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Protein

Neurotensin/neuromedin N

Gene

Nts

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity).By similarity

GO - Molecular functioni

  1. neuropeptide hormone activity Source: MGI

GO - Biological processi

  1. regulation of blood vessel size Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:Nts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1328351. Nts.

Subcellular locationi

Secreted By similarity. Cytoplasmic vesiclesecretory vesicle By similarity
Note: Packaged within secretory vesicles.By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. transport vesicle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 147125Large neuromedin NPRO_0000019526Add
BLAST
Peptidei142 – 1476Neuromedin NPRO_0000019527
Peptidei150 – 16213NeurotensinPRO_0000019528Add
BLAST
Peptidei165 – 1695Tail peptideSequence AnalysisPRO_0000019529

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501Pyrrolidone carboxylic acidBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PRIDEiQ9D3P9.

PTM databases

PhosphoSiteiQ9D3P9.

Miscellaneous databases

PMAP-CutDBQ9D3P9.

Expressioni

Gene expression databases

BgeeiQ9D3P9.
CleanExiMM_NTS.
GenevestigatoriQ9D3P9.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020040.

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46419.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiQ9D3P9.
KOiK05235.
OMAiAFQHWEL.
OrthoDBiEOG7JX35P.
PhylomeDBiQ9D3P9.
TreeFamiTF330765.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D3P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HTSKISKASP
60 70 80 90 100
PSWKMTLLNV CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM
110 120 130 140 150
LTIFQLQKIC RSRAFQHWEI IQEDILDNVN DKNEKEEVIK RKIPYILKRQ
160
LYENKPRRPY ILKRGSYYY
Length:169
Mass (Da):19,608
Last modified:June 1, 2001 - v1
Checksum:iD153319F5F0925DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
CCDSiCCDS24154.1.
RefSeqiNP_077755.1. NM_024435.2.
UniGeneiMm.64201.

Genome annotation databases

EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneIDi67405.
KEGGimmu:67405.
UCSCiuc007gye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
CCDSiCCDS24154.1.
RefSeqiNP_077755.1. NM_024435.2.
UniGeneiMm.64201.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020040.

PTM databases

PhosphoSiteiQ9D3P9.

Proteomic databases

PRIDEiQ9D3P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneIDi67405.
KEGGimmu:67405.
UCSCiuc007gye.1. mouse.

Organism-specific databases

CTDi4922.
MGIiMGI:1328351. Nts.

Phylogenomic databases

eggNOGiNOG46419.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiQ9D3P9.
KOiK05235.
OMAiAFQHWEL.
OrthoDBiEOG7JX35P.
PhylomeDBiQ9D3P9.
TreeFamiTF330765.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_235286. Peptide ligand-binding receptors.

Miscellaneous databases

NextBioi324482.
PMAP-CutDBQ9D3P9.
PROiQ9D3P9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D3P9.
CleanExiMM_NTS.
GenevestigatoriQ9D3P9.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neurotensin-deficient mice show altered responses to antipsychotic drugs."
    Dobner P.R., Fadel J., Deitemeyer N., Carraway R.E., Deutch A.Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:8048-8053(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  2. "Mouse proneurotensin/proneuromedin N is induced in mast cell line after IgE cross-linking."
    Ahn H.-J., Cho J.-J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Intestine.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiNEUT_MOUSE
AccessioniPrimary (citable) accession number: Q9D3P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: March 4, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.