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Protein

C-Maf-inducing protein

Gene

Cmip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in T-cell signaling pathway.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
C-Maf-inducing protein
Short name:
c-Mip
Gene namesi
Name:Cmip
Synonyms:Kiaa1694
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921690 Cmip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176291 – 773C-Maf-inducing proteinAdd BLAST773

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei349PhosphoserineBy similarity1
Modified residuei377PhosphoserineBy similarity1
Modified residuei382PhosphoserineBy similarity1
Modified residuei660PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D486
PaxDbiQ9D486
PeptideAtlasiQ9D486
PRIDEiQ9D486

PTM databases

iPTMnetiQ9D486
PhosphoSitePlusiQ9D486

Expressioni

Gene expression databases

BgeeiENSMUSG00000034390
CleanExiMM_4933407C03RIK
GenevisibleiQ9D486 MM

Interactioni

Subunit structurei

Interacts with FLNA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000130264

Structurei

3D structure databases

ProteinModelPortaliQ9D486
SMRiQ9D486
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 163PHAdd BLAST110
Repeati663 – 686LRR 1Add BLAST24
Repeati687 – 707LRR 2Add BLAST21
Repeati712 – 732LRR 3Add BLAST21
Repeati736 – 756LRR 4Add BLAST21

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IJT4 Eukaryota
ENOG410XSJQ LUCA
GeneTreeiENSGT00390000018220
HOGENOMiHOG000111809
HOVERGENiHBG107725
InParanoidiQ9D486
OMAiCLMVSPT
OrthoDBiEOG091G05SH
TreeFamiTF328575

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D486-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVTSSSGGG DPRQIEETKP LLGSDVSGPE GTKVMGAVPC RRALLLCNGM
60 70 80 90 100
RYKLLQEGDI QVCVIRHPRT FLSKILTSKF LRRWEPHHLT LADNSLASAT
110 120 130 140 150
PSGYMENSVS YSAIEDVQPL SWENAPKYCL QLTIPGGTVL LQAANSYLRD
160 170 180 190 200
QWFHSLQWKK KIYKYKKVLS NPSRWEVVLK EIRTLVDMAL TSPLQDDSIN
210 220 230 240 250
QAPLEIVSKL LSENTNLTTQ EHENIIVAIA PLLENNHPPP DLCEFFCKHC
260 270 280 290 300
RERPRSMVVI EVFTPVVQRI LKHNMDFGKC PRLRLFTQEY ILALNELNAG
310 320 330 340 350
MEVVKKFIQS MHGPTGHCPH PRVLPNLVAV CLAAIYSCYE EFINSRDNSP
360 370 380 390 400
SLKEIRNGCQ QPCDRKPTLP LRLLHPSPDL VSQEATLSEP RLKSVVVASS
410 420 430 440 450
EVHVEVERTS TAKPALTAST GNDSEPNLID CLMVSPACGT MSIELGPQAG
460 470 480 490 500
RTLGCHVEIL KLLSDYDDWR PSLASLLQPI PFPKEALAHE KFTKELKYVI
510 520 530 540 550
QRFAEDPRQE VHSCLLSVRA GKDGWFQLYS PGGVACDDDG ELFASMVHIL
560 570 580 590 600
MGSCYKTKKF LLSLAENKLG PCMLLALRGN QTMAEILCLM LEYNIIDNND
610 620 630 640 650
TQLQIISTLE STDVGKRMYE QLCDRQRELK ELQRKGGPTR LTLPSKSTDA
660 670 680 690 700
DLARLLSSGS FGNLENLSLA FTNVTSACAE HLIKLPSLKQ LNLWSTQFGD
710 720 730 740 750
AGLRLLSEHL TMLQVLNLCE TPVTDAGLLA LSSMKSLCSL NMNSTKLSAD
760 770
TYEDLKAKLP NLKEVDVRYT EAW
Length:773
Mass (Da):86,259
Last modified:October 19, 2011 - v3
Checksum:i1DCCF418339E552C
GO
Isoform 2 (identifier: Q9D486-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MDVTSSSGGG...LADNSLASAT → MKTFGPGDEHPE

Note: No experimental confirmation available.
Show »
Length:685
Mass (Da):76,641
Checksum:iB3F61B004D392D0D
GO
Isoform 3 (identifier: Q9D486-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     486-773: Missing.

Note: No experimental confirmation available.
Show »
Length:485
Mass (Da):54,173
Checksum:i5CDE3C0BF6332413
GO

Sequence cautioni

The sequence BAD32512 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138T → A in BAB30392 (PubMed:19468303).Curated1
Sequence conflicti702G → A in BAB30392 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311131 – 100MDVTS…LASAT → MKTFGPGDEHPE in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_031114486 – 773Missing in isoform 3. 1 PublicationAdd BLAST288

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016712 mRNA Translation: BAB30392.1
AK085367 mRNA Translation: BAC39432.1
AC118207 Genomic DNA No translation available.
AC121116 Genomic DNA No translation available.
BC028834 mRNA Translation: AAH28834.1
AK173234 mRNA Translation: BAD32512.1 Sequence problems.
CCDSiCCDS52680.1 [Q9D486-1]
CCDS52681.1 [Q9D486-2]
RefSeqiNP_001156734.1, NM_001163262.1 [Q9D486-1]
NP_083217.1, NM_028941.1 [Q9D486-2]
UniGeneiMm.233181

Genome annotation databases

EnsembliENSMUST00000095172; ENSMUSP00000092795; ENSMUSG00000034390 [Q9D486-2]
ENSMUST00000166750; ENSMUSP00000130264; ENSMUSG00000034390 [Q9D486-1]
GeneIDi74440
KEGGimmu:74440
UCSCiuc009noz.2 mouse [Q9D486-1]
uc009npa.2 mouse [Q9D486-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCMIP_MOUSE
AccessioniPrimary (citable) accession number: Q9D486
Secondary accession number(s): Q69ZD2, Q8C3N2, Q8K148
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 19, 2011
Last modified: March 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health