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Protein

EF-hand domain-containing family member C2

Gene

Efhc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing family member C2
Gene namesi
Name:Efhc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1921655. Efhc2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750EF-hand domain-containing family member C2PRO_0000251704Add
BLAST

Proteomic databases

PaxDbiQ9D485.
PRIDEiQ9D485.

PTM databases

PhosphoSiteiQ9D485.

Expressioni

Gene expression databases

BgeeiQ9D485.
CleanExiMM_EFHC2.
ExpressionAtlasiQ9D485. baseline and differential.
GenevestigatoriQ9D485.

Structurei

3D structure databases

ProteinModelPortaliQ9D485.
SMRiQ9D485. Positions 71-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 182108DM10 1PROSITE-ProRule annotationAdd
BLAST
Domaini226 – 368143DM10 2PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 537108DM10 3PROSITE-ProRule annotationAdd
BLAST
Domaini557 – 59236EF-handAdd
BLAST

Sequence similaritiesi

Contains 3 DM10 domains.PROSITE-ProRule annotation
Contains 1 EF-hand domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG282456.
GeneTreeiENSGT00530000063528.
HOGENOMiHOG000265451.
HOVERGENiHBG059646.
InParanoidiQ9D485.
OMAiLHYFLCD.
OrthoDBiEOG7BGHK3.
PhylomeDBiQ9D485.
TreeFamiTF314504.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR010554. DUF1126.
IPR011992. EF-hand-dom_pair.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF06565. DUF1126. 3 hits.
[Graphical view]
SMARTiSM00676. DM10. 3 hits.
[Graphical view]
PROSITEiPS51336. DM10. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D485-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPFLPGNS FNRNIGKERF HKSQHWGFCN NVRMLVSENK PGVGGDLLYG
60 70 80 90 100
QKIKPKHSVF PKGDGTDAPS WVAFDKQVLS FDAYLEDEIS DKRQEIFRIR
110 120 130 140 150
YYKIYFYLED DTIQVNEPEV INSGLPQGTS IRRQRIPYPP PNDDQFYTVY
160 170 180 190 200
DFNINISVVF YGRTFKIYDC DPFTKNFLKK IGIKLNPPGQ CPLDPYMKMR
210 220 230 240 250
RETLEFVDPF RPYQSFDTLK RFIQYDGKVL RFFCLWDDST SLFGDRREFV
260 270 280 290 300
LHYFLCDGTV EIREVLPSNS GRDAMSSFLR RGKLPKYGPP GIYQPGQITD
310 320 330 340 350
RAVLNVYGGL SEWRADGYLL DKYQLGKVEQ DFYTDQDLSI GATINVWGRK
360 370 380 390 400
VLLCDCDEFT KTYYRTKYGV DNFTPISCKP PHLPKIERKY PPYTGFGSEE
410 420 430 440 450
DSFRSCVGLK PTPHRKNFKK FMELDSFGNI SNILRYFGKL ITHKCADVDR
460 470 480 490 500
IFVIAFYLSD DTISVFEPIE NNSGNAGGMF LKRSRVKKPG QEVFKSEFSE
510 520 530 540 550
YIKAEELYIG ATVNINGYLF ILLNADEYTL NYMENNTDKF PYSNFELAIQ
560 570 580 590 600
KLKQEKSKSR EITQVFAAAD YNHTKVVPYN TFRDILMSIT MGKLIDQELI
610 620 630 640 650
TIARHYRVPE IMDPDLAYLI ARAHEKFKKN IFENFDMFIY NCVYEDREKK
660 670 680 690 700
GVLPTKDIRR MCKSSRLPLD DDFLDCLLSR FEDKDHQINY EIFFSVLNWR
710 720 730 740 750
MNPTPDLQAP PYLKEKCEDV WVGMPSPIPV KYVRYLDFLI DVYGLEDNML
Length:750
Mass (Da):87,646
Last modified:October 3, 2006 - v2
Checksum:i382AF75FDB9CB052
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811P → S in BAB30393 (PubMed:16141072).Curated
Sequence conflicti578 – 5781P → T in BAC26479 (PubMed:16141072).Curated
Sequence conflicti674 – 6741L → V in BAC26479 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016714 mRNA. Translation: BAB30393.1.
AK029501 mRNA. Translation: BAC26479.1.
BC120659 mRNA. Translation: AAI20660.1.
CCDSiCCDS40883.1.
RefSeqiNP_083192.2. NM_028916.4.
XP_006527768.1. XM_006527705.2.
UniGeneiMm.248531.

Genome annotation databases

EnsembliENSMUST00000026014; ENSMUSP00000026014; ENSMUSG00000025038.
GeneIDi74405.
KEGGimmu:74405.
UCSCiuc009sse.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016714 mRNA. Translation: BAB30393.1.
AK029501 mRNA. Translation: BAC26479.1.
BC120659 mRNA. Translation: AAI20660.1.
CCDSiCCDS40883.1.
RefSeqiNP_083192.2. NM_028916.4.
XP_006527768.1. XM_006527705.2.
UniGeneiMm.248531.

3D structure databases

ProteinModelPortaliQ9D485.
SMRiQ9D485. Positions 71-188.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9D485.

Proteomic databases

PaxDbiQ9D485.
PRIDEiQ9D485.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026014; ENSMUSP00000026014; ENSMUSG00000025038.
GeneIDi74405.
KEGGimmu:74405.
UCSCiuc009sse.2. mouse.

Organism-specific databases

CTDi80258.
MGIiMGI:1921655. Efhc2.

Phylogenomic databases

eggNOGiNOG282456.
GeneTreeiENSGT00530000063528.
HOGENOMiHOG000265451.
HOVERGENiHBG059646.
InParanoidiQ9D485.
OMAiLHYFLCD.
OrthoDBiEOG7BGHK3.
PhylomeDBiQ9D485.
TreeFamiTF314504.

Miscellaneous databases

NextBioi340665.
PROiQ9D485.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D485.
CleanExiMM_EFHC2.
ExpressionAtlasiQ9D485. baseline and differential.
GenevestigatoriQ9D485.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR010554. DUF1126.
IPR011992. EF-hand-dom_pair.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF06565. DUF1126. 3 hits.
[Graphical view]
SMARTiSM00676. DM10. 3 hits.
[Graphical view]
PROSITEiPS51336. DM10. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiEFHC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D485
Secondary accession number(s): Q0VBF5, Q8CDV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 1, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.