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Q9D485 (EFHC2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
EF-hand domain-containing family member C2
Gene names
Name:Efhc2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 3 DM10 domains.

Contains 1 EF-hand domain.

Ontologies

Keywords
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750EF-hand domain-containing family member C2
PRO_0000251704

Regions

Domain75 – 182108DM10 1
Domain226 – 368143DM10 2
Domain430 – 537108DM10 3
Domain557 – 59236EF-hand

Experimental info

Sequence conflict3811P → S in BAB30393. Ref.1
Sequence conflict5781P → T in BAC26479. Ref.1
Sequence conflict6741L → V in BAC26479. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D485 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 382AF75FDB9CB052

FASTA75087,646
        10         20         30         40         50         60 
MALPFLPGNS FNRNIGKERF HKSQHWGFCN NVRMLVSENK PGVGGDLLYG QKIKPKHSVF 

        70         80         90        100        110        120 
PKGDGTDAPS WVAFDKQVLS FDAYLEDEIS DKRQEIFRIR YYKIYFYLED DTIQVNEPEV 

       130        140        150        160        170        180 
INSGLPQGTS IRRQRIPYPP PNDDQFYTVY DFNINISVVF YGRTFKIYDC DPFTKNFLKK 

       190        200        210        220        230        240 
IGIKLNPPGQ CPLDPYMKMR RETLEFVDPF RPYQSFDTLK RFIQYDGKVL RFFCLWDDST 

       250        260        270        280        290        300 
SLFGDRREFV LHYFLCDGTV EIREVLPSNS GRDAMSSFLR RGKLPKYGPP GIYQPGQITD 

       310        320        330        340        350        360 
RAVLNVYGGL SEWRADGYLL DKYQLGKVEQ DFYTDQDLSI GATINVWGRK VLLCDCDEFT 

       370        380        390        400        410        420 
KTYYRTKYGV DNFTPISCKP PHLPKIERKY PPYTGFGSEE DSFRSCVGLK PTPHRKNFKK 

       430        440        450        460        470        480 
FMELDSFGNI SNILRYFGKL ITHKCADVDR IFVIAFYLSD DTISVFEPIE NNSGNAGGMF 

       490        500        510        520        530        540 
LKRSRVKKPG QEVFKSEFSE YIKAEELYIG ATVNINGYLF ILLNADEYTL NYMENNTDKF 

       550        560        570        580        590        600 
PYSNFELAIQ KLKQEKSKSR EITQVFAAAD YNHTKVVPYN TFRDILMSIT MGKLIDQELI 

       610        620        630        640        650        660 
TIARHYRVPE IMDPDLAYLI ARAHEKFKKN IFENFDMFIY NCVYEDREKK GVLPTKDIRR 

       670        680        690        700        710        720 
MCKSSRLPLD DDFLDCLLSR FEDKDHQINY EIFFSVLNWR MNPTPDLQAP PYLKEKCEDV 

       730        740        750 
WVGMPSPIPV KYVRYLDFLI DVYGLEDNML 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK016714 mRNA. Translation: BAB30393.1.
AK029501 mRNA. Translation: BAC26479.1.
BC120659 mRNA. Translation: AAI20660.1.
CCDSCCDS40883.1.
RefSeqNP_083192.2. NM_028916.4.
XP_006527768.1. XM_006527705.1.
UniGeneMm.248531.

3D structure databases

ProteinModelPortalQ9D485.
SMRQ9D485. Positions 71-188, 637-697.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9D485.

Proteomic databases

PaxDbQ9D485.
PRIDEQ9D485.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026014; ENSMUSP00000026014; ENSMUSG00000025038.
GeneID74405.
KEGGmmu:74405.
UCSCuc009sse.2. mouse.

Organism-specific databases

CTD80258.
MGIMGI:1921655. Efhc2.

Phylogenomic databases

eggNOGNOG282456.
GeneTreeENSGT00530000063528.
HOGENOMHOG000265451.
HOVERGENHBG059646.
InParanoidQ9D485.
OMAMEKDSYG.
OrthoDBEOG7BGHK3.
PhylomeDBQ9D485.
TreeFamTF314504.

Gene expression databases

ArrayExpressQ9D485.
BgeeQ9D485.
CleanExMM_EFHC2.
GenevestigatorQ9D485.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR010554. DUF1126.
IPR011992. EF-hand-dom_pair.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamPF06565. DUF1126. 3 hits.
[Graphical view]
SMARTSM00676. DM10. 3 hits.
[Graphical view]
PROSITEPS51336. DM10. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio340665.
PROQ9D485.
SOURCESearch...

Entry information

Entry nameEFHC2_MOUSE
AccessionPrimary (citable) accession number: Q9D485
Secondary accession number(s): Q0VBF5, Q8CDV9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot