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Protein

F-box only protein 24

Gene

Fbxo24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 24
Gene namesi
Name:Fbxo24
Synonyms:Fbx24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918426. Fbxo24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 589589F-box only protein 24PRO_0000119910Add
BLAST

Proteomic databases

PaxDbiQ9D417.
PRIDEiQ9D417.

PTM databases

PhosphoSiteiQ9D417.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089984.
CleanExiMM_FBXO24.
ExpressionAtlasiQ9D417. baseline and differential.
GenevisibleiQ9D417. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi214532. 2 interactions.
STRINGi10090.ENSMUSP00000031732.

Structurei

3D structure databases

ProteinModelPortaliQ9D417.
SMRiQ9D417. Positions 346-453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 6947F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati386 – 43550RCC1Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 RCC1 repeat.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQCV. Eukaryota.
ENOG41100N3. LUCA.
GeneTreeiENSGT00390000017455.
HOGENOMiHOG000253007.
HOVERGENiHBG051571.
InParanoidiQ9D417.
KOiK10304.
OMAiEPTQVHY.
OrthoDBiEOG091G043B.
PhylomeDBiQ9D417.
TreeFamiTF328722.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR001810. F-box_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00415. RCC1. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50012. RCC1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKRSCPSCG LEAGSEKKER GNPISVQLFP PELVEHIVSF LPVKDLVALG
60 70 80 90 100
QTCHYFHEVC DAEGVWRRIC RRLSPRIRDQ SSGARPWKRA AILNYTKGLY
110 120 130 140 150
FQAFGGRRRC LSKSVAPMLA HGYRRFLPTK DHVFILDYVG TLFFLKNALV
160 170 180 190 200
SSTLGQIQWK RACRYVVLCR GAKDFASDPR CDTVYRKYLY VLATREQPAV
210 220 230 240 250
VGTTGSRACD CVEVYLQSSG QRVFKMTFHH SMSFKQIVLV GQETQRALLL
260 270 280 290 300
LTEEGKIYSL VVNETQLDQP RSYTVQLALR KVSRCLPHLR VTCMASNQSS
310 320 330 340 350
TLYITGGTLI PRKQVPKAAE LRAPDPPDQG GVYFEVHTPG VYRDLFGTLQ
360 370 380 390 400
AFDPLDHQMP LALSLPAKVL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG
410 420 430 440 450
TGDKMDRGEP TQVHYLQRPI ALWCGLNHSL VLSQTSDFSK ELLGCGCGAG
460 470 480 490 500
GRLPGWPKGS ASFVKLHIKV PLCACSLCST RECLYMLSSH DIEQCPVYRD
510 520 530 540 550
LPASRVGGSP EPSQGAGAPQ DPGGTAQACE EYLSQIHSCP TLQDRMEKMK
560 570 580
EIVGWMPLMA AQKDFFWEAL DMLQRAAGGA GPDTSTPES
Length:589
Mass (Da):65,429
Last modified:June 1, 2001 - v1
Checksum:iF4FB50703BD4D270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016870 mRNA. Translation: BAB30476.1.
CCDSiCCDS51674.1.
RefSeqiNP_081984.1. NM_027708.1.
XP_006504682.1. XM_006504619.2.
UniGeneiMm.474695.

Genome annotation databases

EnsembliENSMUST00000031732; ENSMUSP00000031732; ENSMUSG00000089984.
GeneIDi71176.
KEGGimmu:71176.
UCSCiuc009adc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016870 mRNA. Translation: BAB30476.1.
CCDSiCCDS51674.1.
RefSeqiNP_081984.1. NM_027708.1.
XP_006504682.1. XM_006504619.2.
UniGeneiMm.474695.

3D structure databases

ProteinModelPortaliQ9D417.
SMRiQ9D417. Positions 346-453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214532. 2 interactions.
STRINGi10090.ENSMUSP00000031732.

PTM databases

PhosphoSiteiQ9D417.

Proteomic databases

PaxDbiQ9D417.
PRIDEiQ9D417.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031732; ENSMUSP00000031732; ENSMUSG00000089984.
GeneIDi71176.
KEGGimmu:71176.
UCSCiuc009adc.1. mouse.

Organism-specific databases

CTDi26261.
MGIiMGI:1918426. Fbxo24.

Phylogenomic databases

eggNOGiENOG410IQCV. Eukaryota.
ENOG41100N3. LUCA.
GeneTreeiENSGT00390000017455.
HOGENOMiHOG000253007.
HOVERGENiHBG051571.
InParanoidiQ9D417.
KOiK10304.
OMAiEPTQVHY.
OrthoDBiEOG091G043B.
PhylomeDBiQ9D417.
TreeFamiTF328722.

Miscellaneous databases

ChiTaRSiFbxo24. mouse.
PROiQ9D417.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000089984.
CleanExiMM_FBXO24.
ExpressionAtlasiQ9D417. baseline and differential.
GenevisibleiQ9D417. MM.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR001810. F-box_dom.
IPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00415. RCC1. 1 hit.
[Graphical view]
SMARTiSM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF50985. SSF50985. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS50012. RCC1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX24_MOUSE
AccessioniPrimary (citable) accession number: Q9D417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.