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Q9D3P9 (NEUT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin/neuromedin N

Cleaved into the following 4 chains:

  1. Large neuromedin N
    Alternative name(s):
    NmN-125
  2. Neuromedin N
    Short name=NN
    Short name=NmN
  3. Neurotensin
    Short name=NT
  4. Tail peptide
Gene names
Name:Nts
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle By similarity.

Subunit structure

Interacts with NTSR1. Interacts with SORT1 By similarity.

Subcellular location

Secreted By similarity. Cytoplasmic vesiclesecretory vesicle By similarity. Note: Packaged within secretory vesicles By similarity.

Sequence similarities

Belongs to the neurotensin family.

Ontologies

Keywords
   Cellular componentCytoplasmic vesicle
Secreted
   DomainSignal
   Molecular functionVasoactive
   PTMCleavage on pair of basic residues
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of blood vessel size

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

transport vesicle

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionneuropeptide hormone activity

Traceable author statement PubMed 10390649. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 By similarity
Chain23 – 147125Large neuromedin N
PRO_0000019526
Peptide142 – 1476Neuromedin N
PRO_0000019527
Peptide150 – 16213Neurotensin
PRO_0000019528
Peptide165 – 1695Tail peptide Potential
PRO_0000019529

Amino acid modifications

Modified residue1501Pyrrolidone carboxylic acid By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9D3P9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D153319F5F0925DC

FASTA16919,608
        10         20         30         40         50         60 
MRGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HTSKISKASP PSWKMTLLNV 

        70         80         90        100        110        120 
CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM LTIFQLQKIC RSRAFQHWEI 

       130        140        150        160 
IQEDILDNVN DKNEKEEVIK RKIPYILKRQ LYENKPRRPY ILKRGSYYY 

« Hide

References

« Hide 'large scale' references
[1]"Neurotensin-deficient mice show altered responses to antipsychotic drugs."
Dobner P.R., Fadel J., Deitemeyer N., Carraway R.E., Deutch A.Y.
Proc. Natl. Acad. Sci. U.S.A. 98:8048-8053(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129.
[2]"Mouse proneurotensin/proneuromedin N is induced in mast cell line after IgE cross-linking."
Ahn H.-J., Cho J.-J.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Intestine.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
RefSeqNP_077755.1. NM_024435.2.
UniGeneMm.64201.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000020040.

PTM databases

PhosphoSiteQ9D3P9.

Proteomic databases

PRIDEQ9D3P9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneID67405.
KEGGmmu:67405.
UCSCuc007gye.1. mouse.

Organism-specific databases

CTD4922.
MGIMGI:1328351. Nts.

Phylogenomic databases

eggNOGNOG46419.
GeneTreeENSGT00640000091574.
HOGENOMHOG000113770.
HOVERGENHBG003785.
InParanoidQ9D3P9.
KOK05235.
OMAAFQHWEL.
OrthoDBEOG7JX35P.
PhylomeDBQ9D3P9.
TreeFamTF330765.

Gene expression databases

BgeeQ9D3P9.
CleanExMM_NTS.
GenevestigatorQ9D3P9.

Family and domain databases

InterProIPR008055. NeurotensiN.
[Graphical view]
PANTHERPTHR15356. PTHR15356. 1 hit.
PfamPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSPR01668. NEUROTENSIN.
ProDomPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other

NextBio324482.
PMAP-CutDBQ9D3P9.
PROQ9D3P9.
SOURCESearch...

Entry information

Entry nameNEUT_MOUSE
AccessionPrimary (citable) accession number: Q9D3P9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot