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Q9D404

- OXSM_MOUSE

UniProt

Q9D404 - OXSM_MOUSE

Protein

3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial

Gene

Oxsm

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.By similarity

    Catalytic activityi

    Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Enzyme regulationi

    Inhibited by cerulenin.By similarity

    Pathwayi

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: HGNC

    GO - Biological processi

    1. acyl-CoA metabolic process Source: HGNC
    2. medium-chain fatty acid biosynthetic process Source: HGNC
    3. short-chain fatty acid biosynthetic process Source: HGNC

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial (EC:2.3.1.41)
    Alternative name(s):
    Beta-ketoacyl-ACP synthase
    Gene namesi
    Name:Oxsm
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1918397. Oxsm.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: HGNC

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
    BLAST
    Chaini28 – 4594323-oxoacyl-[acyl-carrier-protein] synthase, mitochondrialPRO_0000232661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei109 – 1091N6-acetyllysine; alternate1 Publication
    Modified residuei109 – 1091N6-succinyllysine; alternate1 Publication
    Modified residuei113 – 1131N6-succinyllysine1 Publication
    Modified residuei174 – 1741N6-acetyllysine; alternate1 Publication
    Modified residuei174 – 1741N6-succinyllysine; alternate1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9D404.
    PaxDbiQ9D404.
    PRIDEiQ9D404.

    PTM databases

    PhosphoSiteiQ9D404.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D404.
    BgeeiQ9D404.
    CleanExiMM_OXSM.
    GenevestigatoriQ9D404.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9D404. 2 interactions.
    MINTiMINT-4126973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D404.
    SMRiQ9D404. Positions 40-459.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0304.
    GeneTreeiENSGT00530000063309.
    HOGENOMiHOG000060166.
    HOVERGENiHBG082096.
    InParanoidiQ9D404.
    KOiK09458.
    OMAiWMEPKEQ.
    OrthoDBiEOG77DJ5Z.
    PhylomeDBiQ9D404.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D404-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKCLQHFL KATISHPYPA SYSWLISKHR FYGTVPAAML RRRVVITGIG    50
    LVTPLGVGTQ LVWDRLLRGE SGIVSVVGDE YKNIPCSVAA YVPRGPHEGQ 100
    FNEENFVSKS DAKSMSSSTI MAVGAAELAL KDSGWHPKRE ADQVATGVAI 150
    GMGMVPLEVI SETALLFQTK GYNKVSPFFV PKILINMAAG QVSIRYKLKG 200
    PNHSVSTACT TGAHAVGDSF RFIAHGDADV MVAGGTDSCI SPLSLAGFSR 250
    ARALSSNPDP KLACRPFHPE RDGFVMGEGA AVLVLEEHEH AVQRGARIYA 300
    EILGYGLSGD AGHITAPDPE GEGALRCMAA AVKDAGVSPE QISYVNAHAT 350
    STPLGDAAEN RAIKRLFRDH ACALAISSTK GATGHLLGAA GAVEATFTAL 400
    ACYHQKLPPT LNLDCTEPEF DLNYVPLESQ EWKAEGRCIG LTNSFGFGGT 450
    NATLCIAGM 459
    Length:459
    Mass (Da):48,628
    Last modified:June 1, 2001 - v1
    Checksum:i47F9733FBBF08BE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016905 mRNA. Translation: BAB30490.1.
    AK083617 mRNA. Translation: BAC38969.1.
    AK084829 mRNA. Translation: BAC39286.1.
    CCDSiCCDS26831.1.
    RefSeqiNP_081971.1. NM_027695.3.
    XP_006518163.1. XM_006518100.1.
    XP_006518164.1. XM_006518101.1.
    XP_006518165.1. XM_006518102.1.
    XP_006518166.1. XM_006518103.1.
    UniGeneiMm.197960.

    Genome annotation databases

    EnsembliENSMUST00000022311; ENSMUSP00000022311; ENSMUSG00000021786.
    ENSMUST00000112624; ENSMUSP00000108243; ENSMUSG00000021786.
    ENSMUST00000112625; ENSMUSP00000108244; ENSMUSG00000021786.
    GeneIDi71147.
    KEGGimmu:71147.
    UCSCiuc007sgw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016905 mRNA. Translation: BAB30490.1 .
    AK083617 mRNA. Translation: BAC38969.1 .
    AK084829 mRNA. Translation: BAC39286.1 .
    CCDSi CCDS26831.1.
    RefSeqi NP_081971.1. NM_027695.3.
    XP_006518163.1. XM_006518100.1.
    XP_006518164.1. XM_006518101.1.
    XP_006518165.1. XM_006518102.1.
    XP_006518166.1. XM_006518103.1.
    UniGenei Mm.197960.

    3D structure databases

    ProteinModelPortali Q9D404.
    SMRi Q9D404. Positions 40-459.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D404. 2 interactions.
    MINTi MINT-4126973.

    PTM databases

    PhosphoSitei Q9D404.

    Proteomic databases

    MaxQBi Q9D404.
    PaxDbi Q9D404.
    PRIDEi Q9D404.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022311 ; ENSMUSP00000022311 ; ENSMUSG00000021786 .
    ENSMUST00000112624 ; ENSMUSP00000108243 ; ENSMUSG00000021786 .
    ENSMUST00000112625 ; ENSMUSP00000108244 ; ENSMUSG00000021786 .
    GeneIDi 71147.
    KEGGi mmu:71147.
    UCSCi uc007sgw.1. mouse.

    Organism-specific databases

    CTDi 54995.
    MGIi MGI:1918397. Oxsm.

    Phylogenomic databases

    eggNOGi COG0304.
    GeneTreei ENSGT00530000063309.
    HOGENOMi HOG000060166.
    HOVERGENi HBG082096.
    InParanoidi Q9D404.
    KOi K09458.
    OMAi WMEPKEQ.
    OrthoDBi EOG77DJ5Z.
    PhylomeDBi Q9D404.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Miscellaneous databases

    ChiTaRSi OXSM. mouse.
    NextBioi 333127.
    PROi Q9D404.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D404.
    Bgeei Q9D404.
    CleanExi MM_OXSM.
    Genevestigatori Q9D404.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Heart and Testis.
    2. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-109; LYS-113 AND LYS-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    3. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-109 AND LYS-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiOXSM_MOUSE
    AccessioniPrimary (citable) accession number: Q9D404
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3