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Protein

ATP synthase subunit delta, mitochondrial

Gene

Atp5f1d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha3beta3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-163210 Formation of ATP by chemiosmotic coupling
R-MMU-8949613 Cristae formation

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit delta, mitochondrialCurated
Alternative name(s):
ATP synthase F1 subunit deltaBy similarity
F-ATPase delta subunit
Gene namesi
Name:Atp5f1dBy similarity
Synonyms:Atp5d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913293 Atp5d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CF(1), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionBy similarityAdd BLAST22
ChainiPRO_000000266223 – 168ATP synthase subunit delta, mitochondrialAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136N6-acetyllysine; alternateCombined sources1
Modified residuei136N6-succinyllysine; alternateCombined sources1
Modified residuei165N6-acetyllysine; alternateCombined sources1
Modified residuei165N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9D3D9
MaxQBiQ9D3D9
PaxDbiQ9D3D9
PeptideAtlasiQ9D3D9
PRIDEiQ9D3D9
TopDownProteomicsiQ9D3D9

2D gel databases

UCD-2DPAGEQ9D3D9

PTM databases

iPTMnetiQ9D3D9
PhosphoSitePlusiQ9D3D9

Expressioni

Gene expression databases

BgeeiENSMUSG00000003072
ExpressionAtlasiQ9D3D9 baseline and differential
GenevisibleiQ9D3D9 MM

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 seems to have nine subunits: a, b, c, d, e, f, g, F6 and 8 (or A6L). Component of an ATP synthase complex composed of ATP5F1, ATP5MC1, ATP5F1E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211172, 3 interactors
IntActiQ9D3D9, 8 interactors
MINTiQ9D3D9
STRINGi10090.ENSMUSP00000003156

Structurei

3D structure databases

ProteinModelPortaliQ9D3D9
SMRiQ9D3D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase epsilon chain family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1758 Eukaryota
COG0355 LUCA
GeneTreeiENSGT00390000017576
HOGENOMiHOG000216023
HOVERGENiHBG001856
InParanoidiQ9D3D9
KOiK02134
OMAiAANKTFY
OrthoDBiEOG091G1AP6
PhylomeDBiQ9D3D9
TreeFamiTF313029

Family and domain databases

CDDicd12152 F1-ATPase_delta, 1 hit
Gene3Di2.60.15.10, 1 hit
HAMAPiMF_00530 ATP_synth_epsil_bac, 1 hit
InterProiView protein in InterPro
IPR036794 ATP_F1_dsu/esu_C_sf
IPR001469 ATP_synth_F1_dsu/esu
IPR020546 ATP_synth_F1_dsu/esu_N
IPR036771 ATPsynth_dsu/esu_N
PANTHERiPTHR13822 PTHR13822, 1 hit
PfamiView protein in Pfam
PF02823 ATP-synt_DE_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000944 ATPase_F1-cplx_dsu/esu, 1 hit
SUPFAMiSSF46604 SSF46604, 1 hit
SSF51344 SSF51344, 1 hit
TIGRFAMsiTIGR01216 ATP_synt_epsi, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D3D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPASLLRHP GLRRLMLQAR TYAEAAAAPA PAAGPGQMSF TFASPTQVFF
60 70 80 90 100
DSANVKQVDV PTLTGAFGIL ASHVPTLQVL RPGLVVVHTE DGTTTKYFVS
110 120 130 140 150
SGSVTVNADS SVQLLAEEAV TLDMLDLGAA RANLEKAQSE LSGAADEAAR
160
AEIQIRIEAN EALVKALE
Length:168
Mass (Da):17,600
Last modified:June 1, 2001 - v1
Checksum:iEC3DF1B581B630E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018011 mRNA Translation: BAB31035.1
BC008273 mRNA Translation: AAH08273.1
CCDSiCCDS24010.1
RefSeqiNP_079589.2, NM_025313.2
XP_017169541.1, XM_017314052.1
UniGeneiMm.278560

Genome annotation databases

EnsembliENSMUST00000003156; ENSMUSP00000003156; ENSMUSG00000003072
ENSMUST00000105367; ENSMUSP00000101006; ENSMUSG00000003072
GeneIDi66043
KEGGimmu:66043
UCSCiuc007gby.2 mouse

Similar proteinsi

Entry informationi

Entry nameiATPD_MOUSE
AccessioniPrimary (citable) accession number: Q9D3D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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