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Protein

Lysosome-associated membrane glycoprotein 5

Gene

Lamp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 5
Alternative name(s):
Brain and dendritic cell-associated LAMP
Brain-associated LAMP-like protein
Short name:
BAD-LAMP
Lysosome-associated membrane protein 5
Short name:
LAMP-5
Gene namesi
Name:Lamp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1923411. Lamp5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 235ExtracellularSequence analysisAdd BLAST206
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 280CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Gross morphology and brain structure are normal. Behavioral assays of locomotory activity, exploratory behavior and motor coordination are also normal. However, some subtle behavioral defects are observed: anxiety levels are decreased and animals also show mild defects in odor discrimination. Electrophysiological assays of striatopallidal synapses indicate defects in short-term synaptic plasticity.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi276Y → A: Cell surface localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000002103230 – 280Lysosome-associated membrane glycoprotein 5Add BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D387.
PaxDbiQ9D387.
PeptideAtlasiQ9D387.
PRIDEiQ9D387.

PTM databases

PhosphoSitePlusiQ9D387.

Expressioni

Tissue specificityi

In brain, strongly expressed in the globus pallidus/ventral pallidum complex, the substantia nigra pars reticulata and the entopeduncular nucleus (at protein level) (PubMed:27272053). Expressed in the external plexiform layer of the olfactory bulb (at protein level). May be weakly expressed in neocortex and striatum (at protein level) (PubMed:27272053). Highly expressed in brain; not detected in other tissues tested (PubMed:17215451). Detected in the cingulate cortex, cortical plate and caudate putamen (PubMed:17215451). In neocortex, specifically expressed in neurons of layers II/III and V (PubMed:17215451).2 Publications

Developmental stagei

Expressed in embryo at 14 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000027270.
CleanExiMM_6330527O06RIK.
ExpressionAtlasiQ9D387. baseline and differential.
GenevisibleiQ9D387. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9D387. 1 interactor.
MINTiMINT-4092431.

Structurei

3D structure databases

ProteinModelPortaliQ9D387.
SMRiQ9D387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE1D. Eukaryota.
ENOG410YUG5. LUCA.
GeneTreeiENSGT00390000012584.
HOGENOMiHOG000231912.
HOVERGENiHBG051186.
InParanoidiQ9D387.
OMAiIYHIHHK.
OrthoDBiEOG091G0O9R.
PhylomeDBiQ9D387.
TreeFamiTF330776.

Family and domain databases

InterProiView protein in InterPro
IPR002000. Lysosome-assoc_membr_glycop.
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiView protein in Pfam
PF01299. Lamp. 1 hit.
PROSITEiView protein in PROSITE
PS00310. LAMP_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRVRTLLG GDRLRILLMF FHVMVQTVAE QEVENLSGLS TNPEKDIFVV
60 70 80 90 100
RENGTTCLMA EFAAKFIVPY DVWASNYVDL ITEQAEISLT RGAEVKGHCG
110 120 130 140 150
HNESELEVFW VDHAYTLRML FVKESHNTSK GPEATWNLNK VHFVYDSSEK
160 170 180 190 200
THFKAPVKVN KYIASSHHLS ALVTPAGMSY ECQAQQTISL ASSDPQKTVT
210 220 230 240 250
MILSAVHIQP FDIISDFVFS EEHKCPVDEQ EQLEETLPLI LGLILGLVIV
260 270 280
ITLVIYHIHH KMTANQVQIP RDRSQYKHMG
Length:280
Mass (Da):31,721
Last modified:December 6, 2002 - v2
Checksum:iFA11D7BF9FD5CCEF
GO

Sequence cautioni

The sequence AAH04791 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AK018222 differs from that shown. Reason: Frameshift at positions 174 and 239.Curated
The sequence BAB29169 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221E → V in AK018222 (PubMed:16141072).Curated1
Sequence conflicti230Q → P in AK018222 (PubMed:16141072).Curated1
Sequence conflicti238P → A in AK018222 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014127 mRNA. Translation: BAB29169.1. Different initiation.
AK018222 mRNA. No translation available.
BC004791 mRNA. Translation: AAH04791.1. Different initiation.
CCDSiCCDS16789.1.
RefSeqiNP_083806.2. NM_029530.2.
XP_006500427.1. XM_006500364.3.
XP_017174807.1. XM_017319318.1.
UniGeneiMm.41638.

Genome annotation databases

EnsembliENSMUST00000057503; ENSMUSP00000061180; ENSMUSG00000027270.
GeneIDi76161.
KEGGimmu:76161.
UCSCiuc008mog.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiLAMP5_MOUSE
AccessioniPrimary (citable) accession number: Q9D387
Secondary accession number(s): Q9CXQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: November 22, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families