Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysosome-associated membrane glycoprotein 5

Gene

Lamp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Brain and dendritic cell-associated LAMP
Brain-associated LAMP-like protein
Short name:
BAD-LAMP
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:Lamp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923411. Lamp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 235206ExtracellularSequence AnalysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence AnalysisAdd
BLAST
Topological domaini257 – 28024CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic vesicle membrane Source: UniProtKB
  • dendrite Source: UniProtKB-SubCell
  • dendrite membrane Source: UniProtKB
  • early endosome membrane Source: UniProtKB
  • endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB
  • endosome membrane Source: UniProtKB
  • growth cone membrane Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB
  • recycling endosome membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi276 – 2761Y → A: Cell surface localization. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 280251Lysosome-associated membrane glycoprotein 5PRO_0000021032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi35 – 351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D387.
PaxDbiQ9D387.
PRIDEiQ9D387.

Expressioni

Tissue specificityi

Expressed in the forebrain. Expressed in the cingulate cortex, cortical plate, caudate putamen. Expressed in brain. Expressed in neurons of layers II/III and V of the neocortex.1 Publication

Developmental stagei

Expressed in embryo at 14 dpc.1 Publication

Gene expression databases

BgeeiQ9D387.
CleanExiMM_6330527O06RIK.
ExpressionAtlasiQ9D387. baseline and differential.
GenevestigatoriQ9D387.

Interactioni

Protein-protein interaction databases

IntActiQ9D387. 1 interaction.
MINTiMINT-4092431.

Structurei

3D structure databases

ProteinModelPortaliQ9D387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiQ9D387.
OMAiCPVDERE.
PhylomeDBiQ9D387.
TreeFamiTF330776.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRVRTLLG GDRLRILLMF FHVMVQTVAE QEVENLSGLS TNPEKDIFVV
60 70 80 90 100
RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGHCG
110 120 130 140 150
HNESELEVFW VDHAYTLRML FVKESHNTSK GPEATWNLNK VHFVYDSSEK
160 170 180 190 200
THFKAPVKVN KYIASSHHLS ALVTPAGMSY ECQAQQTISL ASSDPQKTVT
210 220 230 240 250
MILSAVHIQP FDIISDFVFS EEHKCPVDEQ EQLEETLPLI LGLILGLVIV
260 270 280
ITLVIYHIHH KMTANQVQIP RDRSQYKHMG
Length:280
Mass (Da):31,721
Last modified:December 6, 2002 - v2
Checksum:iFA11D7BF9FD5CCEF
GO

Sequence cautioni

The sequence AAH04791.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AK018222 differs from that shown. Reason: Frameshift at positions 174 and 239. Curated
The sequence BAB29169.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211E → V in AK018222 (PubMed:16141072).Curated
Sequence conflicti230 – 2301Q → P in AK018222 (PubMed:16141072).Curated
Sequence conflicti238 – 2381P → A in AK018222 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014127 mRNA. Translation: BAB29169.1. Different initiation.
AK018222 mRNA. No translation available.
BC004791 mRNA. Translation: AAH04791.1. Different initiation.
CCDSiCCDS16789.1.
RefSeqiNP_083806.2. NM_029530.2.
XP_006500427.1. XM_006500364.2.
UniGeneiMm.41638.

Genome annotation databases

EnsembliENSMUST00000057503; ENSMUSP00000061180; ENSMUSG00000027270.
GeneIDi76161.
KEGGimmu:76161.
UCSCiuc008mog.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014127 mRNA. Translation: BAB29169.1. Different initiation.
AK018222 mRNA. No translation available.
BC004791 mRNA. Translation: AAH04791.1. Different initiation.
CCDSiCCDS16789.1.
RefSeqiNP_083806.2. NM_029530.2.
XP_006500427.1. XM_006500364.2.
UniGeneiMm.41638.

3D structure databases

ProteinModelPortaliQ9D387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D387. 1 interaction.
MINTiMINT-4092431.

Proteomic databases

MaxQBiQ9D387.
PaxDbiQ9D387.
PRIDEiQ9D387.

Protocols and materials databases

DNASUi76161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057503; ENSMUSP00000061180; ENSMUSG00000027270.
GeneIDi76161.
KEGGimmu:76161.
UCSCiuc008mog.1. mouse.

Organism-specific databases

CTDi24141.
MGIiMGI:1923411. Lamp5.

Phylogenomic databases

eggNOGiNOG41798.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiQ9D387.
OMAiCPVDERE.
PhylomeDBiQ9D387.
TreeFamiTF330776.

Miscellaneous databases

NextBioi344693.
PROiQ9D387.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D387.
CleanExiMM_6330527O06RIK.
ExpressionAtlasiQ9D387. baseline and differential.
GenevestigatoriQ9D387.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PROSITEiPS00310. LAMP_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic head and Medulla oblongata.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-280.
    Strain: Czech II.
    Tissue: Mammary fibroblast.
  3. "BAD-LAMP defines a subset of early endocytic organelles in subpopulations of cortical projection neurons."
    David A., Tiveron M.C., Defays A., Beclin C., Camosseto V., Gatti E., Cremer H., Pierre P.
    J. Cell Sci. 120:353-365(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-276, GLYCOSYLATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiLAMP5_MOUSE
AccessioniPrimary (citable) accession number: Q9D387
Secondary accession number(s): Q9CXQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: April 1, 2015
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.