Reviewed, UniProtKB/Swiss-Prot Q9D358 (PPAC_MOUSE)

Names and origin

Protein names

Recommended name:
    Low molecular weight phosphotyrosine protein phosphatase
      Short name=LMW-PTPase
      Short name=LMW-PTP
    EC=3.1.3.48
Alternative name(s):
    Low molecular weight cytosolic acid phosphatase
    EC=3.1.3.2

Gene names

Name:

Acp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates By similarity. UniProtKB P11064
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. UniProtKB P11064 A phosphate monoester + H2O = an alcohol + phosphate.
Subunit structure	Isoform 1 interacts with the SH3 domain of SPTAN1 By similarity. UniProtKB P41498
Subcellular location	Cytoplasm By similarity. UniProtKB P41498
Tissue specificity	Widely expressed with highest levels in brain and liver and lowest levels in muscle. Ref.1
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Hydrolase Protein phosphatase
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	protein amino acid dephosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acid phosphatase activity Inferred from direct assay. Source: MGI non-membrane spanning protein tyrosine phosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.1 (identifier: Q9D358-1) Also known as: m-IF1; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 Ref.1 (identifier: Q9D358-2) Also known as: m-IF2; The sequence of this isoform differs from the canonical sequence as follows:      41-74: RIDSAATSTYEVGNPPDYRGQNCMRKHGIHMQHI → AIDSSAVSDWNVGRPPDPRAVSCLRNRGISTAHK
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	67	1	R → H

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P41498
	Chain	2 – 158	157	Low molecular weight phosphotyrosine protein phosphatase		PRO_0000046559
Sites
	Active site	13	1	Nucleophile By similarity UniProtKB P11064
	Active site	19	1	By similarity UniProtKB P11064
	Active site	130	1	Proton donor By similarity UniProtKB P11064
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity UniProtKB P41498
	Modified residue	132	1	Phosphotyrosine By similarity UniProtKB P24666
	Modified residue	133	1	Phosphotyrosine By similarity
	Modified residue	156	1	N6-acetyllysine By similarity
Natural variations
	Alternative sequence	41 – 74	34	RIDSA…HMQHI → AIDSSAVSDWNVGRPPDPRA VSCLRNRGISTAHK in isoform 2. Ref.1		VSP_050726
	Natural variant	14	1	L → P Ref.1
	Natural variant	157	1	T → P Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (m-IF1) [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A374BE5C183226AE	FASTA	158	18,192
	10 20 30 40 50 60 MAEVGSKSVL FVCLGNICRS PIAEAVFRKL VTDEKVSDNW RIDSAATSTY EVGNPPDYRG 70 80 90 100 110 120 QNCMRKHGIH MQHIARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKNC KAKIELLGSY 130 140 150 DPQKQLIIED PYYGNDSDFE VVYQQCLRCC KAFLEKTY
	Isoform 2 (m-IF2). Checksum: A2A1AF4BF774889E	FASTA	158	17,941
	10 20 30 40 50 60 MAEVGSKSVL FVCLGNICRS PIAEAVFRKL VTDEKVSDNW AIDSSAVSDW NVGRPPDPRA 70 80 90 100 110 120 VSCLRNRGIS TAHKARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKNC KAKIELLGSY 130 140 150 DPQKQLIIED PYYGNDSDFE VVYQQCLRCC KAFLEKTY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of murine low molecular weight phosphotyrosine protein phosphatase cDNA: identification of a new isoform." Magherini F., Giannoni E., Raugei G., Cirri P., Paoli P., Modesti A., Camici G., Ramponi G. FEBS Lett. 437:263-266(1998) [PubMed: 9824304] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, VARIANTS PRO-14 AND PRO-157. Tissue: Liver.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J. Tissue: Cerebellum, Embryo, Skin and Spinal cord.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: FVB/N.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y17343 mRNA. Translation: CAA76753.1. Y17344 mRNA. Translation: CAA76754.1. Y17345 mRNA. Translation: CAA76755.1. AK014603 mRNA. Translation: BAB29458.1. AK018329 mRNA. Translation: BAB31164.1. AK019186 mRNA. Translation: BAB31593.1. AK082955 mRNA. Translation: BAC38707.1. BC039744 mRNA. Translation: AAH39744.1.
IPI	IPI00134135. IPI00828470.
RefSeq	NP_001103709.1. NP_067305.2. XP_910741.1.
UniGene	Mm.359831
3D structure databases
HSSP	HSSP built from PDB template 1PHR based on UniProtKB P11064.
SMR	Q9D358. Positions 2-158.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9D358.
PTM databases
PhosphoSite	Q9D358.
2-D gel databases
REPRODUCTION-2DPAGE	Q9D358.
Proteomic databases
PRIDE	Q9D358.
Genome annotation databases
Ensembl	ENSMUST00000062740; ENSMUSP00000106509; ENSMUSG00000044573; Mus musculus. [Genome view] ENSMUST00000074038; ENSMUSP00000073686; ENSMUSG00000044573; Mus musculus. [Genome view]
GeneID	11431. 631286.
KEGG	mmu:11431. mmu:631286.
UCSC	uc007ngw.1. mouse.
Organism-specific databases
CTD	11431.
MGI	MGI:87881. Acp1.
Phylogenomic databases
HOGENOM	Q9D358.
HOVERGEN	Q9D358.
OMA	CHGNICR.
Enzyme and pathway databases
BRENDA	3.1.3.2. 244. 3.1.3.48. 244.
Gene expression databases
ArrayExpress	Q9D358.
Bgee	Q9D358.
CleanEx	MM_ACP1.
Genevestigator	Q9D358.
GermOnline	ENSMUSG00000059722. Mus musculus.
Family and domain databases
InterPro	IPR002115. Tyr_Pase_low_mol_wt_mml. IPR000106. Tyr_phospatase/Ars_reductase. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
PRINTS	PR00719. LMWPTPASE. PR00720. MAMMALPTPASE.
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278712.
SOURCE	Search...

Entry information

Entry name

PPAC_MOUSE

Accession

Primary (citable) accession number: Q9D358
Secondary accession number(s): O88739, O88740, Q9QWF5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	January 23, 2007
Last modified:	November 3, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)