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Protein

Major facilitator superfamily domain-containing protein 10

Gene

Mfsd10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Protein family/group databases

TCDBi2.A.1.2.73. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 10
Alternative name(s):
Tetracycline transporter-like protein
Gene namesi
Name:Mfsd10
Synonyms:Tetran
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1915544. Mfsd10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei114 – 136HelicalSequence analysisAdd BLAST23
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei311 – 328HelicalSequence analysisAdd BLAST18
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246591 – 456Major facilitator superfamily domain-containing protein 10Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9D2V8.
MaxQBiQ9D2V8.
PaxDbiQ9D2V8.
PRIDEiQ9D2V8.

PTM databases

PhosphoSitePlusiQ9D2V8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000001082.
ExpressionAtlasiQ9D2V8. baseline and differential.
GenevisibleiQ9D2V8. MM.

Interactioni

Protein-protein interaction databases

BioGridi212789. 1 interactor.
STRINGi10090.ENSMUSP00000001109.

Structurei

3D structure databases

ProteinModelPortaliQ9D2V8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2615. Eukaryota.
ENOG410XSE0. LUCA.
GeneTreeiENSGT00830000128422.
HOGENOMiHOG000209369.
HOVERGENiHBG053800.
InParanoidiQ9D2V8.
OMAiWAGDAGC.
OrthoDBiEOG091G0814.
PhylomeDBiQ9D2V8.
TreeFamiTF314512.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9D2V8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWAGDAGCT PRPPIRPRPA SERRVIIVLF LGLLLDLLAF TLLLPLLPGL
60 70 80 90 100
LERHGREQDP LYGSWQRGVD WFASAIGMPA EKRYNSVLFG GLIGSAFSLL
110 120 130 140 150
QFFSAPLTGA ASDYLGRRPV MMLSLTGLAI SYAVWATSRS FKAFLASRVI
160 170 180 190 200
GGISKGNVNL STAIVADLGS PPTRSQGMAV IGVAFSLAFT LGPMLGAFLS
210 220 230 240 250
VEMVPWISLL FAISDMLFIF CFLPETLPQE KRASSVTLGF HTAAHLLSPL
260 270 280 290 300
ALLRFAAVTH SQDPPAEHRL RNLRRLGLVY FLYLFLFSGL EYTLSFLAHQ
310 320 330 340 350
RFQFSSLQQG KMFFFIGLTM ATIQGTYARR ISPGKEAAAV TRAMLLLVPA
360 370 380 390 400
FLLIGWAHSL PTLGLGLMLY SFAAAVVVPG LSTMVSSYGS PGQKGTIMGI
410 420 430 440 450
LRSLGALGRA LGPVVAASVY WLTGAQVCFT VCSALFLLPF LLLWKLKHPA

ETSKEE
Length:456
Mass (Da):49,369
Last modified:June 1, 2001 - v1
Checksum:i242AD79516B266F6
GO

Sequence cautioni

The sequence BAB22982 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177G → R in BAB22982 (PubMed:16141072).Curated1
Sequence conflicti340V → M in BAE31219 (PubMed:16141072).Curated1
Sequence conflicti384M → L in BAE31219 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003763 mRNA. Translation: BAB22982.1. Different initiation.
AK018736 mRNA. Translation: BAB31378.1.
AK089055 mRNA. Translation: BAC40724.1.
AK144407 mRNA. Translation: BAE25874.1.
AK152438 mRNA. Translation: BAE31219.1.
BC023012 mRNA. Translation: AAH23012.1.
BC064775 mRNA. Translation: AAH64775.1.
CCDSiCCDS19217.1.
RefSeqiNP_080936.1. NM_026660.2.
XP_006504140.1. XM_006504077.3.
XP_006504141.1. XM_006504078.3.
XP_011239069.1. XM_011240767.2.
XP_011239070.1. XM_011240768.2.
XP_017176573.1. XM_017321084.1.
UniGeneiMm.34564.

Genome annotation databases

EnsembliENSMUST00000001109; ENSMUSP00000001109; ENSMUSG00000001082.
ENSMUST00000114329; ENSMUSP00000109968; ENSMUSG00000001082.
ENSMUST00000114331; ENSMUSP00000109970; ENSMUSG00000001082.
GeneIDi68294.
KEGGimmu:68294.
UCSCiuc008xct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003763 mRNA. Translation: BAB22982.1. Different initiation.
AK018736 mRNA. Translation: BAB31378.1.
AK089055 mRNA. Translation: BAC40724.1.
AK144407 mRNA. Translation: BAE25874.1.
AK152438 mRNA. Translation: BAE31219.1.
BC023012 mRNA. Translation: AAH23012.1.
BC064775 mRNA. Translation: AAH64775.1.
CCDSiCCDS19217.1.
RefSeqiNP_080936.1. NM_026660.2.
XP_006504140.1. XM_006504077.3.
XP_006504141.1. XM_006504078.3.
XP_011239069.1. XM_011240767.2.
XP_011239070.1. XM_011240768.2.
XP_017176573.1. XM_017321084.1.
UniGeneiMm.34564.

3D structure databases

ProteinModelPortaliQ9D2V8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212789. 1 interactor.
STRINGi10090.ENSMUSP00000001109.

Protein family/group databases

TCDBi2.A.1.2.73. the major facilitator superfamily (mfs).

PTM databases

PhosphoSitePlusiQ9D2V8.

Proteomic databases

EPDiQ9D2V8.
MaxQBiQ9D2V8.
PaxDbiQ9D2V8.
PRIDEiQ9D2V8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001109; ENSMUSP00000001109; ENSMUSG00000001082.
ENSMUST00000114329; ENSMUSP00000109968; ENSMUSG00000001082.
ENSMUST00000114331; ENSMUSP00000109970; ENSMUSG00000001082.
GeneIDi68294.
KEGGimmu:68294.
UCSCiuc008xct.1. mouse.

Organism-specific databases

CTDi10227.
MGIiMGI:1915544. Mfsd10.

Phylogenomic databases

eggNOGiKOG2615. Eukaryota.
ENOG410XSE0. LUCA.
GeneTreeiENSGT00830000128422.
HOGENOMiHOG000209369.
HOVERGENiHBG053800.
InParanoidiQ9D2V8.
OMAiWAGDAGC.
OrthoDBiEOG091G0814.
PhylomeDBiQ9D2V8.
TreeFamiTF314512.

Miscellaneous databases

ChiTaRSiMfsd10. mouse.
PROiQ9D2V8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001082.
ExpressionAtlasiQ9D2V8. baseline and differential.
GenevisibleiQ9D2V8. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMFS10_MOUSE
AccessioniPrimary (citable) accession number: Q9D2V8
Secondary accession number(s): Q3U800, Q3UN73, Q9D1A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.