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Q9D479

- UVSSA_MOUSE

UniProt

Q9D479 - UVSSA_MOUSE

Protein

UV-stimulated scaffold protein A

Gene

Uvssa

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 2 (13 Jun 2012)
      Previous versions | rss
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    Functioni

    Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage By similarity.By similarity

    GO - Molecular functioni

    1. RNA polymerase II core binding Source: UniProtKB

    GO - Biological processi

    1. protein ubiquitination Source: UniProtKB
    2. response to UV Source: UniProtKB
    3. transcription-coupled nucleotide-excision repair Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UV-stimulated scaffold protein A
    Gene namesi
    Name:Uvssa
    Synonyms:Kiaa1530
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1918351. Uvssa.

    Subcellular locationi

    Chromosome By similarity
    Note: Accumulates at UV DNA damage sites.By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 717717UV-stimulated scaffold protein APRO_0000317283Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei284 – 2841PhosphoserineBy similarity
    Modified residuei291 – 2911PhosphoserineBy similarity

    Post-translational modificationi

    Monoubiquitinated: ubiquitination does not increase in response to UV.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ9D479.

    PTM databases

    PhosphoSiteiQ9D479.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D479.
    BgeeiQ9D479.
    CleanExiMM_4933407H18RIK.
    GenevestigatoriQ9D479.

    Interactioni

    Subunit structurei

    Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000085170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 145144VHS-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili169 – 19931Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi654 – 6629Poly-Lys

    Sequence similaritiesi

    Belongs to the UVSSA family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG313134.
    GeneTreeiENSGT00390000000377.
    HOVERGENiHBG076421.
    InParanoidiQ9D479.
    OMAiRMDQKKH.
    OrthoDBiEOG7X0VHQ.
    PhylomeDBiQ9D479.
    TreeFamiTF321660.

    Family and domain databases

    Gene3Di1.25.40.90. 1 hit.
    InterProiIPR018610. DUF2043.
    IPR008942. ENTH_VHS.
    [Graphical view]
    PfamiPF09740. DUF2043. 1 hit.
    [Graphical view]
    SUPFAMiSSF48464. SSF48464. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9D479-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKLSQLIE ELTTSGESQL NAQKMKELKK ICKSSEEQLS HAYRLLITQL    50
    TQGHAEIRLS AFQIVDELFT RSHQFRMLLV SDFQEFLELT LGTDSDRPLP 100
    PPREAAQRLR QAAMQAVEGW NEKFGQAYKK LALGYHFLKH TKKVDFRDIN 150
    VRTVAERKRE EEKQKHLDKI HRESADRAKR EMEEMYDEIE CCLTEVENCF 200
    KLLVPLDFVP CPEDKFFGEA SSMTEGYAPC PLSPDLATPR ESGLSGPQDE 250
    EQPCCSKDLV ASAYHVGSVV GLKALPQTAM KDSSRDEDEP SDPDDFLRSH 300
    GLGSHKYTLD VEVPSDGLKV QENEDNLAVL HAARDSLKLI QNKFLPTVCS 350
    WVQRFTRAGT YSAHLKQAID LKMELELALK KYEELNIEPG RGQRSRTEAL 400
    EDSEDEDQDF VEVPEKEGYE PRIPDHLRAE YGLEPKAPLK TLEKGTAVCK 450
    LQERTRMRRE EEASDPTSAA AQMLRLQDCL SSPSPSSTRV LPGPEEAQKQ 500
    AERARAPIVP FGVDLCYWGQ EQLTAGKILK SDSQHRFWKP SEVEEEVDSA 550
    HVSEMLHSRH ITFSGTFEPV QHKCRALRPN GRLCERQDRL KCPFHGKIIP 600
    RDDKGQPLNP EDRAREQRQQ LQRQQAHPDW QDPEFLKDVE AATGVDLGSS 650
    RSSKKGKGKK KKHPNLTDLR ERTNTARARL EKKVFAKAAV QRVVAAMNQM 700
    DQKKHEKFAN QFNYALK 717
    Length:717
    Mass (Da):81,759
    Last modified:June 13, 2012 - v2
    Checksum:iACC97A8DFAB47BB5
    GO

    Sequence cautioni

    The sequence BAB30399.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC98194.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti82 – 821D → G in AAI44921. (PubMed:15489334)Curated
    Sequence conflicti397 – 44246Missing in BAC98194. (PubMed:14621295)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016722 mRNA. Translation: BAB30399.1. Different initiation.
    AK156117 mRNA. Translation: BAE33591.1.
    AC145072 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37418.1.
    BC061483 mRNA. Translation: AAH61483.1.
    BC137803 mRNA. Translation: AAI37804.1.
    BC144920 mRNA. Translation: AAI44921.1.
    AK129384 Transcribed RNA. Translation: BAC98194.1. Different initiation.
    CCDSiCCDS39064.1.
    RefSeqiNP_001074570.1. NM_001081101.2.
    XP_006504171.1. XM_006504108.1.
    UniGeneiMm.132178.

    Genome annotation databases

    EnsembliENSMUST00000087864; ENSMUSP00000085170; ENSMUSG00000037355.
    GeneIDi71101.
    KEGGimmu:71101.
    UCSCiuc008xas.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016722 mRNA. Translation: BAB30399.1 . Different initiation.
    AK156117 mRNA. Translation: BAE33591.1 .
    AC145072 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37418.1 .
    BC061483 mRNA. Translation: AAH61483.1 .
    BC137803 mRNA. Translation: AAI37804.1 .
    BC144920 mRNA. Translation: AAI44921.1 .
    AK129384 Transcribed RNA. Translation: BAC98194.1 . Different initiation.
    CCDSi CCDS39064.1.
    RefSeqi NP_001074570.1. NM_001081101.2.
    XP_006504171.1. XM_006504108.1.
    UniGenei Mm.132178.

    3D structure databases

    ProteinModelPortali Q9D479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000085170.

    PTM databases

    PhosphoSitei Q9D479.

    Proteomic databases

    PRIDEi Q9D479.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087864 ; ENSMUSP00000085170 ; ENSMUSG00000037355 .
    GeneIDi 71101.
    KEGGi mmu:71101.
    UCSCi uc008xas.2. mouse.

    Organism-specific databases

    CTDi 57654.
    MGIi MGI:1918351. Uvssa.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG313134.
    GeneTreei ENSGT00390000000377.
    HOVERGENi HBG076421.
    InParanoidi Q9D479.
    OMAi RMDQKKH.
    OrthoDBi EOG7X0VHQ.
    PhylomeDBi Q9D479.
    TreeFami TF321660.

    Miscellaneous databases

    NextBioi 333027.
    PROi Q9D479.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D479.
    Bgeei Q9D479.
    CleanExi MM_4933407H18RIK.
    Genevestigatori Q9D479.

    Family and domain databases

    Gene3Di 1.25.40.90. 1 hit.
    InterProi IPR018610. DUF2043.
    IPR008942. ENTH_VHS.
    [Graphical view ]
    Pfami PF09740. DUF2043. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48464. SSF48464. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Spleen and Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Limb.
    5. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 84-717.
      Tissue: Brain.

    Entry informationi

    Entry nameiUVSSA_MOUSE
    AccessioniPrimary (citable) accession number: Q9D479
    Secondary accession number(s): B2RQ84
    , B7ZN03, Q3U1A8, Q6P7V8, Q6ZPN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 13, 2012
    Last modified: October 1, 2014
    This is version 76 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3