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Protein

Transmembrane protein 35A

Gene

Tmem35a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 35A
Alternative name(s):
Peroxisomal membrane protein 52
Short name:
PMP52
Gene namesi
Name:Tmem35aImported
Synonyms:Tmem35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1914814. Tmem35a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Transmembranei115 – 132HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716091 – 167Transmembrane protein 35AAdd BLAST167

Proteomic databases

EPDiQ9D328.
MaxQBiQ9D328.
PaxDbiQ9D328.
PeptideAtlasiQ9D328.
PRIDEiQ9D328.

PTM databases

iPTMnetiQ9D328.
PhosphoSitePlusiQ9D328.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033578.
CleanExiMM_TMEM35.
GenevisibleiQ9D328. MM.

Interactioni

Subunit structurei

May interact with NGFR.By similarity

Protein-protein interaction databases

IntActiQ9D328. 1 interactor.
MINTiMINT-4126843.
STRINGi10090.ENSMUSP00000044926.

Structurei

3D structure databases

ProteinModelPortaliQ9D328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni43 – 54Interaction with NGFRBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the DoxX family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ9D328.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ9D328.
TreeFamiTF300206.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASPRTITIM ALSVALGLFF VFMGTIKLTP RLSKDAYSEM KRAYKSYVRA
60 70 80 90 100
LPLLKKMGIN SILLRKSIGA LEVACGIVMT LVPGRPKDVA NFFLLLLVLA
110 120 130 140 150
VLFFHQLVGD PLKRYAHALV FGILLTCRLL IARKPEDRSS EKKALPESAE
160
EQPSLYEKAP QGKVKVS
Length:167
Mass (Da):18,505
Last modified:June 1, 2001 - v1
Checksum:iFC79B4CCF69335F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88D → N in BAB23865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005180 mRNA. Translation: BAB23865.1.
AK018535 mRNA. Translation: BAB31260.1.
AK042538 mRNA. Translation: BAC31285.1.
AK043881 mRNA. Translation: BAC31693.1.
BC042623 mRNA. Translation: AAH42623.1.
BC050880 mRNA. Translation: AAH50880.1.
CCDSiCCDS30392.1.
RefSeqiNP_080515.1. NM_026239.2.
UniGeneiMm.41489.

Genome annotation databases

EnsembliENSMUST00000037687; ENSMUSP00000044926; ENSMUSG00000033578.
GeneIDi67564.
KEGGimmu:67564.
UCSCiuc009uft.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005180 mRNA. Translation: BAB23865.1.
AK018535 mRNA. Translation: BAB31260.1.
AK042538 mRNA. Translation: BAC31285.1.
AK043881 mRNA. Translation: BAC31693.1.
BC042623 mRNA. Translation: AAH42623.1.
BC050880 mRNA. Translation: AAH50880.1.
CCDSiCCDS30392.1.
RefSeqiNP_080515.1. NM_026239.2.
UniGeneiMm.41489.

3D structure databases

ProteinModelPortaliQ9D328.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9D328. 1 interactor.
MINTiMINT-4126843.
STRINGi10090.ENSMUSP00000044926.

PTM databases

iPTMnetiQ9D328.
PhosphoSitePlusiQ9D328.

Proteomic databases

EPDiQ9D328.
MaxQBiQ9D328.
PaxDbiQ9D328.
PeptideAtlasiQ9D328.
PRIDEiQ9D328.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037687; ENSMUSP00000044926; ENSMUSG00000033578.
GeneIDi67564.
KEGGimmu:67564.
UCSCiuc009uft.1. mouse.

Organism-specific databases

CTDi67564.
MGIiMGI:1914814. Tmem35a.

Phylogenomic databases

eggNOGiENOG410IGYA. Eukaryota.
ENOG4111K2N. LUCA.
GeneTreeiENSGT00390000014255.
HOGENOMiHOG000046204.
HOVERGENiHBG054829.
InParanoidiQ9D328.
OMAiVVWYQTS.
OrthoDBiEOG091G0TZU.
PhylomeDBiQ9D328.
TreeFamiTF300206.

Miscellaneous databases

PROiQ9D328.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033578.
CleanExiMM_TMEM35.
GenevisibleiQ9D328. MM.

Family and domain databases

InterProiIPR032808. DoxX.
IPR029693. TMEM35.
[Graphical view]
PANTHERiPTHR13163:SF0. PTHR13163:SF0. 1 hit.
PfamiPF13564. DoxX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM35A_MOUSE
AccessioniPrimary (citable) accession number: Q9D328
Secondary accession number(s): Q9DB64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.