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Q9D3P9

- NEUT_MOUSE

UniProt

Q9D3P9 - NEUT_MOUSE

Protein

Neurotensin/neuromedin N

Gene

Nts

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle By similarity.By similarity

    GO - Molecular functioni

    1. neuropeptide hormone activity Source: MGI

    GO - Biological processi

    1. regulation of blood vessel size Source: UniProtKB-KW

    Keywords - Molecular functioni

    Vasoactive

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotensin/neuromedin N
    Cleaved into the following 4 chains:
    Alternative name(s):
    NmN-125
    Neuromedin N
    Short name:
    NN
    Short name:
    NmN
    Neurotensin
    Short name:
    NT
    Gene namesi
    Name:Nts
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1328351. Nts.

    Subcellular locationi

    Secreted By similarity. Cytoplasmic vesiclesecretory vesicle By similarity
    Note: Packaged within secretory vesicles.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 147125Large neuromedin NPRO_0000019526Add
    BLAST
    Peptidei142 – 1476Neuromedin NPRO_0000019527
    Peptidei150 – 16213NeurotensinPRO_0000019528Add
    BLAST
    Peptidei165 – 1695Tail peptideSequence AnalysisPRO_0000019529

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei150 – 1501Pyrrolidone carboxylic acidBy similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

    Proteomic databases

    PRIDEiQ9D3P9.

    PTM databases

    PhosphoSiteiQ9D3P9.

    Miscellaneous databases

    PMAP-CutDBQ9D3P9.

    Expressioni

    Gene expression databases

    BgeeiQ9D3P9.
    CleanExiMM_NTS.
    GenevestigatoriQ9D3P9.

    Interactioni

    Subunit structurei

    Interacts with NTSR1. Interacts with SORT1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000020040.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the neurotensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46419.
    GeneTreeiENSGT00640000091574.
    HOGENOMiHOG000113770.
    HOVERGENiHBG003785.
    InParanoidiQ9D3P9.
    KOiK05235.
    OMAiTNMYTSK.
    OrthoDBiEOG7JX35P.
    PhylomeDBiQ9D3P9.
    TreeFamiTF330765.

    Family and domain databases

    InterProiIPR008055. NeurotensiN.
    [Graphical view]
    PANTHERiPTHR15356. PTHR15356. 1 hit.
    PfamiPF07421. Pro-NT_NN. 1 hit.
    [Graphical view]
    PRINTSiPR01668. NEUROTENSIN.
    ProDomiPD016590. NeurotensiN. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D3P9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HTSKISKASP    50
    PSWKMTLLNV CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM 100
    LTIFQLQKIC RSRAFQHWEI IQEDILDNVN DKNEKEEVIK RKIPYILKRQ 150
    LYENKPRRPY ILKRGSYYY 169
    Length:169
    Mass (Da):19,608
    Last modified:June 1, 2001 - v1
    Checksum:iD153319F5F0925DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348489 Genomic DNA. Translation: AAK28626.1.
    AF304160 mRNA. Translation: AAK15263.1.
    AK017212 mRNA. Translation: BAB30636.1.
    BC043024 mRNA. Translation: AAH43024.1.
    CCDSiCCDS24154.1.
    RefSeqiNP_077755.1. NM_024435.2.
    UniGeneiMm.64201.

    Genome annotation databases

    EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
    GeneIDi67405.
    KEGGimmu:67405.
    UCSCiuc007gye.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF348489 Genomic DNA. Translation: AAK28626.1 .
    AF304160 mRNA. Translation: AAK15263.1 .
    AK017212 mRNA. Translation: BAB30636.1 .
    BC043024 mRNA. Translation: AAH43024.1 .
    CCDSi CCDS24154.1.
    RefSeqi NP_077755.1. NM_024435.2.
    UniGenei Mm.64201.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000020040.

    PTM databases

    PhosphoSitei Q9D3P9.

    Proteomic databases

    PRIDEi Q9D3P9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020040 ; ENSMUSP00000020040 ; ENSMUSG00000019890 .
    GeneIDi 67405.
    KEGGi mmu:67405.
    UCSCi uc007gye.1. mouse.

    Organism-specific databases

    CTDi 4922.
    MGIi MGI:1328351. Nts.

    Phylogenomic databases

    eggNOGi NOG46419.
    GeneTreei ENSGT00640000091574.
    HOGENOMi HOG000113770.
    HOVERGENi HBG003785.
    InParanoidi Q9D3P9.
    KOi K05235.
    OMAi TNMYTSK.
    OrthoDBi EOG7JX35P.
    PhylomeDBi Q9D3P9.
    TreeFami TF330765.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 324482.
    PMAP-CutDB Q9D3P9.
    PROi Q9D3P9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D3P9.
    CleanExi MM_NTS.
    Genevestigatori Q9D3P9.

    Family and domain databases

    InterProi IPR008055. NeurotensiN.
    [Graphical view ]
    PANTHERi PTHR15356. PTHR15356. 1 hit.
    Pfami PF07421. Pro-NT_NN. 1 hit.
    [Graphical view ]
    PRINTSi PR01668. NEUROTENSIN.
    ProDomi PD016590. NeurotensiN. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Neurotensin-deficient mice show altered responses to antipsychotic drugs."
      Dobner P.R., Fadel J., Deitemeyer N., Carraway R.E., Deutch A.Y.
      Proc. Natl. Acad. Sci. U.S.A. 98:8048-8053(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    2. "Mouse proneurotensin/proneuromedin N is induced in mast cell line after IgE cross-linking."
      Ahn H.-J., Cho J.-J.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Intestine.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNEUT_MOUSE
    AccessioniPrimary (citable) accession number: Q9D3P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 11, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3