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Protein

Sperm acrosome-associated protein 7

Gene

Spaca7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell wall macromolecule catabolic process Source: GO_Central
  • defense response to Gram-negative bacterium Source: GO_Central
  • defense response to Gram-positive bacterium Source: GO_Central
  • negative regulation of cell adhesion Source: MGI
  • single fertilization Source: MGI

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm acrosome-associated protein 7Imported
Gene namesi
Name:Spaca7Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1925884. Spaca7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000035056925 – 182Sperm acrosome-associated protein 7Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9D2S4.
PRIDEiQ9D2S4.

PTM databases

PhosphoSitePlusiQ9D2S4.

Expressioni

Tissue specificityi

Testis-specific (PubMed:22495889, PubMed:24307706). Expressed in zygotene and pachytene spermatocytes, round spermatids, elongating spermatids and spermatozoa (at protein level) (PubMed:22495889, PubMed:24307706). Testis-specific (PubMed:22495889).2 Publications

Gene expression databases

BgeeiENSMUSG00000010435.
ExpressionAtlasiQ9D2S4. baseline and differential.
GenevisibleiQ9D2S4. MM.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J5PZ. Eukaryota.
ENOG411168G. LUCA.
GeneTreeiENSGT00390000018090.
HOVERGENiHBG058480.
InParanoidiQ9D2S4.
OMAiCCWQETE.
OrthoDBiEOG091G0Z0J.
PhylomeDBiQ9D2S4.
TreeFamiTF338340.

Family and domain databases

InterProiView protein in InterPro
IPR029301. SPACA7.
PfamiView protein in Pfam
PF15307. SPACA7. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9D2S4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAANRGSRTF LSVFLLCCWQ GAELQPIKTT SGPITEGSLN STTENIPEAL
60 70 80 90 100
DEILAQEILE PKTSAVSETS PRPRSSILTT VQTKEINAGI DENYQEEAFE
110 120 130 140 150
NYHEVLENIE HLPTKEESGK NDRSTVANLH DHSSQTKHEP PSSPEGKGSS
160 170 180
NDDVYGKLSV LDKILENIGQ SEGSLELTES IF
Length:182
Mass (Da):19,943
Last modified:June 1, 2001 - v1
Checksum:iEFDC925007409BB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK018926 mRNA. Translation: BAB31486.1.
CCDSiCCDS40222.1.
RefSeqiNP_077241.1. NM_024279.2.
UniGeneiMm.116871.

Genome annotation databases

EnsembliENSMUST00000010579; ENSMUSP00000010579; ENSMUSG00000010435.
GeneIDi78634.
KEGGimmu:78634.
UCSCiuc009kwc.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiSPAC7_MOUSE
AccessioniPrimary (citable) accession number: Q9D2S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot