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Q9D387

- LAMP5_MOUSE

UniProt

Q9D387 - LAMP5_MOUSE

Protein

Lysosome-associated membrane glycoprotein 5

Gene

Lamp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 2 (06 Dec 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 5
    Alternative name(s):
    Brain and dendritic cell-associated LAMP
    Brain-associated LAMP-like protein
    Short name:
    BAD-LAMP
    Lysosome-associated membrane protein 5
    Short name:
    LAMP-5
    Gene namesi
    Name:Lamp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1923411. Lamp5.

    Subcellular locationi

    Cytoplasmic vesicle 1 Publication. Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Cell projectiondendrite 1 Publication. Cell projectiongrowth cone membrane 1 Publication. Early endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Recycling endosome 1 Publication. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Single-pass type I membrane protein By similarity. Endosome membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes By similarity. Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB
    2. dendrite Source: UniProtKB-SubCell
    3. dendrite membrane Source: UniProtKB
    4. early endosome membrane Source: UniProtKB
    5. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
    6. endosome membrane Source: UniProtKB
    7. growth cone membrane Source: UniProtKB
    8. integral component of membrane Source: UniProtKB-KW
    9. plasma membrane Source: UniProtKB
    10. recycling endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi276 – 2761Y → A: Cell surface localization. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000021032Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9D387.
    PaxDbiQ9D387.
    PRIDEiQ9D387.

    Expressioni

    Tissue specificityi

    Expressed in the forebrain. Expressed in the cingulate cortex, cortical plate, caudate putamen. Expressed in brain. Expressed in neurons of layers II/III and V of the neocortex.1 Publication

    Developmental stagei

    Expressed in embryo at 14 dpc.1 Publication

    Gene expression databases

    BgeeiQ9D387.
    CleanExiMM_6330527O06RIK.
    GenevestigatoriQ9D387.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9D387. 1 interaction.
    MINTiMINT-4092431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D387.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei236 – 25621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAMP family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41798.
    GeneTreeiENSGT00390000012584.
    HOGENOMiHOG000231912.
    HOVERGENiHBG051186.
    InParanoidiQ9D387.
    OMAiCPVDERE.
    PhylomeDBiQ9D387.
    TreeFamiTF330776.

    Family and domain databases

    InterProiIPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PROSITEiPS00310. LAMP_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D387-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLRVRTLLG GDRLRILLMF FHVMVQTVAE QEVENLSGLS TNPEKDIFVV    50
    RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGHCG 100
    HNESELEVFW VDHAYTLRML FVKESHNTSK GPEATWNLNK VHFVYDSSEK 150
    THFKAPVKVN KYIASSHHLS ALVTPAGMSY ECQAQQTISL ASSDPQKTVT 200
    MILSAVHIQP FDIISDFVFS EEHKCPVDEQ EQLEETLPLI LGLILGLVIV 250
    ITLVIYHIHH KMTANQVQIP RDRSQYKHMG 280
    Length:280
    Mass (Da):31,721
    Last modified:December 6, 2002 - v2
    Checksum:iFA11D7BF9FD5CCEF
    GO

    Sequence cautioni

    The sequence AK018222 differs from that shown. Reason: Frameshift at positions 174 and 239.
    The sequence AAH04791.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB29169.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti221 – 2211E → V in AK018222. (PubMed:16141072)Curated
    Sequence conflicti230 – 2301Q → P in AK018222. (PubMed:16141072)Curated
    Sequence conflicti238 – 2381P → A in AK018222. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014127 mRNA. Translation: BAB29169.1. Different initiation.
    AK018222 mRNA. No translation available.
    BC004791 mRNA. Translation: AAH04791.1. Different initiation.
    CCDSiCCDS16789.1.
    RefSeqiNP_083806.2. NM_029530.2.
    XP_006500427.1. XM_006500364.1.
    UniGeneiMm.41638.

    Genome annotation databases

    EnsembliENSMUST00000057503; ENSMUSP00000061180; ENSMUSG00000027270.
    GeneIDi76161.
    KEGGimmu:76161.
    UCSCiuc008mog.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014127 mRNA. Translation: BAB29169.1 . Different initiation.
    AK018222 mRNA. No translation available.
    BC004791 mRNA. Translation: AAH04791.1 . Different initiation.
    CCDSi CCDS16789.1.
    RefSeqi NP_083806.2. NM_029530.2.
    XP_006500427.1. XM_006500364.1.
    UniGenei Mm.41638.

    3D structure databases

    ProteinModelPortali Q9D387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9D387. 1 interaction.
    MINTi MINT-4092431.

    Proteomic databases

    MaxQBi Q9D387.
    PaxDbi Q9D387.
    PRIDEi Q9D387.

    Protocols and materials databases

    DNASUi 76161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057503 ; ENSMUSP00000061180 ; ENSMUSG00000027270 .
    GeneIDi 76161.
    KEGGi mmu:76161.
    UCSCi uc008mog.1. mouse.

    Organism-specific databases

    CTDi 24141.
    MGIi MGI:1923411. Lamp5.

    Phylogenomic databases

    eggNOGi NOG41798.
    GeneTreei ENSGT00390000012584.
    HOGENOMi HOG000231912.
    HOVERGENi HBG051186.
    InParanoidi Q9D387.
    OMAi CPVDERE.
    PhylomeDBi Q9D387.
    TreeFami TF330776.

    Miscellaneous databases

    NextBioi 344693.
    PROi Q9D387.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D387.
    CleanExi MM_6330527O06RIK.
    Genevestigatori Q9D387.

    Family and domain databases

    InterProi IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PROSITEi PS00310. LAMP_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic head and Medulla oblongata.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-280.
      Strain: Czech II.
      Tissue: Mammary fibroblast.
    3. "BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons."
      David A., Tiveron M.C., Defays A., Beclin C., Camosseto V., Gatti E., Cremer H., Pierre P.
      J. Cell Sci. 120:353-365(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-276, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiLAMP5_MOUSE
    AccessioniPrimary (citable) accession number: Q9D387
    Secondary accession number(s): Q9CXQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: December 6, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3