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Protein

Calcium-binding tyrosine phosphorylation-regulated protein

Gene

Cabyr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: MGI
  • enzyme binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

GO - Biological processi

  • calcium-mediated signaling Source: BHF-UCL
  • protein oligomerization Source: BHF-UCL
  • sperm capacitation Source: BHF-UCL
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding tyrosine phosphorylation-regulated protein
Alternative name(s):
Calcium-binding protein 86
Testis-specific calcium-binding protein CBP86
Gene namesi
Name:Cabyr
Synonyms:Cbp86
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1918382. Cabyr.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • cytoskeleton Source: UniProtKB-SubCell
  • motile cilium Source: BHF-UCL
  • nucleus Source: MGI
  • sperm end piece Source: MGI
  • sperm fibrous sheath Source: BHF-UCL
  • sperm principal piece Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000892701 – 453Calcium-binding tyrosine phosphorylation-regulated proteinAdd BLAST453

Post-translational modificationi

Phosphorylated on tyrosine residues during in vitro capacitation. Dephosphorylation affects its ability to bind calcium (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D424.
PRIDEiQ9D424.

PTM databases

iPTMnetiQ9D424.
PhosphoSitePlusiQ9D424.

Expressioni

Tissue specificityi

Expressed in spermatozoa.1 Publication

Gene expression databases

BgeeiENSMUSG00000024430.
ExpressionAtlasiQ9D424. baseline and differential.
GenevisibleiQ9D424. MM.

Interactioni

Subunit structurei

Interacts with FSCB.1 Publication

GO - Molecular functioni

  • enzyme binding Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • protein heterodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi214495. 5 interactors.
STRINGi10090.ENSMUSP00000079277.

Structurei

3D structure databases

ProteinModelPortaliQ9D424.
SMRiQ9D424.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 49RIIaAdd BLAST38

Sequence similaritiesi

Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiENOG410IFPT. Eukaryota.
ENOG410ZQAQ. LUCA.
GeneTreeiENSGT00390000000444.
HOGENOMiHOG000059568.
HOVERGENiHBG080982.
InParanoidiQ9D424.
OMAiEQIVIPF.
OrthoDBiEOG091G18VB.
PhylomeDBiQ9D424.
TreeFamiTF332959.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
PfamiPF02197. RIIa. 1 hit.
[Graphical view]
SMARTiSM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D424-1) [UniParc]FASTAAdd to basket
Also known as: CBP86-1, CBP86-6

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISSKPRLVV PYGLKTLLEG VSRAILKTNP TNITQFAAVY FKELIVFREG
60 70 80 90 100
NSSLDIKDLI KQFHQMKVEK WAEGVTVEKK ECIKEPIKPP PVPCKPTHME
110 120 130 140 150
KSTDTEEDNV AGPLFSNKTT QFPSVHAEVQ SEETSEGARG PSDKPTTPKT
160 170 180 190 200
DYTPPSSPPP APVSAEYAYV PADPAQFAAQ MLGNVPSTYS EVLMVDVATS
210 220 230 240 250
TPAVPQDVLS AEFAEEVVLS APLVCSGETV EVQVVSKTSA QVVVGPVSEA
260 270 280 290 300
EPPKASSAPL QGEQEPPAHE APDTQVTSAS RISSIYNDVP VNEGVVYVEE
310 320 330 340 350
IPGYIVIPFT DHDQVACVKE IEQSPPGSPK AVEPKTKISI ESLKTVQVEE
360 370 380 390 400
NSQHKSSVHV EAEATVLLSN TALDGQPEVP AEPLDAEGFF KVASENSLHL
410 420 430 440 450
ETEIVIINPD DPGQEESGGN AAPHSSGDPF PPAPGGLTEP EMQPDGEAAP

EQV
Length:453
Mass (Da):48,333
Last modified:June 1, 2001 - v1
Checksum:i7BCA9EB34D89F472
GO
Isoform 2 (identifier: Q9D424-2) [UniParc]FASTAAdd to basket
Also known as: CBP86-2

The sequence of this isoform differs from the canonical sequence as follows:
     183-381: GNVPSTYSEV...ALDGQPEVPA → ALATSEAGQP...TTAHVRRAEP
     382-453: Missing.

Show »
Length:381
Mass (Da):41,307
Checksum:i123A4CE9826DD44F
GO
Isoform 3 (identifier: Q9D424-3) [UniParc]FASTAAdd to basket
Also known as: CBP86-4

The sequence of this isoform differs from the canonical sequence as follows:
     183-220: GNVPSTYSEV...AEFAEEVVLS → EDVAKKSSGS...TTAHVRRAEP
     221-453: Missing.

