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Protein

Myelin-associated oligodendrocyte basic protein

Gene

Mobp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin-associated oligodendrocyte basic protein
Gene namesi
Name:Mobp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108511. Mobp.

Subcellular locationi

GO - Cellular componenti

  • cortical actin cytoskeleton Source: GO_Central
  • mitochondrion Source: MGI
  • myelin sheath Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002810261 – 170Myelin-associated oligodendrocyte basic proteinAdd BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineCombined sources1
Modified residuei98PhosphoserineBy similarity1
Modified residuei107PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9D2P8.
PeptideAtlasiQ9D2P8.
PRIDEiQ9D2P8.

PTM databases

iPTMnetiQ9D2P8.
PhosphoSitePlusiQ9D2P8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032517.
CleanExiMM_MOBP.
GenevisibleiQ9D2P8. MM.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ9D2P8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati93 – 10119
Repeati105 – 11026
Repeati111 – 1153; half-length5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni93 – 1153 X 9 AA approximate tandem repeatsAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 155Pro-richAdd BLAST81

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JBJP. Eukaryota.
ENOG41115IU. LUCA.
GeneTreeiENSGT00390000013933.
HOVERGENiHBG081977.
InParanoidiQ9D2P8.
OMAiCACQKTS.
OrthoDBiEOG091G14LC.
PhylomeDBiQ9D2P8.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9D2P8-1) [UniParc]FASTAAdd to basket
Also known as: MOBP170

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSQKMAKEGP RLSKNQKFSE HFSIHCCPPF TFLNSKREIV DRKYSICKSG
60 70 80 90 100
CFYQKKEEDW ICCACQKTSR RATSPQRPKH QPAASPVVVR APPAKPKSPL
110 120 130 140 150
MPAKPRSPPR PAKPRSPSRT ERQPRPRPEV RPPPAKQKPP QKSKQPARSS
160 170
PLRGPGTSRG GSPTRAPRFW
Length:170
Mass (Da):19,197
Last modified:June 1, 2001 - v1
Checksum:iE3132C958C631BC4
GO
Isoform 2 (identifier: Q9D2P8-2) [UniParc]FASTAAdd to basket
Also known as: MOBP81

The sequence of this isoform differs from the canonical sequence as follows:
     69-81: SRRATSPQRPKHQ → RLRRRSRSTPRKK
     82-170: Missing.

Show »
Length:81
Mass (Da):9,708
Checksum:iD4592F1D8DEB9F52
GO
Isoform 3 (identifier: Q9D2P8-3) [UniParc]FASTAAdd to basket
Also known as: MOBP73

The sequence of this isoform differs from the canonical sequence as follows:
     69-73: SRRAT → RTVRK
     74-170: Missing.

Show »
Length:73
Mass (Da):8,670
Checksum:i753DBC7123E90C05
GO
Isoform 4 (identifier: Q9D2P8-4) [UniParc]FASTAAdd to basket
Also known as: MOBP69

The sequence of this isoform differs from the canonical sequence as follows:
     69-69: S → R
     70-170: Missing.

Show »
Length:69
Mass (Da):8,186
Checksum:iA3E90C0518F0D11C
GO
Isoform 5 (identifier: Q9D2P8-5) [UniParc]FASTAAdd to basket
Also known as: MOBP74

The sequence of this isoform differs from the canonical sequence as follows:
     70-73: RRAT → MTFW
     74-170: Missing.

Show »
Length:73
Mass (Da):8,682
Checksum:i65607F0612590C05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5M → V in AAF60192 (PubMed:10328883).Curated1
Sequence conflicti5M → V in AAF60193 (PubMed:10328883).Curated1
Sequence conflicti5M → V in AAF60194 (PubMed:10328883).Curated1
Sequence conflicti5M → V in AAF60195 (PubMed:10328883).Curated1
Sequence conflicti5M → V in AAF60196 (PubMed:10328883).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02393669 – 81SRRAT…RPKHQ → RLRRRSRSTPRKK in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_02393769 – 73SRRAT → RTVRK in isoform 3. Curated5
Alternative sequenceiVSP_02393869S → R in isoform 4. Curated1
Alternative sequenceiVSP_02393970 – 170Missing in isoform 4. CuratedAdd BLAST101
Alternative sequenceiVSP_02394070 – 73RRAT → MTFW in isoform 5. Curated4
Alternative sequenceiVSP_02394174 – 170Missing in isoform 3 and isoform 5. CuratedAdd BLAST97
Alternative sequenceiVSP_02394282 – 170Missing in isoform 2. 2 PublicationsAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81317 mRNA. Translation: AAB65617.1.
AF120475 Genomic DNA. Translation: AAF60192.1.
AF120476, AF120475 Genomic DNA. Translation: AAF60193.1.
AF120475 Genomic DNA. Translation: AAF60194.1.
AF120476, AF120475 Genomic DNA. Translation: AAF60195.1.
AF120477, AF120475 Genomic DNA. Translation: AAF60196.1.
DQ360291 Genomic DNA. Translation: ABC95974.1.
DQ360292 Genomic DNA. Translation: ABC95978.1.
AK013799 mRNA. Translation: BAB28998.1.
AK019323 mRNA. Translation: BAB31666.1.
AK028057 mRNA. Translation: BAC25727.1.
AK083103 mRNA. Translation: BAC38761.1.
AK140055 mRNA. Translation: BAE24224.1.
BC048492 mRNA. Translation: AAH48492.1.
CCDSiCCDS23626.1. [Q9D2P8-1]
CCDS40808.1. [Q9D2P8-2]
RefSeqiNP_001034453.1. NM_001039364.2. [Q9D2P8-2]
NP_001034454.1. NM_001039365.2. [Q9D2P8-1]
NP_032640.1. NM_008614.2. [Q9D2P8-2]
UniGeneiMm.486167.

