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Q9D2W0

- FXYD4_MOUSE

UniProt

Q9D2W0 - FXYD4_MOUSE

Protein

FXYD domain-containing ion transport regulator 4

Gene

Fxyd4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. ATPase binding Source: MGI
    2. potassium channel activity Source: Ensembl

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FXYD domain-containing ion transport regulator 4
    Alternative name(s):
    Channel-inducing factor
    Short name:
    CHIF
    Gene namesi
    Name:Fxyd4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1889005. Fxyd4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 8868FXYD domain-containing ion transport regulator 4PRO_0000010367Add
    BLAST

    Proteomic databases

    PRIDEiQ9D2W0.

    PTM databases

    PhosphoSiteiQ9D2W0.

    Expressioni

    Gene expression databases

    BgeeiQ9D2W0.
    CleanExiMM_FXYD4.
    GenevestigatoriQ9D2W0.

    Interactioni

    Protein-protein interaction databases

    BioGridi223770. 1 interaction.
    STRINGi10090.ENSMUSP00000005114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9D2W0.
    SMRiQ9D2W0. Positions 23-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 3818ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini60 – 8829CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FXYD family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39705.
    GeneTreeiENSGT00530000063998.
    HOGENOMiHOG000234469.
    HOVERGENiHBG008212.
    InParanoidiQ9D2W0.
    KOiK13359.
    OMAiPGSASTC.
    OrthoDBiEOG7DNNXZ.
    PhylomeDBiQ9D2W0.
    TreeFamiTF333443.

    Family and domain databases

    InterProiIPR000272. Ion-transport_regulator_FXYD.
    [Graphical view]
    PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
    [Graphical view]
    ProDomiPD005989. PD005989. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS01310. FXYD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9D2W0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEITCAFLL LLAGLPALEA SDPVDKDSPF YYDWESLQLG GLIFGGLLCI   50
    AGIAMALSGK CKCRRTHKPS SLPGKATPLI IPGSANTC 88
    Length:88
    Mass (Da):9,269
    Last modified:June 1, 2001 - v1
    Checksum:i7EB0140941CFE926
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF362729 Genomic DNA. Translation: AAK51508.1.
    AK018728 mRNA. Translation: BAB31372.1.
    BC086918 mRNA. Translation: AAH86918.1.
    CCDSiCCDS20468.1.
    RefSeqiNP_001166843.1. NM_001173372.1.
    NP_387468.1. NM_033648.1.
    XP_006505358.1. XM_006505295.1.
    UniGeneiMm.250392.

    Genome annotation databases

    EnsembliENSMUST00000005114; ENSMUSP00000005114; ENSMUSG00000004988.
    GeneIDi108017.
    KEGGimmu:108017.
    UCSCiuc009dlh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF362729 Genomic DNA. Translation: AAK51508.1 .
    AK018728 mRNA. Translation: BAB31372.1 .
    BC086918 mRNA. Translation: AAH86918.1 .
    CCDSi CCDS20468.1.
    RefSeqi NP_001166843.1. NM_001173372.1.
    NP_387468.1. NM_033648.1.
    XP_006505358.1. XM_006505295.1.
    UniGenei Mm.250392.

    3D structure databases

    ProteinModelPortali Q9D2W0.
    SMRi Q9D2W0. Positions 23-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223770. 1 interaction.
    STRINGi 10090.ENSMUSP00000005114.

    PTM databases

    PhosphoSitei Q9D2W0.

    Proteomic databases

    PRIDEi Q9D2W0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005114 ; ENSMUSP00000005114 ; ENSMUSG00000004988 .
    GeneIDi 108017.
    KEGGi mmu:108017.
    UCSCi uc009dlh.1. mouse.

    Organism-specific databases

    CTDi 53828.
    MGIi MGI:1889005. Fxyd4.

    Phylogenomic databases

    eggNOGi NOG39705.
    GeneTreei ENSGT00530000063998.
    HOGENOMi HOG000234469.
    HOVERGENi HBG008212.
    InParanoidi Q9D2W0.
    KOi K13359.
    OMAi PGSASTC.
    OrthoDBi EOG7DNNXZ.
    PhylomeDBi Q9D2W0.
    TreeFami TF333443.

    Miscellaneous databases

    NextBioi 359895.
    PROi Q9D2W0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9D2W0.
    CleanExi MM_FXYD4.
    Genevestigatori Q9D2W0.

    Family and domain databases

    InterProi IPR000272. Ion-transport_regulator_FXYD.
    [Graphical view ]
    Pfami PF02038. ATP1G1_PLM_MAT8. 1 hit.
    [Graphical view ]
    ProDomi PD005989. PD005989. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS01310. FXYD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic sequence of mouse CHIF (FXYD4)."
      Garty H.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiFXYD4_MOUSE
    AccessioniPrimary (citable) accession number: Q9D2W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3