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Protein

ADP-ribosylation factor-like protein 2-binding protein

Gene

Arl2bp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 2-binding protein
Short name:
ARF-like 2-binding protein
Alternative name(s):
Binder of ARF2 protein 1
Gene namesi
Name:Arl2bp
Synonyms:Bart, Bart1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1349429 Arl2bp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871151 – 163ADP-ribosylation factor-like protein 2-binding proteinAdd BLAST163

Proteomic databases

PaxDbiQ9D385
PeptideAtlasiQ9D385
PRIDEiQ9D385

PTM databases

iPTMnetiQ9D385
PhosphoSitePlusiQ9D385

Expressioni

Tissue specificityi

Widely expressed, with most abundant activity in brain, especially in hippocampus and cortex. Also expressed in lung, cerebellum, liver, kidney, retina, spleen, muscle and heart (at protein level).4 Publications

Gene expression databases

BgeeiENSMUSG00000031776
CleanExiMM_ARL2BP
ExpressionAtlasiQ9D385 baseline and differential
GenevisibleiQ9D385 MM

Interactioni

Subunit structurei

Interacts with GTP bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body (By similarity). Interacts with STAT3; interaction is enhanced with ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6 (By similarity). Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4.By similarity2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034228

Structurei

3D structure databases

ProteinModelPortaliQ9D385
SMRiQ9D385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARL2BP family.Curated

Phylogenomic databases

eggNOGiENOG410IKTQ Eukaryota
ENOG4111IGT LUCA
GeneTreeiENSGT00390000015052
HOGENOMiHOG000024955
HOVERGENiHBG105565
InParanoidiQ9D385
KOiK16742
OMAiQQHKDEM
OrthoDBiEOG091G09PN
PhylomeDBiQ9D385
TreeFamiTF315143

Family and domain databases

InterProiView protein in InterPro
IPR023379 ARF-like_2-bdp_dom
PfamiView protein in Pfam
PF11527 ARL2_Bind_BART, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D385-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDALEEESFA LSFSSASDAE FDAVVGCLED IIMDDEFQLL QRNFMDKYYQ
60 70 80 90 100
EFEDTEENKL TYTPIFNEYI SLVEKYIEEQ LLERIPGFNM AAFTTTLQHH
110 120 130 140 150
KDEVAGDIFD MLLTFTDFLA FKEMFLDYRA EKEGRGLDLS SGLVVTSLCK
160
SSSTPASQNN LRH
Length:163
Mass (Da):18,754
Last modified:June 1, 2001 - v1
Checksum:iAE489178C0382255
GO
Isoform 2 (identifier: Q9D385-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.
     12-13: SF → MR

Show »
Length:152
Mass (Da):17,571
Checksum:i4DE5F01744ED1E58
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253201 – 11Missing in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_02531912 – 13SF → MR in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006418 mRNA Translation: BAB24578.1
AK006646 mRNA Translation: BAB24686.1
AK018229 mRNA Translation: BAB31126.1
AK155242 mRNA Translation: BAE33143.1
AK161325 mRNA Translation: BAE36323.1
CT010168 mRNA Translation: CAJ18376.1
BC002131 mRNA Translation: AAH02131.1
BC024708 mRNA Translation: AAH24708.1
CCDSiCCDS22545.1 [Q9D385-1]
CCDS40440.1 [Q9D385-2]
RefSeqiNP_077153.1, NM_024191.2 [Q9D385-1]
NP_077231.1, NM_024269.4 [Q9D385-2]
UniGeneiMm.393247

Genome annotation databases

EnsembliENSMUST00000034228; ENSMUSP00000034228; ENSMUSG00000031776 [Q9D385-1]
ENSMUST00000109527; ENSMUSP00000105153; ENSMUSG00000031776 [Q9D385-2]
GeneIDi107566
KEGGimmu:107566
UCSCiuc009mwt.3 mouse [Q9D385-1]
uc009mwu.3 mouse [Q9D385-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAR2BP_MOUSE
AccessioniPrimary (citable) accession number: Q9D385
Secondary accession number(s): Q9CQW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome