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Protein

Growth hormone-regulated TBC protein 1

Gene

Grtp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-regulated TBC protein 1
Alternative name(s):
TBC1 domain family member 6
Gene namesi
Name:Grtp1
Synonyms:Tbc1d6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914040. Grtp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Growth hormone-regulated TBC protein 1PRO_0000288709Add
BLAST

Proteomic databases

MaxQBiQ9D3N8.
PaxDbiQ9D3N8.
PeptideAtlasiQ9D3N8.
PRIDEiQ9D3N8.

PTM databases

iPTMnetiQ9D3N8.
PhosphoSiteiQ9D3N8.

Expressioni

Tissue specificityi

Highly expressed in testes, expression greatly increased at postnatal day 20 and remained high up to day 90. Moderately expressed in kidney and liver, weakly expressed in intestine, lung, ovaries and stomach. Expression of Growth hormone increased the expression in testis but decreased expression in liver and kidney.1 Publication

Developmental stagei

Weakly expressed in the testis of the embryo and neonate.1 Publication

Gene expression databases

BgeeiENSMUSG00000038515.
CleanExiMM_GRTP1.
GenevisibleiQ9D3N8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9D3N8. 1 interaction.
STRINGi10090.ENSMUSP00000130324.

Structurei

3D structure databases

ProteinModelPortaliQ9D3N8.
SMRiQ9D3N8. Positions 49-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 281208Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000045576.
HOVERGENiHBG107100.
InParanoidiQ9D3N8.
KOiK19953.
OMAiTFVTECH.
OrthoDBiEOG091G0AID.
PhylomeDBiQ9D3N8.
TreeFamiTF105771.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 2 hits.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D3N8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK
60 70 80 90 100
WSKLLKGNGG VRKSVTVKRY VRKGIPLEHR ARVWMAVSGA QARMDQSPGY
110 120 130 140 150
YHRLLEGESS SSLDEAIRTD LNRTFPDNVM FRKTADPCLQ KTLYNVLLAY
160 170 180 190 200
GLHNPDVGYC QCCAQKPGSS AGLRSSLTGM NFIAGYLILI TKNEEESFWL
210 220 230 240 250
LDALVGRILP DYYSPAMLGL KTDQEVLAEL VRMKLPAVAA LMDGHGVLWT
260 270 280 290 300
LLVSRWFICL FVDILPVETV LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI
310 320 330 340 350
LEASSIPDIC DKFKQITKGD FVTECHAFMQ KIFSEPGSLS MTTITRLRKS

CRAALQAQS
Length:359
Mass (Da):40,628
Last modified:June 1, 2001 - v1
Checksum:i1D5FD2C296B38B18
GO
Isoform 2 (identifier: Q9D3N8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-178: Missing.

Show »
Length:342
Mass (Da):38,980
Checksum:i907DAC6C1A31584F
GO
Isoform 3 (identifier: Q9D3N8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     162-178: Missing.

Show »
Length:258
Mass (Da):29,155
Checksum:i2C835B627F7EB768
GO
Isoform 4 (identifier: Q9D3N8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-178: Missing.
     331-359: KIFSEPGSLSMTTITRLRKSCRAALQAQS → AATTSLLP

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):36,571
Checksum:iE61DF1959F2653AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti216 – 2161A → P in BAB30630 (PubMed:16141072).Curated
Sequence conflicti273 – 2731I → T in AAL67673 (PubMed:11564724).Curated
Sequence conflicti324 – 3241E → G in AAL67673 (PubMed:11564724).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 3. 2 PublicationsVSP_025756Add
BLAST
Alternative sequencei162 – 17817Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsVSP_025757Add
BLAST
Alternative sequencei331 – 35929KIFSE…LQAQS → AATTSLLP in isoform 4. 1 PublicationVSP_025758Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329833 mRNA. Translation: AAL67673.1.
AK007905 mRNA. Translation: BAB25339.1.
AK017197 mRNA. Translation: BAB30630.1.
AK017251 mRNA. Translation: BAB30653.1.
AK082863 mRNA. Translation: BAC38658.1.
AK149322 mRNA. Translation: BAE28813.1.
BC029096 mRNA. Translation: AAH29096.1.
CCDSiCCDS22107.1. [Q9D3N8-2]
RefSeqiNP_080044.2. NM_025768.2. [Q9D3N8-2]
XP_006508914.1. XM_006508851.2. [Q9D3N8-4]
UniGeneiMm.34901.

Genome annotation databases

EnsembliENSMUST00000165605; ENSMUSP00000130324; ENSMUSG00000038515. [Q9D3N8-2]
GeneIDi66790.
KEGGimmu:66790.
UCSCiuc009kxc.1. mouse. [Q9D3N8-3]
uc009kxd.1. mouse. [Q9D3N8-2]
uc012fzv.1. mouse. [Q9D3N8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329833 mRNA. Translation: AAL67673.1.
AK007905 mRNA. Translation: BAB25339.1.
AK017197 mRNA. Translation: BAB30630.1.
AK017251 mRNA. Translation: BAB30653.1.
AK082863 mRNA. Translation: BAC38658.1.
AK149322 mRNA. Translation: BAE28813.1.
BC029096 mRNA. Translation: AAH29096.1.
CCDSiCCDS22107.1. [Q9D3N8-2]
RefSeqiNP_080044.2. NM_025768.2. [Q9D3N8-2]
XP_006508914.1. XM_006508851.2. [Q9D3N8-4]
UniGeneiMm.34901.

3D structure databases

ProteinModelPortaliQ9D3N8.
SMRiQ9D3N8. Positions 49-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D3N8. 1 interaction.
STRINGi10090.ENSMUSP00000130324.

PTM databases

iPTMnetiQ9D3N8.
PhosphoSiteiQ9D3N8.

Proteomic databases

MaxQBiQ9D3N8.
PaxDbiQ9D3N8.
PeptideAtlasiQ9D3N8.
PRIDEiQ9D3N8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000165605; ENSMUSP00000130324; ENSMUSG00000038515. [Q9D3N8-2]
GeneIDi66790.
KEGGimmu:66790.
UCSCiuc009kxc.1. mouse. [Q9D3N8-3]
uc009kxd.1. mouse. [Q9D3N8-2]
uc012fzv.1. mouse. [Q9D3N8-1]

Organism-specific databases

CTDi79774.
MGIiMGI:1914040. Grtp1.

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119202.
HOGENOMiHOG000045576.
HOVERGENiHBG107100.
InParanoidiQ9D3N8.
KOiK19953.
OMAiTFVTECH.
OrthoDBiEOG091G0AID.
PhylomeDBiQ9D3N8.
TreeFamiTF105771.

Miscellaneous databases

PROiQ9D3N8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038515.
CleanExiMM_GRTP1.
GenevisibleiQ9D3N8. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 2 hits.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
PROSITEiPS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRTP1_MOUSE
AccessioniPrimary (citable) accession number: Q9D3N8
Secondary accession number(s): Q8BUR0
, Q8VI03, Q9D3Q5, Q9D8L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.