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Q9D2W0

- FXYD4_MOUSE

UniProt

Q9D2W0 - FXYD4_MOUSE

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Protein
FXYD domain-containing ion transport regulator 4
Gene
Fxyd4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase binding Source: MGI
  2. potassium channel activity Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 4
Alternative name(s):
Channel-inducing factor
Short name:
CHIF
Gene namesi
Name:Fxyd4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1889005. Fxyd4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 3818Extracellular Reviewed prediction
Add
BLAST
Transmembranei39 – 5921Helical; Reviewed prediction
Add
BLAST
Topological domaini60 – 8829Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 8868FXYD domain-containing ion transport regulator 4
PRO_0000010367Add
BLAST

Proteomic databases

PRIDEiQ9D2W0.

PTM databases

PhosphoSiteiQ9D2W0.

Expressioni

Gene expression databases

BgeeiQ9D2W0.
CleanExiMM_FXYD4.
GenevestigatoriQ9D2W0.

Interactioni

Protein-protein interaction databases

BioGridi223770. 1 interaction.
STRINGi10090.ENSMUSP00000005114.

Structurei

3D structure databases

ProteinModelPortaliQ9D2W0.
SMRiQ9D2W0. Positions 23-87.

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39705.
GeneTreeiENSGT00530000063998.
HOGENOMiHOG000234469.
HOVERGENiHBG008212.
InParanoidiQ9D2W0.
KOiK13359.
OMAiPGSASTC.
OrthoDBiEOG7DNNXZ.
PhylomeDBiQ9D2W0.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2W0-1 [UniParc]FASTAAdd to Basket

« Hide

MEEITCAFLL LLAGLPALEA SDPVDKDSPF YYDWESLQLG GLIFGGLLCI   50
AGIAMALSGK CKCRRTHKPS SLPGKATPLI IPGSANTC 88
Length:88
Mass (Da):9,269
Last modified:June 1, 2001 - v1
Checksum:i7EB0140941CFE926
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF362729 Genomic DNA. Translation: AAK51508.1.
AK018728 mRNA. Translation: BAB31372.1.
BC086918 mRNA. Translation: AAH86918.1.
CCDSiCCDS20468.1.
RefSeqiNP_001166843.1. NM_001173372.1.
NP_387468.1. NM_033648.1.
XP_006505358.1. XM_006505295.1.
UniGeneiMm.250392.

Genome annotation databases

EnsembliENSMUST00000005114; ENSMUSP00000005114; ENSMUSG00000004988.
GeneIDi108017.
KEGGimmu:108017.
UCSCiuc009dlh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF362729 Genomic DNA. Translation: AAK51508.1 .
AK018728 mRNA. Translation: BAB31372.1 .
BC086918 mRNA. Translation: AAH86918.1 .
CCDSi CCDS20468.1.
RefSeqi NP_001166843.1. NM_001173372.1.
NP_387468.1. NM_033648.1.
XP_006505358.1. XM_006505295.1.
UniGenei Mm.250392.

3D structure databases

ProteinModelPortali Q9D2W0.
SMRi Q9D2W0. Positions 23-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223770. 1 interaction.
STRINGi 10090.ENSMUSP00000005114.

PTM databases

PhosphoSitei Q9D2W0.

Proteomic databases

PRIDEi Q9D2W0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005114 ; ENSMUSP00000005114 ; ENSMUSG00000004988 .
GeneIDi 108017.
KEGGi mmu:108017.
UCSCi uc009dlh.1. mouse.

Organism-specific databases

CTDi 53828.
MGIi MGI:1889005. Fxyd4.

Phylogenomic databases

eggNOGi NOG39705.
GeneTreei ENSGT00530000063998.
HOGENOMi HOG000234469.
HOVERGENi HBG008212.
InParanoidi Q9D2W0.
KOi K13359.
OMAi PGSASTC.
OrthoDBi EOG7DNNXZ.
PhylomeDBi Q9D2W0.
TreeFami TF333443.

Miscellaneous databases

NextBioi 359895.
PROi Q9D2W0.
SOURCEi Search...

Gene expression databases

Bgeei Q9D2W0.
CleanExi MM_FXYD4.
Genevestigatori Q9D2W0.

Family and domain databases

InterProi IPR000272. Ion-transport_regulator_FXYD.
[Graphical view ]
Pfami PF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view ]
ProDomi PD005989. PD005989. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS01310. FXYD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic sequence of mouse CHIF (FXYD4)."
    Garty H.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiFXYD4_MOUSE
AccessioniPrimary (citable) accession number: Q9D2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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