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Protein

F-box only protein 25

Gene

Fbxo25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).2 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • protein ubiquitination Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 25
Gene namesi
Name:Fbxo25
Synonyms:Fbx25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914072. Fbxo25.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357F-box only protein 25PRO_0000119912Add
BLAST

Proteomic databases

MaxQBiQ9D2Y6.
PaxDbiQ9D2Y6.
PRIDEiQ9D2Y6.

PTM databases

iPTMnetiQ9D2Y6.
PhosphoSiteiQ9D2Y6.

Expressioni

Tissue specificityi

Expressded in all tissues tested, except striated muscle (at protein level). Expressed predominanltly in the cerebral cortex, the hippocampus and the Purkinje cell layer of the brain. Intestine and kidney show also significant levels.3 Publications

Developmental stagei

Expressed in neuronal tissues of E14.5 mice.1 Publication

Gene expression databases

BgeeiENSMUSG00000038365.
CleanExiMM_FBXO25.
GenevisibleiQ9D2Y6. MM.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1 and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus) (By similarity).By similarity

Protein-protein interaction databases

BioGridi211742. 2 interactions.
STRINGi10090.ENSMUSP00000039544.

Structurei

3D structure databases

ProteinModelPortaliQ9D2Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 27349F-boxAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8383Interaction with beta-actinBy similarityAdd
BLAST

Domaini

The F-box is necessary for the interaction with SKP1.

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiKOG3926. Eukaryota.
ENOG410YPWK. LUCA.
GeneTreeiENSGT00390000004915.
HOGENOMiHOG000263478.
HOVERGENiHBG051572.
InParanoidiQ9D2Y6.
KOiK10305.
OMAiMPVSPQH.
OrthoDBiEOG091G0M92.
PhylomeDBiQ9D2Y6.
TreeFamiTF313070.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D2Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLGQDWRS PGWSWIKTED GWKRCDPCSH ELRSEDSQYT INHSIILNSG
60 70 80 90 100
EEEIFNNECE YAAKKRKKEH FGNDTAAHSF YREKWIYVHK ESTKERHGYC
110 120 130 140 150
TLGEAFNRLD FSSAIQDIRR FTYVVKLLQL IAKSQLTSLS GVAQKNYFNI
160 170 180 190 200
LDKIVQKVLD DHQNPRLIKG LLQDLSSTLG ILVRGVGKSV LVGNINIWIC
210 220 230 240 250
RLETVLSWQQ QLQNLQVTKQ VNTGLTLSDL PLHMLNNILY RFSDGWDIVT
260 270 280 290 300
LGQVTPTLYM LSEDRRLWKR LCQYHFAEQQ FCRHLILSEK GHIEWKLMYF
310 320 330 340 350
TLQKYYPTKE QYGDTLHFCR HCSILFWKDS GHPCTAADPD SCFTPVSPEH

FIDLFKF
Length:357
Mass (Da):41,826
Last modified:June 1, 2001 - v1
Checksum:iC262131D76036ADD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti237 – 2371N → K in BAB25418 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008027 mRNA. Translation: BAB25418.1.
AK018626 mRNA. Translation: BAB31315.1.
BC014749 mRNA. Translation: AAH14749.1.
CCDSiCCDS22118.1.
RefSeqiNP_080061.1. NM_025785.2.
UniGeneiMm.37950.

Genome annotation databases

EnsembliENSMUST00000043520; ENSMUSP00000039544; ENSMUSG00000038365.
GeneIDi66822.
KEGGimmu:66822.
UCSCiuc009kys.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008027 mRNA. Translation: BAB25418.1.
AK018626 mRNA. Translation: BAB31315.1.
BC014749 mRNA. Translation: AAH14749.1.
CCDSiCCDS22118.1.
RefSeqiNP_080061.1. NM_025785.2.
UniGeneiMm.37950.

3D structure databases

ProteinModelPortaliQ9D2Y6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211742. 2 interactions.
STRINGi10090.ENSMUSP00000039544.

PTM databases

iPTMnetiQ9D2Y6.
PhosphoSiteiQ9D2Y6.

Proteomic databases

MaxQBiQ9D2Y6.
PaxDbiQ9D2Y6.
PRIDEiQ9D2Y6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043520; ENSMUSP00000039544; ENSMUSG00000038365.
GeneIDi66822.
KEGGimmu:66822.
UCSCiuc009kys.1. mouse.

Organism-specific databases

CTDi26260.
MGIiMGI:1914072. Fbxo25.

Phylogenomic databases

eggNOGiKOG3926. Eukaryota.
ENOG410YPWK. LUCA.
GeneTreeiENSGT00390000004915.
HOGENOMiHOG000263478.
HOVERGENiHBG051572.
InParanoidiQ9D2Y6.
KOiK10305.
OMAiMPVSPQH.
OrthoDBiEOG091G0M92.
PhylomeDBiQ9D2Y6.
TreeFamiTF313070.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ9D2Y6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038365.
CleanExiMM_FBXO25.
GenevisibleiQ9D2Y6. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFBX25_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Y6
Secondary accession number(s): Q9D8H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.