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Protein

Kinesin-like protein KIF12

Gene

Kif12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 111ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF12
Gene namesi
Name:Kif12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1098232 Kif12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001254451 – 642Kinesin-like protein KIF12Add BLAST642

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei369PhosphoserineCombined sources1
Modified residuei634PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2Z8
PRIDEiQ9D2Z8

PTM databases

iPTMnetiQ9D2Z8
PhosphoSitePlusiQ9D2Z8

Expressioni

Gene expression databases

BgeeiENSMUSG00000028357
CleanExiMM_KIF12
ExpressionAtlasiQ9D2Z8 baseline and differential
GenevisibleiQ9D2Z8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030042

Structurei

3D structure databases

ProteinModelPortaliQ9D2Z8
SMRiQ9D2Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 360Kinesin motorPROSITE-ProRule annotationAdd BLAST336

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili376 – 465Sequence analysisAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi469 – 554Pro-richAdd BLAST86

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000144010
HOGENOMiHOG000049053
HOVERGENiHBG052248
InParanoidiQ9D2Z8
KOiK10399
OMAiERSHSDW
OrthoDBiEOG091G0SNP
PhylomeDBiQ9D2Z8
TreeFamiTF324584

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR028763 Kif12
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF418 PTHR24115:SF418, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D2Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEERGSPDGD PARNLEQGPE GSETPIQVVL RVRPMSTVEL RRGEQSALHC
60 70 80 90 100
SGTRTLQVSP DVAFRFGAVL DGARTQEDVF RACGVKRLGE LALRGFSCTV
110 120 130 140 150
FTFGQTGSGK TYTLTGPPPQ GEGVPVPPSL AGIMQRTFTW LLDRVQHLDS
160 170 180 190 200
PVTLRASYLE IYNEQVWDLL SLGSPRPLPV RWTKARGFYV EQLRVVEFGS
210 220 230 240 250
LEALMELLQM GLSRRRSSSH TLNQASSRSH ALLTLHISRP TSQQVPPVDL
260 270 280 290 300
GEPPVGGKLC FVDLAGSEKV AATGSQGQLM LEANSINRSL LALGHCISLL
310 320 330 340 350
LDPQRKQNHI PFRDSKLTKL LADSLGGRGV TLMVACVSPS AQCLPETLST
360 370 380 390 400
LRYASRAQRI TTRPQGPKSP GVKPPQQVEN ELLRLQEENR HLRFQLDQMH
410 420 430 440 450
TTAPGAHGAR MAWAQRNLYG MLQEFMLENE RLRKEMRQLR SSRDLARAEQ
460 470 480 490 500
RVLAQQVHDL ERRLLSACPL PQQGSTPVCP CRMVPAASCH ALPPLCYCHH
510 520 530 540 550
FCPLCRVPLA HWTCPRRECH MPQVLEPEAP GHISQSVWPP PWAPPPSPGS
560 570 580 590 600
AKPPRERSQS DWTQTRVLAE MLMGEEVVPS APPLSAGPSN MPYGLRGGSG
610 620 630 640
IPNLTPRLET LTQQINSSLH LSQRQPQPSE DTQSPGQGLS SC
Length:642
Mass (Da):70,706
Last modified:June 1, 2001 - v1
Checksum:i57D3F37B759EE31F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100 – 103VFTF → IFAY in BAA22388 (PubMed:9275178).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018598 mRNA Translation: BAB31300.1
AL691496 Genomic DNA No translation available.
AB001428 mRNA Translation: BAA22388.1
CCDSiCCDS18249.1
RefSeqiNP_034746.1, NM_010616.3
UniGeneiMm.216057

Genome annotation databases

EnsembliENSMUST00000030042; ENSMUSP00000030042; ENSMUSG00000028357
GeneIDi16552
KEGGimmu:16552
UCSCiuc008tfq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKIF12_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Z8
Secondary accession number(s): O35061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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