Show »
Length:220
Mass (Da):23,985
Checksum:iE1665615F2F0A7B3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17L → P in AAK49988 (PubMed:12801634).Curated1
Sequence conflicti41F → L in AAK49988 (PubMed:12801634).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016252183 – 381GNVPS…PEVPA → ALATSEAGQPPPYSNMWTLY CLTDMNQQSRPSPPPAPGPF PQATLYLPNPKEPQFLQNPP KVTSPTYVMMDDSKKTNAPP FILVGSNVQEAQDWNPLPGH AVVSQAEALKRYAAVQVPIA VPADQTFQRPAPNPQNASPP TSGQDGPRPKSPVFLSVAFP VEDVAKKSSGSGDKRTPFGS YGIAGEITVTTAHVRRAEP in isoform 2. 1 PublicationAdd BLAST199
Alternative sequenceiVSP_016253183 – 220GNVPS…EVVLS → EDVAKKSSGSGDKRTPFGSY GIAGEITVTTAHVRRAEP in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_016254221 – 453Missing in isoform 3. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_016255382 – 453Missing in isoform 2. 1 PublicationAdd BLAST72

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359382 mRNA. Translation: AAK49987.1.
AF359383 mRNA. Translation: AAK49988.1.
AF359384 mRNA. Translation: AAK49989.1.
AF359385 mRNA. Translation: AAK49990.1.
AK016856 mRNA. Translation: BAB30467.1.
CCDSiCCDS37739.1. [Q9D424-1]
CCDS50223.1. [Q9D424-2]
CCDS50224.1. [Q9D424-3]
RefSeqiNP_001035883.1. NM_001042418.1. [Q9D424-1]
NP_001035884.1. NM_001042419.1. [Q9D424-3]
NP_001035885.1. NM_001042420.1. [Q9D424-1]
NP_081963.1. NM_027687.2. [Q9D424-1]
NP_859420.2. NM_181731.3. [Q9D424-2]
XP_017173468.1. XM_017317979.1. [Q9D424-1]
UniGeneiMm.179740.

Genome annotation databases

EnsembliENSMUST00000080415; ENSMUSP00000079277; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000115857; ENSMUSP00000111523; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000119108; ENSMUSP00000113760; ENSMUSG00000024430. [Q9D424-3]
ENSMUST00000121018; ENSMUSP00000113131; ENSMUSG00000024430. [Q9D424-2]
ENSMUST00000150758; ENSMUSP00000118330; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000186263; ENSMUSP00000140870; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000191078; ENSMUSP00000140894; ENSMUSG00000024430. [Q9D424-1]
GeneIDi71132.
KEGGimmu:71132.
UCSCiuc008ecl.1. mouse. [Q9D424-3]
uc008ecm.1. mouse. [Q9D424-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF359382 mRNA. Translation: AAK49987.1.
AF359383 mRNA. Translation: AAK49988.1.
AF359384 mRNA. Translation: AAK49989.1.
AF359385 mRNA. Translation: AAK49990.1.
AK016856 mRNA. Translation: BAB30467.1.
CCDSiCCDS37739.1. [Q9D424-1]
CCDS50223.1. [Q9D424-2]
CCDS50224.1. [Q9D424-3]
RefSeqiNP_001035883.1. NM_001042418.1. [Q9D424-1]
NP_001035884.1. NM_001042419.1. [Q9D424-3]
NP_001035885.1. NM_001042420.1. [Q9D424-1]
NP_081963.1. NM_027687.2. [Q9D424-1]
NP_859420.2. NM_181731.3. [Q9D424-2]
XP_017173468.1. XM_017317979.1. [Q9D424-1]
UniGeneiMm.179740.

3D structure databases

ProteinModelPortaliQ9D424.
SMRiQ9D424.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214495. 5 interactors.
STRINGi10090.ENSMUSP00000079277.

PTM databases

iPTMnetiQ9D424.
PhosphoSitePlusiQ9D424.

Proteomic databases

PaxDbiQ9D424.
PRIDEiQ9D424.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080415; ENSMUSP00000079277; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000115857; ENSMUSP00000111523; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000119108; ENSMUSP00000113760; ENSMUSG00000024430. [Q9D424-3]
ENSMUST00000121018; ENSMUSP00000113131; ENSMUSG00000024430. [Q9D424-2]
ENSMUST00000150758; ENSMUSP00000118330; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000186263; ENSMUSP00000140870; ENSMUSG00000024430. [Q9D424-1]
ENSMUST00000191078; ENSMUSP00000140894; ENSMUSG00000024430. [Q9D424-1]
GeneIDi71132.
KEGGimmu:71132.
UCSCiuc008ecl.1. mouse. [Q9D424-3]
uc008ecm.1. mouse. [Q9D424-1]

Organism-specific databases

CTDi26256.
MGIiMGI:1918382. Cabyr.

Phylogenomic databases

eggNOGiENOG410IFPT. Eukaryota.
ENOG410ZQAQ. LUCA.
GeneTreeiENSGT00390000000444.
HOGENOMiHOG000059568.
HOVERGENiHBG080982.
InParanoidiQ9D424.
OMAiEQIVIPF.
OrthoDBiEOG091G18VB.
PhylomeDBiQ9D424.
TreeFamiTF332959.

Miscellaneous databases

ChiTaRSiCabyr. mouse.
PROiQ9D424.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024430.
ExpressionAtlasiQ9D424. baseline and differential.
GenevisibleiQ9D424. MM.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
PfamiPF02197. RIIa. 1 hit.
[Graphical view]
SMARTiSM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCABYR_MOUSE
AccessioniPrimary (citable) accession number: Q9D424
Secondary accession number(s): Q91Y41, Q91Y42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.