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Protein

DNA-directed RNA polymerase III subunit RPC3

Gene

Polr3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Antiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC3
Short name:
RNA polymerase III subunit C3
Alternative name(s):
DNA-directed RNA polymerase III subunit C
Gene namesi
Name:Polr3c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1921664. Polr3c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533DNA-directed RNA polymerase III subunit RPC3PRO_0000073964Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D483.
MaxQBiQ9D483.
PaxDbiQ9D483.
PeptideAtlasiQ9D483.
PRIDEiQ9D483.

PTM databases

iPTMnetiQ9D483.
PhosphoSiteiQ9D483.

Expressioni

Gene expression databases

BgeeiQ9D483.
CleanExiMM_POLR3C.
ExpressionAtlasiQ9D483. baseline and differential.
GenevisibleiQ9D483. MM.

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex. Interacts with GTF3C4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029741.

Structurei

3D structure databases

ProteinModelPortaliQ9D483.
SMRiQ9D483. Positions 1-163, 230-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2587. Eukaryota.
ENOG410XPVH. LUCA.
GeneTreeiENSGT00390000002799.
HOGENOMiHOG000046475.
HOVERGENiHBG059543.
InParanoidiQ9D483.
KOiK03023.
OMAiNQLPTAR.
OrthoDBiEOG7TMZS8.
PhylomeDBiQ9D483.
TreeFamiTF103048.

Family and domain databases

InterProiIPR013197. RNA_pol_III_RPC82-rel_HTH.
IPR008806. RNA_pol_III_Rpc82_C.
[Graphical view]
PfamiPF08221. HTH_9. 1 hit.
PF05645. RNA_pol_Rpc82. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D483-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTQAEIKLCS LLLQEHFGEI VEKIGVHLVR TGSQPLRVIA HDTKASLDQV
60 70 80 90 100
KKALCVLIHH NLVLYHVHKR GVVEYEAQCS RVLRMLRYPR YIYTTKTLYG
110 120 130 140 150
DTGELIVEEL LLNGKMTMSA VVKKVADRLT ETMEDGKTMD YAEVSNAFVR
160 170 180 190 200
LADTHFVQRC PLVPDTDSSD RGPPPPAPTL VINEKDMYLV PKLSLIGKGK
210 220 230 240 250
RRRSSDEDAT GEPKAKKPRY TDNKEPSPDD GIYWQVNLDR FHQHFRDQAI
260 270 280 290 300
VSAVANRMDQ TSSEIVRTML RMSEITTPSS APYTQPLSSN EIFRSLPVGY
310 320 330 340 350
NISKQVLDQY LTLLADDPLE FIGKSGDSGG GMFVINLHKA LASLATATLE
360 370 380 390 400
SVIQERFGSR CARIFRLVLQ KKHLEQKQVE DFAMIPAKEA KDMLYKMLSE
410 420 430 440 450
NFILLQEIPK TPDHAPSRTF YLYTVNVLSA ARMLLHRCYK SIANLIERRQ
460 470 480 490 500
FETKENKRLL EKSQRVEAIM ASMQATGAEE VQLQEIEEMI TAPERQQLET
510 520 530
LKRNVNKLDA SEIQVDETIF LLESYIESTM KRQ
Length:533
Mass (Da):60,706
Last modified:June 1, 2001 - v1
Checksum:i6869DE76F7CBC2B0
GO
Isoform 2 (identifier: Q9D483-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     199-202: GKRR → DFTS
     203-533: Missing.

Note: No experimental confirmation available.
Show »
Length:202
Mass (Da):22,778
Checksum:iCBAB01637344A122
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711R → P in AAH26793 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei199 – 2024GKRR → DFTS in isoform 2. 1 PublicationVSP_010678
Alternative sequencei203 – 533331Missing in isoform 2. 1 PublicationVSP_010679Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016716 mRNA. Translation: BAB30395.1.
BC026793 mRNA. Translation: AAH26793.1.
CCDSiCCDS51010.1. [Q9D483-1]
RefSeqiNP_083201.1. NM_028925.1. [Q9D483-1]
XP_006502250.1. XM_006502187.2. [Q9D483-1]
UniGeneiMm.276043.

Genome annotation databases

EnsembliENSMUST00000029741; ENSMUSP00000029741; ENSMUSG00000028099. [Q9D483-1]
ENSMUST00000141377; ENSMUSP00000115300; ENSMUSG00000028099. [Q9D483-2]
ENSMUST00000154679; ENSMUSP00000122435; ENSMUSG00000028099. [Q9D483-1]
GeneIDi74414.
KEGGimmu:74414.
UCSCiuc008qoa.2. mouse. [Q9D483-1]
uc008qoc.2. mouse. [Q9D483-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016716 mRNA. Translation: BAB30395.1.
BC026793 mRNA. Translation: AAH26793.1.
CCDSiCCDS51010.1. [Q9D483-1]
RefSeqiNP_083201.1. NM_028925.1. [Q9D483-1]
XP_006502250.1. XM_006502187.2. [Q9D483-1]
UniGeneiMm.276043.

3D structure databases

ProteinModelPortaliQ9D483.
SMRiQ9D483. Positions 1-163, 230-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029741.

PTM databases

iPTMnetiQ9D483.
PhosphoSiteiQ9D483.

Proteomic databases

EPDiQ9D483.
MaxQBiQ9D483.
PaxDbiQ9D483.
PeptideAtlasiQ9D483.
PRIDEiQ9D483.

Protocols and materials databases

DNASUi74414.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029741; ENSMUSP00000029741; ENSMUSG00000028099. [Q9D483-1]
ENSMUST00000141377; ENSMUSP00000115300; ENSMUSG00000028099. [Q9D483-2]
ENSMUST00000154679; ENSMUSP00000122435; ENSMUSG00000028099. [Q9D483-1]
GeneIDi74414.
KEGGimmu:74414.
UCSCiuc008qoa.2. mouse. [Q9D483-1]
uc008qoc.2. mouse. [Q9D483-2]

Organism-specific databases

CTDi10623.
MGIiMGI:1921664. Polr3c.

Phylogenomic databases

eggNOGiKOG2587. Eukaryota.
ENOG410XPVH. LUCA.
GeneTreeiENSGT00390000002799.
HOGENOMiHOG000046475.
HOVERGENiHBG059543.
InParanoidiQ9D483.
KOiK03023.
OMAiNQLPTAR.
OrthoDBiEOG7TMZS8.
PhylomeDBiQ9D483.
TreeFamiTF103048.

Enzyme and pathway databases

ReactomeiR-MMU-1834949. Cytosolic sensors of pathogen-associated DNA.
R-MMU-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-MMU-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
R-MMU-76071. RNA Polymerase III Transcription Initiation From Type 3 Promoter.

Miscellaneous databases

PROiQ9D483.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D483.
CleanExiMM_POLR3C.
ExpressionAtlasiQ9D483. baseline and differential.
GenevisibleiQ9D483. MM.

Family and domain databases

InterProiIPR013197. RNA_pol_III_RPC82-rel_HTH.
IPR008806. RNA_pol_III_Rpc82_C.
[Graphical view]
PfamiPF08221. HTH_9. 1 hit.
PF05645. RNA_pol_Rpc82. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Salivary gland.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiRPC3_MOUSE
AccessioniPrimary (citable) accession number: Q9D483
Secondary accession number(s): Q8R0I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.