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Protein

Neurotensin/neuromedin N

Gene

Nts

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Vasoactive

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin/neuromedin N
Cleaved into the following 4 chains:
Alternative name(s):
NmN-125
Neuromedin N
Short name:
NN
Short name:
NmN
Neurotensin
Short name:
NT
Gene namesi
Name:Nts
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1328351. Nts.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001952623 – 147Large neuromedin NAdd BLAST125
PeptideiPRO_0000019527142 – 147Neuromedin N6
PeptideiPRO_0000019528150 – 162NeurotensinAdd BLAST13
PeptideiPRO_0000019529165 – 169Tail peptideSequence analysis5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei150Pyrrolidone carboxylic acidBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9D3P9.
PRIDEiQ9D3P9.

PTM databases

PhosphoSitePlusiQ9D3P9.

Miscellaneous databases

PMAP-CutDBQ9D3P9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000019890.
CleanExiMM_NTS.
GenevisibleiQ9D3P9. MM.

Interactioni

Subunit structurei

Interacts with NTSR1. Interacts with SORT1 (By similarity).By similarity

GO - Molecular functioni

  • neuropeptide hormone activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020040.

Structurei

3D structure databases

ProteinModelPortaliQ9D3P9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the neurotensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiQ9D3P9.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
PhylomeDBiQ9D3P9.
TreeFamiTF330765.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D3P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGMNLQLVC LTLLAFSSWS LCSDSEEDVR ALEADLLTNM HTSKISKASP
60 70 80 90 100
PSWKMTLLNV CSLINNVNSP AEEAGDMHDD DLVGKRKLPL VLDGFSLEAM
110 120 130 140 150
LTIFQLQKIC RSRAFQHWEI IQEDILDNVN DKNEKEEVIK RKIPYILKRQ
160
LYENKPRRPY ILKRGSYYY
Length:169
Mass (Da):19,608
Last modified:June 1, 2001 - v1
Checksum:iD153319F5F0925DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
CCDSiCCDS24154.1.
RefSeqiNP_077755.1. NM_024435.2.
UniGeneiMm.64201.

Genome annotation databases

EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneIDi67405.
KEGGimmu:67405.
UCSCiuc007gye.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF348489 Genomic DNA. Translation: AAK28626.1.
AF304160 mRNA. Translation: AAK15263.1.
AK017212 mRNA. Translation: BAB30636.1.
BC043024 mRNA. Translation: AAH43024.1.
CCDSiCCDS24154.1.
RefSeqiNP_077755.1. NM_024435.2.
UniGeneiMm.64201.

3D structure databases

ProteinModelPortaliQ9D3P9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020040.

PTM databases

PhosphoSitePlusiQ9D3P9.

Proteomic databases

PaxDbiQ9D3P9.
PRIDEiQ9D3P9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020040; ENSMUSP00000020040; ENSMUSG00000019890.
GeneIDi67405.
KEGGimmu:67405.
UCSCiuc007gye.1. mouse.

Organism-specific databases

CTDi4922.
MGIiMGI:1328351. Nts.

Phylogenomic databases

eggNOGiENOG410IKDE. Eukaryota.
ENOG410YV74. LUCA.
GeneTreeiENSGT00640000091574.
HOGENOMiHOG000113770.
HOVERGENiHBG003785.
InParanoidiQ9D3P9.
KOiK05235.
OMAiLTNMYTS.
OrthoDBiEOG091G0PRU.
PhylomeDBiQ9D3P9.
TreeFamiTF330765.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PMAP-CutDBQ9D3P9.
PROiQ9D3P9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019890.
CleanExiMM_NTS.
GenevisibleiQ9D3P9. MM.

Family and domain databases

InterProiIPR008055. NeurotensiN.
[Graphical view]
PANTHERiPTHR15356. PTHR15356. 1 hit.
PfamiPF07421. Pro-NT_NN. 1 hit.
[Graphical view]
PRINTSiPR01668. NEUROTENSIN.
ProDomiPD016590. NeurotensiN. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNEUT_MOUSE
AccessioniPrimary (citable) accession number: Q9D3P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.