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Q9D485

- EFHC2_MOUSE

UniProt

Q9D485 - EFHC2_MOUSE

Protein

EF-hand domain-containing family member C2

Gene

Efhc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    EF-hand domain-containing family member C2
    Gene namesi
    Name:Efhc2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1921655. Efhc2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 750750EF-hand domain-containing family member C2PRO_0000251704Add
    BLAST

    Proteomic databases

    PaxDbiQ9D485.
    PRIDEiQ9D485.

    PTM databases

    PhosphoSiteiQ9D485.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D485.
    BgeeiQ9D485.
    CleanExiMM_EFHC2.
    GenevestigatoriQ9D485.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D485.
    SMRiQ9D485. Positions 71-188, 637-697.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini75 – 182108DM10 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 368143DM10 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini430 – 537108DM10 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini557 – 59236EF-handAdd
    BLAST

    Sequence similaritiesi

    Contains 3 DM10 domains.PROSITE-ProRule annotation
    Contains 1 EF-hand domain.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG282456.
    GeneTreeiENSGT00530000063528.
    HOGENOMiHOG000265451.
    HOVERGENiHBG059646.
    InParanoidiQ9D485.
    OMAiMEKDSYG.
    OrthoDBiEOG7BGHK3.
    PhylomeDBiQ9D485.
    TreeFamiTF314504.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR010554. DUF1126.
    IPR011992. EF-hand-dom_pair.
    IPR006602. Uncharacterised_DM10.
    [Graphical view]
    PfamiPF06565. DUF1126. 3 hits.
    [Graphical view]
    SMARTiSM00676. DM10. 3 hits.
    [Graphical view]
    PROSITEiPS51336. DM10. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9D485-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPFLPGNS FNRNIGKERF HKSQHWGFCN NVRMLVSENK PGVGGDLLYG    50
    QKIKPKHSVF PKGDGTDAPS WVAFDKQVLS FDAYLEDEIS DKRQEIFRIR 100
    YYKIYFYLED DTIQVNEPEV INSGLPQGTS IRRQRIPYPP PNDDQFYTVY 150
    DFNINISVVF YGRTFKIYDC DPFTKNFLKK IGIKLNPPGQ CPLDPYMKMR 200
    RETLEFVDPF RPYQSFDTLK RFIQYDGKVL RFFCLWDDST SLFGDRREFV 250
    LHYFLCDGTV EIREVLPSNS GRDAMSSFLR RGKLPKYGPP GIYQPGQITD 300
    RAVLNVYGGL SEWRADGYLL DKYQLGKVEQ DFYTDQDLSI GATINVWGRK 350
    VLLCDCDEFT KTYYRTKYGV DNFTPISCKP PHLPKIERKY PPYTGFGSEE 400
    DSFRSCVGLK PTPHRKNFKK FMELDSFGNI SNILRYFGKL ITHKCADVDR 450
    IFVIAFYLSD DTISVFEPIE NNSGNAGGMF LKRSRVKKPG QEVFKSEFSE 500
    YIKAEELYIG ATVNINGYLF ILLNADEYTL NYMENNTDKF PYSNFELAIQ 550
    KLKQEKSKSR EITQVFAAAD YNHTKVVPYN TFRDILMSIT MGKLIDQELI 600
    TIARHYRVPE IMDPDLAYLI ARAHEKFKKN IFENFDMFIY NCVYEDREKK 650
    GVLPTKDIRR MCKSSRLPLD DDFLDCLLSR FEDKDHQINY EIFFSVLNWR 700
    MNPTPDLQAP PYLKEKCEDV WVGMPSPIPV KYVRYLDFLI DVYGLEDNML 750
    Length:750
    Mass (Da):87,646
    Last modified:October 3, 2006 - v2
    Checksum:i382AF75FDB9CB052
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti381 – 3811P → S in BAB30393. (PubMed:16141072)Curated
    Sequence conflicti578 – 5781P → T in BAC26479. (PubMed:16141072)Curated
    Sequence conflicti674 – 6741L → V in BAC26479. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016714 mRNA. Translation: BAB30393.1.
    AK029501 mRNA. Translation: BAC26479.1.
    BC120659 mRNA. Translation: AAI20660.1.
    CCDSiCCDS40883.1.
    RefSeqiNP_083192.2. NM_028916.4.
    XP_006527768.1. XM_006527705.1.
    UniGeneiMm.248531.

    Genome annotation databases

    EnsembliENSMUST00000026014; ENSMUSP00000026014; ENSMUSG00000025038.
    GeneIDi74405.
    KEGGimmu:74405.
    UCSCiuc009sse.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016714 mRNA. Translation: BAB30393.1 .
    AK029501 mRNA. Translation: BAC26479.1 .
    BC120659 mRNA. Translation: AAI20660.1 .
    CCDSi CCDS40883.1.
    RefSeqi NP_083192.2. NM_028916.4.
    XP_006527768.1. XM_006527705.1.
    UniGenei Mm.248531.

    3D structure databases

    ProteinModelPortali Q9D485.
    SMRi Q9D485. Positions 71-188, 637-697.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D485.

    Proteomic databases

    PaxDbi Q9D485.
    PRIDEi Q9D485.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026014 ; ENSMUSP00000026014 ; ENSMUSG00000025038 .
    GeneIDi 74405.
    KEGGi mmu:74405.
    UCSCi uc009sse.2. mouse.

    Organism-specific databases

    CTDi 80258.
    MGIi MGI:1921655. Efhc2.

    Phylogenomic databases

    eggNOGi NOG282456.
    GeneTreei ENSGT00530000063528.
    HOGENOMi HOG000265451.
    HOVERGENi HBG059646.
    InParanoidi Q9D485.
    OMAi MEKDSYG.
    OrthoDBi EOG7BGHK3.
    PhylomeDBi Q9D485.
    TreeFami TF314504.

    Miscellaneous databases

    NextBioi 340665.
    PROi Q9D485.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D485.
    Bgeei Q9D485.
    CleanExi MM_EFHC2.
    Genevestigatori Q9D485.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR010554. DUF1126.
    IPR011992. EF-hand-dom_pair.
    IPR006602. Uncharacterised_DM10.
    [Graphical view ]
    Pfami PF06565. DUF1126. 3 hits.
    [Graphical view ]
    SMARTi SM00676. DM10. 3 hits.
    [Graphical view ]
    PROSITEi PS51336. DM10. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiEFHC2_MOUSE
    AccessioniPrimary (citable) accession number: Q9D485
    Secondary accession number(s): Q0VBF5, Q8CDV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3