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Protein

Kinesin-like protein KIF12

Gene

Kif12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1118ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF12
Gene namesi
Name:Kif12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098232. Kif12.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: MGI
  • microtubule Source: UniProtKB-KW
  • microtubule organizing center Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Kinesin-like protein KIF12PRO_0000125445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity
Modified residuei369 – 3691PhosphoserineCombined sources
Modified residuei634 – 6341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2Z8.
PRIDEiQ9D2Z8.

PTM databases

iPTMnetiQ9D2Z8.
PhosphoSiteiQ9D2Z8.

Expressioni

Gene expression databases

BgeeiQ9D2Z8.
CleanExiMM_KIF12.
GenevisibleiQ9D2Z8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030042.

Structurei

3D structure databases

ProteinModelPortaliQ9D2Z8.
SMRiQ9D2Z8. Positions 25-364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 360336Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili376 – 46590Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi469 – 55486Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00810000125470.
HOGENOMiHOG000049053.
HOVERGENiHBG052248.
InParanoidiQ9D2Z8.
KOiK10399.
OMAiPLAHWAC.
OrthoDBiEOG725DJ5.
PhylomeDBiQ9D2Z8.
TreeFamiTF324584.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR028763. Kif12.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF418. PTHR24115:SF418. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERGSPDGD PARNLEQGPE GSETPIQVVL RVRPMSTVEL RRGEQSALHC
60 70 80 90 100
SGTRTLQVSP DVAFRFGAVL DGARTQEDVF RACGVKRLGE LALRGFSCTV
110 120 130 140 150
FTFGQTGSGK TYTLTGPPPQ GEGVPVPPSL AGIMQRTFTW LLDRVQHLDS
160 170 180 190 200
PVTLRASYLE IYNEQVWDLL SLGSPRPLPV RWTKARGFYV EQLRVVEFGS
210 220 230 240 250
LEALMELLQM GLSRRRSSSH TLNQASSRSH ALLTLHISRP TSQQVPPVDL
260 270 280 290 300
GEPPVGGKLC FVDLAGSEKV AATGSQGQLM LEANSINRSL LALGHCISLL
310 320 330 340 350
LDPQRKQNHI PFRDSKLTKL LADSLGGRGV TLMVACVSPS AQCLPETLST
360 370 380 390 400
LRYASRAQRI TTRPQGPKSP GVKPPQQVEN ELLRLQEENR HLRFQLDQMH
410 420 430 440 450
TTAPGAHGAR MAWAQRNLYG MLQEFMLENE RLRKEMRQLR SSRDLARAEQ
460 470 480 490 500
RVLAQQVHDL ERRLLSACPL PQQGSTPVCP CRMVPAASCH ALPPLCYCHH
510 520 530 540 550
FCPLCRVPLA HWTCPRRECH MPQVLEPEAP GHISQSVWPP PWAPPPSPGS
560 570 580 590 600
AKPPRERSQS DWTQTRVLAE MLMGEEVVPS APPLSAGPSN MPYGLRGGSG
610 620 630 640
IPNLTPRLET LTQQINSSLH LSQRQPQPSE DTQSPGQGLS SC
Length:642
Mass (Da):70,706
Last modified:June 1, 2001 - v1
Checksum:i57D3F37B759EE31F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1034VFTF → IFAY in BAA22388 (PubMed:9275178).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018598 mRNA. Translation: BAB31300.1.
AL691496 Genomic DNA. Translation: CAD83045.1.
AB001428 mRNA. Translation: BAA22388.1.
CCDSiCCDS18249.1.
RefSeqiNP_034746.1. NM_010616.3.
UniGeneiMm.216057.

Genome annotation databases

EnsembliENSMUST00000030042; ENSMUSP00000030042; ENSMUSG00000028357.
GeneIDi16552.
KEGGimmu:16552.
UCSCiuc008tfq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018598 mRNA. Translation: BAB31300.1.
AL691496 Genomic DNA. Translation: CAD83045.1.
AB001428 mRNA. Translation: BAA22388.1.
CCDSiCCDS18249.1.
RefSeqiNP_034746.1. NM_010616.3.
UniGeneiMm.216057.

3D structure databases

ProteinModelPortaliQ9D2Z8.
SMRiQ9D2Z8. Positions 25-364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030042.

PTM databases

iPTMnetiQ9D2Z8.
PhosphoSiteiQ9D2Z8.

Proteomic databases

PaxDbiQ9D2Z8.
PRIDEiQ9D2Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030042; ENSMUSP00000030042; ENSMUSG00000028357.
GeneIDi16552.
KEGGimmu:16552.
UCSCiuc008tfq.1. mouse.

Organism-specific databases

CTDi113220.
MGIiMGI:1098232. Kif12.

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00810000125470.
HOGENOMiHOG000049053.
HOVERGENiHBG052248.
InParanoidiQ9D2Z8.
KOiK10399.
OMAiPLAHWAC.
OrthoDBiEOG725DJ5.
PhylomeDBiQ9D2Z8.
TreeFamiTF324584.

Miscellaneous databases

PROiQ9D2Z8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D2Z8.
CleanExiMM_KIF12.
GenevisibleiQ9D2Z8. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR028763. Kif12.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PTHR24115:SF418. PTHR24115:SF418. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  2. Matthews L.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-268.
    Strain: ICR.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-369, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiKIF12_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Z8
Secondary accession number(s): O35061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.