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Protein

Probable serine carboxypeptidase CPVL

Gene

Cpvl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei206PROSITE-ProRule annotation1
Active sitei390PROSITE-ProRule annotation1
Active sitei450PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERimouse-CPMac. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine carboxypeptidase CPVL (EC:3.4.16.-)
Gene namesi
Name:Cpvl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918537. Cpvl.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000331587? – 478Probable serine carboxypeptidase CPVL
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000033158623 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9D3S9.
PRIDEiQ9D3S9.

PTM databases

iPTMnetiQ9D3S9.
PhosphoSitePlusiQ9D3S9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000052955.
GenevisibleiQ9D3S9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131462.

Structurei

3D structure databases

ProteinModelPortaliQ9D3S9.
SMRiQ9D3S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9D3S9.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG091G08SS.
PhylomeDBiQ9D3S9.
TreeFamiTF354323.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D3S9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRAKWKMVV SLILFMVSPG DGLFHAVYRS ILVSQSFKGD AGQPLFLSPY
60 70 80 90 100
IKNGKIKEGQ RKSMVSPFPG MNDKSYAGYI TVNQTYNSNL FFWFFPARMQ
110 120 130 140 150
PEDAPVVLWL QGGPGGSSMF GLFVEHGPYI ITSNMTVVAR DFPWTFTLSM
160 170 180 190 200
LYIDNPVGTG FSFTDHFQGY ATSEDDVAQD LYSALIQFFT LFPEYAKNDF
210 220 230 240 250
YVTGESYAGK YVPALAHYIH SLNPVRKFKI RLKGIAIGDA YTDPESIIGG
260 270 280 290 300
YAAFLYEIGL LDEQQQKYFQ KQCSKCVKYI KEQEWMKAFE ILDKLLDGDV
310 320 330 340 350
TTGSSFFQNV TGCTNYYNIL QCTEPKEQSY FAKFLTLPQV RQAIHVGNQN
360 370 380 390 400
FSDGAEVEKH LREDTVKSVK PWLSEIMNYY KVLIYNGQLD IIVAAALTER
410 420 430 440 450
SLMAMDWKGS RAYRRARRKV WKIFKSDNEV AGYVRRVGKF HQVIVRGGGH
460 470
ILPYDQPMRS FDMINRFIYD RGWEPYNS
Length:478
Mass (Da):54,763
Last modified:April 29, 2008 - v2
Checksum:i3BD766AD8498A441
GO
Isoform 2 (identifier: Q9D3S9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-290: Missing.

Show »
Length:434
Mass (Da):49,484
Checksum:iAE842557C8F52B31
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033260247 – 290Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017087 mRNA. Translation: BAB30589.1.
AC073297 Genomic DNA. No translation available.
AC079218 Genomic DNA. No translation available.
BC137839 mRNA. Translation: AAI37840.1.
CCDSiCCDS51777.1. [Q9D3S9-1]
RefSeqiNP_001276642.1. NM_001289713.1. [Q9D3S9-1]
NP_001276643.1. NM_001289714.1. [Q9D3S9-2]
NP_082025.1. NM_027749.2. [Q9D3S9-1]
XP_006506678.1. XM_006506615.3. [Q9D3S9-1]
UniGeneiMm.158654.

Genome annotation databases

EnsembliENSMUST00000166545; ENSMUSP00000131462; ENSMUSG00000052955. [Q9D3S9-1]
ENSMUST00000203101; ENSMUSP00000145288; ENSMUSG00000052955. [Q9D3S9-2]
ENSMUST00000204674; ENSMUSP00000144942; ENSMUSG00000052955. [Q9D3S9-1]
GeneIDi71287.
KEGGimmu:71287.
UCSCiuc009bzm.3. mouse. [Q9D3S9-2]
uc012emc.2. mouse. [Q9D3S9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017087 mRNA. Translation: BAB30589.1.
AC073297 Genomic DNA. No translation available.
AC079218 Genomic DNA. No translation available.
BC137839 mRNA. Translation: AAI37840.1.
CCDSiCCDS51777.1. [Q9D3S9-1]
RefSeqiNP_001276642.1. NM_001289713.1. [Q9D3S9-1]
NP_001276643.1. NM_001289714.1. [Q9D3S9-2]
NP_082025.1. NM_027749.2. [Q9D3S9-1]
XP_006506678.1. XM_006506615.3. [Q9D3S9-1]
UniGeneiMm.158654.

3D structure databases

ProteinModelPortaliQ9D3S9.
SMRiQ9D3S9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131462.

Protein family/group databases

ESTHERimouse-CPMac. Carboxypeptidase_S10.
MEROPSiS10.003.

PTM databases

iPTMnetiQ9D3S9.
PhosphoSitePlusiQ9D3S9.

Proteomic databases

PaxDbiQ9D3S9.
PRIDEiQ9D3S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166545; ENSMUSP00000131462; ENSMUSG00000052955. [Q9D3S9-1]
ENSMUST00000203101; ENSMUSP00000145288; ENSMUSG00000052955. [Q9D3S9-2]
ENSMUST00000204674; ENSMUSP00000144942; ENSMUSG00000052955. [Q9D3S9-1]
GeneIDi71287.
KEGGimmu:71287.
UCSCiuc009bzm.3. mouse. [Q9D3S9-2]
uc012emc.2. mouse. [Q9D3S9-1]

Organism-specific databases

CTDi54504.
MGIiMGI:1918537. Cpvl.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
GeneTreeiENSGT00860000133774.
HOGENOMiHOG000252949.
HOVERGENiHBG010805.
InParanoidiQ9D3S9.
KOiK09645.
OMAiEYAKNDF.
OrthoDBiEOG091G08SS.
PhylomeDBiQ9D3S9.
TreeFamiTF354323.

Miscellaneous databases

PROiQ9D3S9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052955.
GenevisibleiQ9D3S9. MM.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCPVL_MOUSE
AccessioniPrimary (citable) accession number: Q9D3S9
Secondary accession number(s): B2RQB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 30, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.