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Q9D3P9

- NEUT_MOUSE

UniProt

Q9D3P9 - NEUT_MOUSE

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Protein
Neurotensin/neuromedin N
Gene
Nts
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle By similarity.

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. regulation of blood vessel size Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:Nts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1328351. Nts.

Subcellular locationi

Secreted By similarity. Cytoplasmic vesiclesecretory vesicle By similarity
Note: Packaged within secretory vesicles By similarity.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 By similarity
Add
BLAST
Chaini23 – 147125Large neuromedin N
PRO_0000019526Add
BLAST
Peptidei142 – 1476Neuromedin N
PRO_0000019527
Peptidei150 – 16213Neurotensin
PRO_0000019528Add
BLAST
Peptidei165 – 1695Tail peptide Reviewed prediction
PRO_0000019529

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501Pyrrolidone carboxylic acid By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ9D3P9.

PTM databases

PhosphoSiteiQ9D3P9.

Miscellaneous databases

PMAP-CutDBQ9D3P9.

Expressioni

Gene expression databases

BgeeiQ9D3P9.
CleanExiMM_NTS.
GenevestigatoriQ9D3P9.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020040.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46419.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiQ9D3P9.
KOiK05235.
OMAiTNMYTSK.
OrthoDBiEOG7JX35P.
PhylomeDBiQ9D3P9.
TreeFamiTF330765.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D3P9-1 [UniParc]FASTAAdd to Basket

« Hide

MRGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HTSKISKASP    50
PSWKMTLLNV CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM 100
LTIFQLQKIC RSRAFQHWEI IQEDILDNVN DKNEKEEVIK RKIPYILKRQ 150
LYENKPRRPY ILKRGSYYY 169
Length:169
Mass (Da):19,608
Last modified:June 1, 2001 - v1
Checksum:iD153319F5F0925DC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
CCDSiCCDS24154.1.
RefSeqiNP_077755.1. NM_024435.2.
UniGeneiMm.64201.

Genome annotation databases

EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneIDi67405.
KEGGimmu:67405.
UCSCiuc007gye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1 .
AF304160 mRNA. Translation: AAK15263.1 .
AK017212 mRNA. Translation: BAB30636.1 .
BC043024 mRNA. Translation: AAH43024.1 .
CCDSi CCDS24154.1.
RefSeqi NP_077755.1. NM_024435.2.
UniGenei Mm.64201.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000020040.

PTM databases

PhosphoSitei Q9D3P9.

Proteomic databases

PRIDEi Q9D3P9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020040 ; ENSMUSP00000020040 ; ENSMUSG00000019890 .
GeneIDi 67405.
KEGGi mmu:67405.
UCSCi uc007gye.1. mouse.

Organism-specific databases

CTDi 4922.
MGIi MGI:1328351. Nts.

Phylogenomic databases

eggNOGi NOG46419.
GeneTreei ENSGT00640000091574.
HOGENOMi HOG000113770.
HOVERGENi HBG003785.
InParanoidi Q9D3P9.
KOi K05235.
OMAi TNMYTSK.
OrthoDBi EOG7JX35P.
PhylomeDBi Q9D3P9.
TreeFami TF330765.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 324482.
PMAP-CutDB Q9D3P9.
PROi Q9D3P9.
SOURCEi Search...

Gene expression databases

Bgeei Q9D3P9.
CleanExi MM_NTS.
Genevestigatori Q9D3P9.

Family and domain databases

InterProi IPR008055. NeurotensiN.
[Graphical view ]
PANTHERi PTHR15356. PTHR15356. 1 hit.
Pfami PF07421. Pro-NT_NN. 1 hit.
[Graphical view ]
PRINTSi PR01668. NEUROTENSIN.
ProDomi PD016590. NeurotensiN. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Neurotensin-deficient mice show altered responses to antipsychotic drugs."
    Dobner P.R., Fadel J., Deitemeyer N., Carraway R.E., Deutch A.Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:8048-8053(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Mouse proneurotensin/proneuromedin N is induced in mast cell line after IgE cross-linking."
    Ahn H.-J., Cho J.-J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNEUT_MOUSE
AccessioniPrimary (citable) accession number: Q9D3P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi