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Q9D3A8

- CAPON_MOUSE

UniProt

Q9D3A8 - CAPON_MOUSE

Protein

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Gene

Nos1ap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
    Alternative name(s):
    C-terminal PDZ ligand of neuronal nitric oxide synthase protein
    Nitric oxide synthase 1 adaptor protein
    Gene namesi
    Name:Nos1ap
    Synonyms:Capon, Kiaa0464
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1917979. Nos1ap.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 503503Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinPRO_0000089317Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei183 – 1831Phosphoserine1 Publication
    Modified residuei187 – 1871Phosphoserine1 Publication
    Modified residuei190 – 1901Phosphoserine1 Publication
    Modified residuei262 – 2621PhosphoserineBy similarity
    Modified residuei370 – 3701Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9D3A8.
    PRIDEiQ9D3A8.

    PTM databases

    PhosphoSiteiQ9D3A8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9D3A8.
    BgeeiQ9D3A8.
    GenevestigatoriQ9D3A8.

    Interactioni

    Subunit structurei

    Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and SYN1 By similarity. Forms a ternary complex with NOS1 and RASD1.By similarity1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D3A8.
    SMRiQ9D3A8. Positions 29-162.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 191166PIDPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni491 – 50313Interaction with NOS1By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili318 – 35942Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi501 – 5033PDZ-bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi269 – 2724Poly-Ser
    Compositional biasi297 – 3048Poly-Gln

    Sequence similaritiesi

    Contains 1 PID domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG244289.
    GeneTreeiENSGT00510000046975.
    HOGENOMiHOG000111298.
    HOVERGENiHBG050788.
    InParanoidiQ9D3A8.
    KOiK16513.
    OMAiQNTMGSQ.
    OrthoDBiEOG7JDQXM.
    TreeFamiTF317226.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view]
    PfamiPF00640. PID. 1 hit.
    [Graphical view]
    SMARTiSM00462. PTB. 1 hit.
    [Graphical view]
    PROSITEiPS01179. PID. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9D3A8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI SFEAKYVGSL DVPRPNSRVE    50
    IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK KKEWTWDESK 100
    MLVMQDPIYR IFYVSHDSQD LKIFSYIARD GASNIFRCNV FKSKKKSQAM 150
    RIVRTVGQAF EVCHKLSLQH TQQNADGQED GESERNSDGS GDPGRQLTGA 200
    ERVSTAAAEE TDIDAVEVPL PGNDILEFSR GVTDLDAVGK DGGSHIDSTV 250
    SPHPQEPMLT ASPRMLLPSS SSKPPGLGTG TPLSTHHQMQ LLQQLLQQQQ 300
    QQTQVAVAQV HLLKDQLAAE AAARLEAQAR VHQLLLQNKD MLQHISLLVK 350
    QVQELELKLS GQNTMGSQDS LLEITFRSGA LPVLCESTTP KPEDLHSPLL 400
    GAGLADFAHP AGSPLGRHDC LVKLECFRFL PPEDTQPMMA QGEPLLGGLE 450
    LIKFRESGIA SEYESNTDES EERDSWSQEE LPRLLNVLQR QELGDSLDDE 500
    IAV 503

    Note: No experimental confirmation available.

    Length:503
    Mass (Da):55,873
    Last modified:July 27, 2011 - v3
    Checksum:i1BD365C67437C8A5
    GO
    Isoform 2 (identifier: Q9D3A8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         313-325: LKDQLAAEAAARL → SLLPSSQAPLSWA
         326-503: Missing.

    Show »
    Length:325
    Mass (Da):36,122
    Checksum:i1A7EE296CA7A9D87
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251A → S in BAB31095. (PubMed:16141072)Curated
    Sequence conflicti110 – 1101R → K in BAB31095. (PubMed:16141072)Curated
    Sequence conflicti157 – 1571G → A in BAB31095. (PubMed:16141072)Curated
    Sequence conflicti311 – 3111H → L in BAB31095. (PubMed:16141072)Curated
    Sequence conflicti311 – 3111H → L in BAC65572. (PubMed:12693553)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei313 – 32513LKDQL…AAARL → SLLPSSQAPLSWA in isoform 2. 1 PublicationVSP_012462Add
    BLAST
    Alternative sequencei326 – 503178Missing in isoform 2. 1 PublicationVSP_012463Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018149 mRNA. Translation: BAB31095.1.
    AC119431 Genomic DNA. No translation available.
    AC123650 Genomic DNA. No translation available.
    AC125017 Genomic DNA. No translation available.
    AC125021 Genomic DNA. No translation available.
    AK122290 Transcribed RNA. Translation: BAC65572.3.
    CCDSiCCDS48438.1. [Q9D3A8-1]
    RefSeqiNP_001103455.1. NM_001109985.1. [Q9D3A8-1]
    UniGeneiMm.487078.

    Genome annotation databases

    EnsembliENSMUST00000160456; ENSMUSP00000125251; ENSMUSG00000038473. [Q9D3A8-1]
    GeneIDi70729.
    KEGGimmu:70729.
    UCSCiuc011wvt.1. mouse. [Q9D3A8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK018149 mRNA. Translation: BAB31095.1 .
    AC119431 Genomic DNA. No translation available.
    AC123650 Genomic DNA. No translation available.
    AC125017 Genomic DNA. No translation available.
    AC125021 Genomic DNA. No translation available.
    AK122290 Transcribed RNA. Translation: BAC65572.3 .
    CCDSi CCDS48438.1. [Q9D3A8-1 ]
    RefSeqi NP_001103455.1. NM_001109985.1. [Q9D3A8-1 ]
    UniGenei Mm.487078.

    3D structure databases

    ProteinModelPortali Q9D3A8.
    SMRi Q9D3A8. Positions 29-162.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D3A8.

    Proteomic databases

    MaxQBi Q9D3A8.
    PRIDEi Q9D3A8.

    Protocols and materials databases

    DNASUi 70729.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000160456 ; ENSMUSP00000125251 ; ENSMUSG00000038473 . [Q9D3A8-1 ]
    GeneIDi 70729.
    KEGGi mmu:70729.
    UCSCi uc011wvt.1. mouse. [Q9D3A8-1 ]

    Organism-specific databases

    CTDi 9722.
    MGIi MGI:1917979. Nos1ap.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG244289.
    GeneTreei ENSGT00510000046975.
    HOGENOMi HOG000111298.
    HOVERGENi HBG050788.
    InParanoidi Q9D3A8.
    KOi K16513.
    OMAi QNTMGSQ.
    OrthoDBi EOG7JDQXM.
    TreeFami TF317226.

    Miscellaneous databases

    NextBioi 332169.
    PROi Q9D3A8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9D3A8.
    Bgeei Q9D3A8.
    Genevestigatori Q9D3A8.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR011993. PH_like_dom.
    IPR006020. PTB/PI_dom.
    [Graphical view ]
    Pfami PF00640. PID. 1 hit.
    [Graphical view ]
    SMARTi SM00462. PTB. 1 hit.
    [Graphical view ]
    PROSITEi PS01179. PID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Medulla oblongata.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-503 (ISOFORM 1).
      Tissue: Brain.
    4. "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON."
      Fang M., Jaffrey S.R., Sawa A., Ye K., Luo X., Snyder S.H.
      Neuron 28:183-193(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RASD1 AND NOS1.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-187; SER-190 AND SER-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiCAPON_MOUSE
    AccessioniPrimary (citable) accession number: Q9D3A8
    Secondary accession number(s): E9Q7B9, Q80TZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 88 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3