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Q9D3A8

- CAPON_MOUSE

UniProt

Q9D3A8 - CAPON_MOUSE

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Protein

Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Gene

Nos1ap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
Alternative name(s):
C-terminal PDZ ligand of neuronal nitric oxide synthase protein
Nitric oxide synthase 1 adaptor protein
Gene namesi
Name:Nos1ap
Synonyms:Capon, Kiaa0464
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1917979. Nos1ap.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase proteinPRO_0000089317Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei187 – 1871Phosphoserine1 Publication
Modified residuei190 – 1901Phosphoserine1 Publication
Modified residuei262 – 2621PhosphoserineBy similarity
Modified residuei370 – 3701Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9D3A8.
PRIDEiQ9D3A8.

PTM databases

PhosphoSiteiQ9D3A8.

Expressioni

Gene expression databases

BgeeiQ9D3A8.
ExpressionAtlasiQ9D3A8. baseline and differential.
GenevestigatoriQ9D3A8.

Interactioni

Subunit structurei

Interacts with the PDZ domain of NOS1 or the second PDZ domain of DLG4 through its C-terminus. Interacts with RASD1 and SYN1, SYN2 and SYN3 via its PID domain. Forms a ternary complex with NOS1 and SYN1 (By similarity). Forms a ternary complex with NOS1 and RASD1.By similarity1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9D3A8.
SMRiQ9D3A8. Positions 29-162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 191166PIDPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni491 – 50313Interaction with NOS1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili318 – 35942Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi501 – 5033PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi269 – 2724Poly-Ser
Compositional biasi297 – 3048Poly-Gln

Sequence similaritiesi

Contains 1 PID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG244289.
GeneTreeiENSGT00510000046975.
HOGENOMiHOG000111298.
HOVERGENiHBG050788.
InParanoidiQ9D3A8.
KOiK16513.
OMAiQNTMGSQ.
OrthoDBiEOG7JDQXM.
TreeFamiTF317226.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF00640. PID. 1 hit.
[Graphical view]
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9D3A8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSKTKYNLV DDGHDLRIPL HNEDAFQHGI SFEAKYVGSL DVPRPNSRVE
60 70 80 90 100
IVAAMRRIRY EFKAKNIKKK KVSIMVSVDG VKVILKKKKK KKEWTWDESK
110 120 130 140 150
MLVMQDPIYR IFYVSHDSQD LKIFSYIARD GASNIFRCNV FKSKKKSQAM
160 170 180 190 200
RIVRTVGQAF EVCHKLSLQH TQQNADGQED GESERNSDGS GDPGRQLTGA
210 220 230 240 250
ERVSTAAAEE TDIDAVEVPL PGNDILEFSR GVTDLDAVGK DGGSHIDSTV
260 270 280 290 300
SPHPQEPMLT ASPRMLLPSS SSKPPGLGTG TPLSTHHQMQ LLQQLLQQQQ
310 320 330 340 350
QQTQVAVAQV HLLKDQLAAE AAARLEAQAR VHQLLLQNKD MLQHISLLVK
360 370 380 390 400
QVQELELKLS GQNTMGSQDS LLEITFRSGA LPVLCESTTP KPEDLHSPLL
410 420 430 440 450
GAGLADFAHP AGSPLGRHDC LVKLECFRFL PPEDTQPMMA QGEPLLGGLE
460 470 480 490 500
LIKFRESGIA SEYESNTDES EERDSWSQEE LPRLLNVLQR QELGDSLDDE

IAV

Note: No experimental confirmation available.

Length:503
Mass (Da):55,873
Last modified:July 27, 2011 - v3
Checksum:i1BD365C67437C8A5
GO
Isoform 2 (identifier: Q9D3A8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     313-325: LKDQLAAEAAARL → SLLPSSQAPLSWA
     326-503: Missing.

