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Protein
Submitted name:

BCL2-like 12 (Proline rich), isoform CRA_b

Gene

Bcl2l12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. p53 binding Source: MGI

GO - Biological processi

  1. inhibition of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. negative regulation of cellular senescence Source: MGI
  3. negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
BCL2-like 12 (Proline rich), isoform CRA_bImported
Submitted name:
Protein Bcl2l12Imported
Gene namesi
Name:Bcl2l12Imported
ORF Names:mCG_23151Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1922986. Bcl2l12.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9D3J3.

Structurei

3D structure databases

ProteinModelPortaliQ9D3J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000001825.
HOGENOMiHOG000294149.
HOVERGENiHBG050647.
OMAiQEEPTDF.
OrthoDBiEOG7XM2ZJ.
TreeFamiTF338350.

Sequencei

Sequence statusi: Complete.

Q9D3J3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGSEELGLR EDTLKVLTAF LKRGEVAGSP VPTPPRSPAQ EETTDFLSRL
60 70 80 90 100
RRCLPCPLGR GAPPTESSRP HFLPLRPCYG SEPGPASSEF YALVAQRLEQ
110 120 130 140 150
LVQEQLKSPP SSEFQGPPPT EKEALLRRLV ALLEEEAEVI NQKLASDPAL
160 170 180 190 200
HRKLARLSAG SFARLVELFS SRESSSSPNC SSPSLPCPGP PPPSPDPLAR
210 220 230 240 250
LALAMELSRR VAGLGGPLAN LSVEHVHSFL PWVQAHGGWA GILASSPVDL

NLPLD
Length:255
Mass (Da):27,333
Last modified:June 1, 2001 - v1
Checksum:i014F4C46294A51D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155806 Genomic DNA. No translation available.
AK017362 mRNA. Translation: BAB30709.1.
CH466603 Genomic DNA. Translation: EDL22781.1.
RefSeqiNP_083686.1. NM_029410.3.
UniGeneiMm.261006.

Genome annotation databases

EnsembliENSMUST00000003290; ENSMUSP00000003290; ENSMUSG00000003190.
GeneIDi75736.
KEGGimmu:75736.
UCSCiuc009gsk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155806 Genomic DNA. No translation available.
AK017362 mRNA. Translation: BAB30709.1.
CH466603 Genomic DNA. Translation: EDL22781.1.
RefSeqiNP_083686.1. NM_029410.3.
UniGeneiMm.261006.

3D structure databases

ProteinModelPortaliQ9D3J3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003290; ENSMUSP00000003290; ENSMUSG00000003190.
GeneIDi75736.
KEGGimmu:75736.
UCSCiuc009gsk.2. mouse.

Organism-specific databases

CTDi83596.
MGIiMGI:1922986. Bcl2l12.

Phylogenomic databases

GeneTreeiENSGT00390000001825.
HOGENOMiHOG000294149.
HOVERGENiHBG050647.
OMAiQEEPTDF.
OrthoDBiEOG7XM2ZJ.
TreeFamiTF338350.

Miscellaneous databases

ChiTaRSiBcl2l12. mouse.
NextBioi343818.
PROiQ9D3J3.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ9D3J3.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  9. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: HeadImported.
  10. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  12. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ9D3J3_MOUSE
AccessioniPrimary (citable) accession number: Q9D3J3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.