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Q9D309 (FAM3B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM3B
Alternative name(s):
Cytokine-like protein 2-21
Pancreatic-derived factor
Short name=PANDER
Gene names
Name:Fam3b
Synonyms:ORF9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner. Ref.7

Subcellular location

Secreted By similarity. Note: Present in insulin secretory granules and likely cosecreted with insulin By similarity.

Tissue specificity

Expressed at high levels in the pancreas and, to a lesser extent, in small intestine and prostate. Also detected in stomach, testis and fetal liver. In the pancreas, localized in the islets of Langerhans; in the testis, found primarily in the round spermatids; in the CNS, found in the Purkinje cell layer of the cerebellum and in nerve cell bodies of numerous brainstem nuclei.

Induction

By glucose. Ref.6

Post-translational modification

O-glycosylated. Ref.7

Miscellaneous

It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46.

Sequence similarities

Belongs to the FAM3 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

insulin secretion

Inferred from direct assay Ref.1. Source: UniProtKB

   Cellular_componentextracellular region

Non-traceable author statement Ref.1. Source: UniProtKB

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

nuclear envelope lumen

Inferred from sequence alignment Ref.3. Source: MGI

   Molecular_functioncytokine activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 235206Protein FAM3B
PRO_0000008751

Amino acid modifications

Glycosylation2081N-linked (GlcNAc...) Potential
Disulfide bond63 ↔ 91 Ref.7
Disulfide bond69 ↔ 229 Ref.7

Experimental info

Sequence conflict1621K → R in AAC21456. Ref.5

Secondary structure

.................................... 235
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9D309 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 2539E5ED009D9C3C

FASTA23526,152
        10         20         30         40         50         60 
MRPVATGIFK ALVFIFSSLC AWYSGYLLAE LIPDVPLSST LYNIRSIGER PVLKAPAPKR 

        70         80         90        100        110        120 
QKCDHWSPCP PDTYAYRLLS GGGRDKYAKI CFEDEVLIGE KTGNVARGIN IAVVNYETGK 

       130        140        150        160        170        180 
VIATKYFDMY EGDNSGPMAK FIQSTPSKSL LFMVTHDDGS SKLKAQAKDA IEALGSKEIK 

       190        200        210        220        230 
NMKFRSSWVF VAAKGFELPS EIEREKINHS DQSRNRYAGW PAEIQIEGCI PKGLR 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression, and initial characterization of a novel cytokine-like gene family."
Zhu Y., Xu G., Patel A., McLaughlin M.M., Silverman C., Knecht K.A., Sweitzer S., Li X., McDonnell P., Mirabile R., Zimmerman D., Boyce R., Tierney L.A., Hu E., Livi G.P., Wolf B.A., Abdel-Meguid S.S., Rose G.D. expand/collapse author list , Aurora R., Hensley P., Briggs M., Young P.R.
Genomics 80:144-150(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
Strain: C57BL/6.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Colon.
[3]"From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[5]"Physical and comparative mapping of distal mouse chromosome 16. 5 p5."
Cabin D.E., McKee-Johnson J.W., Matesic L.E., Wiltshire T., Rue E.E., Mjaatvedt A.E., Huo Y.K., Korenberg J.R., Reeves R.H.
Genome Res. 8:940-950(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-205.
[6]"Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells."
Wang O., Cai K., Pang S., Wang T., Qi D., Zhu Q., Ni Z., Le Y.
Endocrinology 149:672-680(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
[7]"FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold."
Johansson P., Bernstrom J., Gorman T., Oster L., Backstrom S., Schweikart F., Xu B., Xue Y., Schiavone L.H.
Structure 21:306-313(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 46-235, PARTIAL PROTEIN SEQUENCE, FUNCTION, GLYCOSYLATION, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF494380 mRNA. Translation: AAM94281.1.
AK018571 mRNA. Translation: BAB31283.1.
AF360358 mRNA. Translation: AAL34461.1.
BC048949 mRNA. Translation: AAH48949.1.
AF045953 Genomic DNA. Translation: AAC21456.1.
RefSeqNP_065647.1. NM_020622.2.
UniGeneMm.327932.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YOPX-ray2.30A/B/C46-235[»]
2YOQX-ray2.35A/B/C30-235[»]
ProteinModelPortalQ9D309.
SMRQ9D309. Positions 58-235.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9D309.

Proteomic databases

PRIDEQ9D309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049721; ENSMUSP00000062006; ENSMUSG00000022938.
GeneID52793.
KEGGmmu:52793.
UCSCuc008adj.1. mouse.

Organism-specific databases

CTD54097.
MGIMGI:1270150. Fam3b.

Phylogenomic databases

eggNOGNOG75571.
GeneTreeENSGT00530000063020.
HOGENOMHOG000285992.
HOVERGENHBG099991.
InParanoidQ9D309.
OMACDHWSPC.
OrthoDBEOG79KPG6.
PhylomeDBQ9D309.
TreeFamTF353414.

Gene expression databases

BgeeQ9D309.
GenevestigatorQ9D309.

Family and domain databases

InterProIPR026101. FAM3.
[Graphical view]
PANTHERPTHR14592. PTHR14592. 1 hit.
ProtoNetSearch...

Other

ChiTaRSFAM3B. mouse.
NextBio309551.
PROQ9D309.
SOURCESearch...

Entry information

Entry nameFAM3B_MOUSE
AccessionPrimary (citable) accession number: Q9D309
Secondary accession number(s): O88417
Entry history
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot