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Protein

MAU2 chromatid cohesion factor homolog

Gene

Mau2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through prometaphase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Enzyme and pathway databases

ReactomeiR-MMU-2470946. Cohesin Loading onto Chromatin.

Names & Taxonomyi

Protein namesi
Recommended name:
MAU2 chromatid cohesion factor homolog
Short name:
MAU-2
Alternative name(s):
Cohesin loading complex subunit SCC4 homolog
Gene namesi
Name:Mau2
Synonyms:Kiaa0892
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1921799. Mau2.

Subcellular locationi

  • Nucleusnucleoplasm By similarity

  • Note: Binds to chromatin from the end of mitosis until prophase.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619MAU2 chromatid cohesion factor homologPRO_0000254549Add
BLAST

Proteomic databases

EPDiQ9D2X5.
MaxQBiQ9D2X5.
PaxDbiQ9D2X5.
PRIDEiQ9D2X5.

PTM databases

iPTMnetiQ9D2X5.
PhosphoSiteiQ9D2X5.

Expressioni

Gene expression databases

BgeeiQ9D2X5.
CleanExiMM_9130404D08RIK.
ExpressionAtlasiQ9D2X5. baseline and differential.
GenevisibleiQ9D2X5. MM.

Interactioni

Subunit structurei

Interacts (via N-terminus) with NIPBL to form the cohesin loading complex.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216835. 10 interactions.
IntActiQ9D2X5. 11 interactions.
STRINGi10090.ENSMUSP00000054763.

Structurei

3D structure databases

ProteinModelPortaliQ9D2X5.
SMRiQ9D2X5. Positions 114-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati113 – 14634TPR 1Add
BLAST
Repeati385 – 41834TPR 2Add
BLAST
Repeati465 – 49834TPR 3Add
BLAST
Repeati505 – 53834TPR 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 121121Sufficient for interaction with NIPBLBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SCC4/mau-2 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2300. Eukaryota.
ENOG410XSAK. LUCA.
GeneTreeiENSGT00390000012198.
InParanoidiQ9D2X5.
KOiK11266.
OrthoDBiEOG7V49XZ.
PhylomeDBiQ9D2X5.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019440. MAU2.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR21394. PTHR21394. 1 hit.
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2X5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAQAAAAAQ AAAAAQAAAA QAAQAEAAES WYLALLGFAE HFRTSSPPKI
60 70 80 90 100
RLCVHCLQAV FPFKPPQRIE ARTHLQLGSV LYHHTKNSEQ ARSHLEKAWL
110 120 130 140 150
ISQQIPQFED VKFEAASLLS ELYCQENSVD AAKPLLRKAI QISQQTPYWH
160 170 180 190 200
CRLLFQLAQL HTLEKDLVSA CDLLGVGAEY ARVVGSEYTR ALFLLSKGML
210 220 230 240 250
LLMERKLQEV HPLLTLCGQI VENWQGNPIQ KESLRVFFLV LQVTHYLDAG
260 270 280 290 300
QVKSVKPCLK QLQQCIQTIS TLHDDEILPS NPADLFHWLP KEHMCVLVYL
310 320 330 340 350
VTVMHSMQAG YLEKAQKYTD KALMQLEKLK MLDCSPILSS FQVILLEHII
360 370 380 390 400
MCRLVTGHKA TALQEISQVC QLCQQSPRLF SNHAAQLHTL LGLYCVSVNC
410 420 430 440 450
MDNAEAQFTT ALRLTNHQEL WAFIVTNLAS VYIREGNRHQ EVLYSLLERI
460 470 480 490 500
NPDHSFPVSS HCLRAAAFYV RGLFSFFQGR YNEAKRFLRE TLKMSNAEDL
510 520 530 540 550
NRLTACSLVL LGHIFYVLGN HRESNNMVVP AMQLASKIPD MSVQLWSSAL
560 570 580 590 600
LRDLNKACGN AMDAHEAAQM HQNFSQQLLQ DHIEACSLPE HNLITWTDGP
610
PPVQFQAQNG PNTSLASLL
Length:619
Mass (Da):69,579
Last modified:September 1, 2009 - v3
Checksum:i27D2FF1AE5E9337D
GO
Isoform 2 (identifier: Q9D2X5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     442-442: Missing.

