Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9D387 (LAMP5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Brain and dendritic cell-associated LAMP
Brain-associated LAMP-like protein
Short name=BAD-LAMP
Lysosome-associated membrane protein 5
Short name=LAMP-5
Gene names
Name:Lamp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasmic vesicle. Cell membrane; Single-pass type I membrane protein. Cell projectiondendrite. Cell projectiongrowth cone membrane. Early endosome membrane; Single-pass type I membrane protein. Recycling endosome. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Note: Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity. Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Ref.3

Tissue specificity

Expressed in the forebrain. Expressed in the cingulate cortex, cortical plate, caudate putamen. Expressed in brain. Expressed in neurons of layers II/III and V of the neocortex. Ref.3

Developmental stage

Expressed in embryo at 14 dpc. Ref.3

Post-translational modification

Glycosylated. Ref.3

Sequence similarities

Belongs to the LAMP family.

Sequence caution

The sequence AAH04791.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AK018222 differs from that shown. Reason: Frameshift at positions 174 and 239.

The sequence BAB29169.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 280251Lysosome-associated membrane glycoprotein 5
PRO_0000021032

Regions

Topological domain30 – 235206Extracellular Potential
Transmembrane236 – 25621Helical; Potential
Topological domain257 – 28024Cytoplasmic Potential

Amino acid modifications

Glycosylation351N-linked (GlcNAc...) Potential
Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis2761Y → A: Cell surface localization. Ref.3
Sequence conflict2211E → V in AK018222. Ref.1
Sequence conflict2301Q → P in AK018222. Ref.1
Sequence conflict2381P → A in AK018222. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9D387 [UniParc].

Last modified December 6, 2002. Version 2.
Checksum: FA11D7BF9FD5CCEF

FASTA28031,721
        10         20         30         40         50         60 
MDLRVRTLLG GDRLRILLMF FHVMVQTVAE QEVENLSGLS TNPEKDIFVV RENGTTCLMA 

        70         80         90        100        110        120 
EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGHCG HNESELEVFW VDHAYTLRML 

       130        140        150        160        170        180 
FVKESHNTSK GPEATWNLNK VHFVYDSSEK THFKAPVKVN KYIASSHHLS ALVTPAGMSY 

       190        200        210        220        230        240 
ECQAQQTISL ASSDPQKTVT MILSAVHIQP FDIISDFVFS EEHKCPVDEQ EQLEETLPLI 

       250        260        270        280 
LGLILGLVIV ITLVIYHIHH KMTANQVQIP RDRSQYKHMG 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryonic head and Medulla oblongata.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-280.
Strain: Czech II.
Tissue: Mammary fibroblast.
[3]"BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons."
David A., Tiveron M.C., Defays A., Beclin C., Camosseto V., Gatti E., Cremer H., Pierre P.
J. Cell Sci. 120:353-365(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-276, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK014127 mRNA. Translation: BAB29169.1. Different initiation.
AK018222 mRNA. No translation available.
BC004791 mRNA. Translation: AAH04791.1. Different initiation.
CCDSCCDS16789.1.
RefSeqNP_083806.2. NM_029530.2.
XP_006500427.1. XM_006500364.1.
UniGeneMm.41638.

3D structure databases

ProteinModelPortalQ9D387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9D387. 1 interaction.
MINTMINT-4092431.

Proteomic databases

MaxQBQ9D387.
PaxDbQ9D387.
PRIDEQ9D387.

Protocols and materials databases

DNASU76161.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057503; ENSMUSP00000061180; ENSMUSG00000027270.
GeneID76161.
KEGGmmu:76161.
UCSCuc008mog.1. mouse.

Organism-specific databases

CTD24141.
MGIMGI:1923411. Lamp5.

Phylogenomic databases

eggNOGNOG41798.
GeneTreeENSGT00390000012584.
HOGENOMHOG000231912.
HOVERGENHBG051186.
InParanoidQ9D387.
OMACPVDERE.
PhylomeDBQ9D387.
TreeFamTF330776.

Gene expression databases

BgeeQ9D387.
CleanExMM_6330527O06RIK.
GenevestigatorQ9D387.

Family and domain databases

InterProIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio344693.
PROQ9D387.
SOURCESearch...

Entry information

Entry nameLAMP5_MOUSE
AccessionPrimary (citable) accession number: Q9D387
Secondary accession number(s): Q9CXQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot