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Protein

Protein FAM3B

Gene

Fam3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • insulin secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3B
Alternative name(s):
Cytokine-like protein 2-21
Pancreatic-derived factor
Short name:
PANDER
Gene namesi
Name:Fam3b
Synonyms:ORF9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1270150. Fam3b.

Subcellular locationi

  • Secreted By similarity

  • Note: Present in insulin secretory granules and likely cosecreted with insulin.By similarity

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB-KW
  • nuclear envelope lumen Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000875130 – 235Protein FAM3BAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi63 ↔ 911 Publication
Disulfide bondi69 ↔ 2291 Publication
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9D309.
PaxDbiQ9D309.
PeptideAtlasiQ9D309.
PRIDEiQ9D309.

PTM databases

PhosphoSitePlusiQ9D309.

Expressioni

Tissue specificityi

Expressed at high levels in the pancreas and, to a lesser extent, in small intestine and prostate. Also detected in stomach, testis and fetal liver. In the pancreas, localized in the islets of Langerhans; in the testis, found primarily in the round spermatids; in the CNS, found in the Purkinje cell layer of the cerebellum and in nerve cell bodies of numerous brainstem nuclei.

Inductioni

By glucose.1 Publication

Gene expression databases

BgeeiENSMUSG00000022938.
GenevisibleiQ9D309. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062006.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi62 – 64Combined sources3
Beta strandi73 – 79Combined sources7
Turni83 – 85Combined sources3
Beta strandi89 – 92Combined sources4
Beta strandi95 – 99Combined sources5
Turni100 – 103Combined sources4
Beta strandi107 – 115Combined sources9
Turni116 – 118Combined sources3
Beta strandi121 – 127Combined sources7
Beta strandi129 – 133Combined sources5
Helixi135 – 144Combined sources10
Beta strandi147 – 157Combined sources11
Helixi165 – 172Combined sources8
Turni173 – 175Combined sources3
Helixi179 – 181Combined sources3
Beta strandi187 – 196Combined sources10
Beta strandi205 – 208Combined sources4
Turni212 – 214Combined sources3
Beta strandi225 – 231Combined sources7
Turni232 – 235Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YOPX-ray2.30A/B/C46-235[»]
2YOQX-ray2.35A/B/C30-235[»]
ProteinModelPortaliQ9D309.
SMRiQ9D309.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJKD. Eukaryota.
ENOG4111GER. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG099991.
InParanoidiQ9D309.
OMAiCDHWSPC.
OrthoDBiEOG091G0JEF.
PhylomeDBiQ9D309.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D309-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPVATGIFK ALVFIFSSLC AWYSGYLLAE LIPDVPLSST LYNIRSIGER
60 70 80 90 100
PVLKAPAPKR QKCDHWSPCP PDTYAYRLLS GGGRDKYAKI CFEDEVLIGE
110 120 130 140 150
KTGNVARGIN IAVVNYETGK VIATKYFDMY EGDNSGPMAK FIQSTPSKSL
160 170 180 190 200
LFMVTHDDGS SKLKAQAKDA IEALGSKEIK NMKFRSSWVF VAAKGFELPS
210 220 230
EIEREKINHS DQSRNRYAGW PAEIQIEGCI PKGLR
Length:235
Mass (Da):26,152
Last modified:June 1, 2001 - v1
Checksum:i2539E5ED009D9C3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti162K → R in AAC21456 (PubMed:9750193).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494380 mRNA. Translation: AAM94281.1.
AK018571 mRNA. Translation: BAB31283.1.
AF360358 mRNA. Translation: AAL34461.1.
BC048949 mRNA. Translation: AAH48949.1.
AF045953 Genomic DNA. Translation: AAC21456.1.
CCDSiCCDS37416.1.
RefSeqiNP_065647.1. NM_020622.2.
UniGeneiMm.327932.

Genome annotation databases

EnsembliENSMUST00000049721; ENSMUSP00000062006; ENSMUSG00000022938.
GeneIDi52793.
KEGGimmu:52793.
UCSCiuc008adj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494380 mRNA. Translation: AAM94281.1.
AK018571 mRNA. Translation: BAB31283.1.
AF360358 mRNA. Translation: AAL34461.1.
BC048949 mRNA. Translation: AAH48949.1.
AF045953 Genomic DNA. Translation: AAC21456.1.
CCDSiCCDS37416.1.
RefSeqiNP_065647.1. NM_020622.2.
UniGeneiMm.327932.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YOPX-ray2.30A/B/C46-235[»]
2YOQX-ray2.35A/B/C30-235[»]
ProteinModelPortaliQ9D309.
SMRiQ9D309.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000062006.

PTM databases

PhosphoSitePlusiQ9D309.

Proteomic databases

MaxQBiQ9D309.
PaxDbiQ9D309.
PeptideAtlasiQ9D309.
PRIDEiQ9D309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049721; ENSMUSP00000062006; ENSMUSG00000022938.
GeneIDi52793.
KEGGimmu:52793.
UCSCiuc008adj.1. mouse.

Organism-specific databases

CTDi54097.
MGIiMGI:1270150. Fam3b.

Phylogenomic databases

eggNOGiENOG410IJKD. Eukaryota.
ENOG4111GER. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG099991.
InParanoidiQ9D309.
OMAiCDHWSPC.
OrthoDBiEOG091G0JEF.
PhylomeDBiQ9D309.
TreeFamiTF353414.

Miscellaneous databases

ChiTaRSiFam3b. mouse.
PROiQ9D309.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022938.
GenevisibleiQ9D309. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiFAM3B_MOUSE
AccessioniPrimary (citable) accession number: Q9D309
Secondary accession number(s): O88417
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

It is unclear whether the N-terminus residue of the mature protein is Glu-30 or Ser-46.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.