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Protein

Acetoacetyl-CoA synthetase

Gene

Aacs

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity

Catalytic activityi

ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-77111 Synthesis of Ketone Bodies

Names & Taxonomyi

Protein namesi
Recommended name:
Acetoacetyl-CoA synthetase (EC:6.2.1.16)
Gene namesi
Name:Aacs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926144 Aacs

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157861 – 672Acetoacetyl-CoA synthetaseAdd BLAST672

Proteomic databases

EPDiQ9D2R0
MaxQBiQ9D2R0
PaxDbiQ9D2R0
PeptideAtlasiQ9D2R0
PRIDEiQ9D2R0

PTM databases

iPTMnetiQ9D2R0
PhosphoSitePlusiQ9D2R0
SwissPalmiQ9D2R0

Expressioni

Gene expression databases

BgeeiENSMUSG00000029482
CleanExiMM_AACS
GenevisibleiQ9D2R0 MM

Interactioni

Protein-protein interaction databases

BioGridi219689, 1 interactor
IntActiQ9D2R0, 2 interactors
MINTiQ9D2R0
STRINGi10090.ENSMUSP00000031445

Structurei

3D structure databases

ProteinModelPortaliQ9D2R0
SMRiQ9D2R0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1175 Eukaryota
COG0365 LUCA
GeneTreeiENSGT00900000141060
HOGENOMiHOG000229992
HOVERGENiHBG059947
InParanoidiQ9D2R0
KOiK01907
OMAiYEYVYRC
OrthoDBiEOG091G05B0
PhylomeDBiQ9D2R0
TreeFamiTF354241

Family and domain databases

InterProiView protein in InterPro
IPR005914 Acac_CoA_synth
IPR032387 ACAS_N
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF16177 ACAS_N, 1 hit
PF00501 AMP-binding, 1 hit
TIGRFAMsiTIGR01217 ac_ac_CoA_syn, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q9D2R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLARLERE EIMECQVMWE PDSKKDTQMD RFRAAVGTAC GLALGNYNDL
60 70 80 90 100
YHWSVRSYMD FWAEFWKFSG IVYSRMYDEV VDTSKGIADV PEWFRGSRLN
110 120 130 140 150
YAENLLRHKE NDRVALYVAR EGREEIVKVT FEELRQQVAL FAAAMRKMGV
160 170 180 190 200
KKGDRVVGYL PNSAHAVEAM LAAASIGAIW SSTSPDFGVN GVLDRFSQIQ
210 220 230 240 250
PKLIFSVEAV VYNGKEHGHL EKLQRVVKGL PDLQRVVLIP YVLPREKIDI
260 270 280 290 300
SKIPNSVFLD DFLASGTGAQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
310 320 330 340 350
VHSAGGTLIQ HLKEHMLHGN MTSSDILLYY TTVGWMMWNW MVSALATGAS
360 370 380 390 400
LVLYDGSPLV PTPNVLWDLV DRIGITILGT GAKWLSVLEE KDMKPVETHN
410 420 430 440 450
LHTLHTILST GSPLKAQSYE YVYRCIKSSV LLGSISGGTD IISCFMGQNS
460 470 480 490 500
SIPVYKGEIQ ARNLGMAVEA WDEEGKAVWG ASGELVCTKP IPCQPTHFWN
510 520 530 540 550
DENGSKYRKA YFSKFPGVWA HGDYCRINPK TGGIIMLGRS DGTLNPNGVR
560 570 580 590 600
FGSSEIYNIV EAFDEVEDSL CVPQYNRDGE ERVVLFLKMA SGHTFQPDLV
610 620 630 640 650
KRIRDAIRLG LSARHVPSLI LETRGIPYTL NGKKVEVAVK QVMAGRTVEH
660 670
RGAFSNPETL DLYRDIPELQ DF
Length:672
Mass (Da):75,200
Last modified:June 1, 2001 - v1
Checksum:i547E7F9B14C8BF7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti260 – 261DD → EY in BAF44057 (Ref. 1) Curated2
Sequence conflicti401L → P in BAF44057 (Ref. 1) Curated1
Sequence conflicti427K → T in BAF44057 (Ref. 1) Curated1
Sequence conflicti515F → S in BAE29423 (PubMed:16141072).Curated1
Sequence conflicti649E → G in BAE41938 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054122 mRNA Translation: BAF44057.1
AB056114 mRNA Translation: BAB63403.1
AK019063 mRNA Translation: BAB31530.1
AK034184 mRNA Translation: BAC28621.1
AK043848 mRNA Translation: BAC31680.1
AK044017 mRNA Translation: BAC31740.1
AK147189 mRNA Translation: BAE27749.1
AK150266 mRNA Translation: BAE29423.1
AK165418 mRNA Translation: BAE38173.1
AK165457 mRNA Translation: BAE38197.1
AK170120 mRNA Translation: BAE41577.1
AK170653 mRNA Translation: BAE41938.1
AK170856 mRNA Translation: BAE42076.1
BC026817 mRNA Translation: AAH26817.1
CCDSiCCDS19687.1
RefSeqiNP_084486.1, NM_030210.1
UniGeneiMm.431573
Mm.478133

Genome annotation databases

EnsembliENSMUST00000031445; ENSMUSP00000031445; ENSMUSG00000029482
GeneIDi78894
KEGGimmu:78894
UCSCiuc008zrs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAACS_MOUSE
AccessioniPrimary (citable) accession number: Q9D2R0
Secondary accession number(s): A1IG47, Q3TCL8, Q3UD39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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