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Protein

FXYD domain-containing ion transport regulator 4

Gene

Fxyd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • ATPase binding Source: MGI
  • potassium channel activity Source: Ensembl
  • sodium channel regulator activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 4
Alternative name(s):
Channel-inducing factor
Short name:
CHIF
Gene namesi
Name:Fxyd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1889005. Fxyd4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 38ExtracellularSequence analysisAdd BLAST18
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Topological domaini60 – 88CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001036721 – 88FXYD domain-containing ion transport regulator 4Add BLAST68

Proteomic databases

PaxDbiQ9D2W0.
PRIDEiQ9D2W0.

PTM databases

iPTMnetiQ9D2W0.
PhosphoSitePlusiQ9D2W0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000004988.
CleanExiMM_FXYD4.
ExpressionAtlasiQ9D2W0. baseline and differential.
GenevisibleiQ9D2W0. MM.

Interactioni

GO - Molecular functioni

  • ATPase binding Source: MGI

Protein-protein interaction databases

BioGridi223770. 1 interactor.
STRINGi10090.ENSMUSP00000005114.

Structurei

3D structure databases

ProteinModelPortaliQ9D2W0.
SMRiQ9D2W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ9D2W0.
KOiK13359.
OrthoDBiEOG091G17M7.
PhylomeDBiQ9D2W0.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEITCAFLL LLAGLPALEA SDPVDKDSPF YYDWESLQLG GLIFGGLLCI
60 70 80
AGIAMALSGK CKCRRTHKPS SLPGKATPLI IPGSANTC
Length:88
Mass (Da):9,269
Last modified:June 1, 2001 - v1
Checksum:i7EB0140941CFE926
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362729 Genomic DNA. Translation: AAK51508.1.
AK018728 mRNA. Translation: BAB31372.1.
BC086918 mRNA. Translation: AAH86918.1.
CCDSiCCDS20468.1.
RefSeqiNP_001166843.1. NM_001173372.1.
NP_387468.1. NM_033648.1.
XP_006505358.1. XM_006505295.3.
UniGeneiMm.250392.

Genome annotation databases

EnsembliENSMUST00000005114; ENSMUSP00000005114; ENSMUSG00000004988.
ENSMUST00000203082; ENSMUSP00000144700; ENSMUSG00000004988.
ENSMUST00000204214; ENSMUSP00000145302; ENSMUSG00000004988.
GeneIDi108017.
KEGGimmu:108017.
UCSCiuc009dlh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF362729 Genomic DNA. Translation: AAK51508.1.
AK018728 mRNA. Translation: BAB31372.1.
BC086918 mRNA. Translation: AAH86918.1.
CCDSiCCDS20468.1.
RefSeqiNP_001166843.1. NM_001173372.1.
NP_387468.1. NM_033648.1.
XP_006505358.1. XM_006505295.3.
UniGeneiMm.250392.

3D structure databases

ProteinModelPortaliQ9D2W0.
SMRiQ9D2W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223770. 1 interactor.
STRINGi10090.ENSMUSP00000005114.

PTM databases

iPTMnetiQ9D2W0.
PhosphoSitePlusiQ9D2W0.

Proteomic databases

PaxDbiQ9D2W0.
PRIDEiQ9D2W0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005114; ENSMUSP00000005114; ENSMUSG00000004988.
ENSMUST00000203082; ENSMUSP00000144700; ENSMUSG00000004988.
ENSMUST00000204214; ENSMUSP00000145302; ENSMUSG00000004988.
GeneIDi108017.
KEGGimmu:108017.
UCSCiuc009dlh.1. mouse.

Organism-specific databases

CTDi53828.
MGIiMGI:1889005. Fxyd4.

Phylogenomic databases

GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ9D2W0.
KOiK13359.
OrthoDBiEOG091G17M7.
PhylomeDBiQ9D2W0.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-MMU-5578775. Ion homeostasis.
R-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9D2W0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004988.
CleanExiMM_FXYD4.
ExpressionAtlasiQ9D2W0. baseline and differential.
GenevisibleiQ9D2W0. MM.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXYD4_MOUSE
AccessioniPrimary (citable) accession number: Q9D2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.