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Protein

ELL-associated factor 1

Gene

Eaf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional transactivator of ELL and ELL2 elongation activities.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-112382 Formation of RNA Pol II elongation complex
R-MMU-674695 RNA Polymerase II Pre-transcription Events
R-MMU-75955 RNA Polymerase II Transcription Elongation

Names & Taxonomyi

Protein namesi
Recommended name:
ELL-associated factor 1
Gene namesi
Name:Eaf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1921677 Eaf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001303351 – 268ELL-associated factor 1Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D4C5
MaxQBiQ9D4C5
PaxDbiQ9D4C5
PeptideAtlasiQ9D4C5
PRIDEiQ9D4C5

PTM databases

iPTMnetiQ9D4C5
PhosphoSitePlusiQ9D4C5

Expressioni

Gene expression databases

BgeeiENSMUSG00000021890
CleanExiMM_EAF1
GenevisibleiQ9D4C5 MM

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with ELL and ELL2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022446

Structurei

3D structure databases

ProteinModelPortaliQ9D4C5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 262Necessary for transactivation activityBy similarityAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi127 – 168Pro-richAdd BLAST42
Compositional biasi188 – 211Ser-richAdd BLAST24

Sequence similaritiesi

Belongs to the EAF family.Curated

Phylogenomic databases

eggNOGiKOG4795 Eukaryota
ENOG4111KQJ LUCA
GeneTreeiENSGT00390000017724
HOGENOMiHOG000070137
HOVERGENiHBG054898
InParanoidiQ9D4C5
KOiK15186
OMAiSCNIQVK
OrthoDBiEOG091G0MMP
PhylomeDBiQ9D4C5
TreeFamiTF320864

Family and domain databases

InterProiView protein in InterPro
IPR027093 EAF_fam
IPR019194 Tscrpt_elong_fac_Eaf_N
PANTHERiPTHR15970 PTHR15970, 1 hit
PfamiView protein in Pfam
PF09816 EAF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D4C5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGTANPLLD REEHCLRLGE SFEKRPRASF HTIRYDFKPA SIDTSCEGEL
60 70 80 90 100
QVGKGDEVTI TLPHIPGSTP PMTVFKGNKR PYQKDCVLII NHDTGEYVLE
110 120 130 140 150
KLSSSIQVKK TRAEGSSKIQ ARMEQQPARP PQPSQPPPPP PPMPFRAPTK
160 170 180 190 200
PPAGPKTSPL KDNPSPEPQL DDIKRELRAE VDIIEQMSSS SGSSSSDSES
210 220 230 240 250
SSGSDDDSSS SAGEDNGPAS PPQPSHQQPY NSRPAVANGT SRPQGSSQLM
260
NTLRNDLQLS ESGSDSDD
Length:268
Mass (Da):28,967
Last modified:March 1, 2003 - v2
Checksum:i02ACBA8F33200C20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016628 mRNA Translation: BAB30346.2
AK044181 mRNA Translation: BAC31806.1
AK044737 mRNA Translation: BAC32058.1
BC079658 mRNA Translation: AAH79658.1
CCDSiCCDS26914.1
RefSeqiNP_083208.1, NM_028932.4
UniGeneiMm.491208

Genome annotation databases

EnsembliENSMUST00000022446; ENSMUSP00000022446; ENSMUSG00000021890
GeneIDi74427
KEGGimmu:74427
UCSCiuc007sxt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiEAF1_MOUSE
AccessioniPrimary (citable) accession number: Q9D4C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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