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Protein

DNA-directed RNA polymerase III subunit RPC3

Gene

Polr3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF-Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Nucleotidyltransferase, Transferase
Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-MMU-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-MMU-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC3
Short name:
RNA polymerase III subunit C3
Alternative name(s):
DNA-directed RNA polymerase III subunit C
Gene namesi
Name:Polr3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921664 Polr3c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000739641 – 533DNA-directed RNA polymerase III subunit RPC3Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D483
PaxDbiQ9D483
PeptideAtlasiQ9D483
PRIDEiQ9D483

PTM databases

iPTMnetiQ9D483
PhosphoSitePlusiQ9D483

Expressioni

Gene expression databases

BgeeiENSMUSG00000028099
CleanExiMM_POLR3C
ExpressionAtlasiQ9D483 baseline and differential
GenevisibleiQ9D483 MM

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits (By similarity). RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (By similarity). Directly interacts with POLR3G and POLR3GL. Directly interacts with POLR3F/RPC39. Interacts with GTF3C4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029741

Structurei

3D structure databases

ProteinModelPortaliQ9D483
SMRiQ9D483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2587 Eukaryota
ENOG410XPVH LUCA
GeneTreeiENSGT00390000002799
HOGENOMiHOG000046475
HOVERGENiHBG059543
InParanoidiQ9D483
KOiK03023
OMAiEQCFGKV
OrthoDBiEOG091G186Z
PhylomeDBiQ9D483
TreeFamiTF103048

Family and domain databases

Gene3Di1.10.10.10, 4 hits
InterProiView protein in InterPro
IPR013197 RNA_pol_III_RPC82-rel_HTH
IPR008806 RNA_pol_III_Rpc82_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF08221 HTH_9, 1 hit
PF05645 RNA_pol_Rpc82, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D483-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQAEIKLCS LLLQEHFGEI VEKIGVHLVR TGSQPLRVIA HDTKASLDQV
60 70 80 90 100
KKALCVLIHH NLVLYHVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYG
110 120 130 140 150
DTGELIVEEL LLNGKMTMSA VVKKVADRLT ETMEDGKTMD YAEVSNAFVR
160 170 180 190 200
LADTHFVQRC PLVPDTDSSD RGPPPPAPTL VINEKDMYLV PKLSLIGKGK
210 220 230 240 250
RRRSSDEDAT GEPKAKKPRY TDNKEPSPDD GIYWQVNLDR FHQHFRDQAI
260 270 280 290 300
VSAVANRMDQ TSSEIVRTML RMSEITTPSS APYTQPLSSN EIFRSLPVGY
310 320 330 340 350
NISKQVLDQY LTLLADDPLE FIGKSGDSGG GMFVINLHKA LASLATATLE
360 370 380 390 400
SVIQERFGSR CARIFRLVLQ KKHLEQKQVE DFAMIPAKEA KDMLYKMLSE
410 420 430 440 450
NFILLQEIPK TPDHAPSRTF YLYTVNVLSA ARMLLHRCYK SIANLIERRQ
460 470 480 490 500
FETKENKRLL EKSQRVEAIM ASMQATGAEE VQLQEIEEMI TAPERQQLET
510 520 530
LKRNVNKLDA SEIQVDETIF LLESYIESTM KRQ
Length:533
Mass (Da):60,706
Last modified:June 1, 2001 - v1
Checksum:i6869DE76F7CBC2B0
GO
Isoform 2 (identifier: Q9D483-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-202: GKRR → DFTS
     203-533: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,778
Checksum:iCBAB01637344A122
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171R → P in AAH26793 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010678199 – 202GKRR → DFTS in isoform 2. 1 Publication4
Alternative sequenceiVSP_010679203 – 533Missing in isoform 2. 1 PublicationAdd BLAST331

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016716 mRNA Translation: BAB30395.1
BC026793 mRNA Translation: AAH26793.1
CCDSiCCDS51010.1 [Q9D483-1]
RefSeqiNP_083201.1, NM_028925.1 [Q9D483-1]
XP_006502250.1, XM_006502187.3 [Q9D483-1]
UniGeneiMm.276043

Genome annotation databases

EnsembliENSMUST00000029741; ENSMUSP00000029741; ENSMUSG00000028099 [Q9D483-1]
ENSMUST00000141377; ENSMUSP00000115300; ENSMUSG00000028099 [Q9D483-2]
ENSMUST00000154679; ENSMUSP00000122435; ENSMUSG00000028099 [Q9D483-1]
GeneIDi74414
KEGGimmu:74414
UCSCiuc008qoa.2 mouse [Q9D483-1]
uc008qoc.2 mouse [Q9D483-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D483
Secondary accession number(s): Q8R0I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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