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Protein

Probable tRNA (uracil-O(2)-)-methyltransferase

Gene

Trmt44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O2-)-methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + uridine(44) in tRNA(Ser) = S-adenosyl-L-homocysteine + 2'-O-methyluridine(44) in tRNA(Ser).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 698C3H1-typePROSITE-ProRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable tRNA (uracil-O(2)-)-methyltransferase (EC:2.1.1.211)
Alternative name(s):
Methyltransferase-like protein 19
Gene namesi
Name:Trmt44
Synonyms:Mettl19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1926140. Trmt44.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002498951 – 713Probable tRNA (uracil-O(2)-)-methyltransferaseAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei76PhosphoserineBy similarity1
Modified residuei489PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9D2Q2.
MaxQBiQ9D2Q2.
PaxDbiQ9D2Q2.
PeptideAtlasiQ9D2Q2.
PRIDEiQ9D2Q2.

PTM databases

iPTMnetiQ9D2Q2.
PhosphoSitePlusiQ9D2Q2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029097.
CleanExiMM_2310079F23RIK.
ExpressionAtlasiQ9D2Q2. baseline and differential.
GenevisibleiQ9D2Q2. MM.

Structurei

3D structure databases

ProteinModelPortaliQ9D2Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRM44 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri669 – 698C3H1-typePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3790. Eukaryota.
ENOG410YQ45. LUCA.
GeneTreeiENSGT00390000000645.
HOGENOMiHOG000004858.
InParanoidiQ9D2Q2.
KOiK15447.
OMAiECGGIKT.
OrthoDBiEOG091G05XY.
TreeFamiTF106127.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiView protein in InterPro
IPR029063. SAM-dependent_MTases.
IPR011671. tRNA_uracil_MeTrfase.
IPR000571. Znf_CCCH.
PfamiView protein in Pfam
PF07757. AdoMet_MTase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS50103. ZF_C3H1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9D2Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELGRVRLS DPDALLPAGF WAAVTVWLER PQVANKRLCG ARMEARGRTL
60 70 80 90 100
RSHAQAECGP RQGQGHGLER EPGQASPKGE PESGPRASRE GTAPAADLNS
110 120 130 140 150
LWDRVSQSLV HANPEMLAFL CGPSLGPQPE AAQELDLILR TVIPKASPHS
160 170 180 190 200
PLTEPKKELV VQDVSSGSVT FLPLEEDNEG NLEVKTSNVY QLHLHHNEGE
210 220 230 240 250
WFISVLIFCP ERWHSDGVVY PKPAWLGEEL LSKLARWAVE NRKSEFKSTL
260 270 280 290 300
SLVSILRYSR MYQELKEKYR DMVKVWPEVT DPEKFVYEDV AIATYLLILW
310 320 330 340 350
EEERAEKGVT TKQSFVDLGC GNGLLVHILS NEGHPGRGID IRRRKIWDMY
360 370 380 390 400
GPQTQLEEGS ITPSDETLFP GVDWLIGNHS DELTPWIPVI AARSSYTCRF
410 420 430 440 450
FVLPCCFFDF VGRYQRQQSR KTQYREYLDF VLEVGLSCGF HVQEDCLRIP
460 470 480 490 500
STKRVCLIGK SRTYPPSAEV WMDEQRTRYL HSRQGHPQSR PGGAHAPSAP
510 520 530 540 550
QTAAHDAGLQ DSCRTVNAGS ECVLEGLAAE RGAGAPAPGL WVPGFCPREK
560 570 580 590 600
AERVRNCAAL PRDFVDQVVL QVANLLLDRK KFNTGNSEAR SLKPWNGGGS
610 620 630 640 650
LSLAEVAAEL NSETLQRLKR ECGGLQTLLK NSHQVFEVLN GRVHIRDWRQ
660 670 680 690 700
ELQRGKPPEA KQNLSAAVFK TRICWFFAHH PDGCVLPAAQ CPFAHGPEEL
710
RLSQTLKKQR QAP
Length:713
Mass (Da):79,836
Last modified:July 27, 2011 - v2
Checksum:iD95B2353192FF449
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti511D → Y in BAB31547 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019101 mRNA. Translation: BAB31547.1.
AK132402 mRNA. Translation: BAE21147.1.
CH466524 Genomic DNA. Translation: EDL37486.1.
BC152332 mRNA. Translation: AAI52333.1.
CCDSiCCDS19230.1.
RefSeqiNP_084484.2. NM_030208.3.
UniGeneiMm.98522.

Genome annotation databases

EnsembliENSMUST00000030980; ENSMUSP00000030980; ENSMUSG00000029097.
GeneIDi78890.
KEGGimmu:78890.
UCSCiuc008xdu.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTRM44_MOUSE
AccessioniPrimary (citable) accession number: Q9D2Q2
Secondary accession number(s): A7MCV4, Q3V1K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 27, 2011
Last modified: July 5, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families