. Translation: AAH51150.1.
CCDSiCCDS22286.1. [Q9D4C6-1]
RefSeqiNP_080554.1. NM_026278.3. [Q9D4C6-1]
UniGeneiMm.383914.

3D structure databases

ProteinModelPortaliQ9D4C6.
SMRiQ9D4C6. Positions 46-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000106009.

PTM databases

PhosphoSiteiQ9D4C6.

Proteomic databases

PaxDbiQ9D4C6.
PRIDEiQ9D4C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110380; ENSMUSP00000106009; ENSMUSG00000031637. [Q9D4C6-1]
ENSMUST00000110381; ENSMUSP00000106010; ENSMUSG00000031637. [Q9D4C6-1]
GeneIDi67620.
KEGGimmu:67620.
UCSCiuc009lpt.1. mouse. [Q9D4C6-1]

Organism-specific databases

CTDi55805.
MGIiMGI:1914870. Lrp2bp.

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000013490.
HOGENOMiHOG000007246.
HOVERGENiHBG108096.
InParanoidiQ9D4C6.
PhylomeDBiQ9D4C6.
TreeFamiTF315257.

Miscellaneous databases

PROiQ9D4C6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031637.
CleanExiMM_LRP2BP.
ExpressionAtlasiQ9D4C6. baseline and differential.
GenevisibleiQ9D4C6. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR006597. Sel1-like.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
PROSITEiPS50005. TPR. 1 hit.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLR2BP_MOUSE
AccessioniPrimary (citable) accession number: Q9D4C6
Secondary accession number(s): Q3UV46, Q8CF18, Q8K0N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.