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Q9D309

- FAM3B_MOUSE

UniProt

Q9D309 - FAM3B_MOUSE

Protein

Protein FAM3B

Gene

Fam3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.1 Publication

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. insulin secretion Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM3B
    Alternative name(s):
    Cytokine-like protein 2-21
    Pancreatic-derived factor
    Short name:
    PANDER
    Gene namesi
    Name:Fam3b
    Synonyms:ORF9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1270150. Fam3b.

    Subcellular locationi

    Secreted By similarity
    Note: Present in insulin secretory granules and likely cosecreted with insulin.By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB
    2. extracellular space Source: UniProtKB-KW
    3. nuclear envelope lumen Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 235206Protein FAM3BPRO_0000008751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi63 ↔ 911 Publication
    Disulfide bondi69 ↔ 2291 Publication
    Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    O-glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9D309.
    PRIDEiQ9D309.

    PTM databases

    PhosphoSiteiQ9D309.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the pancreas and, to a lesser extent, in small intestine and prostate. Also detected in stomach, testis and fetal liver. In the pancreas, localized in the islets of Langerhans; in the testis, found primarily in the round spermatids; in the CNS, found in the Purkinje cell layer of the cerebellum and in nerve cell bodies of numerous brainstem nuclei.

    Inductioni

    By glucose.1 Publication

    Gene expression databases

    BgeeiQ9D309.
    GenevestigatoriQ9D309.

    Structurei

    Secondary structure

    1
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi62 – 643
    Beta strandi73 – 797
    Turni83 – 853
    Beta strandi89 – 924
    Beta strandi95 – 995
    Turni100 – 1034
    Beta strandi107 – 1159
    Turni116 – 1183
    Beta strandi121 – 1277
    Beta strandi129 – 1335
    Helixi135 – 14410
    Beta strandi147 – 15711
    Helixi165 – 1728
    Turni173 – 1753
    Helixi179 – 1813
    Beta strandi187 – 19610
    Beta strandi205 – 2084
    Turni212 – 2143
    Beta strandi225 – 2317
    Turni232 – 2354

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YOPX-ray2.30A/B/C46-235[»]
    2YOQX-ray2.35A/B/C30-235[»]
    ProteinModelPortaliQ9D309.
    SMRiQ9D309. Positions 58-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM3 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG75571.
    GeneTreeiENSGT00530000063020.
    HOGENOMiHOG000285992.
    HOVERGENiHBG099991.
    InParanoidiQ9D309.
    OMAiWVFLTAK.
    OrthoDBiEOG79KPG6.
    PhylomeDBiQ9D309.
    TreeFamiTF353414.

    Family and domain databases

    InterProiIPR026101. FAM3.
    [Graphical view]
    PANTHERiPTHR14592. PTHR14592. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D309-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPVATGIFK ALVFIFSSLC AWYSGYLLAE LIPDVPLSST LYNIRSIGER    50
    PVLKAPAPKR QKCDHWSPCP PDTYAYRLLS GGGRDKYAKI CFEDEVLIGE 100
    KTGNVARGIN IAVVNYETGK VIATKYFDMY EGDNSGPMAK FIQSTPSKSL 150
    LFMVTHDDGS SKLKAQAKDA IEALGSKEIK NMKFRSSWVF VAAKGFELPS 200
    EIEREKINHS DQSRNRYAGW PAEIQIEGCI PKGLR 235
    Length:235
    Mass (Da):26,152
    Last modified:June 1, 2001 - v1
    Checksum:i2539E5ED009D9C3C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti162 – 1621K → R in AAC21456. (PubMed:9750193)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494380 mRNA. Translation: AAM94281.1.
    AK018571 mRNA. Translation: BAB31283.1.
    AF360358 mRNA. Translation: AAL34461.1.
    BC048949 mRNA. Translation: AAH48949.1.
    AF045953 Genomic DNA. Translation: AAC21456.1.
    CCDSiCCDS37416.1.
    RefSeqiNP_065647.1. NM_020622.2.
    UniGeneiMm.327932.

    Genome annotation databases

    EnsembliENSMUST00000049721; ENSMUSP00000062006; ENSMUSG00000022938.
    GeneIDi52793.
    KEGGimmu:52793.
    UCSCiuc008adj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF494380 mRNA. Translation: AAM94281.1 .
    AK018571 mRNA. Translation: BAB31283.1 .
    AF360358 mRNA. Translation: AAL34461.1 .
    BC048949 mRNA. Translation: AAH48949.1 .
    AF045953 Genomic DNA. Translation: AAC21456.1 .
    CCDSi CCDS37416.1.
    RefSeqi NP_065647.1. NM_020622.2.
    UniGenei Mm.327932.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YOP X-ray 2.30 A/B/C 46-235 [» ]
    2YOQ X-ray 2.35 A/B/C 30-235 [» ]
    ProteinModelPortali Q9D309.
    SMRi Q9D309. Positions 58-235.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9D309.

    Proteomic databases

    MaxQBi Q9D309.
    PRIDEi Q9D309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049721 ; ENSMUSP00000062006 ; ENSMUSG00000022938 .
    GeneIDi 52793.
    KEGGi mmu:52793.
    UCSCi uc008adj.1. mouse.

    Organism-specific databases

    CTDi 54097.
    MGIi MGI:1270150. Fam3b.

    Phylogenomic databases

    eggNOGi NOG75571.
    GeneTreei ENSGT00530000063020.
    HOGENOMi HOG000285992.
    HOVERGENi HBG099991.
    InParanoidi Q9D309.
    OMAi WVFLTAK.
    OrthoDBi EOG79KPG6.
    PhylomeDBi Q9D309.
    TreeFami TF353414.

    Miscellaneous databases

    ChiTaRSi FAM3B. mouse.
    NextBioi 309551.
    PROi Q9D309.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D309.
    Genevestigatori Q9D309.

    Family and domain databases

    InterProi IPR026101. FAM3.
    [Graphical view ]
    PANTHERi PTHR14592. PTHR14592. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Colon.
    3. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
      Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
      Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    5. "Physical and comparative mapping of distal mouse chromosome 16. 5 p5."
      Cabin D.E., McKee-Johnson J.W., Matesic L.E., Wiltshire T., Rue E.E., Mjaatvedt A.E., Huo Y.K., Korenberg J.R., Reeves R.H.
      Genome Res. 8:940-950(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-205.
    6. "Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells."
      Wang O., Cai K., Pang S., Wang T., Qi D., Zhu Q., Ni Z., Le Y.
      Endocrinology 149:672-680(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    7. "FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold."
      Johansson P., Bernstrom J., Gorman T., Oster L., Backstrom S., Schweikart F., Xu B., Xue Y., Schiavone L.H.
      Structure 21:306-313(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 46-235, PARTIAL PROTEIN SEQUENCE, FUNCTION, GLYCOSYLATION, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiFAM3B_MOUSE
    AccessioniPrimary (citable) accession number: Q9D309
    Secondary accession number(s): O88417
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 19, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3