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Protein

Elongation of very long chain fatty acids protein 7

Gene

Elovl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-75876. Synthesis of very long-chain fatty acyl-CoAs.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 7UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity)
Alternative name(s):
3-keto acyl-CoA synthase Elovl7UniRule annotation
ELOVL fatty acid elongase 7UniRule annotation
Short name:
ELOVL FA elongase 7UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 7UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 7UniRule annotation
Gene namesi
Name:Elovl7UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1921809. Elovl7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei143 – 162HelicalUniRule annotationAdd BLAST20
Transmembranei172 – 194HelicalUniRule annotationAdd BLAST23
Transmembranei207 – 227HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 257HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119891 – 281Elongation of very long chain fatty acids protein 7Add BLAST281

Proteomic databases

MaxQBiQ9D2Y9.
PaxDbiQ9D2Y9.
PRIDEiQ9D2Y9.

PTM databases

PhosphoSitePlusiQ9D2Y9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021696.
GenevisibleiQ9D2Y9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022207.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 281Di-lysine motifUniRule annotation5

Domaini

The C-terminal di-lysine motif may confer endoplasmic reticulum localization.UniRule annotation

Sequence similaritiesi

Belongs to the ELO family. ELOVL7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3071. Eukaryota.
ENOG410XRWT. LUCA.
GeneTreeiENSGT00760000119122.
HOGENOMiHOG000038120.
HOVERGENiHBG051468.
InParanoidiQ9D2Y9.
KOiK10250.
OMAiFRECDYP.
OrthoDBiEOG091G0N2V.
PhylomeDBiQ9D2Y9.
TreeFamiTF323454.

Family and domain databases

HAMAPiMF_03207. VLCF_elongase_7. 1 hit.
InterProiView protein in InterPro
IPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033670. ELOVL7.
PANTHERiPTHR11157. PTHR11157. 1 hit.
PfamiView protein in Pfam
PF01151. ELO. 1 hit.
PROSITEiView protein in PROSITE
PS01188. ELO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D2Y9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSDLTSRT VRFYDNWIKD ADPRVEDYLL MSSPLPQTII LGLYVYFVTS
60 70 80 90 100
LGPKLMENRK PFELKKAMIT YNFFIVLFSV YMCYEFVMSG WGTGYSFRCD
110 120 130 140 150
IVDYSQSPRA MRMVHTCWLY YFSKFIELLD TIFFVLRKKN SQVTFLHVFH
160 170 180 190 200
HTIMPWTWWF GVKFAAGGLG TFHAFLNTAV HVVMYSYYGL CAMGPAYQKY
210 220 230 240 250
LWWKKHLTSL QLVQFVLVTI HIGQIFFMED CNYQYPVFLY IIMSYGCIFL
260 270 280
LLFLHFWYRA YTKGQRLPKT LENGNCKSKR H
Length:281
Mass (Da):33,479
Last modified:June 1, 2001 - v1
Checksum:i025B3239F29BCB90
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25V → F in BAC29727 (PubMed:16141072).Curated1
Sequence conflicti249F → S in BAC33552 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018616 mRNA. Translation: BAB31310.1.
AK037162 mRNA. Translation: BAC29727.1.
AK049118 mRNA. Translation: BAC33552.1.
AK137668 mRNA. Translation: BAE23454.1.
BC005602 mRNA. Translation: AAH05602.1.
CCDSiCCDS36779.1.
RefSeqiNP_083277.3. NM_029001.5.
UniGeneiMm.286127.

Genome annotation databases

EnsembliENSMUST00000022207; ENSMUSP00000022207; ENSMUSG00000021696.
GeneIDi74559.
KEGGimmu:74559.
UCSCiuc007rva.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiELOV7_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Y9
Secondary accession number(s): Q8BX38, Q8BYY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families