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Q9D485

- EFHC2_MOUSE

UniProt

Q9D485 - EFHC2_MOUSE

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Protein

EF-hand domain-containing family member C2

Gene

Efhc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
EF-hand domain-containing family member C2
Gene namesi
Name:Efhc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1921655. Efhc2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750EF-hand domain-containing family member C2PRO_0000251704Add
BLAST

Proteomic databases

PaxDbiQ9D485.
PRIDEiQ9D485.

PTM databases

PhosphoSiteiQ9D485.

Expressioni

Gene expression databases

BgeeiQ9D485.
CleanExiMM_EFHC2.
ExpressionAtlasiQ9D485. baseline and differential.
GenevestigatoriQ9D485.

Structurei

3D structure databases

ProteinModelPortaliQ9D485.
SMRiQ9D485. Positions 71-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 182108DM10 1PROSITE-ProRule annotationAdd
BLAST
Domaini226 – 368143DM10 2PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 537108DM10 3PROSITE-ProRule annotationAdd
BLAST
Domaini557 – 59236EF-handAdd
BLAST

Sequence similaritiesi

Contains 3 DM10 domains.PROSITE-ProRule annotation
Contains 1 EF-hand domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG282456.
GeneTreeiENSGT00530000063528.
HOGENOMiHOG000265451.
HOVERGENiHBG059646.
InParanoidiQ9D485.
OMAiMEKDSYG.
OrthoDBiEOG7BGHK3.
PhylomeDBiQ9D485.
TreeFamiTF314504.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR010554. DUF1126.
IPR011992. EF-hand-dom_pair.
IPR006602. Uncharacterised_DM10.
[Graphical view]
PfamiPF06565. DUF1126. 3 hits.
[Graphical view]
SMARTiSM00676. DM10. 3 hits.
[Graphical view]
PROSITEiPS51336. DM10. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D485-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPFLPGNS FNRNIGKERF HKSQHWGFCN NVRMLVSENK PGVGGDLLYG
60 70 80 90 100
QKIKPKHSVF PKGDGTDAPS WVAFDKQVLS FDAYLEDEIS DKRQEIFRIR
110 120 130 140 150
YYKIYFYLED DTIQVNEPEV INSGLPQGTS IRRQRIPYPP PNDDQFYTVY
160 170 180 190 200
DFNINISVVF YGRTFKIYDC DPFTKNFLKK IGIKLNPPGQ CPLDPYMKMR
210 220 230 240 250
RETLEFVDPF RPYQSFDTLK RFIQYDGKVL RFFCLWDDST SLFGDRREFV
260 270 280 290 300
LHYFLCDGTV EIREVLPSNS GRDAMSSFLR RGKLPKYGPP GIYQPGQITD
310 320 330 340 350
RAVLNVYGGL SEWRADGYLL DKYQLGKVEQ DFYTDQDLSI GATINVWGRK
360 370 380 390 400
VLLCDCDEFT KTYYRTKYGV DNFTPISCKP PHLPKIERKY PPYTGFGSEE
410 420 430 440 450
DSFRSCVGLK PTPHRKNFKK FMELDSFGNI SNILRYFGKL ITHKCADVDR
460 470 480 490 500
IFVIAFYLSD DTISVFEPIE NNSGNAGGMF LKRSRVKKPG QEVFKSEFSE
510 520 530 540 550
YIKAEELYIG ATVNINGYLF ILLNADEYTL NYMENNTDKF PYSNFELAIQ
560 570 580 590 600
KLKQEKSKSR EITQVFAAAD YNHTKVVPYN TFRDILMSIT MGKLIDQELI
610 620 630 640 650
TIARHYRVPE IMDPDLAYLI ARAHEKFKKN IFENFDMFIY NCVYEDREKK
660 670 680 690 700
GVLPTKDIRR MCKSSRLPLD DDFLDCLLSR FEDKDHQINY EIFFSVLNWR
710 720 730 740 750
MNPTPDLQAP PYLKEKCEDV WVGMPSPIPV KYVRYLDFLI DVYGLEDNML
Length:750
Mass (Da):87,646
Last modified:October 3, 2006 - v2
Checksum:i382AF75FDB9CB052
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti381 – 3811P → S in BAB30393. (PubMed:16141072)Curated
Sequence conflicti578 – 5781P → T in BAC26479. (PubMed:16141072)Curated
Sequence conflicti674 – 6741L → V in BAC26479. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016714 mRNA. Translation: BAB30393.1.
AK029501 mRNA. Translation: BAC26479.1.
BC120659 mRNA. Translation: AAI20660.1.
CCDSiCCDS40883.1.
RefSeqiNP_083192.2. NM_028916.4.
XP_006527768.1. XM_006527705.1.
UniGeneiMm.248531.

Genome annotation databases

EnsembliENSMUST00000026014; ENSMUSP00000026014; ENSMUSG00000025038.
GeneIDi74405.
KEGGimmu:74405.
UCSCiuc009sse.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016714 mRNA. Translation: BAB30393.1 .
AK029501 mRNA. Translation: BAC26479.1 .
BC120659 mRNA. Translation: AAI20660.1 .
CCDSi CCDS40883.1.
RefSeqi NP_083192.2. NM_028916.4.
XP_006527768.1. XM_006527705.1.
UniGenei Mm.248531.

3D structure databases

ProteinModelPortali Q9D485.
SMRi Q9D485. Positions 71-188.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D485.

Proteomic databases

PaxDbi Q9D485.
PRIDEi Q9D485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026014 ; ENSMUSP00000026014 ; ENSMUSG00000025038 .
GeneIDi 74405.
KEGGi mmu:74405.
UCSCi uc009sse.2. mouse.

Organism-specific databases

CTDi 80258.
MGIi MGI:1921655. Efhc2.

Phylogenomic databases

eggNOGi NOG282456.
GeneTreei ENSGT00530000063528.
HOGENOMi HOG000265451.
HOVERGENi HBG059646.
InParanoidi Q9D485.
OMAi MEKDSYG.
OrthoDBi EOG7BGHK3.
PhylomeDBi Q9D485.
TreeFami TF314504.

Miscellaneous databases

NextBioi 340665.
PROi Q9D485.
SOURCEi Search...

Gene expression databases

Bgeei Q9D485.
CleanExi MM_EFHC2.
ExpressionAtlasi Q9D485. baseline and differential.
Genevestigatori Q9D485.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR010554. DUF1126.
IPR011992. EF-hand-dom_pair.
IPR006602. Uncharacterised_DM10.
[Graphical view ]
Pfami PF06565. DUF1126. 3 hits.
[Graphical view ]
SMARTi SM00676. DM10. 3 hits.
[Graphical view ]
PROSITEi PS51336. DM10. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiEFHC2_MOUSE
AccessioniPrimary (citable) accession number: Q9D485
Secondary accession number(s): Q0VBF5, Q8CDV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3