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Protein

C-Maf-inducing protein

Gene

Cmip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in T-cell signaling pathway.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
C-Maf-inducing protein
Short name:
c-Mip
Gene namesi
Name:Cmip
Synonyms:Kiaa1694
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921690. Cmip.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Isoform 2 is translocated to the nucleus and is specifically recruited during minimal change nephrotic syndrome (MCNS). Detected in nuclear and cytoplasmic compartments during MCNS relapse. Expressed in cytoplasm only during MCNS remission and absent in normal patients.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773C-Maf-inducing proteinPRO_0000317629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei349 – 3491PhosphoserineBy similarity
Modified residuei377 – 3771PhosphoserineBy similarity
Modified residuei660 – 6601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D486.
MaxQBiQ9D486.
PaxDbiQ9D486.
PRIDEiQ9D486.

PTM databases

iPTMnetiQ9D486.
PhosphoSiteiQ9D486.

Expressioni

Gene expression databases

BgeeiQ9D486.
CleanExiMM_4933407C03RIK.
GenevisibleiQ9D486. MM.

Interactioni

Subunit structurei

Interacts with FLNA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130264.

Structurei

3D structure databases

ProteinModelPortaliQ9D486.
SMRiQ9D486. Positions 636-769.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 163110PHAdd
BLAST
Repeati663 – 68624LRR 1Add
BLAST
Repeati687 – 70721LRR 2Add
BLAST
Repeati712 – 73221LRR 3Add
BLAST
Repeati736 – 75621LRR 4Add
BLAST

Sequence similaritiesi

Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 PH domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJT4. Eukaryota.
ENOG410XSJQ. LUCA.
GeneTreeiENSGT00390000018220.
HOGENOMiHOG000111809.
HOVERGENiHBG107725.
InParanoidiQ9D486.
OMAiCLMVSPT.
OrthoDBiEOG71G9TG.
TreeFamiTF328575.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR011993. PH_dom-like.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D486-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVTSSSGGG DPRQIEETKP LLGSDVSGPE GTKVMGAVPC RRALLLCNGM
60 70 80 90 100
RYKLLQEGDI QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT
110 120 130 140 150
PSGYMENSVS YSAIEDVQPL SWENAPKYCL QLTIPGGTVL LQAANSYLRD
160 170 180 190 200
QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK EIRTLVDMAL TSPLQDDSIN
210 220 230 240 250
QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP DLCEFFCKHC
260 270 280 290 300
RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
310 320 330 340 350
MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP
360 370 380 390 400
SLKEIRNGCQ QPCDRKPTLP LRLLHPSPDL VSQEATLSEP RLKSVVVASS
410 420 430 440 450
EVHVEVERTS TAKPALTAST GNDSEPNLID CLMVSPACGT MSIELGPQAG
460 470 480 490 500
RTLGCHVEIL KLLSDYDDWR PSLASLLQPI PFPKEALAHE KFTKELKYVI
510 520 530 540 550
QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG ELFASMVHIL
560 570 580 590 600
MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMAEILCLM LEYNIIDNND
610 620 630 640 650
TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA
660 670 680 690 700
DLARLLSSGS FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD
710 720 730 740 750
AGLRLLSEHL TMLQVLNLCE TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD
760 770
TYEDLKAKLP NLKEVDVRYT EAW
Length:773
Mass (Da):86,259
Last modified:October 19, 2011 - v3
Checksum:i1DCCF418339E552C
GO
Isoform 2 (identifier: Q9D486-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MDVTSSSGGG...LADNSLASAT → MKTFGPGDEHPE

Note: No experimental confirmation available.
Show »
Length:685
Mass (Da):76,641
Checksum:iB3F61B004D392D0D
GO
Isoform 3 (identifier: Q9D486-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     486-773: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,173
Checksum:i5CDE3C0BF6332413
GO

Sequence cautioni

The sequence BAD32512.1 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1381T → A in BAB30392 (PubMed:19468303).Curated
Sequence conflicti702 – 7021G → A in BAB30392 (PubMed:19468303).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 100100MDVTS…LASAT → MKTFGPGDEHPE in isoform 2. 1 PublicationVSP_031113Add
BLAST
Alternative sequencei486 – 773288Missing in isoform 3. 1 PublicationVSP_031114Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016712 mRNA. Translation: BAB30392.1.
AK085367 mRNA. Translation: BAC39432.1.
AC118207 Genomic DNA. No translation available.
AC121116 Genomic DNA. No translation available.
BC028834 mRNA. Translation: AAH28834.1.
AK173234 mRNA. Translation: BAD32512.1. Sequence problems.
CCDSiCCDS52680.1. [Q9D486-1]
CCDS52681.1. [Q9D486-2]
RefSeqiNP_001156734.1. NM_001163262.1. [Q9D486-1]
NP_083217.1. NM_028941.1. [Q9D486-2]
UniGeneiMm.233181.

Genome annotation databases

EnsembliENSMUST00000095172; ENSMUSP00000092795; ENSMUSG00000034390. [Q9D486-2]
ENSMUST00000166750; ENSMUSP00000130264; ENSMUSG00000034390. [Q9D486-1]
GeneIDi74440.
KEGGimmu:74440.
UCSCiuc009noz.2. mouse. [Q9D486-1]
uc009npa.2. mouse. [Q9D486-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016712 mRNA. Translation: BAB30392.1.
AK085367 mRNA. Translation: BAC39432.1.
AC118207 Genomic DNA. No translation available.
AC121116 Genomic DNA. No translation available.
BC028834 mRNA. Translation: AAH28834.1.
AK173234 mRNA. Translation: BAD32512.1. Sequence problems.
CCDSiCCDS52680.1. [Q9D486-1]
CCDS52681.1. [Q9D486-2]
RefSeqiNP_001156734.1. NM_001163262.1. [Q9D486-1]
NP_083217.1. NM_028941.1. [Q9D486-2]
UniGeneiMm.233181.

3D structure databases

ProteinModelPortaliQ9D486.
SMRiQ9D486. Positions 636-769.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130264.

PTM databases

iPTMnetiQ9D486.
PhosphoSiteiQ9D486.

Proteomic databases

EPDiQ9D486.
MaxQBiQ9D486.
PaxDbiQ9D486.
PRIDEiQ9D486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095172; ENSMUSP00000092795; ENSMUSG00000034390. [Q9D486-2]
ENSMUST00000166750; ENSMUSP00000130264; ENSMUSG00000034390. [Q9D486-1]
GeneIDi74440.
KEGGimmu:74440.
UCSCiuc009noz.2. mouse. [Q9D486-1]
uc009npa.2. mouse. [Q9D486-2]

Organism-specific databases

CTDi80790.
MGIiMGI:1921690. Cmip.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IJT4. Eukaryota.
ENOG410XSJQ. LUCA.
GeneTreeiENSGT00390000018220.
HOGENOMiHOG000111809.
HOVERGENiHBG107725.
InParanoidiQ9D486.
OMAiCLMVSPT.
OrthoDBiEOG71G9TG.
TreeFamiTF328575.

Miscellaneous databases

PROiQ9D486.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D486.
CleanExiMM_4933407C03RIK.
GenevisibleiQ9D486. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR011993. PH_dom-like.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: C57BL/6J.
    Tissue: Kidney and Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 143-773 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Liver.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-773 (ISOFORM 1).
    Tissue: Pancreatic islet.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiCMIP_MOUSE
AccessioniPrimary (citable) accession number: Q9D486
Secondary accession number(s): Q69ZD2, Q8C3N2, Q8K148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 19, 2011
Last modified: June 8, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.