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Q9D309

- FAM3B_MOUSE

UniProt

Q9D309 - FAM3B_MOUSE

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Protein

Protein FAM3B

Gene

Fam3b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. insulin secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3B
Alternative name(s):
Cytokine-like protein 2-21
Pancreatic-derived factor
Short name:
PANDER
Gene namesi
Name:Fam3b
Synonyms:ORF9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1270150. Fam3b.

Subcellular locationi

Secreted By similarity
Note: Present in insulin secretory granules and likely cosecreted with insulin.By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
  3. extracellular vesicular exosome Source: Ensembl
  4. nuclear envelope lumen Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 235206Protein FAM3BPRO_0000008751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 911 Publication
Disulfide bondi69 ↔ 2291 Publication
Glycosylationi208 – 2081N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D309.
PRIDEiQ9D309.

PTM databases

PhosphoSiteiQ9D309.

Expressioni

Tissue specificityi

Expressed at high levels in the pancreas and, to a lesser extent, in small intestine and prostate. Also detected in stomach, testis and fetal liver. In the pancreas, localized in the islets of Langerhans; in the testis, found primarily in the round spermatids; in the CNS, found in the Purkinje cell layer of the cerebellum and in nerve cell bodies of numerous brainstem nuclei.

Inductioni

By glucose.1 Publication

Gene expression databases

BgeeiQ9D309.
GenevestigatoriQ9D309.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi62 – 643Combined sources
Beta strandi73 – 797Combined sources
Turni83 – 853Combined sources
Beta strandi89 – 924Combined sources
Beta strandi95 – 995Combined sources
Turni100 – 1034Combined sources
Beta strandi107 – 1159Combined sources
Turni116 – 1183Combined sources
Beta strandi121 – 1277Combined sources
Beta strandi129 – 1335Combined sources
Helixi135 – 14410Combined sources
Beta strandi147 – 15711Combined sources
Helixi165 – 1728Combined sources
Turni173 – 1753Combined sources
Helixi179 – 1813Combined sources
Beta strandi187 – 19610Combined sources
Beta strandi205 – 2084Combined sources
Turni212 – 2143Combined sources
Beta strandi225 – 2317Combined sources
Turni232 – 2354Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YOPX-ray2.30A/B/C46-235[»]
2YOQX-ray2.35A/B/C30-235[»]
ProteinModelPortaliQ9D309.
SMRiQ9D309. Positions 58-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG75571.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG099991.
InParanoidiQ9D309.
OMAiWVFLTAK.
OrthoDBiEOG79KPG6.
PhylomeDBiQ9D309.
TreeFamiTF353414.

Family and domain databases

InterProiIPR026101. FAM3.
[Graphical view]
PANTHERiPTHR14592. PTHR14592. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D309-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPVATGIFK ALVFIFSSLC AWYSGYLLAE LIPDVPLSST LYNIRSIGER
60 70 80 90 100
PVLKAPAPKR QKCDHWSPCP PDTYAYRLLS GGGRDKYAKI CFEDEVLIGE
110 120 130 140 150
KTGNVARGIN IAVVNYETGK VIATKYFDMY EGDNSGPMAK FIQSTPSKSL
160 170 180 190 200
LFMVTHDDGS SKLKAQAKDA IEALGSKEIK NMKFRSSWVF VAAKGFELPS
210 220 230
EIEREKINHS DQSRNRYAGW PAEIQIEGCI PKGLR
Length:235
Mass (Da):26,152
Last modified:June 1, 2001 - v1
Checksum:i2539E5ED009D9C3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti162 – 1621K → R in AAC21456. (PubMed:9750193)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494380 mRNA. Translation: AAM94281.1.
AK018571 mRNA. Translation: BAB31283.1.
AF360358 mRNA. Translation: AAL34461.1.
BC048949 mRNA. Translation: AAH48949.1.
AF045953 Genomic DNA. Translation: AAC21456.1.
CCDSiCCDS37416.1.
RefSeqiNP_065647.1. NM_020622.2.
UniGeneiMm.327932.

Genome annotation databases

EnsembliENSMUST00000049721; ENSMUSP00000062006; ENSMUSG00000022938.
GeneIDi52793.
KEGGimmu:52793.
UCSCiuc008adj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494380 mRNA. Translation: AAM94281.1 .
AK018571 mRNA. Translation: BAB31283.1 .
AF360358 mRNA. Translation: AAL34461.1 .
BC048949 mRNA. Translation: AAH48949.1 .
AF045953 Genomic DNA. Translation: AAC21456.1 .
CCDSi CCDS37416.1.
RefSeqi NP_065647.1. NM_020622.2.
UniGenei Mm.327932.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YOP X-ray 2.30 A/B/C 46-235 [» ]
2YOQ X-ray 2.35 A/B/C 30-235 [» ]
ProteinModelPortali Q9D309.
SMRi Q9D309. Positions 58-235.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9D309.

Proteomic databases

MaxQBi Q9D309.
PRIDEi Q9D309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049721 ; ENSMUSP00000062006 ; ENSMUSG00000022938 .
GeneIDi 52793.
KEGGi mmu:52793.
UCSCi uc008adj.1. mouse.

Organism-specific databases

CTDi 54097.
MGIi MGI:1270150. Fam3b.

Phylogenomic databases

eggNOGi NOG75571.
GeneTreei ENSGT00530000063020.
HOGENOMi HOG000285992.
HOVERGENi HBG099991.
InParanoidi Q9D309.
OMAi WVFLTAK.
OrthoDBi EOG79KPG6.
PhylomeDBi Q9D309.
TreeFami TF353414.

Miscellaneous databases

ChiTaRSi Fam3b. mouse.
NextBioi 309551.
PROi Q9D309.
SOURCEi Search...

Gene expression databases

Bgeei Q9D309.
Genevestigatori Q9D309.

Family and domain databases

InterProi IPR026101. FAM3.
[Graphical view ]
PANTHERi PTHR14592. PTHR14592. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE, PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION.
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon.
  3. "From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map."
    Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S., Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.
    Genomics 78:46-54(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  5. "Physical and comparative mapping of distal mouse chromosome 16. 5 p5."
    Cabin D.E., McKee-Johnson J.W., Matesic L.E., Wiltshire T., Rue E.E., Mjaatvedt A.E., Huo Y.K., Korenberg J.R., Reeves R.H.
    Genome Res. 8:940-950(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 162-205.
  6. "Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells."
    Wang O., Cai K., Pang S., Wang T., Qi D., Zhu Q., Ni Z., Le Y.
    Endocrinology 149:672-680(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold."
    Johansson P., Bernstrom J., Gorman T., Oster L., Backstrom S., Schweikart F., Xu B., Xue Y., Schiavone L.H.
    Structure 21:306-313(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 46-235, PARTIAL PROTEIN SEQUENCE, FUNCTION, GLYCOSYLATION, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiFAM3B_MOUSE
AccessioniPrimary (citable) accession number: Q9D309
Secondary accession number(s): O88417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3