Genome annotation databases

EnsembliENSMUST00000068698; ENSMUSP00000071084; ENSMUSG00000032517. [Q9D2P8-1]
ENSMUST00000093773; ENSMUSP00000091287; ENSMUSG00000032517. [Q9D2P8-2]
ENSMUST00000111627; ENSMUSP00000107254; ENSMUSG00000032517. [Q9D2P8-2]
ENSMUST00000174193; ENSMUSP00000134410; ENSMUSG00000032517. [Q9D2P8-2]
GeneIDi17433.
KEGGimmu:17433.
UCSCiuc009scj.1. mouse. [Q9D2P8-1]
uc009sck.1. mouse. [Q9D2P8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81317 mRNA. Translation: AAB65617.1.
AF120475 Genomic DNA. Translation: AAF60192.1.
AF120476, AF120475 Genomic DNA. Translation: AAF60193.1.
AF120475 Genomic DNA. Translation: AAF60194.1.
AF120476, AF120475 Genomic DNA. Translation: AAF60195.1.
AF120477, AF120475 Genomic DNA. Translation: AAF60196.1.
DQ360291 Genomic DNA. Translation: ABC95974.1.
DQ360292 Genomic DNA. Translation: ABC95978.1.
AK013799 mRNA. Translation: BAB28998.1.
AK019323 mRNA. Translation: BAB31666.1.
AK028057 mRNA. Translation: BAC25727.1.
AK083103 mRNA. Translation: BAC38761.1.
AK140055 mRNA. Translation: BAE24224.1.
BC048492 mRNA. Translation: AAH48492.1.
CCDSiCCDS23626.1. [Q9D2P8-1]
CCDS40808.1. [Q9D2P8-2]
RefSeqiNP_001034453.1. NM_001039364.2. [Q9D2P8-2]
NP_001034454.1. NM_001039365.2. [Q9D2P8-1]
NP_032640.1. NM_008614.2. [Q9D2P8-2]
UniGeneiMm.486167.

3D structure databases

ProteinModelPortaliQ9D2P8.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ9D2P8.
PhosphoSitePlusiQ9D2P8.

Proteomic databases

PaxDbiQ9D2P8.
PeptideAtlasiQ9D2P8.
PRIDEiQ9D2P8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068698; ENSMUSP00000071084; ENSMUSG00000032517. [Q9D2P8-1]
ENSMUST00000093773; ENSMUSP00000091287; ENSMUSG00000032517. [Q9D2P8-2]
ENSMUST00000111627; ENSMUSP00000107254; ENSMUSG00000032517. [Q9D2P8-2]
ENSMUST00000174193; ENSMUSP00000134410; ENSMUSG00000032517. [Q9D2P8-2]
GeneIDi17433.
KEGGimmu:17433.
UCSCiuc009scj.1. mouse. [Q9D2P8-1]
uc009sck.1. mouse. [Q9D2P8-2]

Organism-specific databases

CTDi4336.
MGIiMGI:108511. Mobp.

Phylogenomic databases

eggNOGiENOG410JBJP. Eukaryota.
ENOG41115IU. LUCA.
GeneTreeiENSGT00390000013933.
HOVERGENiHBG081977.
InParanoidiQ9D2P8.
OMAiCACQKTS.
OrthoDBiEOG091G14LC.
PhylomeDBiQ9D2P8.

Miscellaneous databases

ChiTaRSiMobp. mouse.
PROiQ9D2P8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032517.
CleanExiMM_MOBP.
GenevisibleiQ9D2P8. MM.

Family and domain databases

InterProiIPR026666. Mobp.
IPR011011. Znf_FYVE_PHD.
[Graphical view]
PANTHERiPTHR14555:SF5. PTHR14555:SF5. 1 hit.
PfamiPF02318. FYVE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOBP_MOUSE
AccessioniPrimary (citable) accession number: Q9D2P8
Secondary accession number(s): O35713
, Q792D7, Q792D8, Q9JLY4, Q9JLY5, Q9JLY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.