Show »
Length:325
Mass (Da):36,122
Checksum:i1A7EE296CA7A9D87
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251A → S in BAB31095. (PubMed:16141072)Curated
Sequence conflicti110 – 1101R → K in BAB31095. (PubMed:16141072)Curated
Sequence conflicti157 – 1571G → A in BAB31095. (PubMed:16141072)Curated
Sequence conflicti311 – 3111H → L in BAB31095. (PubMed:16141072)Curated
Sequence conflicti311 – 3111H → L in BAC65572. (PubMed:12693553)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei313 – 32513LKDQL…AAARL → SLLPSSQAPLSWA in isoform 2. 1 PublicationVSP_012462Add
BLAST
Alternative sequencei326 – 503178Missing in isoform 2. 1 PublicationVSP_012463Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018149 mRNA. Translation: BAB31095.1.
AC119431 Genomic DNA. No translation available.
AC123650 Genomic DNA. No translation available.
AC125017 Genomic DNA. No translation available.
AC125021 Genomic DNA. No translation available.
AK122290 Transcribed RNA. Translation: BAC65572.3.
CCDSiCCDS48438.1. [Q9D3A8-1]
RefSeqiNP_001103455.1. NM_001109985.1. [Q9D3A8-1]
UniGeneiMm.487078.

Genome annotation databases

EnsembliENSMUST00000160456; ENSMUSP00000125251; ENSMUSG00000038473. [Q9D3A8-1]
GeneIDi70729.
KEGGimmu:70729.
UCSCiuc011wvt.1. mouse. [Q9D3A8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018149 mRNA. Translation: BAB31095.1 .
AC119431 Genomic DNA. No translation available.
AC123650 Genomic DNA. No translation available.
AC125017 Genomic DNA. No translation available.
AC125021 Genomic DNA. No translation available.
AK122290 Transcribed RNA. Translation: BAC65572.3 .
CCDSi CCDS48438.1. [Q9D3A8-1 ]
RefSeqi NP_001103455.1. NM_001109985.1. [Q9D3A8-1 ]
UniGenei Mm.487078.

3D structure databases

ProteinModelPortali Q9D3A8.
SMRi Q9D3A8. Positions 29-162.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D3A8.

Proteomic databases

MaxQBi Q9D3A8.
PRIDEi Q9D3A8.

Protocols and materials databases

DNASUi 70729.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000160456 ; ENSMUSP00000125251 ; ENSMUSG00000038473 . [Q9D3A8-1 ]
GeneIDi 70729.
KEGGi mmu:70729.
UCSCi uc011wvt.1. mouse. [Q9D3A8-1 ]

Organism-specific databases

CTDi 9722.
MGIi MGI:1917979. Nos1ap.
Rougei Search...

Phylogenomic databases

eggNOGi NOG244289.
GeneTreei ENSGT00510000046975.
HOGENOMi HOG000111298.
HOVERGENi HBG050788.
InParanoidi Q9D3A8.
KOi K16513.
OMAi QNTMGSQ.
OrthoDBi EOG7JDQXM.
TreeFami TF317226.

Miscellaneous databases

NextBioi 332169.
PROi Q9D3A8.
SOURCEi Search...

Gene expression databases

Bgeei Q9D3A8.
ExpressionAtlasi Q9D3A8. baseline and differential.
Genevestigatori Q9D3A8.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view ]
Pfami PF00640. PID. 1 hit.
[Graphical view ]
SMARTi SM00462. PTB. 1 hit.
[Graphical view ]
PROSITEi PS01179. PID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 195-503 (ISOFORM 1).
    Tissue: Brain.
  4. "Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON."
    Fang M., Jaffrey S.R., Sawa A., Ye K., Luo X., Snyder S.H.
    Neuron 28:183-193(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RASD1 AND NOS1.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183; SER-187; SER-190 AND SER-370, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCAPON_MOUSE
AccessioniPrimary (citable) accession number: Q9D3A8
Secondary accession number(s): E9Q7B9, Q80TZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3