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Protein

Syntaxin-11

Gene

Stx11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytotoxic T cell degranulation Source: MGI
  • intracellular protein transport Source: GO_Central
  • natural killer cell degranulation Source: MGI
  • natural killer cell mediated cytotoxicity Source: MGI
  • neutrophil degranulation Source: MGI
  • synaptic vesicle fusion to presynaptic membrane Source: GO_Central
  • T cell mediated cytotoxicity Source: MGI
  • vesicle docking Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-11
Gene namesi
Name:Stx11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921982. Stx11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Syntaxin-11PRO_0000210222Add
BLAST

Proteomic databases

MaxQBiQ9D3G5.
PaxDbiQ9D3G5.
PRIDEiQ9D3G5.

PTM databases

PhosphoSiteiQ9D3G5.

Expressioni

Gene expression databases

CleanExiMM_STX11.
GenevisibleiQ9D3G5. MM.

Interactioni

Subunit structurei

Interacts with the SNARE proteins SNAP-23 and VAMP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046243.

Structurei

3D structure databases

ProteinModelPortaliQ9D3G5.
SMRiQ9D3G5. Positions 38-286.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 26663t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili41 – 7131Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the syntaxin family.Curated
Contains 1 t-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG296694.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ9D3G5.
KOiK08487.
PhylomeDBiQ9D3G5.

Family and domain databases

InterProiIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D3G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDRLAELQE LSRSYDQQFP DGDNDFDAPR EDIVFETDNI LESLYRVIQD
60 70 80 90 100
IQDENQLLLI DVRRLGRQNV RFLTSMRRLS SIKRDTNSIA KAIKTRGEGI
110 120 130 140 150
HQKLRSMKEL SEQAEARHGA HSAVARISHA QYSALARAFQ QAMYEYNQAE
160 170 180 190 200
MKQRDNCKIR IQRQLEIMGK DMSGEQIEDM FEQGKWDVFS ENLLADLKGA
210 220 230 240 250
RAALNEIESR HRELLRLEGR IRDVHELFLQ MAVLVEKQED TLNVIELNVQ
260 270 280
KTLDYTGEAK AQVRKAVQYK KKNPCRTICC FCCPCVN
Length:287
Mass (Da):33,369
Last modified:June 1, 2001 - v1
Checksum:iFD5D10842B7C5415
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017897 mRNA. Translation: BAB30994.1.
CCDSiCCDS48500.1.
RefSeqiNP_083351.1. NM_029075.1.
UniGeneiMm.248648.

Genome annotation databases

GeneIDi74732.
KEGGimmu:74732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017897 mRNA. Translation: BAB30994.1.
CCDSiCCDS48500.1.
RefSeqiNP_083351.1. NM_029075.1.
UniGeneiMm.248648.

3D structure databases

ProteinModelPortaliQ9D3G5.
SMRiQ9D3G5. Positions 38-286.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046243.

PTM databases

PhosphoSiteiQ9D3G5.

Proteomic databases

MaxQBiQ9D3G5.
PaxDbiQ9D3G5.
PRIDEiQ9D3G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi74732.
KEGGimmu:74732.

Organism-specific databases

CTDi8676.
MGIiMGI:1921982. Stx11.

Phylogenomic databases

eggNOGiNOG296694.
HOGENOMiHOG000286023.
HOVERGENiHBG099780.
InParanoidiQ9D3G5.
KOiK08487.
PhylomeDBiQ9D3G5.

Miscellaneous databases

NextBioi341502.
PROiQ9D3G5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_STX11.
GenevisibleiQ9D3G5. MM.

Family and domain databases

InterProiIPR028672. STX11.
IPR006012. Syntaxin/epimorphin_CS.
IPR006011. Syntaxin_N.
IPR010989. t-SNARE.
IPR000727. T_SNARE_dom.
[Graphical view]
PANTHERiPTHR19957:SF30. PTHR19957:SF30. 1 hit.
PfamiPF05739. SNARE. 1 hit.
PF00804. Syntaxin. 1 hit.
[Graphical view]
SMARTiSM00503. SynN. 1 hit.
SM00397. t_SNARE. 1 hit.
[Graphical view]
SUPFAMiSSF47661. SSF47661. 1 hit.
PROSITEiPS00914. SYNTAXIN. 1 hit.
PS50192. T_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.

Entry informationi

Entry nameiSTX11_MOUSE
AccessioniPrimary (citable) accession number: Q9D3G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.