Show »
Length:618
Mass (Da):69,480
Checksum:i3F4F54D913413B69
GO

Sequence cautioni

The sequence AAH23401.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti308 – 3081Q → H in BAC33653 (PubMed:16141072).Curated
Sequence conflicti325 – 3251Q → R in BAC38382 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei442 – 4421Missing in isoform 2. 2 PublicationsVSP_037924

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018662 mRNA. Translation: BAB31331.2.
AK049277 mRNA. Translation: BAC33653.1.
AK081967 mRNA. Translation: BAC38382.1.
BC023401 mRNA. Translation: AAH23401.1. Different initiation.
BC125568 mRNA. Translation: AAI25569.1.
BC132139 mRNA. Translation: AAI32140.1.
BC144990 mRNA. Translation: AAI44991.1.
AK220358 mRNA. Translation: BAD90246.1.
CCDSiCCDS40364.1. [Q9D2X5-2]
RefSeqiNP_001161411.1. NM_001167939.1.
NP_083269.4. NM_028993.4. [Q9D2X5-2]
XP_006509839.1. XM_006509776.2. [Q9D2X5-1]
UniGeneiMm.269061.

Genome annotation databases

EnsembliENSMUST00000050561; ENSMUSP00000054763; ENSMUSG00000031858. [Q9D2X5-2]
GeneIDi74549.
KEGGimmu:74549.
UCSCiuc009lyj.2. mouse. [Q9D2X5-1]
uc009lyk.2. mouse. [Q9D2X5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018662 mRNA. Translation: BAB31331.2.
AK049277 mRNA. Translation: BAC33653.1.
AK081967 mRNA. Translation: BAC38382.1.
BC023401 mRNA. Translation: AAH23401.1. Different initiation.
BC125568 mRNA. Translation: AAI25569.1.
BC132139 mRNA. Translation: AAI32140.1.
BC144990 mRNA. Translation: AAI44991.1.
AK220358 mRNA. Translation: BAD90246.1.
CCDSiCCDS40364.1. [Q9D2X5-2]
RefSeqiNP_001161411.1. NM_001167939.1.
NP_083269.4. NM_028993.4. [Q9D2X5-2]
XP_006509839.1. XM_006509776.2. [Q9D2X5-1]
UniGeneiMm.269061.

3D structure databases

ProteinModelPortaliQ9D2X5.
SMRiQ9D2X5. Positions 114-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216835. 10 interactions.
IntActiQ9D2X5. 11 interactions.
STRINGi10090.ENSMUSP00000054763.

PTM databases

iPTMnetiQ9D2X5.
PhosphoSiteiQ9D2X5.

Proteomic databases

EPDiQ9D2X5.
MaxQBiQ9D2X5.
PaxDbiQ9D2X5.
PRIDEiQ9D2X5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050561; ENSMUSP00000054763; ENSMUSG00000031858. [Q9D2X5-2]
GeneIDi74549.
KEGGimmu:74549.
UCSCiuc009lyj.2. mouse. [Q9D2X5-1]
uc009lyk.2. mouse. [Q9D2X5-2]

Organism-specific databases

CTDi23383.
MGIiMGI:1921799. Mau2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2300. Eukaryota.
ENOG410XSAK. LUCA.
GeneTreeiENSGT00390000012198.
InParanoidiQ9D2X5.
KOiK11266.
OrthoDBiEOG7V49XZ.
PhylomeDBiQ9D2X5.

Enzyme and pathway databases

ReactomeiR-MMU-2470946. Cohesin Loading onto Chromatin.

Miscellaneous databases

ChiTaRSiMau2. mouse.
PROiQ9D2X5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9D2X5.
CleanExiMM_9130404D08RIK.
ExpressionAtlasiQ9D2X5. baseline and differential.
GenevisibleiQ9D2X5. MM.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019440. MAU2.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PANTHERiPTHR21394. PTHR21394. 1 hit.
PfamiPF10345. Cohesin_load. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 3 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Brain, Cecum and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Brain and Kidney.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 502-619 (ISOFORMS 1/2).
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiSCC4_MOUSE
AccessioniPrimary (citable) accession number: Q9D2X5
Secondary accession number(s): B7ZN38
, Q059Q4, Q5DU12, Q78IR4, Q8BUW9, Q8BX04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: September 1, 2009
Last modified: June 8, 2016
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.