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Protein

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Gene

Oxsm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Enzyme regulationi

Inhibited by cerulenin.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC:2.3.1.41)
Alternative name(s):
Beta-ketoacyl-ACP synthase
Gene namesi
Name:Oxsm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1918397 Oxsm

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
ChainiPRO_000023266128 – 4593-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialAdd BLAST432

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109N6-acetyllysine; alternateCombined sources1
Modified residuei109N6-succinyllysine; alternateCombined sources1
Modified residuei113N6-succinyllysineCombined sources1
Modified residuei174N6-acetyllysine; alternateCombined sources1
Modified residuei174N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D404
MaxQBiQ9D404
PaxDbiQ9D404
PRIDEiQ9D404

PTM databases

iPTMnetiQ9D404
PhosphoSitePlusiQ9D404
SwissPalmiQ9D404

Expressioni

Gene expression databases

BgeeiENSMUSG00000021786
CleanExiMM_OXSM
GenevisibleiQ9D404 MM

Interactioni

Protein-protein interaction databases

IntActiQ9D404, 2 interactors
MINTiQ9D404
STRINGi10090.ENSMUSP00000022311

Structurei

3D structure databases

ProteinModelPortaliQ9D404
SMRiQ9D404
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1394 Eukaryota
COG0304 LUCA
GeneTreeiENSGT00530000063309
HOGENOMiHOG000060166
HOVERGENiHBG082096
InParanoidiQ9D404
KOiK09458
OMAiPFFVPKI
OrthoDBiEOG091G071V
PhylomeDBiQ9D404

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR017568 3-oxoacyl-ACP_synth-2
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PIRSFiPIRSF000447 KAS_II, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR03150 fabF, 1 hit
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D404-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKCLQHFL KATISHPYPA SYSWLISKHR FYGTVPAAML RRRVVITGIG
60 70 80 90 100
LVTPLGVGTQ LVWDRLLRGE SGIVSVVGDE YKNIPCSVAA YVPRGPHEGQ
110 120 130 140 150
FNEENFVSKS DAKSMSSSTI MAVGAAELAL KDSGWHPKRE ADQVATGVAI
160 170 180 190 200
GMGMVPLEVI SETALLFQTK GYNKVSPFFV PKILINMAAG QVSIRYKLKG
210 220 230 240 250
PNHSVSTACT TGAHAVGDSF RFIAHGDADV MVAGGTDSCI SPLSLAGFSR
260 270 280 290 300
ARALSSNPDP KLACRPFHPE RDGFVMGEGA AVLVLEEHEH AVQRGARIYA
310 320 330 340 350
EILGYGLSGD AGHITAPDPE GEGALRCMAA AVKDAGVSPE QISYVNAHAT
360 370 380 390 400
STPLGDAAEN RAIKRLFRDH ACALAISSTK GATGHLLGAA GAVEATFTAL
410 420 430 440 450
ACYHQKLPPT LNLDCTEPEF DLNYVPLESQ EWKAEGRCIG LTNSFGFGGT

NATLCIAGM
Length:459
Mass (Da):48,628
Last modified:June 1, 2001 - v1
Checksum:i47F9733FBBF08BE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK016905 mRNA Translation: BAB30490.1
AK083617 mRNA Translation: BAC38969.1
AK084829 mRNA Translation: BAC39286.1
CCDSiCCDS26831.1
RefSeqiNP_081971.1, NM_027695.3
XP_006518163.1, XM_006518100.3
XP_006518164.1, XM_006518101.2
XP_006518165.1, XM_006518102.2
XP_006518166.1, XM_006518103.3
UniGeneiMm.197960

Genome annotation databases

EnsembliENSMUST00000022311; ENSMUSP00000022311; ENSMUSG00000021786
ENSMUST00000112624; ENSMUSP00000108243; ENSMUSG00000021786
ENSMUST00000112625; ENSMUSP00000108244; ENSMUSG00000021786
GeneIDi71147
KEGGimmu:71147
UCSCiuc007sgw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiOXSM_MOUSE
AccessioniPrimary (citable) accession number: Q9D404
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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