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Protein

Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

Gene

Mgat4c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity).By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 3-(2,4-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

Cofactori

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-975577. N-Glycan antennae elongation.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT54. Glycosyltransferase Family 54.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C (EC:2.4.1.145)
Alternative name(s):
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc
Short name:
GnT-IVc
Short name:
N-acetylglucosaminyltransferase IVc
UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc
Gene namesi
Name:Mgat4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914819. Mgat4c.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence analysisAdd
BLAST
Transmembranei26 – 4318Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini44 – 478435LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase CPRO_0000288598Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9D306.
PaxDbiQ9D306.
PRIDEiQ9D306.

PTM databases

PhosphoSiteiQ9D306.

Expressioni

Gene expression databases

BgeeiQ9D306.
ExpressionAtlasiQ9D306. baseline and differential.
GenevisibleiQ9D306. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020039.

Structurei

3D structure databases

ProteinModelPortaliQ9D306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 54 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II76. Eukaryota.
ENOG410XPSP. LUCA.
GeneTreeiENSGT00550000074578.
HOGENOMiHOG000070065.
HOVERGENiHBG103174.
InParanoidiQ9D306.
KOiK13748.
OMAiVMVQDIT.
PhylomeDBiQ9D306.
TreeFamiTF324570.

Family and domain databases

InterProiIPR006759. Glyco_transf_54.
[Graphical view]
PANTHERiPTHR12062. PTHR12062. 1 hit.
PfamiPF04666. Glyco_transf_54. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D306-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFYQMKYI FQILDKMRCL RKRSTVSFLG VLVVFLLFMN LYIEDSYVLE
60 70 80 90 100
GDKQLIRETS THQLNSERYV HTFKDLSNFS GTINVTYRYL AATPLQRKRY
110 120 130 140 150
LTIGLSSVKR KKGNYLLDTI KSIFEQSSYE ELKEISVVVH LADFNSSWRD
160 170 180 190 200
AMVQDITQKF AHHIIAGRLM VIHAPEEYYP VLDGLKRNYN DPEDRVRFRS
210 220 230 240 250
KQNVDYAFLL NFCANTSDYY VMLEDDVRCS RNFLTAIKKV IASLEGTYWV
260 270 280 290 300
TLEFSKLGYI GKLYHSHDLP RLAHFLLMFY QEMPCDWLLT HFRGLLAQKN
310 320 330 340 350
VIRFKPSLFQ HMGYYSSYKG TENKLKDDDF EEESFDIPDN PPASFYTNMN
360 370 380 390 400
VFENYEASKA YSSVDEYFWG KSPSMGDTFV IVFENPITIK KIKVNTGTED
410 420 430 440 450
RQNDILQHGA LDVGEKLIFS KQIRQCDTYL RLGEFKNGYF EMSDVNQKIP
460 470
FDIHCMRICV TKTQKEWLII RSISIWTS
Length:478
Mass (Da):56,250
Last modified:June 1, 2001 - v1
Checksum:iEC8EC991A802F1BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018574 mRNA. Translation: BAB31286.1.
AK018672 mRNA. Translation: BAB31336.1.
AK033482 mRNA. Translation: BAC28312.1.
BC046987 mRNA. Translation: AAH46987.1.
CCDSiCCDS24153.1.
RefSeqiNP_001155840.1. NM_001162368.1.
NP_001155841.1. NM_001162369.1.
NP_001192027.1. NM_001205098.1.
NP_080519.2. NM_026243.4.
XP_006514065.1. XM_006514002.1.
XP_006514066.1. XM_006514003.1.
XP_006514067.1. XM_006514004.2.
XP_006514068.1. XM_006514005.1.
XP_011241840.1. XM_011243538.1.
XP_011241841.1. XM_011243539.1.
UniGeneiMm.25252.
Mm.403713.

Genome annotation databases

EnsembliENSMUST00000020039; ENSMUSP00000020039; ENSMUSG00000019888.
ENSMUST00000120748; ENSMUSP00000114010; ENSMUSG00000019888.
ENSMUST00000163753; ENSMUSP00000131551; ENSMUSG00000019888.
ENSMUST00000179929; ENSMUSP00000135959; ENSMUSG00000019888.
GeneIDi67569.
KEGGimmu:67569.
UCSCiuc007gyc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018574 mRNA. Translation: BAB31286.1.
AK018672 mRNA. Translation: BAB31336.1.
AK033482 mRNA. Translation: BAC28312.1.
BC046987 mRNA. Translation: AAH46987.1.
CCDSiCCDS24153.1.
RefSeqiNP_001155840.1. NM_001162368.1.
NP_001155841.1. NM_001162369.1.
NP_001192027.1. NM_001205098.1.
NP_080519.2. NM_026243.4.
XP_006514065.1. XM_006514002.1.
XP_006514066.1. XM_006514003.1.
XP_006514067.1. XM_006514004.2.
XP_006514068.1. XM_006514005.1.
XP_011241840.1. XM_011243538.1.
XP_011241841.1. XM_011243539.1.
UniGeneiMm.25252.
Mm.403713.

3D structure databases

ProteinModelPortaliQ9D306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020039.

Protein family/group databases

CAZyiGT54. Glycosyltransferase Family 54.

PTM databases

PhosphoSiteiQ9D306.

Proteomic databases

MaxQBiQ9D306.
PaxDbiQ9D306.
PRIDEiQ9D306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020039; ENSMUSP00000020039; ENSMUSG00000019888.
ENSMUST00000120748; ENSMUSP00000114010; ENSMUSG00000019888.
ENSMUST00000163753; ENSMUSP00000131551; ENSMUSG00000019888.
ENSMUST00000179929; ENSMUSP00000135959; ENSMUSG00000019888.
GeneIDi67569.
KEGGimmu:67569.
UCSCiuc007gyc.2. mouse.

Organism-specific databases

CTDi25834.
MGIiMGI:1914819. Mgat4c.

Phylogenomic databases

eggNOGiENOG410II76. Eukaryota.
ENOG410XPSP. LUCA.
GeneTreeiENSGT00550000074578.
HOGENOMiHOG000070065.
HOVERGENiHBG103174.
InParanoidiQ9D306.
KOiK13748.
OMAiVMVQDIT.
PhylomeDBiQ9D306.
TreeFamiTF324570.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-MMU-975577. N-Glycan antennae elongation.

Miscellaneous databases

PROiQ9D306.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D306.
ExpressionAtlasiQ9D306. baseline and differential.
GenevisibleiQ9D306. MM.

Family and domain databases

InterProiIPR006759. Glyco_transf_54.
[Graphical view]
PANTHERiPTHR12062. PTHR12062. 1 hit.
PfamiPF04666. Glyco_transf_54. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Colon.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiMGT4C_MOUSE
AccessioniPrimary (citable) accession number: Q9D306
Secondary accession number(s): Q9D2X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.